Secretory molecules

ABSTRACT

The present invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.

TECHNICAL FIELD

[0001] The present invention relates to secretory molecules and to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, the expression of secretory molecules.

BACKGROUND OF THE INVENTION

[0002] Protein transport and secretion are essential for cellular function. Protein transport is mediated by a signal peptide located at the amino terminus of the protein to be transported or secreted. The signal peptide is comprised of about ten to twenty hydrophobic amino acids which target the nascent protein from the ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Proteins targeted to the ER may either proceed through the secretory pathway or remain in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that transit through the secretory pathway are either secreted into the extracellular space or retained in the plasma membrane. Proteins that are retained in the plasma membrane contain one or more transmembrane domains, each comprised of about 20 hydrophobic amino acid residues. Proteins that are secreted from the cell are generally synthesized as inactive precursors that are activated by post-translational processing events during transit through the secretory pathway. Such events include glycosylation, proteolysis, and removal of the signal peptide by a signal peptidase. Other events that may occur during protein transport include chaperone-dependent unfolding and folding of the nascent protein and interaction of the protein with a receptor or pore complex. Examples of secretory proteins with amino terminal signal peptides are discussed below and include proteins with important roles in cell-to-cell signaling. Such proteins include transmembrane receptors and cell surface markers, extracellular matrix molecules, cytokines, hormones, growth and differentiation factors, neuropeptides, vasomediators, ion channels, transporters/pumps, and proteases. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of The Cell, Garland Publishing, New York N.Y., pp. 557-560, 582-592.)

[0003] G-protein coupled receptors (GPCRs) comprise a superfamily of integral membrane proteins which transduce extracellular signals. Not all GPCRs contain N-terminal signal peptides. GPCRs include receptors for biogenic amines such as dopamine, epinephrine, histamine, glutamate (metabotropic-type), acetylcholine (muscarinic-type), and serotonin; for lipid mediators of inflammation such as prostaglandins, platelet activating factor, and leukotrienes; for peptide hormones such as calcitonin, C5a anaphylatoxin, follicle stimulating hormone, gonadotropin releasing hormone, neurokinin, oxytocin, and thrombin; and for sensory signal mediators such as retinal photopigments and olfactory stimulatory molecules. The structure of these highly conserved receptors consists of seven hydrophobic transmembrane regions, cysteine disulfide bridges between the second and third extracellular loops, an extracellular N-terminus, and a cytoplasmic C-terminus. The N-terminus interacts with ligands, the disulfide bridges interact with agonists and antagonists, and the large third intracellular loop interacts with G proteins to activate second messengers such as cyclic AMP, phospholipase C, inositol triphosphate, or ion channels. (Reviewed in Watson, S. and Arlinstall, S. (1994) The G-protein Linked Receptor Facts Book, Academic Press, San Diego Calif., pp. 2-6; and Bolander, F. F. (1994) Molecular Endocrinology, Academic Press, San Diego Calif., pp. 162-176.)

[0004] Other types of receptors include cell surface antigens identified on leukocytic cells of the immune system. These antigens have been identified using systematic, monoclonal antibody (mAb)-based “shot gun” techniques. These techniques have resulted in the production of hundreds of mAbs directed against unknown cell surface leukocytic antigens. These antigens have been grouped into “clusters of differentiation” based on common immunocytochemical localization patterns in various differentiated and undifferentiated leukocytic cell types. Antigens in a given cluster are presumed to identify a single cell surface protein and are assigned a “cluster of differentiation” or “CD” designation. Some of the genes encoding proteins identified by CD antigens have been cloned and verified by standard molecular biology techniques. CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatidylinositol (GPI). (Reviewed in Barclay, A. N. et al. (1995) The Leucocyte Antigen Facts Book, Academic Press, San Diego Calif., pp. 17-20.)

[0005] Matrix proteins (MPs) are transmembrane and extracellular proteins which function in formation, growth, remodeling, and maintenance of tissues and as important mediators and regulators of the inflammatory response. The expression and balance of MPs may be perturbed by biochemical changes that result from congenital, epigenetic, or infectious diseases. In addition, MPs affect leukocyte migration, proliferation, differentiation, and activation in the immune response. MPs are frequently characterized by the presence of one or more domains which may include collagen-like domains, EGF-like domains, immunoglobulin-like domains, and fibronectin-like domains. In addition, MPs may be heavily glycosylated and may contain an Arginine-Glycine-Aspartate (RGD) tripeptide motif which may play a role in adhesive interactions. MPs include extracellular proteins such as fibronectin, collagen, galectin, vitronectin and its proteolytic derivative somatomedin B; and cell adhesion receptors such as cell adhesion molecules (CAMs), cadherins, and integrins. (Reviewed in Ayad, S. et al. (1994) The Extracellular Matrix Facts Book, Academic Press, San Diego Calif., pp. 2-16; Ruoslahti, E. (1997) Kidney Int. 51:1413-1417; Sjaastad, M. D. and Nelson, W. J. (1997) BioEssays 19:47-55.)

[0006] Cytokines are secreted by hematopoietic cells in response to injury or infection. Interleukins, neurotrophins, growth factors, interferons, and chemokines all define cytokine families that work in conjunction with cellular receptors to regulate cell proliferation and differentiation. In addition, cytokines effect activities such as leukocyte migration and function, hematopoietic cell proliferation, temperature regulation, acute response to infection, tissue remodeling, and apoptosis.

[0007] Chemokines, in particular, are small chemoattractant cytokines involved in inflammation, leukocyte proliferation and migration, angiogenesis and angiostasis, regulation of hematopoiesis, HIV infectivity, and stimulation of cytokine secretion. Chemokines generally contain 70-100 amino acids and are subdivided into four subfamilies based on the presence of conserved cysteine-based motifs. (Callard, R. and Gearing, A. (1994) The Cytokine Facts Book, Academic Press, New York N.Y., pp. 181-190, 210-213, 223-227.)

[0008] Growth and differentiation factors are secreted proteins which function in intercellular communication. Some factors require oligomerization or association with MPs for activity. Complex interactions among these factors and their receptors trigger intracellular signal transduction pathways that stimulate or inhibit cell division, cell differentiation, cell signaling, and cell motility. Most growth and differentiation factors act on cells in their local environment (paracrine signaling). There are three broad classes of growth and differentiation factors. The first class includes the large polypeptide growth factors such as epidermal growth factor, fibroblast growth factor, transforming growth factor, insulin-like growth factor, and platelet-derived growth factor. The second class includes the hematopoietic growth factors such as the colony stimulating factors (CSFs). Hematopoietic growth factors stimulate the proliferation and differentiation of blood cells such as B-lymphocytes, T-lymphocytes, erythrocytes, platelets, eosinophils, basophils, neutrophils, macrophages, and their stem cell precursors. The third class includes small peptide factors such as bombesin, vasopressin, oxytocin, endothelin, transferrin, angiotensin II, vasoactive intestinal peptide, and bradykinin which function as hormones to regulate cellular functions other than proliferation.

[0009] Growth and differentiation factors play critical roles in neoplastic transformation of cells in vitro and in tumor progression in vivo. Inappropriate expression of growth factors by tumor cells may contribute to vascularization and metastasis of tumors. During hematopoiesis, growth factor misregulation can result in anemias, leukemias, and lymphomas. Certain growth factors such as interferon are cytotoxic to tumor cells both in vivo and in vitro. Moreover, some growth factors and growth factor receptors are related both structurally and functionally to oncoproteins. In addition, growth factors affect transcriptional regulation of both proto-oncogenes and oncosuppressor genes. (Reviewed in Pimentel, E. (1994) Handbook of Growth Factors, CRC Press, Ann Arbor Mich., pp. 1-9.)

[0010] Proteolytic enzymes or proteases either activate or deactivate proteins by hydrolyzing peptide bonds. Proteases are found in the cytosol, in membrane-bound compartments, and in the extracellular space. The major families are the zinc, serine, cysteine, thiol, and carboxyl proteases.

[0011] Ion channels, ion pumps, and transport proteins mediate the transport of molecules across cellular membranes. Transport can occur by a passive, concentration-dependent mechanism or can be linked to an energy source such as ATP hydrolysis. Symporters and antiporters transport ions and small molecules such as amino acids, glucose, and drugs. Symporters transport molecules and ions unidirectionally, and antiporters transport molecules and ions bidirectionally. Transporter superfamilies include facilitative transporters and active ATP-binding cassette transporters which are involved in multipledrug resistance and the targeting of antigenic peptides to MHC Class I molecules. These transporters bind to a specific ion or other molecule and undergo a conformational change in order to transfer the ion or molecule across the membrane. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of The Cell, Garland Publishing, New York N.Y., pp. 523-546.)

[0012] Ion channels are formed by transmembrane proteins which create a lined passageway across the membrane through which water and ions, such as Na⁺, K⁺, Ca²⁺, and Cl⁻, enter and exit the cell. For example, chloride channels are involved in the regulation of the membrane electric potential as well as absorption and secretion of ions across the membrane. Chloride channels also regulate the internal pH of membrane-bound organelles.

[0013] Ion pumps are ATPases which actively maintain membrane gradients. Ion pumps are classified as P, V, or F according to their structure and function. All have one or more binding sites for ATP in their cytosolic domains. The P-class ion pumps include Ca²⁺ ATPase and Na⁺/K⁺ ATPase and function in transporting H⁺, Na⁺, K⁺, and Ca²⁺ ions. P-class pumps consist of two a and two β transmembrane subunits. The V- and F-class ion pumps have similar structures but transport only H⁺. F class H⁺ pumps mediate transport across the membranes of mitochondria and chloroplasts, while V-class H⁺ pumps regulate acidity inside lysosomes, endosomes, and plant vacuoles.

[0014] A family of structurally related intrinsic membrane proteins known as facilitative glucose transporters catalyze the movement of glucose and other selected sugars across the plasma membrane. The proteins in this family contain a highly conserved, large transmembrane domain comprised of 12 α-helices, and several weakly conserved, cytoplasmic and exoplasmic domains. (Pessin, J. E. and Bell, G. I. (1992) Annu. Rev. Physiol. 54:911-930.)

[0015] Amino acid transport is mediated by Na⁺ dependent amino acid transporters. These transporters are involved in gastrointestinal and renal uptake of dietary and cellular amino acids and in neuronal reuptake of neurotransmitters. Transport of cationic amino acids is mediated by the system y+ family and the cationic amino acid transporter (CAT) family. Members of the CAT family share a high degree of sequence homology, and each contains 12-14 putative transmembrane domains. (Ito, K. and Groudine, M. (1997) J. Biol. Chem. 272:26780-26786.)

[0016] Hormones are secreted molecules that travel through the circulation and bind to specific receptors on the surface of, or within, target cells. Although they have diverse biochemical compositions and mechanisms of action, hormones can be grouped into two categories. One category includes small lipophilic hormones that diffuse through the plasma membrane of target cells, bind to cytosolic or nuclear receptors, and form a complex that alters gene expression. Examples of these molecules include retinoic acid, thyroxine, and the cholesterol-derived steroid hormones such as progesterone, estrogen, testosterone, cortisol, and aldosterone. The second category includes hydrophilic hormones that function by binding to cell surface receptors that transduce signals across the plasma membrane. Examples of such hormones include amino acid derivatives such as catecholamines and peptide hormones such as glucagon, insulin, gastrin, secretin, cholecystokinin, adrenocorticotropic hormone, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, and vasopressin. (See, for example, Lodish et al. (1995) Molecular Cell Biology, Scientific American Books Inc., New York N.Y., pp. 856-864.)

[0017] Neuropeptides and vasomediators (NP/VM) comprise a large family of endogenous signaling molecules. Included in this family are neuropeptides and neuropeptide hormones such as bombesin, neuropeptide Y, neurotensin, neuromedin N, melanocortins, opioids, galanin, somatostatin, tachykinins, urotensin II and related peptides involved in smooth muscle stimulation, vasopressin, vasoactive intestinal peptide, and circulatory system-borne signaling molecules such as angiotensin, complement, calcitonin, endothelins, formyl-methionyl peptides, glucagon, cholecystoknin and gastrin. NP/VMs can transduce signals directly, modulate the activity or release of other neurotransmitters and hormones, and act as catalytic enzymes in cascades. The effects of NP/VMs range from extremely brief to long-lasting. (Reviewed in Martin, C. R. et al. (1985) Endocrine Physiology, Oxford University Press, New York, N.Y., pp. 57-62.)

[0018] The discovery of new secretory molecules satisfies a need in the art by providing new compositions which are useful in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, cell signaling and the expression of secretory molecules.

SUMMARY OF THE INVENTION

[0019] The present invention relates to nucleic acid sequences comprising human polynucleotides encoding secretory polypeptides that contain signal peptides and/or transmembrane domains. These human polynucleotides (sptm) as presented in the Sequence Listing uniquely identify partial or full length genes encoding structural, functional, and regulatory polypeptides involved in cell signaling.

[0020] The invention provides an isolated polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In one alternative, the polynucleotide comprises a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75. In another alternative, the polynucleotide comprises at least 30 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide comprising a polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In another alternative, the polynucleotide comprises at least 60 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ED NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide comprising a polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The invention further provides a composition for the detection of expression of secretory polynucleotides comprising at least one isolated polynucleotide comprising a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d); and a detectable label.

[0021] The invention also provides a method for detecting a target polynucleotide in a sample, said target polynucleotide having a polynucleotide sequence of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence of a polynucleotide selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The method comprises a) amplifying said target polynucleotide or fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof.

[0022] The invention also provides a method for detecting a target polynucleotide in a sample, said target polynucleotide having a polynucleotide sequence of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The method comprises a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide, and b) detecting the presence or absence of said hybridization complex, and, optionally, if present, the amount thereof. In one alternative, the invention provides a composition comprising a target polynucleotide of the method, wherein said probe comprises at least 30 contiguous nucleotides. In one alternative, the invention provides a composition comprising a target polynucleotide of the method, wherein said probe comprises at least 60 contiguous nucleotides.

[0023] The invention further provides a recombinant polynucleotide comprising a promoter sequence operably linked to an isolated polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In one alternative, the invention provides a cell transformed with the recombinant polynucleotide. In another alternative, the invention provides a transgenic organism comprising the recombinant polynucleotide.

[0024] The invention also provides a method for producing a secretory polypeptide, the method comprising a) culturing a cell under conditions suitable for expression of the secretory polypeptide, wherein said cell is transformed with a recombinant polynucleotide, said recombinant polynucleotide comprising an isolated polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv), and b) recovering the secretory polypeptide so expressed. The invention additionally provides a method wherein the polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NO:76-152.

[0025] The invention also provides an isolated secretory polypeptide (SPTM) encoded by at least one polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75. The invention further provides a method of screening for a test compound that specifically binds to the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152. The method comprises a) combining the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152 with at least one test compound under suitable conditions, and b) detecting binding of the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152 to the test compound, thereby identifying a compound that specifically binds to the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152.

[0026] The invention further provides a microarray wherein at least one element of the microarray is an isolated polynucleotide comprising at least 30 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The invention also provides a method for generating a transcript image of a sample which contains polynucleotides. The method comprises a) labeling the polynucleotides of the sample, b) contacting the elements of the microarray with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample.

[0027] Additionally, the invention provides a method for screening a compound for effectiveness in altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The method comprises a) exposing a sample comprising the target polynucleotide to a compound, b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the compound and in the absence of the compound.

[0028] The invention further provides a method for assessing toxicity of a test compound, said method comprising a) treating a biological sample containing nucleic acids with the test compound; b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv). Hybridization occurs under conditions whereby a specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence of a polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv), and alternatively, the target polynucleotide comprises a polynucleotide sequence of a fragment of a polynucleotide selected from the group consisting of i-v above; c) quantifying the amount of hybridization complex; and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound.

[0029] The invention further provides an isolated polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence/selected from the group consisting of SEQ ID NO:76-152, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152. In one alternative, the invention provides an isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152.

[0030] The invention further provides an isolated polynucleotide encoding a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ D NO:76-152. In one alternative, the polynucleotide encodes a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152. In another alternative, the polynucleotide comprises a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75.

[0031] Additionally, the invention provides an isolated antibody which specifically binds to a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152.

[0032] The invention further provides a composition comprising a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and a pharmaceutically acceptable excipient. In one embodiment, the composition comprises a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152. The invention additionally provides a method of treating a disease or condition associated with decreased expression of functional SPTM, comprising administering to a patient in need of such treatment the composition.

[0033] The invention also provides a method for screening a compound for effectiveness as an agonist of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152. The method comprises a) exposing a sample comprising the polypeptide to a compound, and b) detecting agonist activity in the sample. In one alternative, the invention provides a composition comprising an agonist compound identified by the method and a pharmaceutically acceptable excipient. In another alternative, the invention provides a method of treating a disease or condition associated with decreased expression of functional SPTM, comprising administering to a patient in need of such treatment the composition.

[0034] Additionally, the invention provides a method for screening a compound for effectiveness as an antagonist of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152. The method comprises a) exposing a sample comprising the polypeptide to a compound, and b) detecting antagonist activity in the sample. In one alternative, the invention provides a composition comprising an antagonist compound identified by the method and a pharmaceutically acceptable excipient. In another alternative, the invention provides a method of treating a disease or condition associated with overexpression of functional SPTM, comprising administering to a patient in need of such treatment the composition.

[0035] The invention further provides a method of screening for a compound that modulates the activity of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152. The method comprises a) combining the polypeptide with at least one test compound under conditions permissive for the activity of the polypeptide, b) assessing the activity of the polypeptide in the presence of the test compound, and c) comparing the activity of the polypeptide in the presence of the test compound with the activity of the polypeptide in the absence of the test compound, wherein a change in the activity of the polypeptide in the presence of the test compound is indicative of a compound that modulates the activity of the polypeptide.

Description of the Tables

[0036] Table 1 shows the sequence identification numbers (SEQ ID NO:s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with the sequence identification numbers (SEQ ID NO:s) and open reading frame identification numbers (ORF IDs) corresponding to polypeptides encoded by the template ID.

[0037] Table 2 shows the sequence identification numbers (SEQ ID NO: s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with polynucleotide segments of each template sequence as defined by the indicated “start” and “stop” nucleotide positions. The reading frames of the polynucleotide segments are shown, and the polypeptides encoded by the polynucleotide segments constitute either signal peptide (SP) or transmembrane (TM) domains, as indicated. For TM domains, the membrane topology of the encoded polypeptide sequence is indicated as being transmembrane or on the cytosolic or non-cytosolic side of the cell membrane or organelle.

[0038] Table 3 shows the sequence identification numbers (SEQ ID NO:s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with component sequence identification numbers (component IDs) corresponding to each template. The component sequences, which were used to assemble the template sequences, are defined by the indicated “start” and “stop” nucleotide positions along each template.

[0039] Table 4 shows the tissue distribution profiles for the templates of the invention.

[0040] Table 5 shows the sequence identification numbers (SEQ ID NO:s) corresponding to the polypeptides of the present invention, along with the reading frames used to obtain the polypeptide segments, the lengths of the polypeptide segments, the “start” and “stop” nucleotide positions of the polynucleotide sequences used to define the encoded polypeptide segments, the GenBank hits (GI Numbers), probability scores, and functional annotations corresponding to the GenBank hits.

[0041] Table 6 summarizes the bioinformatics tools which are useful for analysis of the polynucleotides of the present invention. The first column of Table 6 lists analytical tools, programs, and algorithms, the second column provides brief descriptions thereof, the third column presents appropriate references, all of which are incorporated by reference herein in their entirety, and the fourth column presents, where applicable, the scores, probability values, and other parameters used to evaluate the strength of a match between two sequences (the higher the score, the greater the homology between two sequences).

DETAILED DESCRIPTION OF THE INVENTION

[0042] Before the nucleic acid sequences and methods are presented, it is to be understood that this invention is not limited to the particular machines, methods, and materials described. Although particular embodiments are described, machines, methods, and materials similar or equivalent to these embodiments may be used to practice the invention. The preferred machines, methods, and materials set forth are not intended to limit the scope of the invention which is limited only by the appended claims.

[0043] The singular forms “a”, “an”, and “the” include plural reference unless the context clearly dictates otherwise. All technical and scientific terms have the meanings commonly understood by one of ordinary skill in the art. All publications are incorporated by reference for the purpose of describing and disclosing the cell lines, vectors, and methodologies which are presented and which might be used in connection with the invention. Nothing in the specification is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention.

[0044] Definitions

[0045] As used herein, the lower case “sptm” refers to a nucleic acid sequence, while the upper case “SPTM” refers to an amino acid sequence encoded by sptm A “full-length” sptm refers to a nucleic acid sequence containing the entire coding region of a gene endogenously expressed in human tissue.

[0046] “Adjuvants” are materials such as Freund's adjuvant, mineral gels (aluminum hydroxide), and surface active substances (lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, and dinitrophenol) which may be administered to increase a host's immunological response.

[0047] “Allele” refers to an alternative form of a nucleic acid sequence. Alleles result from a “mutation,” a change or an alternative reading of the genetic code. Any given gene may have none, one, or many allelic forms. Mutations which give rise to alleles include deletions, additions, or substitutions of nucleotides. Each of these changes may occur alone, or in combination with the others, one or more times in a given nucleic acid sequence. The present invention encompasses allelic sptm.

[0048] An “allelic variant” is an alternative form of the gene encoding SPTM. Allelic variants may result from at least one mutation in the nucleic acid sequence and may result in altered mRNAs or in polypeptides whose structure or function may or may not be altered. A gene may have none, one, or many allelic variants of its naturally occurring form Common mutational changes which give rise to allelic variants are generally ascribed to natural deletions, additions, or substitutions of nucleotides. Each of these types of changes may occur alone, or in combination with the others, one or more times in a given sequence.

[0049] “Altered” nucleic acid sequences encoding SPTM include those sequences with deletions, insertions, or substitutions of different nucleotides, resulting in a polypeptide the same as SPTM or a polypeptide with at least one functional characteristic of SPTM. Included within this definition are polymorphisms which may or may not be readily detectable using a particular oligonucleotide probe of the polynucleotide encoding SPTM, and improper or unexpected hybridization to allelic variants, with a locus other than the normal chromosomal locus for the polynucleotide sequence encoding SPTM. The encoded protein may also be “altered,” and may contain deletions, insertions, or substitutions of amino acid residues which produce a silent change and result in a functionally equivalent SPTM. Deliberate amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues, as long as the biological or immunological activity of SPTM is retained. For example, negatively charged amino acids may include aspartic acid and glutamic acid, and positively charged amino acids may include lysine and arginine. Amino acids with uncharged polar side chains having similar hydrophilicity values may include: asparagine and glutamine; and serine and threonine. Amino acids with uncharged side chains having similar hydrophilicity values may include: leucine, isoleucine, and valine; glycine and alanine; and phenylalanine and tyrosine.

[0050] “Amino acid sequence” refers to a peptide, a polypeptide, or a protein of either natural or synthetic origin. The amino acid sequence is not limited to the complete, endogenous amino acid sequence and may be a fragment, epitope, variant, or derivative of a protein expressed by a nucleic acid sequence.

[0051] “Amplification” refers to the production of additional copies of a sequence and is carried out using polymerase chain reaction (PCR) technologies well known in the art.

[0052] “Antibody” refers to intact molecules as well as to fragments thereof, such as Fab, F(ab′)₂, and Fv fragments, which are capable of binding the epitopic determinant. Antibodies that bind SPTM polypeptides can be prepared using intact polypeptides or using fragments containing small peptides of interest as the immunizing antigen. The polypeptide or peptide used to immunize an animal (e.g., a mouse, a rat, or a rabbit) can be derived from the translation of RNA, or synthesized chemically, and can be conjugated to a carrier protein if desired. Commonly used carriers that are chemically coupled to peptides include bovine serum albumin, thyroglobulin, and keyhole limpet hemocyanin (KLH). The coupled peptide is then used to immunize the animal.

[0053] The term “aptamer” refers to a nucleic acid or oligonucleotide molecule that binds to a specific molecular target. Aptamers are derived from an in vitro evolutionary process (e.g., SELEX (Systematic Evolution of Ligands by EXponential Enrichment), described in U.S. Pat. No. 5,270,163), which selects for target-specific aptamer sequences from large combinatorial libraries. Aptamer compositions may be double-stranded or single-stranded, and may include deoxyribonucleotides, ribonucleotides, nucleotide derivatives, or other nucleotide-like molecules. The nucleotide components of an aptamer may have modified sugar groups (e.g., the 2′-OH group of a ribonucleotide may be replaced by 2′-F or 2′-NH₂), which may improve a desired property, e.g., resistance to nucleases or longer lifetime in blood. Aptamers may be conjugated to other molecules, e.g., a high molecular weight carrier to slow clearance of the aptamer from the circulatory system. Aptamers may be specifically cross-linked to their cognate ligands, e.g., by photo-activation of a cross-linker. (See, e.g., Brody, E. N. and L. Gold (2000) J. Biotechnol. 74:5-13.)

[0054] The term “intramer” refers to an aptamer which is expressed in vivo. For example, a vaccinia virus-based RNA expression system has been used to express specific RNA aptamers at high levels in the cytoplasm of leukocytes (Blind, M. et al. (1999) Proc. Natl. Acad. Sci. USA 96:3606-3610).

[0055] The term “spiegelmer” refers to an aptamer which includes L-DNA, L-RNA, or other left-handed nucleotide derivatives or nucleotide-like molecules. Aptamers containing left-handed nucleotides are resistant to degradation by naturally occurring enzymes, which normally act on substrates containing right-handed nucleotides.

[0056] “Antisense sequence” refers to a sequence capable of specifically hybridizing to a target sequence. The antisense sequence may include DNA, RNA, or any nucleic acid mimic or analog such as peptide nucleic acid (PNA); oligonucleotides having modified backbone linkages such as phosphorothioates, methylphosphonates, or benzylphosphonates; oligonucleotides having modified sugar groups such as 2′-methoxyethyl sugars or 2′-methoxyethoxy sugars; or oligonucleotides having modified base.

[0057] “Antisense technology” refers to any technology which relies on the specific hybridization of an antisense sequence to a target sequence.

[0058] A “bin” is a portion of computer memory space used by a computer program for storage of data, and bounded in such a manner that data stored in a bin may be retrieved by the program.

[0059] “Biologically active” refers to an amino acid sequence having a structural, regulatory, or biochemical function of a naturally occurring amino acid sequence.

[0060] “Clone joining” is a process for combining gene bins based upon the bins' containing sequence information from the same clone. The sequences may assemble into a primary gene transcript as well as one or more splice variants.

[0061] “Complementary” describes the relationship between two single-stranded nucleic acid sequences that anneal by base-pairing (5′-A-G-T-3′ pairs with its complement 3′-T-C-A-5′).

[0062] A “component sequence” is a nucleic acid sequence selected by a computer program such as PHRED and used to assemble a consensus or template sequence from one or more component sequences.

[0063] A “consensus sequence” or “template sequence” is a nucleic acid sequence which has been assembled from overlapping sequences, using a computer program for fragment assembly such as the GELVIEW fragment assembly system (Genetics Computer Group (GCG), Madison Wis.) or using a relational database management system (RDMS).

[0064] “Conservative amino acid substitutions” are those substitutions that, when made, least interfere with the properties of the original protein, i.e., the structure and especially the function of the protein is conserved and not significantly changed by such substitutions. The table below shows amino acids which may be substituted for an original amino acid in a protein and which are regarded as conservative substitutions. Original Residue Conservative Substitution Ala Gly, Ser Arg His, Lys Asn Asp, Gln, His Asp Asn, Glu Cys Ala, Ser Gln Asn, Glu, His Glu Asp, Gln, His Gly Ala His Asn, Arg, Gln, Glu Ile Leu, Val Leu Ile, Val Lys Arg, Gln, Glu Met Leu, Ile Phe His, Met, Leu, Trp, Tyr Ser Cys,Thr Thr Ser, Val Trp Phe, Tyr Tyr His, Phe, Trp Val Ile, Leu, Thr

[0065] Conservative substitutions generally maintain (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a beta sheet or alpha helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain.

[0066] “Deletion” refers to a change in either a nucleic or amino acid sequence in which at least one nucleotide or amino acid residue, respectively, is absent.

[0067] “Derivative” refers to the chemical modification of a nucleic acid sequence, such as by replacement of hydrogen by an alkyl, acyl, amino, hydroxyl, or other group.

[0068] “Differential expression” refers to increased or upregulated; or decreased, downregulated, or absent gene or protein expression, determined by comparing at least two different samples. Such comparisons may be carried out between, for example, a treated and an untreated sample, or a diseased and a normal sample.

[0069] The terms “element” and “array element” refer to a polynucleotide, polypeptide, or other chemical compound having a unique and defined position on a microarray.

[0070] The term “modulate” refers to a change in the activity of SPTM. For example, modulation may cause an increase or a decrease in protein activity, binding characteristics, or any other biological, functional, or immunological properties of SPTM.

[0071] “E-value” refers to the statistical probability that a match between two sequences occurred by chance.

[0072] “Exon shuffling” refers to the recombination of different coding regions (exons). Since an exon may represent a structural or functional domain of the encoded protein, new proteins may be assembled through the novel reassortment of stable substructures, thus allowing acceleration of the evolution of new protein functions.

[0073] A “fragment” is a unique portion of sptm or SPTM which is identical in sequence to but shorter in length than the parent sequence. A fragment may comprise up to the entire length of the defined sequence, minus one nucleotide/amino acid residue. For example, a fragment may comprise from 10 to 1000 contiguous amino acid residues or nucleotides. A fragment used as a probe, primer, antigen, therapeutic molecule, or for other purposes, may be at least 5, 10, 15, 16, 20, 25, 30, 40, 50, 60, 75, 100, 150, 250 or at least 500 contiguous amino acid residues or nucleotides in length. Fragments may be preferentially selected from certain regions of a molecule. For example, a polypeptide fragment may comprise a certain length of contiguous amino acids selected from the first 250 or 500 amino acids (or first 25% or 50%) of a polypeptide as shown in a certain defined sequence. Clearly these lengths are exemplary, and any length that is supported by the specification, including the Sequence Listing and the figures, may be encompassed by the present embodiments.

[0074] A fragment of sptm comprises a region of unique polynucleotide sequence that specifically identifies sptm, for example, as distinct from any other sequence in the same genome. A fragment of sptm is useful, for example, in hybridization and amplification technologies and in analogous methods that distinguish sptm from related polynucleotide sequences. The precise length of a fragment of sptm and the region of sptm to which the fragment corresponds are routinely determinable by one of ordinary skill in the art based on the intended purpose for the fragment.

[0075] A fragment of SPTM is encoded by a fragment of sptm. A fragment of SPTM comprises a region of unique amino acid sequence that specifically identifies SPTM. For example, a fragment of SPTM is useful as an immunogenic peptide for the development of antibodies that specifically recognize SPTM. The precise length of a fragment of SPTM and the region of SPTM to which the fragment corresponds are routinely determinable by one of ordinary skill in the art based on the intended purpose for the fragment.

[0076] A “full length” nucleotide sequence is one containing at least a start site for translation to a protein sequence, followed by an open reading frame and a stop site, and encoding a “full length” polypeptide.

[0077] “Hit” refers to a sequence whose annotation will be used to describe a given template. Criteria for selecting the top hit are as follows: if the template has one or more exact nucleic acid matches, the top hit is the exact match with highest percent identity. If the template has no exact matches but has significant protein hits, the top hit is the protein hit with the lowest E-value. If the template has no significant protein hits, but does have significant non-exact nucleotide hits, the top hit is the nucleotide hit with the lowest E-value.

[0078] “Homology” refers to sequence similarity either between a reference nucleic acid sequence and at least a fragment of an sptm or between a reference amino acid sequence and a fragment of an SPTM.

[0079] “Hybridization” refers to the process by which a strand of nucleotides anneals with a complementary strand through base pairing. Specific hybridization is an indication that two nucleic acid sequences share a high degree of identity. Specific hybridization complexes form under defined annealing conditions, and remain hybridized after the “washing” step. The defined hybridization conditions include the annealing conditions and the washing step(s), the latter of which is particularly important in determining the stringency of the hybridization process, with more stringent conditions allowing less non-specific binding, i.e., binding between pairs of nucleic acid probes that are not perfectly matched. Permissive conditions for annealing of nucleic acid sequences are routinely determinable and may be consistent among hybridization experiments, whereas wash conditions may be varied among experiments to achieve the desired stringency.

[0080] Generally, stringency of hybridization is expressed with reference to the temperature under which the wash step is carried out. Generally, such wash temperatures are selected to be about 5° C. to 20° C. lower than the thermal melting point (T_(m)) for the specific sequence at a defined ionic strength and pH. The T_(m) is the temperature (under defined ionic strength and pH) at which 50% of the target sequence hybridizes to a perfectly matched probe. An equation for calculating T_(m) and conditions for nucleic acid hybridization is well known and can be found in Sambrook et al., 1989, Molecular Cloning: A Laboratory Manual, 2^(nd) ed., vol. 1-3, Cold Spring Harbor Press, Plainview N.Y.; specifically see volume 2, chapter 9.

[0081] High stringency conditions for hybridization between polynucleotides of the present invention include wash conditions of 68° C. in the presence of about 0.2×SSC and about 0.1% SDS, for 1 hour. Alternatively, temperatures of about 65° C., 60° C., or 55° C. may be used. SSC concentration may be varied from about 0.2 to 2×SSC, with SDS being present at about 0.1%. Typically, blocking reagents are used to block non-specific hybridization. Such blocking reagents include, for instance, denatured salmon sperm DNA at about 100-200 μg/ml. Useful variations on these conditions will be readily apparent to those skilled in the art. Hybridization, particularly under high stringency conditions, may be suggestive of evolutionary similarity between the nucleotides. Such similarity is strongly indicative of a similar role for the nucleotides and their resultant proteins.

[0082] Other parameters, such as temperature, salt concentration, and detergent concentration may be varied to achieve the desired stringency. Denaturants, such as formamide at a concentration of about 35-50% v/v, may also be used under particular circumstances, such as RNA:DNA hybridizations. Appropriate hybridization conditions are routinely determinable by one of ordinary skill in the art.

[0083] “Immunologically active” or “immunogenic” describes the potential for a natural, recombinant, or synthetic peptide, epitope, polypeptide, or protein to induce antibody production in appropriate animals, cells, or cell lines.

[0084] “Immune response” can refer to conditions associated with inflammation, trauma, immune disorders, or infectious or genetic disease, etc. These conditions can be characterized by expression of various factors, e.g., cytokines, chemokines, and other signaling molecules, which may affect cellular and systemic defense systems.

[0085] An “immunogenic fragment” is a polypeptide or oligopeptide fragment of SPTM which is capable of eliciting an immune response when introduced into a living organism, for example, a mammal. The term “immunogenic fragment” also includes any polypeptide or oligopeptide fragment of SPTM which is useful in any of the antibody production methods disclosed herein or known in the art.

[0086] “Insertion” or “addition” refers to a change in either a nucleic or amino acid sequence in which at least one nucleotide or residue, respectively, is added to the sequence.

[0087] “Labeling” refers to the covalent or noncovalent joining of a polynucleotide, polypeptide, or antibody with a reporter molecule capable of producing a detectable or measurable signal.

[0088] “Microarray” is any arrangement of nucleic acids, amino acids, antibodies, etc., on a substrate. The substrate may be a solid support such as beads, glass, paper, nitrocellulose, nylon, or an appropriate membrane.

[0089] “Linkers” are short stretches of nucleotide sequence which may be added to a vector or an sptm to create restriction endonuclease sites to facilitate cloning. “Polylinkers” are engineered to incorporate multiple restriction enzyme sites and to provide for the use of enzymes which leave 5′ or 3′ overhangs (e.g., BamHI, EcoRI, and HindIII) and those which provide blunt ends (e.g., EcoRV, SnaBI, and StuI).

[0090] “Naturally occurring” refers to an endogenous polynucleotide or polypeptide that may be isolated from viruses or prokaryotic or eukaryotic cells.

[0091] “Nucleic acid sequence” refers to the specific order of nucleotides joined by phosphodiester bonds in a linear, polymeric arrangement. Depending on the number of nucleotides, the nucleic acid sequence can be considered an oligomer, oligonucleotide, or polynucleotide. The nucleic acid can be DNA, RNA, or any nucleic acid analog, such as PNA, may be of genomic or synthetic origin, may be either double-stranded or single-stranded, and can represent either the sense or antisense (complementary) strand.

[0092] “Oligomer” refers to a nucleic acid sequence of at least about 6 nucleotides and as many as about 60 nucleotides, preferably about 15 to 40 nucleotides, and most preferably between about 20 and 30 nucleotides, that may be used in hybridization or amplification technologies. Oligomers may be used as, e.g., primers for PCR, and are usually chemically synthesized.

[0093] “Operably linked” refers to the situation in which a first nucleic acid sequence is placed in a functional relationship with the second nucleic acid sequence. For instance, a promoter is operably linked to a coding sequence if the promoter affects the transcription or expression of the coding sequence. Generally, operably linked DNA sequences may be in close proximity or contiguous and, where necessary to join two protein coding regions, in the same reading frame.

[0094] “Peptide nucleic acid” (PNA) refers to a DNA mimic in which nucleotide bases are attached to a pseudopeptide backbone to increase stability. PNAs, also designated antigene agents, can prevent gene expression by targeting complementary messenger RNA.

[0095] The phrases “percent identity” and “% identity”, as applied to polynucleotide sequences, refer to the percentage of residue matches between at least two polynucleotide sequences aligned using a standardized algorithm. Such an algorithm may insert, in a standardized and reproducible way, gaps in the sequences being compared in order to optimize alignment between two sequences, and therefore achieve a more meaningful comparison of the two sequences.

[0096] Percent identity between polynucleotide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEGALIGN version 3.12e sequence alignment program. This program is part of the LASERGENE software package, a suite of molecular biological analysis programs (DNASTAR, Madison Wis.). CLUSTAL V is described in Higgins, D. G. and Sharp, P. M. (1989) CABIOS 5:151-153 and in Higgins, D. G. et al. (1992) CABIOS 8:189-191. For pairwise alignments of polynucleotide sequences, the default parameters are set as follows: Ktuple=2, gap penalty=5, window=4, and “diagonals saved”=4. The “weighted” residue weight table is selected as the default. Percent identity is reported by CLUSTAL V as the “percent similarity” between aligned polynucleotide sequence pairs.

[0097] Alternatively, a suite of commonly used and freely available sequence comparison algorithms is provided by the National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST) (Altschul, S. F. et al. (1990) J. Mol. Biol. 215:403410), which is available from several sources, including the NCBI, Bethesda, Md., and on the Internet at http://www.ncbi.nlm.nih.gov/BLAST/. The BLAST software suite includes various sequence analysis programs including “BLASTN,” that is used to determine alignment between a known polynucleotide sequence and other sequences on a variety of databases. Also available is a tool called “BLAST 2 Sequences” that is used for direct pairwise comparison of two nucleotide sequences. “BLAST 2 Sequences” can be accessed and used interactively at http://www.ncbi.nlm.nih.gov/gorf/bl2/. The “BLAST 2 Sequences” tool can be used for both BLASTN and BLASTP (discussed below). BLAST programs are commonly used with gap and other parameters set to default settings. For example, to compare two nucleotide sequences, one may use BLASTN with the “BLAST 2 Sequences” tool Version 2.0.9 (May 07, 1999) set at default parameters. Such default parameters may be, for example:

[0098] Matrix: BLOSUM62

[0099] Reward for match: 1

[0100] Penalty for mismatch: −2

[0101] Open Gap: 5 and Extension Gap: 2 penalties

[0102] Gap×drop-off 50

[0103] Expect: 10

[0104] Word Size: 11

[0105] Filter: on

[0106] Percent identity may be measured over the length of an entire defined sequence, for example, as defined by a particular SEQ ID number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined sequence, for instance, a fragment of at least 20, at least 30, at least 40, at least 50, at least 70, at least 100, or at least 200 contiguous nucleotides. Such lengths are exemplary only, and it is understood that any fragment length supported by the sequences shown herein, in figures or Sequence Listings, may be used to describe a length over which percentage identity may be measured.

[0107] Nucleic acid sequences that do not show a high degree of identity may nevertheless encode similar amino acid sequences due to the degeneracy of the genetic code. It is understood that changes in nucleic acid sequence can be made using this degeneracy to produce multiple nucleic acid sequences that all encode substantially the same protein.

[0108] The phrases “percent identity” and “% identity”, as applied to polypeptide sequences, refer to the percentage of residue matches between at least two polypeptide sequences aligned using a standardized algorithm. Methods of polypeptide sequence alignment are well-known. Some alignment methods take into account conservative amino acid substitutions. Such conservative substitutions, explained in more detail above, generally preserve the hydrophobicity and acidity of the substituted residue, thus preserving the structure (and therefore function) of the folded polypeptide.

[0109] Percent identity between polypeptide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEGALIGN version 3.12e sequence alignment program (described and referenced above). For pairwise alignments of polypeptide sequences using CLUSTAL V, the default parameters are set as follows: Ktuple=1, gap penalty=3, window=5, and “diagonals saved”-5. The PAM250 matrix is selected as the default residue weight table. As with polynucleotide alignments, the percent identity is reported by CLUSTAL V as the “percent similarity” between aligned polypeptide sequence pairs.

[0110] Alternatively the NCBI BLAST software suite may be used. For example, for a pairwise comparison of two polypeptide sequences, one may use the “BLAST 2 Sequences” tool Version 2.0.9 (May-07-1999) with BLASTP set at default parameters. Such default parameters may be, for example:

[0111] Matrix: BLOSUM62

[0112] Open Gap: 11 and Extension Gap: 1 penalty

[0113] Gap×drop-off: 50

[0114] Expect: 10

[0115] Word Size: 3

[0116] Filter: on

[0117] Percent identity may be measured over the length of an entire defined polypeptide sequence, for example, as defined by a particular SEQ ID number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined polypeptide sequence, for instance, a fragment of at least 15, at least 20, at least 30, at least 40, at least 50, at least 70 or at least 150 contiguous residues. Such lengths are exemplary only, and it is understood that any fragment length supported by the sequences shown herein, in figures or Sequence Listings, may be used to describe a length over which percentage identity may be measured.

[0118] “Post-translational modification” of an SPTM may involve lipidation, glycosylation, phosphorylation, acetylation, racemization, proteolytic cleavage, and other modifications known in the art. These processes may occur synthetically or biochemically. Biochemical modifications will vary by cell type depending on the enzymatic milieu and the SPTM.

[0119] “Probe” refers to sptm or fragments thereof, which are used to detect identical, allelic or related nucleic acid sequences. Probes are isolated oligonucleotides or polynucleotides attached to a detectable label or reporter molecule. Typical labels include radioactive isotopes, ligands, chemiluminescent agents, and enzymes. “Primers” are short nucleic acids, usually DNA oligonucleotides, which may be annealed to a target polynucleotide by complementary base-pairing. The primer may then be extended along the target DNA strand by a DNA polymerase enzyme. Primer pairs can be used for amplification (and identification) of a nucleic acid sequence, e.g., by the polymerase chain reaction (PCR).

[0120] Probes and primers as used in the present invention typically comprise at least 15 contiguous nucleotides of a known sequence. In order to enhance specificity, longer probes and primers may also be employed, such as probes and primers that comprise at least 20, 30, 40, 50, 60, 70, 80, 90, 100, or at least 150 consecutive nucleotides of the disclosed nucleic acid sequences. Probes and primers may be considerably longer than these examples, and it is understood that any length supported by the specification, including the figures and Sequence Listing, may be used.

[0121] Methods for preparing and using probes and primers are described in the references, for example Sambrook et al., 1989, Molecular Cloning: A Laboratory Manual, 2^(nd) ed., vol. 1-3, Cold Spring Harbor Press, Plainview N.Y.; Ausubel et al., 1987, Current Protocols in Molecular Biology, Greene Publ. Assoc. & Wiley-Intersciences, New York N.Y.; Innis et al., 1990, PCR Protocols. A Guide to Methods and Applications, Academic Press, San Diego Calif. PCR primer pairs can be derived from a known sequence, for example, by using computer programs intended for that purpose such as Primer (Version 0.5, 1991, Whitehead Institute for Biomedical Research, Cambridge Mass.).

[0122] Oligonucleotides for use as primers are selected using software known in the art for such purpose. For example, OLIGO 4.06 software is useful for the selection of PCR primer pairs of up to 100 nucleotides each, and for the analysis of oligonucleotides and larger polynucleotides of up to 5,000 nucleotides from an input polynucleotide sequence of up to 32 kilobases. Similar primer selection programs have incorporated additional features for expanded capabilities. For example, the PrimOU primer selection program (available to the public from the Genome Center at University of Texas South West Medical Center, Dallas Tex.) is capable of choosing specific primers from megabase sequences and is thus useful for designing primers on a genome-wide scope. The Primer3 primer selection program (available to the public from the Whitehead Institute/MIT Center for Genome Research, Cambridge Mass.) allows the user to input a “mispriming library,” in which sequences to avoid as primer binding sites are user-specified. Primer3 is useful, in particular, for the selection of oligonucleotides for microarrays. (The source code for the latter two primer selection programs may also be obtained from their respective sources and modified to meet the user's specific needs.) The PrimeGen program (available to the public from the UK Human Genome Mapping Project Resource Centre, Cambridge UK) designs primers based on multiple sequence alignments, thereby allowing selection of primers that hybridize to either the most conserved or least conserved regions of aligned nucleic acid sequences. Hence, this program is useful for identification of both unique and conserved oligonucleotides and polynucleotide fragments. The oligonucleotides and polynucleotide fragments identified by any of the above selection methods are useful in hybridization technologies, for example, as PCR or sequencing primers, microarray elements, or specific probes to identify fully or partially complementary polynucleotides in a sample of nucleic acids. Methods of oligonucleotide selection are not limited to those described above.

[0123] “Purified” refers to molecules, either polynucleotides or polypeptides that are isolated or separated from their natural environment and are at least 60% free, preferably at least 75% free, and most preferably at least 90% free from other compounds with which they are naturally associated.

[0124] A “recombinant nucleic acid” is a sequence that is not naturally occurring or has a sequence that is made by an artificial combination of two or more otherwise separated segments of sequence. This artificial combination is often accomplished by chemical synthesis or, more commonly, by the artificial manipulation of isolated segments of nucleic acids, e.g., by genetic engineering techniques such as those described in Sambrook, supra. The term recombinant includes nucleic acids that have been altered solely by addition, substitution, or deletion of a portion of the nucleic acid. Frequently, a recombinant nucleic acid may include a nucleic acid sequence operably linked to a promoter sequence. Such a recombinant nucleic acid may be part of a vector that is used, for example, to transform a cell.

[0125] Alternatively, such recombinant nucleic acids may be part of a viral vector, e.g., based on a vaccinia virus, that could be use to vaccinate a mammal wherein the recombinant nucleic acid is expressed, inducing a protective immunological response in the mammal.

[0126] “Regulatory element” refers to a nucleic acid sequence from nontranslated regions of a gene, and includes enhancers, promoters, introns, and 3′ untranslated regions, which interact with host proteins to carry out or regulate transcription or translation.

[0127] “Reporter” molecules are chemical or biochemical moieties used for labeling a nucleic acid, an amino acid, or an antibody. They include radionuclides; enzymes; fluorescent, chemiluminescent, or chromogenic agents; substrates; cofactors; inhibitors; magnetic particles; and other moieties known in the art.

[0128] An “RNA equivalent,” in reference to a DNA sequence, is composed of the same linear sequence of nucleotides as the reference DNA sequence with the exception that all occurrences of the nitrogenous base thymine are replaced with uracil, and the sugar backbone is composed of ribose instead of deoxyribose.

[0129] “Sample” is used in its broadest sense. Samples may contain nucleic or amino acids, antibodies, or other materials, and may be derived from any source (e.g., bodily fluids including, but not limited to, saliva, blood, and urine; chromosome(s), organelles, or membranes isolated from a cell; genomic DNA, RNA, or cDNA in solution or bound to a substrate; and cleared cells or tissues or blots or imprints from such cells or tissues).

[0130] “Specific binding” or “specifically binding” refers to the interaction between a protein or peptide and its agonist, antibody, antagonist, or other binding partner. The interaction is dependent upon the presence of a particular structure of the protein, e.g., the antigenic determinant or epitope, recognized by the binding molecule. For example, if an antibody is specific for epitope “A,” the presence of a polypeptide containing epitope A, or the presence of free unlabeled A, in a reaction containing free labeled A and the antibody will reduce the amount of labeled A that binds to the antibody.

[0131] “Substitution” refers to the replacement of at least one nucleotide or amino acid by a different nucleotide or amino acid.

[0132] “Substrate” refers to any suitable rigid or semi-rigid support including, e.g., membranes, filters, chips, slides, wafers, fibers, magnetic or nonmagnetic beads, gels, tubing, plates, polymers, microparticles or capillaries. The substrate can have a variety of surface forms, such as wells, trenches, pins, channels and pores, to which polynucleotides or polypeptides are bound.

[0133] A “transcript image” refers to the collective pattern of gene expression by a particular tissue or cell type under given conditions at a given time.

[0134] “Transformation” refers to a process by which exogenous DNA enters a recipient cell. Transformation may occur under natural or artificial conditions using various methods well known in the art. Transformation may rely on any known method for the insertion of foreign nucleic acid sequences into a prokaryotic or eukaryotic host cell. The method is selected based on the host cell being transformed.

[0135] “Transformants” include stably transformed cells in which the inserted DNA is capable of replication either as an autonomously replicating plasmid or as part of the host chromosome, as well as cells which transiently express inserted DNA or RNA.

[0136] A “transgenic organism,” as used herein, is any organism, including but not limited to animals and plants, in which one or more of the cells of the organism contains heterologous nucleic acid introduced by way of human intervention, such as by transgenic techniques well known in the art. The nucleic acid is introduced into the cell, directly or indirectly by introduction into a precursor of the cell, by way of deliberate genetic manipulation, such as by microinjection or by infection with a recombinant virus. The term genetic manipulation does not include classical cross-breeding, or in vitro fertilization, but rather is directed to the introduction of a recombinant DNA molecule. The transgenic organisms contemplated in accordance with the present invention include bacteria, cyanobacteria, fungi, and plants and animals. The isolated DNA of the present invention can be introduced into the host by methods known in the art, for example infection, transfection, transformation or transconjugation. Techniques for transferring the DNA of the present invention into such organisms are widely known and provided in references such as Sambrook et al. (1989), supra.

[0137] A “variant” of a particular nucleic acid sequence is defined as a nucleic acid sequence having at least 25% sequence identity to the particular nucleic acid sequence over a certain length of one of the nucleic acid sequences using BLASTN with the “BLAST 2 Sequences” tool Version 2.0.9 (May 07, 1999) set at default parameters. Such a pair of nucleic acids may show, for example, at least 30%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% or greater sequence identity over a certain defined length. The variant may result in “conservative” amino acid changes which do not affect structural and/or chemical properties. A variant may be described as, for example, an “allelic” (as defined above), “splice,” “species,” or “polymorphic” variant. A splice variant may have significant identity to a reference molecule, but will generally have a greater or lesser number of polynucleotides due to alternate splicing of exons during mRNA processing. The corresponding polypeptide may possess additional functional domains or lack domains that are present in the reference molecule. Species variants are polynucleotide sequences that vary from one species to another. The resulting polypeptides generally will have significant amino acid identity relative to each other. A polymorphic variant is a variation in the polynucleotide sequence of a particular gene between individuals of a given species. Polymorphic variants also may encompass “single nucleotide polymorphisms” (SNPs) in which the polynucleotide sequence varies by one base. The presence of SNPs may be indicative of, for example, a certain population, a disease state, or a propensity for a disease state.

[0138] In an alternative, variants of the polynucleotides of the present invention may be generated through recombinant methods. One possible method is a DNA shuffling technique such as MOLECULARBREEDING (Maxygen Inc., Santa Clara Calif.; described in U.S. Pat. No. 5,837,458; Chang, C.-C. et al. (1999) Nat. Biotechnol. 17:793-797; Christians, F. C. et al. (1999) Nat. Biotechnol. 17:259-264; and Crameri, A. et al. (1996) Nat. Biotechnol. 14:315-319) to alter or improve the biological properties of SPTM, such as its biological or enzymatic activity or its ability to bind to other molecules or compounds. DNA shuffling is a process by which a library of gene variants is produced using PCR-mediated recombination of gene fragments. The library is then subjected to selection or screening procedures that identify those gene variants with the desired properties. These preferred variants may then be pooled and further subjected to recursive rounds of DNA shuffling and selection/screening. Thus, genetic diversity is created through “artificial” breeding and rapid molecular evolution. For example, fragments of a single gene containing random point mutations may be recombined, screened, and then reshuffled until the desired properties are optimized. Alternatively, fragments of a given gene may be recombined with fragments of homologous genes in the same gene family, either from the same or different species, thereby maximizing the genetic diversity of multiple naturally occurring genes in a directed and controllable manner.

[0139] A “variant” of a particular polypeptide sequence is defined as a polypeptide sequence having at least 40% sequence identity to the particular polypeptide sequence over a certain length of one of the polypeptide sequences using BLASTP with the “BLAST 2 Sequences” tool Version 2.0.9 (May 07, 1999) set at default parameters. Such a pair of polypeptides may show, for example, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% or greater sequence identity over a certain defined length of one of the polypeptides.

[0140] The Invention

[0141] In a particular embodiment, cDNA sequences derived from human tissues and cell lines were aligned based on nucleotide sequence identity and assembled into “consensus” or “template” sequences which are designated by the template identification numbers (template IDs) in column 2 of Table 2. The sequence identification numbers (SEQ ID NO:s) corresponding to the template IDs are shown in column 1. Segments of the template sequences are defined by the “start” and “stop” nucleotide positions listed in columns 3 and 4. These segments, when translated in the reading frames indicated in column 5, have similarity to signal peptide (SP) or transmembrane (TM) domain consensus sequences, as indicated in column 6.

[0142] The invention incorporates the nucleic acid sequences of these templates as disclosed in the Sequence Listing and the use of these sequences in the diagnosis and treatment of disease states characterized by defects in cell signaling. The invention further utilizes these sequences in hybridization and amplification technologies, and in particular, in technologies which assess gene expression patterns correlated with specific cells or tissues and their responses in vivo or in vitro to pharmaceutical agents, toxins, and other treatments. In this manner, the sequences of the present invention are used to develop a transcript image for a particular cell or tissue.

[0143] Derivation of Nucleic Acid Sequences

[0144] cDNA was isolated from libraries constructed using RNA derived from normal and diseased human tissues and cell lines. The human tissues and cell lines used for cDNA library construction were selected from a broad range of sources to provide a diverse population of cDNAs representative of gene transcription throughout the human body. Descriptions of the human tissues and cell lines used for cDNA library construction are provided in the LIFESEQ database (Incyte Genomics, Inc. (Incyte), Palo Alto Calif.). Human tissues were broadly selected from, for example, cardiovascular, dermatologic, endocrine, gastrointestinal, hematopoietic/immune system, musculoskeletal, neural, reproductive, and urologic sources.

[0145] Cell lines used for cDNA library construction were derived from, for example, leukemic cells, teratocarcinomas, neuroepitheliomas, cervical carcinoma, lung fibroblasts, and endothelial cells. Such cell lines include, for example, THP-1, Jurkat, HUVEC, hNT2, WI38, HeLa, and other cell lines commonly used and available from public depositories (American Type Culture Collection, Manassas Va.). Prior to mRNA isolation, cell lines were untreated, treated with a pharmaceutical agent such as 5′-aza-2′-deoxycytidine, treated with an activating agent such as lipopolysaccbaride in the case of leukocytic cell lines, or, in the case of endothelial cell lines, subjected to shear stress.

[0146] Sequencing of the cDNAs

[0147] Methods for DNA sequencing are well known in the art. Conventional enzymatic methods employ the Klenow fragment of DNA polymerase I, SEQUENASE DNA polymerase (U.S. Biochemical Corporation, Cleveland Ohio), Taq polymerase (Applied Biosystems, Foster City Calif.), thermostable T7 polymerase (Amersham Pharmacia Biotech, Inc. (Amersham Pharmacia Biotech), Piscataway N.J.), or combinations of polymerases and proofreading exonucleases such as those found in the ELONGASE amplification system (Life Technologies Inc. (Life Technologies), Gaithersburg Md.), to extend the nucleic acid sequence from an oligonucleotide primer annealed to the DNA template of interest. Methods have been developed for the use of both single-stranded and double-stranded templates. Chain termination reaction products may be electrophoresed on urea-polyacrylamide gels and detected either by autoradiography (for radioisotope-labeled nucleotides) or by fluorescence (for fluorophore-labeled nucleotides). Automated methods for mechanized reaction preparation, sequencing, and analysis using fluorescence detection methods have been developed. Machines used to prepare cDNAs for sequencing can include the MICROLAB 2200 liquid transfer system (Hamilton Company (Hamilton), Reno Nev.), Peltier thermal cycler (PTC200; MJ Research, Inc. (MJ Research), Watertown Mass.), and ABI CATALYST 800 thermal cycler (Applied Biosystems). Sequencing can be carried out using, for example, the ABI 373 or 377 (Applied Biosystems) or MEGABACE 1000 (Molecular Dynamics, Inc. (Molecular Dynamics), Sunnyvale Calif.) DNA sequencing systems, or other automated and manual sequencing systems well known in the art.

[0148] The nucleotide sequences of the Sequence Listing have been prepared by current, state-of-the-art, automated methods and, as such, may contain occasional sequencing errors or unidentified nucleotides. Such unidentified nucleotides are designated by an N. These infrequent unidentified bases do not represent a hindrance to practicing the invention for those skilled in the art. Several methods employing standard recombinant techniques may be used to correct errors and complete the missing sequence information. (See, e.g., those described in Ausubel, F. M. et al. (1997) Short Protocols in Molecular Biology, John Wiley & Sons, New York N.Y.; and Sambrook, J. et al. (1989) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Press, Plainview N.Y.)

[0149] Assembly of cDNA Sequences

[0150] Human polynucleotide sequences may be assembled using programs or algorithms well known in the art. Sequences to be assembled are related, wholly or in part, and may be derived from a single or many different transcripts. Assembly of the sequences can be performed using such programs as PHRAP (Phils Revised Assembly Program) and the GELVIEW fragment assembly system (GCG), or other methods known in the art.

[0151] Alternatively, cDNA sequences are used as “component” sequences that are assembled into “template” or “consensus” sequences as follows. Sequence chromatograms are processed, verified, and quality scores are obtained using PHRED. Raw sequences are edited using an editing pathway known as Block 1 (See, e.g., the LIFESEQ Assembled User Guide, Incyte Genomics, Palo Alto, Calif.). A series of BLAST comparisons is performed and low-information segments and repetitive elements (e.g., dinucleotide repeats, Alu repeats, etc.) are replaced by “n's”, or masked, to prevent spurious matches. Mitochondrial and ribosomal RNA sequences are also removed. The processed sequences are then loaded into a relational database management system (RDMS) which assigns edited sequences to existing templates, if available. When additional sequences are added into the RDMS, a process is initiated which modifies existing templates or creates new templates from works in progress (i.e., nonfinal assembled sequences) containing queued sequences or the sequences themselves. After the new sequences have been assigned to templates, the templates can be merged into bins. If multiple templates exist in one bin, the bin can be split and the templates reannotated.

[0152] Once gene bins have been generated based upon sequence alignments, bins are “clone joined” based upon clone information. Clone joining occurs when the 5′ sequence of one clone is present in one bin and the 3′ sequence from the same clone is present in a different bin, indicating that the two bins should be merged into a single bin. Only bins which share at least two different clones are merged.

[0153] A resultant template sequence may contain either a partial or a full length open reading frame, or all or part of a genetic regulatory element. This variation is due in part to the fact that the full length cDNAs of many genes are several hundred, and sometimes several thousand, bases in length. With current technology, cDNAs comprising the coding regions of large genes cannot be cloned because of vector limitations, incomplete reverse transcription of the mRNA, or incomplete “second strand” synthesis. Template sequences may be extended to include additional contiguous sequences derived from the parent RNA transcript using a variety of methods known to those of skill in the art. Extension may thus be used to achieve the full length coding sequence of a gene.

[0154] Analysis of the cDNA Sequences

[0155] The cDNA sequences are analyzed using a variety of programs and algorithms which are well known in the art. (See, e.g., Ausubel, 1997, supra, Chapter 7.7; Meyers, R. A. Ed.) (1995) Molecular Biology and Biotechnology, Wiley VCH, New York N.Y., pp. 856-853; and Table 6.) These analyses comprise both reading frame determinations, e.g., based on triplet codon periodicity for particular organisms (Fickett, J. W. (1982) Nucleic Acids Res. 10:5303-5318); analyses of potential start and stop codons; and homology searches.

[0156] Computer programs known to those of skill in the art for performing computer-assisted searches for amino acid and nucleic acid sequence similarity, include, for example, Basic Local Alignment Search Tool (BLAST; Altschul, S. F. (1993) J. Mol. Evol. 36:290-300; Altschul, S. F. et al. (1990) J. Mol. Biol. 215:403410). BLAST is especially useful in determining exact matches and comparing two sequence fragments of arbitrary but equal lengths, whose alignment is locally maximal and for which the alignment score meets or exceeds a threshold or cutoff score set by the user (Karlin, S. et al. (1988) Proc. Natl. Acad. Sci. USA 85:841-845). Using an appropriate search tool (e.g., BLAST or HMM), GenBank, SwissProt, BLOCKS, PFAM and other databases may be searched for sequences containing regions of homology to a query sptm or SPTM of the present invention.

[0157] Other approaches to the identification, assembly, storage, and display of nucleotide and polypeptide sequences are provided in “Relational Database for Storing Biomolecule Information,” U.S. Ser. No. 08/947,845, filed Oct. 9, 1997; “Project-Based Full-Length Biomolecular Sequence Database,” U.S. Pat. No. 5,953,727; and “Relational Database and System for Storing Information Relating to Biomolecular Sequences,” U.S. Ser. No. 09/034,807, filed Mar. 4, 1998, all of which are incorporated by reference herein in their entirety.

[0158] Protein hierarchies can be assigned to the putative encoded polypeptide based on, e.g., motif, BLAST, or biological analysis. Methods for assigning these hierarchies are described, for example, in “Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data,” U.S. Pat. No. 6,023,659, incorporated herein by reference.

[0159] Human Secretory Sequences

[0160] The sptm of the present invention may be used for a variety of diagnostic and therapeutic purposes. For example, an sptm may be used to diagnose a particular condition, disease, or disorder associated with cell signaling. Such conditions, diseases, and disorders include, but are not limited to, a cell proliferative disorder such as actinic keratosis, arteriosclerosis, atherosclerosis, bursitis, cirrhosis, hepatitis, mixed connective tissue disease (MCTD), myelofibrosis, paroxysmal nocturnal hemoglobinuria, polycythemia vera, psoriasis, primary thrombocythemia, and cancers including adenocarcinoma, leukemia, lymphoma, melanoma, myeloma, sarcoma, teratocarcinoma, and, in particular, a cancer of the adrenal gland, bladder, bone, bone marrow, brain, breast, cervix, gall bladder, ganglia, gastrointestinal tract, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, and uterus; an immune system disorder such as such as inflammation, actinic keratosis, acquired immunodeficiency syndrome (AIDS), Addison's disease, adult respiratory distress syndrome, allergies, ankylosing spondylitis, amyloidosis, anemia, arteriosclerosis, asthma, atherosclerosis, autoimmune hemolytic anemia, autoimmune thyroiditis, bronchitis, bursitis, cholecystitis, cirrhosis, contact dermatitis, Crohn's disease, atopic dermatitis, dermatomyositis, diabetes mellitus, emphysema, erythroblastosis fetalis, erythema nodosum, atrophic gastritis, glomerulonephritis, Goodpasture's syndrome, gout, Graves' disease, Hashimoto's thyroiditis, paroxysmal nocturnal hemoglobinuria, hepatitis, hypereosinophilia, irritable bowel syndrome, episodic lymphopenia with lymphocytotoxins, mixed connective tissue disease (MCTD), multiple sclerosis, myasthenia gravis, myocardial or pericardial inflammation, myelofibrosis, osteoarthritis, osteoporosis, pancreatitis, polycythemia vera, polymyositis, psoriasis, Reiter's syndrome, rheumatoid arthritis, scleroderma, Sjögren's syndrome, systemic anaphylaxis, systemic lupus erythematosus, systemic sclerosis, primary thrombocythemia, thrombocytopenic purpura, ulcerative colitis, uveitis, Werner syndrome, complications of cancer, hemodialysis, and extracorporeal circulation, trauma, and hematopoietic cancer including lymphoma, leukemia, and myeloma; and a neurological disorder such as epilepsy, ischemic cerebrovascular disease, stroke, cerebral neoplasms, Alzheimer's disease, Pick's disease, Huntington's disease, dementia, Parkinson's disease and other extrapyramidal disorders, amyotrophic lateral sclerosis and other motor neuron disorders, progressive neural muscular atrophy, retinitis pigmentosa, hereditary ataxias, multiple sclerosis and other demyelinating diseases, bacterial and viral meningitis, brain abscess, subdural empyema, epidural abscess, suppurative intracranial thrombophlebitis, myelitis and radiculitis, viral central nervous system disease, prion diseases including kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia, nutritional and metabolic diseases of the nervous system, neurofibromatosis, tuberous sclerosis, cerebelloretinal hemangioblastomatosis, encephalotrigeminal syndrome, mental retardation and other developmental disorder of the central nervous system, cerebral palsy, a neuroskeletal disorder, an autonomic nervous system disorder, a cranial nerve disorder, a spinal cord disease, muscular dystrophy and other neuromuscular disorder, a peripheral nervous system disorder, dermatomyositis and polymyositis, inherited, metabolic, endocrine, and toxic myopathy, myasthenia gravis, periodic paralysis, a mental disorder including mood, anxiety, and schizophrenic disorder, seasonal affective disorder (SAD), akathesia, amnesia, catatonia, diabetic neuropathy, tardive dyskinesia, dystonias, paranoid psychoses, postherpetic neuralgia, and Tourette's disorder. The sptm can be used to detect the presence of, or to quantify the amount of, an sptm-related polynucleotide in a sample. This information is then compared to information obtained from appropriate reference samples, and a diagnosis is established. Alternatively, a polynucleotide complementary to a given sptm can inhibit or inactivate a therapeutically relevant gene related to the sptm.

[0161] Analysis of sptm Expression Patterns

[0162] The expression of sptm may be routinely assessed by hybridization-based methods to determine, for example, the tissue-specificity, disease-specificity, or developmental stage-specificity of sptm expression. For example, the level of expression of sptm may be compared among different cell types or tissues, among diseased and normal cell types or tissues, among cell types or tissues at different developmental stages, or among cell types or tissues undergoing various treatments. This type of analysis is useful, for example, to assess the relative levels of sptm expression in fully or partially differentiated cells or tissues, to determine if changes in sptm expression levels are correlated with the development or progression of specific disease states, and to assess the response of a cell or tissue to a specific therapy, for example, in pharmacological or toxicological studies. Methods for the analysis of sptm expression are based on hybridization and amplification technologies and include membrane-based procedures such as northern blot analysis, high-throughput procedures that utilize, for example, microarrays, and PCR-based procedures.

[0163] Hybridization and Genetic Analysis

[0164] The sptm, their fragments, or complementary sequences, may be used to identify the presence of and/or to determine the degree of similarity between two (or more) nucleic acid sequences. The sptm may be hybridized to naturally occurring or recombinant nucleic acid sequences under appropriately selected temperatures and salt concentrations. Hybridization with a probe based on the nucleic acid sequence of at least one of the sptm allows for the detection of nucleic acid sequences, including genomic sequences, which are identical or related to the sptm of the Sequence Listing. Probes may be selected from non-conserved or unique regions of at least one of the polynucleotides of SEQ ID NO:1-75 and tested for their ability to identify or amplify the target nucleic acid sequence using standard protocols.

[0165] Polynucleotide sequences that are capable of hybridizing, in particular, to those shown in SEQ ID NO:1-75 and fragments thereof, can be identified using various conditions of stringency. (See, e.g., Wahl, G. M. and S. L. Berger (1987) Methods Enzymol. 152:399407; Kimmel, A. R. (1987) Methods Enzymol. 152:507-511.) Hybridization conditions are discussed in “Definitions.”

[0166] A probe for use in Southern or northern hybridization may be derived from a fragment of an sptm sequence, or its complement, that is up to several hundred nucleotides in length and is either single-stranded or double-stranded. Such probes may be hybridized in solution to biological materials such as plasmids, bacterial, yeast, or human artificial chromosomes, cleared or sectioned tissues, or to artificial substrates containing sptm. Microarrays are particularly suitable for identifying the presence of and detecting the level of expression for multiple genes of interest by examining gene expression correlated with, e.g., various stages of development, treatment with a drug or compound, or disease progression. An array analogous to a dot or slot blot may be used to arrange and link polynucleotides to the surface of a substrate using one or more of the following: mechanical (vacuum), chemical, thermal, or UV bonding procedures. Such an array may contain any number of sptm and may be produced by hand or by using available devices, materials, and machines.

[0167] Microarrays may be prepared, used, and analyzed using methods known in the art. (See, e.g., Brennan, T. M. et al. (1995) U.S. Pat. No. 5,474,796; Schena, M. et al. (1996) Proc. Natl. Acad. Sci. USA 93:10614-10619; Baldeschweiler et al. (1995) PCT application WO95/251116; Shalon, D. et al. (1995) PCT application WO95/35505; Heller, R. A. et al. (1997) Proc. Natl. Acad. Sci. USA 94:2150-2155; and Heller, M. J. et al. (1997) U.S. Pat. No. 5,605,662.)

[0168] Probes may be labeled by either PCR or enzymatic techniques using a variety of commercially available reporter molecules. For example, commercial kits are available for radioactive and chemiluminescent labeling (Amersham Pharmacia Biotech) and for alkaline phosphatase labeling (Life Technologies). Alternatively, sptm may be cloned into commercially available vectors for the production of RNA probes. Such probes may be transcribed in the presence of at least one labeled nucleotide (e.g., ³²P-ATP, Amersham Pharmacia Biotech).

[0169] Additionally the polynucleotides of SEQ ID NO:1-75 or suitable fragments thereof can be used to isolate full length cDNA sequences utilizing hybridization and/or amplification procedures well known in the art, e.g., cDNA library screening, PCR amplification, etc. The molecular cloning of such full length cDNA sequences may employ the method of cDNA library screening with probes using the hybridization, stringency, washing, and probing strategies described above and in Ausubel, supra, Chapters 3, 5, and 6. These procedures may also be employed with genomic libraries to isolate genomic sequences of sptm in order to analyze, e.g., regulatory elements.

[0170] Genetic Mapping

[0171] Gene identification and mapping are important in the investigation and treatment of almost all conditions, diseases, and disorders. Cancer, cardiovascular disease, Alzheimer's disease, arthritis, diabetes, and mental illnesses are of particular interest. Each of these conditions is more complex than the single gene defects of sickle cell anemia or cystic fibrosis, with select groups of genes being predictive of predisposition for a particular condition, disease, or disorder. For example, cardiovascular disease may result from malfunctioning receptor molecules that fail to clear cholesterol from the bloodstream, and diabetes may result when a particular individual's immune system is activated by an infection and attacks the insulin-producing cells of the pancreas. In some studies, Alzheimer's disease has been linked to a gene on chromosome 21; other studies predict a different gene and location. Mapping of disease genes is a complex and reiterative process and generally proceeds from genetic linkage analysis to physical mapping.

[0172] As a condition is noted among members of a family, a genetic linkage map traces parts of chromosomes that are inherited in the same pattern as the condition. Statistics link the inheritance of particular conditions to particular regions of chromosomes, as defined by RFLP or other markers. (See, for example, Lander, E. S. and Botstein, D. (1986) Proc. Natl. Acad. Sci. USA 83:7353-7357.) Occasionally, genetic markers and their locations are known from previous studies. More often, however, the markers are simply stretches of DNA that differ among individuals. Examples of genetic linkage maps can be found in various scientific journals or at the Online Mendelian Inheritance in Man (OMIM) World Wide Web site.

[0173] In another embodiment of the invention, sptm sequences may be used to generate hybridization probes useful in chromosomal mapping of naturally occurring genomic sequences. Either coding or noncoding sequences of sptm may be used, and in some instances, noncoding sequences may be preferable over coding sequences. For example, conservation of an sptm coding sequence among members of a multi-gene family may potentially cause undesired cross hybridization during chromosomal mapping. The sequences may be mapped to a particular chromosome, to a specific region of a chromosome, or to artificial chromosome constructions, e.g., human artificial chromosomes (HACs), yeast artificial chromosomes (YACs), bacterial artificial chromosomes (BACs), bacterial P1 constructions, or single chromosome cDNA libraries. (See, e.g., Harrington, J. J. et al. (1997) Nat. Genet. 15:345-355; Price, C. M. (1993) Blood Rev. 7:127-134; and Trask, B. J. (1991) Trends Genet. 7:149-154.)

[0174] Fluorescent in situ hybridization (FISH) may be correlated with other physical chromosome mapping techniques and genetic map data. (See, e.g., Meyers, supra, pp. 965-968.) Correlation between the location of sptm on a physical chromosomal map and a specific disorder, or a predisposition to a specific disorder, may help define the region of DNA associated with that disorder. The sptm sequences may also be used to detect polymorphisms that are genetically linked to the inheritance of a particular condition, disease, or disorder.

[0175] In situ hybridization of chromosomal preparations and genetic mapping techniques, such as linkage analysis using established chromosomal markers, may be used for extending existing genetic maps. Often the placement of a gene on the chromosome of another mammalian species, such as mouse, may reveal associated markers even if the number or arm of the corresponding human chromosome is not known. These new marker sequences can be mapped to human chromosomes and may provide valuable information to investigators searching for disease genes using positional cloning or other gene discovery techniques. Once a disease or syndrome has been crudely correlated by genetic linkage with a particular genomic region, e.g., ataxia-telangiectasia to 11q22-23, any sequences mapping to that area may represent associated or regulatory genes for further investigation. (See, e.g., Gatti, R. A. et al. (1988) Nature 336:577-580.) The nucleotide sequences of the subject invention may also be used to detect differences in chromosomal architecture due to translocation, inversion, etc., among normal, carrier, or affected individuals.

[0176] Once a disease-associated gene is mapped to a chromosomal region, the gene must be cloned in order to identify mutations or other alterations (e.g., translocations or inversions) that may be correlated with disease. This process requires a physical map of the chromosomal region containing the disease-gene of interest along with associated markers. A physical map is necessary for determining the nucleotide sequence of and order of marker genes on a particular chromosomal region. Physical mapping techniques are well known in the art and require the generation of overlapping sets of cloned DNA fragments from a particular organelle, chromosome, or genome. These clones are analyzed to reconstruct and catalog their order. Once the position of a marker is determined, the DNA from that region is obtained by consulting the catalog and selecting clones from that region. The gene of interest is located through positional cloning techniques using hybridization or similar methods.

[0177] Diagnostic Uses

[0178] The sptm of the present invention may be used to design probes useful in diagnostic assays. Such assays, well known to those skilled in the art, may be used to detect or confirm conditions, disorders, or diseases associated with abnormal levels of sptm expression. Labeled probes developed from sptm sequences are added to a sample under hybridizing conditions of desired stringency. In some instances, sptm, or fragments or oligonucleotides derived from sptm, may be used as primers in amplification steps prior to hybridization. The amount of hybridization complex formed is quantified and compared with standards for that cell or tissue. If sptm expression varies significantly from the standard, the assay indicates the presence of the condition, disorder, or disease. Qualitative or quantitative diagnostic methods may include northern, dot blot, or other membrane or dip-stick based technologies or multiple-sample format technologies such as PCR, enzyme-linked immunosorbent assay (ELISA)-like, pin, or chip-based assays.

[0179] The probes described above may also be used to monitor the progress of conditions, disorders, or diseases associated with abnormal levels of sptm expression, or to evaluate the efficacy of a particular therapeutic treatment. The candidate probe may be identified from the sptm that are specific to a given human tissue and have not been observed in GenBank or other genome databases. Such a probe may be used in animal studies, preclinical tests, clinical trials, or in monitoring the treatment of an individual patient. In a typical process, standard expression is established by methods well known in the art for use as a basis of comparison, samples from patients affected by the disorder or disease are combined with the probe to evaluate any deviation from the standard profile, and a therapeutic agent is administered and effects are monitored to generate a treatment profile. Efficacy is evaluated by determining whether the expression progresses toward or returns to the standard normal pattern. Treatment profiles may be generated over a period of several days or several months. Statistical methods well known to those skilled in the art may be use to determine the significance of such therapeutic agents.

[0180] The polynucleotides are also useful for identifying individuals from minute biological samples, for example, by matching the RFLP pattern of a sample's DNA to that of an individual's DNA. The polynucleotides of the present invention can also be used to determine the actual base-by-base DNA sequence of selected portions of an individual's genome. These sequences can be used to prepare PCR primers for amplifying and isolating such selected DNA, which can then be sequenced. Using this technique, an individual can be identified through a unique set of DNA sequences. Once a unique ID database is established for an individual, positive identification of that individual can be made from extremely small tissue samples.

[0181] In a particular aspect, oligonucleotide primers derived from the sptm of the invention may be used to detect single nucleotide polymorphisms (SNPs). SNPs are substitutions, insertions and deletions that are a frequent cause of inherited or acquired genetic disease in humans. Methods of SNP detection include, but are not limited to, single-stranded conformation polymorphism (SSCP) and fluorescent SSCP (fSSCP) methods. In SSCP, oligonucleotide primers derived from sptm are used to amplify DNA using the polymerase chain reaction (PCR). The DNA may be derived, for example, from diseased or normal tissue, biopsy samples, bodily fluids, and the like. SNPs in the DNA cause differences in the secondary and tertiary structures of PCR products in single-stranded form, and these differences are detectable using gel electrophoresis in non-denaturing gels. In fSCCP, the oligonucleotide primers are fluorescently labeled, which allows detection of the amplimers in high-throughput equipment such as DNA sequencing machines. Additionally, sequence database analysis methods, termed in silico SNP (is SNP), are capable of identifying polymorphisms by comparing the sequences of individual overlapping DNA fragments which assemble into a common consensus sequence. These computer-based methods filter out sequence variations due to laboratory preparation of DNA and sequencing errors using statistical models and automated analyses of DNA sequence chromatograms. In the alternative, SNPs may be detected and characterized by mass spectrometry using, for example, the high throughput MASSARRAY system (Sequenom, Inc., San Diego Calif.).

[0182] DNA-based identification techniques are critical in forensic technology. DNA sequences taken from very small biological samples such as tissues, e.g., hair or skin, or body fluids, e.g., blood, saliva, semen, etc., can be amplified using, e.g., PCR, to identify individuals. (See, e.g., Erlich, H. (1992) PCR Technology, Freeman and Co., New York, N.Y.). Similarly, polynucleotides of the present invention can be used as polymorphic markers.

[0183] There is also a need for reagents capable of identifying the source of a particular tissue. Appropriate reagents can comprise, for example, DNA probes or primers prepared from the sequences of the present invention that are specific for particular tissues. Panels of such reagents can identify tissue by species and/or by organ type. In a similar fashion, these reagents can be used to screen tissue cultures for contamination.

[0184] The polynucleotides of the present invention can also be used as molecular weight markers on nucleic acid gels or Southern blots, as diagnostic probes for the presence of a specific mRNA in a particular cell type, in the creation of subtracted cDNA libraries which aid in the discovery of novel polynucleotides, in selection and synthesis of oligomers for attachment to an array or other support, and as an antigen to elicit an immune response.

[0185] Disease Model Systems Using sptm

[0186] The polynucleotides encoding SPTM or their mammalian homologs may be “knocked out” in an animal model system using homologous recombination in embryonic stem (ES) cells. Such techniques are well known in the art and are useful for the generation of animal models of human disease. (See, e.g., U.S. Pat. No. 5,175,383 and U.S. Pat. No. 5,767,337.) For example, mouse ES cells, such as the mouse 129/SvJ cell line, are derived from the early mouse embryo and grown in culture. The ES cells are transformed with a vector containing the gene of interest disrupted by a marker gene, e.g., the neomycin phosphotransferase gene (neo; Capecchi, M. R. (1989) Science 244:1288-1292). The vector integrates into the corresponding region of the host genome by homologous recombination. Alternatively, homologous recombination takes place using the Cre-loxP system to knockout a gene of interest in a tissue- or developmental stage-specific manner (Marti, J. D. (1996) Clin. Invest. 97:1999-2002; Wagner, K. U. et al. (1997) Nucleic Acids Res. 25:4323-4330). Transformed ES cells are identified and microinjected into mouse cell blastocysts such as those from the C57BL/6 mouse strain. The blastocysts are surgically transferred to pseudopregnant dams, and the resulting chimeric progeny are genotyped and bred to produce heterozygous or homozygous strains. Transgenic animals thus generated may be tested with potential therapeutic or toxic agents.

[0187] The polynucleotides encoding SPTM may also be manipulated in vitro in ES cells derived from human blastocysts. Human ES cells have the potential to differentiate into at least eight separate cell lineages including endoderm, mesoderm, and ectodermal cell types. These cell lineages differentiate into, for example, neural cells, hematopoietic lineages, and cardiomyocytes (Thomson, J. A. et al. (1998) Science 282:1145-1147).

[0188] The polynucleotides encoding SPTM of the invention can also be used to create “knockin” humanized animals (pigs) or transgenic animals (mice or rats) to model human disease. With knockin technology, a region of sptm is injected into animal ES cells, and the injected sequence integrates into the animal cell genome. Transformed cells are injected into blastulae, and the blastulae are implanted as described above. Transgenic progeny or inbred lines are studied and treated with potential pharmaceutical agents to obtain information on treatment of a human disease. Alternatively, a mammal inbred to overexpress sptm, resulting, e.g., in the secretion of SPTM in its milk, may also serve as a convenient source of that protein (Janne, J. et al. (1998) Biotechnol. Annu. Rev. 4:55-74).

[0189] Screening Assays

[0190] SPTM encoded by polynucleotides of the present invention may be used to screen for molecules that bind to or are bound by the encoded polypeptides. The binding of the polypeptide and the molecule may activate (agonist), increase, inhibit (antagonist), or decrease activity of the polypeptide or the bound molecule. Examples of such molecules include antibodies, oligonucleotides, proteins (e.g., receptors), or small molecules.

[0191] Preferably, the molecule is closely related to the natural ligand of the polypeptide, e.g., a ligand or fragment thereof, a natural substrate, or a structural or functional mimetic. (See, Coligan et al., (1991) Current Protocols in Immunology 1(2): Chapter 5.) Similarly, the molecule can be closely related to the natural receptor to which the polypeptide binds, or to at least a fragment of the receptor, e.g., the active site. In either case, the molecule can be rationally designed using known techniques. Preferably, the screening for these molecules involves producing appropriate cells which express the polypeptide, either as a secreted protein or on the cell membrane. Preferred cells include cells from mammals, yeast, Drosophila, or E. coli. Cells expressing the polypeptide or cell membrane fractions which contain the expressed polypeptide are then contacted with a test compound and binding, stimulation, or inhibition of activity of either the polypeptide or the molecule is analyzed.

[0192] An assay may simply test binding of a candidate compound to the polypeptide, wherein binding is detected by a fluorophore, radioisotope, enzyme conjugate, or other detectable label. Alternatively, the assay may assess binding in the presence of a labeled competitor.

[0193] Additionally, the assay can be carried out using cell-free preparations, polypeptide/molecule affixed to a solid support, chemical libraries, or natural product mixtures. The assay may also simply comprise the steps of mixing a candidate compound with a solution containing a polypeptide, measuring polypeptide/molecule activity or binding, and comparing the polypeptide/molecule activity or binding to a standard.

[0194] Preferably, an ELISA assay using, e.g., a monoclonal or polyclonal antibody, can measure polypeptide level in a sample. The antibody can measure polypeptide level by either binding, directly or indirectly, to the polypeptide or by competing with the polypeptide for a substrate.

[0195] All of the above assays can be used in a diagnostic or prognostic context. The molecules discovered using these assays can be used to treat disease or to bring about a particular result in a patient (e.g., blood vessel growth) by activating or inhibiting the polypeptide/molecule. Moreover, the assays can discover agents which may inhibit or enhance the production of the polypeptide from suitably manipulated cells or tissues.

[0196] Transcript Imaging and Toxicological Testing

[0197] Another embodiment relates to the use of sptm to develop a transcript image of a tissue or cell type. A transcript image represents the global pattern of gene expression by a particular tissue or cell type. Global gene expression patterns are analyzed by quantifying the number of expressed genes and their relative abundance under given conditions and at a given time. (See Seilhamer et al., “Comparative Gene Transcript Analysis,” U.S. Pat. No. 5,840,484, expressly incorporated by reference herein.) Thus a transcript image may be generated by hybridizing the polynucleotides of the present invention or their complements to the totality of transcripts or reverse transcripts of a particular tissue or cell type. In one embodiment, the hybridization takes place in high-throughput format, wherein the polynucleotides of the present invention or their complements comprise a subset of a plurality of elements on a microarray. The resultant transcript image would provide a profile of gene activity pertaining to cell signaling.

[0198] Transcript images which profile sptm expression may be generated using transcripts isolated from tissues, cell lines, biopsies, or other biological samples. The transcript image may thus reflect sptm expression in vivo, as in the case of a tissue or biopsy sample, or in vitro, as in the case of a cell line.

[0199] Transcript images which profile sptm expression may also be used in conjunction with in vitro model systems and preclinical evaluation of pharmaceuticals, as well as toxicological testing of industrial and naturally-occurring environmental compounds. All compounds induce characteristic gene expression patterns, frequently termed molecular fingerprints or toxicant signatures, which are indicative of mechanisms of action and toxicity (Nuwaysir, E. F. et al. (1999) Mol. Carcinog. 24:153-159; Steiner, S. and Anderson, N. L. (2000) Toxicol. Lett. 112-113:467-71, expressly incorporated by reference herein). If a test compound has a signature similar to that of a compound with known toxicity, it is likely to share those toxic properties. These fingerprints or signatures are most useful and refined when they contain expression information from a large number of genes and gene families. Ideally, a genome-wide measurement of expression provides the highest quality signature. Even genes whose expression is not altered by any tested compounds are important as well, as the levels of expression of these genes are used to normalize the rest of the expression data. The normalization procedure is useful for comparison of expression data after treatment with different compounds. While the assignment of gene function to elements of a toxicant signature aids in interpretation of toxicity mechanisms, knowledge of gene function is not necessary for the statistical matching of signatures which leads to prediction of toxicity. (See, for example, Press Release 00-02 from the National Institute of Environmental Health Sciences, released Feb. 29, 2000, available at http://www.niehs.nih.gov/oc/news/toxchip.htm.) Therefore, it is important and desirable in toxicological screening using toxicant signatures to include all expressed gene sequences.

[0200] In one embodiment, the toxicity of a test compound is assessed by treating a biological sample containing nucleic acids with the test compound. Nucleic acids that are expressed in the treated biological sample are hybridized with one or more probes specific to the polynucleotides of the present invention, so that transcript levels corresponding to the polynucleotides of the present invention may be quantified. The transcript levels in the treated biological sample are compared with levels in an untreated biological sample. Differences in the transcript levels between the two samples are indicative of a toxic response caused by the test compound in the treated sample.

[0201] Another particular embodiment relates to the use of SPTM encoded by polynucleotides of the present invention to analyze the proteome of a tissue or cell type. The term proteome refers to the global pattern of protein expression in a particular tissue or cell type. Each protein component of a proteome can be subjected individually to further analysis. Proteome expression patterns, or profiles, are analyzed by quantifying the number of expressed proteins and their relative abundance under given conditions and at a given time. A profile of a cell's proteome may thus be generated by separating and analyzing the polypeptides of a particular tissue or cell type. In one embodiment, the separation is achieved using two-dimensional gel electrophoresis, in which proteins from a sample are separated by isoelectric focusing in the first dimension, and then according to molecular weight by sodium dodecyl sulfate slab gel electrophoresis in the second dimension (Steiner and Anderson, supra). The proteins are visualized in the gel as discrete and uniquely positioned spots, typically by staining the gel with an agent such as Coomassie Blue or silver or fluorescent stains. The optical density of each protein spot is generally proportional to the level of the protein in the sample. The optical densities of equivalently positioned protein spots from different samples, for example, from biological samples either treated or untreated with a test compound or therapeutic agent, are compared to identify any changes in protein spot density related to the treatment. The proteins in the spots are partially sequenced using, for example, standard methods employing chemical or enzymatic cleavage followed by mass spectrometry. The identity of the protein in a spot may be determined by comparing its partial sequence, preferably of at least 5 contiguous amino acid residues, to the polypeptide sequences of the present invention. In some cases, further sequence data may be obtained for definitive protein identification.

[0202] A proteomic profile may also be generated using antibodies specific for SPTM to quantify the levels of SPTM expression. In one embodiment, the antibodies are used as elements on a microarray, and protein expression levels are quantified by exposing the microarray to the sample and detecting the levels of protein bound to each array element (Lueling, A. et al. (1999) Anal. Biochem. 270:103-11; Mendoze, L. G. et al. (1999) Biotechniques 27:778-88). Detection may be performed by a variety of methods known in the art, for example, by reacting the proteins in the sample with a thiol- or amino-reactive fluorescent compound and detecting the amount of fluorescence bound at each array element.

[0203] Toxicant signatures at the proteome level are also useful for toxicological screening, and should be analyzed in parallel with toxicant signatures at the transcript level. There is a poor correlation between transcript and protein abundances for some proteins in some tissues (Anderson, N. L. and Seilhamer, J. (1997) Electrophoresis 18:533-537), so proteome toxicant signatures may be useful in the analysis of compounds which do not significantly affect the transcript image, but which alter the proteomic profile. In addition, the analysis of transcripts in body fluids is difficult, due to rapid degradation of mRNA, so proteomic profiling may be more reliable and informative in such cases.

[0204] In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins that are expressed in the treated biological sample are separated so that the amount of each protein can be quantified. The amount of each protein is compared to the amount of the corresponding protein in an untreated biological sample. A difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample. Individual proteins are identified by sequencing the amino acid residues of the individual proteins and comparing these partial sequences to the SPTM encoded by polynucleotides of the present invention.

[0205] In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins from the biological sample are incubated with antibodies specific to the SPTM encoded by polynucleotides of the present invention. The amount of protein recognized by the antibodies is quantified. The amount of protein in the treated biological sample is compared with the amount in an untreated biological sample. A difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample.

[0206] Transcript images may be used to profile sptm expression in distinct tissue types. This process can be used to determine cell signaling activity in a particular tissue type relative to this activity in a different tissue type. Transcript images may be used to generate a profile of sptm expression characteristic of diseased tissue. Transcript images of tissues before and after treatment may be used for diagnostic purposes, to monitor the progression of disease, and to monitor the efficacy of drug treatments for diseases which affect cell signaling activity.

[0207] Transcript images of cell lines can be used to assess cell signaling activity and/or to identify cell lines that lack or misregulate this activity. Such cell lines may then be treated with pharmaceutical agents, and a transcript image following treatment may indicate the efficacy of these agents in restoring desired levels of this activity. A similar approach may be used to assess the toxicity of pharmaceutical agents as reflected by undesirable changes in cell signaling activity. Candidate pharmaceutical agents may be evaluated by comparing their associated transcript images with those of pharmaceutical agents of known effectiveness.

[0208] Antisense Molecules

[0209] The polynucleotides of the present invention are useful in antisense technology. Antisense technology or therapy relies on the modulation of expression of a target protein through the specific binding of an antisense sequence to a target sequence encoding the target protein or directing its expression. (See, e.g., Agrawal, S., ed. (1996) Antisense Therapeutics, Humana Press Inc., Totawa N.J.; Alama, A. et al. (1997) Pharmacol. Res. 36(3):171-178; Crooke, S. T. (1997) Adv. Pharmacol. 40:1-49; Sharma, H. W. and R. Narayanan (1995) Bioessays 17(12):1055-1063; and Lavrosky, Y. et al. (1997) Biochem. Mol. Med. 62(1):11-22.) An antisense sequence is a polynucleotide sequence capable of specifically hybridizing to at least a portion of the target sequence. Antisense sequences bind to cellular mRNA and/or genomic DNA, affecting translation and/or transcription. Antisense sequences can be DNA, RNA, or nucleic acid mimics and analogs. (See, e.g., Rossi, J. J. et al. (1991) Antisense Res. Dev. 1(3):285-288; Lee, R. et al. (1998) Biochemistry 37(3):900-1010; Pardridge, W. M. et al. (1995) Proc. Natl. Acad. Sci. USA 92(12):5592-5596; and Nielsen, P. E. and Haaima, G. (1997) Chem. Soc. Rev. 96:73-78.) Typically, the binding which results in modulation of expression occurs through hybridization or binding of complementary base pairs. Antisense sequences can also bind to DNA duplexes through specific interactions in the major groove of the double helix.

[0210] The polynucleotides of the present invention and fragments thereof can be used as antisense sequences to modify the expression of the polypeptide encoded by sptm. The antisense sequences can be produced ex vivo, such as by using any of the ABI nucleic acid synthesizer series (Applied Biosystems) or other automated systems known in the art. Antisense sequences can also be produced biologically, such as by transforming an appropriate host cell with an expression vector containing the sequence of interest. (See, e.g., Agrawal, supra.)

[0211] In therapeutic use, any gene delivery system suitable for introduction of the antisense sequences into appropriate target cells can be used. Antisense sequences can be delivered intracellularly in the form of an expression plasmid which, upon transcription, produces a sequence complementary to at least a portion of the cellular sequence encoding the target protein. (See, e.g., Slater, J. E., et al. (1998) J. Allergy Clin. Immunol. 102(3):469-475; and Scanlon, K. J., et al. (1995) 9(13):1288-1296.) Antisense sequences can also be introduced intracellularly through the use of viral vectors, such as retrovirus and adeno-associated virus vectors. (See, e.g., Miller, A. D. (1990) Blood 76:271; Ausubel, F. M. et al. (1995) Current Protocols in Molecular Biology, John Wiley & Sons, New York N.Y.; Uckert, W. and W. Walther (1994) Pharmacol. Ther. 63(3):323-347.) Other gene delivery mechanisms include liposome-derived systems, artificial viral envelopes, and other systems known in the art. (See, e.g., Rossi, J. J. (1995) Br. Med. Bull. 51(1):217-225; Boado, R. J. et al. (1998) J. Pharm. Sci. 87(11):1308-1315; and Morris, M. C. et al. (1997) Nucleic Acids Res. 25(14):2730-2736.)

[0212] Expression

[0213] In order to express a biologically active SPTM, the nucleotide sequences encoding SPTM or fragments thereof may be inserted into an appropriate expression vector, i.e., a vector which contains the necessary elements for transcriptional and translational control of the inserted coding sequence in a suitable host. Methods which are well known to those skilled in the art may be used to construct expression vectors containing sequences encoding SPTM and appropriate transcriptional and translational control elements. These methods include in vitro recombinant DNA techniques, synthetic techniques, and in vivo genetic recombination. (See, e.g., Sambrook, supra, Chapters 4, 8, 16, and 17; and Ausubel, supra, Chapters 9, 10, 13, and 16.)

[0214] A variety of expression vector/host systems may be utilized to contain and express sequences encoding SPTM. These include, but are not limited to, microorganisms such as bacteria transformed with recombinant bacteriophage, plasmid, or cosmid DNA expression vectors; yeast transformed with yeast expression vectors; insect cell systems infected with viral expression vectors (e.g., baculovirus); plant cell systems transformed with viral expression vectors (e.g., cauliflower mosaic virus, CaMV, or tobacco mosaic virus, TMV) or with bacterial expression vectors (e.g., Ti or pBR322 plasmids); or animal (mammalian) cell systems. (See, e.g., Sambrook, supra; Ausubel, 1995, supra, Van Heeke, G. and S. M. Schuster (1989) J. Biol. Chem. 264:5503-5509; Bitter, G. A. et al. (1987) Methods Enzymol. 153:516-544; Scorer, C. A. et al. (1994) Bio/Technology 12:181-184; Engelhard, E. K. et al. (1994) Proc. Natl. Acad. Sci. USA 91:3224-3227; Sandig, V. et al. (1996) Hum Gene Ther. 7:1937-1945; Takamatsu, N. (1987) EMBO J. 6:307-311; Coruzzi, G. et al. (1984) EMBO J. 3:1671-1680; Broglie, R. et al. (1984) Science 224:838-843; Winter, J. et al. (1991) Results Probl. Cell Differ. 17:85-105; The McGraw Hill Yearbook of Science and Technology (1992) McGraw Hill, New York N.Y., pp. 191-196; Logan, J. and T. Shenk (1984) Proc. Natl. Acad. Sci. USA 81:3655-3659; and Harrington, J. J. et al. (1997) Nat. Genet. 15:345-355.) Expression vectors derived from retroviruses, adenoviruses, or herpes or vaccinia viruses, or from various bacterial plasmids, may be used for delivery of nucleotide sequences to the targeted organ, tissue, or cell population. (See, e.g., Di Nicola, M. et al. (1998) Cancer Gen. Ther. 5(6):350-356; Yu, M. et al., (1993) Proc. Natl. Acad. Sci. USA 90(13):6340-6344; Buller, R. M. et al. (1985) Nature 317(6040):813-815; McGregor, D. P. et al. (1994) Mol. Immunol. 31(3):219-226; and Verma, I. M. and N. Somia (1997) Nature 389:239-242.) The invention is not limited by the host cell employed.

[0215] For long term production of recombinant proteins in mammalian systems, stable expression of SPTM in cell lines is preferred. For example, sequences encoding SPTM can be transformed into cell lines using expression vectors which may contain viral origins of replication and/or endogenous expression elements and a selectable marker gene on the same or on a separate vector. Any number of selection systems may be used to recover transformed cell lines. (See, e.g., Wigler, M. et al. (1977) Cell 11:223-232; Lowy, I. et al. (1980) Cell 22:817-823; Wigler, M. et al. (1980) Proc. Natl. Acad. Sci. USA 77:3567-3570; Colbere-Garapin, F. et al. (1981) J. Mol. Biol. 150:1-14; Hartman, S. C. and R. C. Mulligan (1988) Proc. Natl. Acad. Sci. USA 85:8047-8051; Rhodes, C. A. (1995) Methods Mol. Biol. 55:121-131.)

[0216] Therapeutic Uses of sptm

[0217] The polynucleotides encoding SPTM of the invention may be used for somatic or germline gene therapy. Gene therapy may be performed to (i) correct a genetic deficiency (e.g., in the cases of severe combined immunodeficiency (SCID)-X1 disease characterized by X-linked inheritance (Cavazzana-Calvo, M. et al. (2000) Science 288:669-672), severe combined immunodeficiency syndrome associated with an inherited adenosine deaminase (ADA) deficiency (Blaese, R. M. et al. (1995) Science 270:475480; Bordignon, C. et al. (1995) Science 270:470475), cystic fibrosis (Zabner, J. et al. (1993) Cell 75:207-216; Crystal, R. G. et al. (1995) Hum. Gene Therapy 6:643-666; Crystal, R. G. et al. (1995) Hum Gene Therapy 6:667-703), thalassemias, familial hypercholesterolemia, and hemophilia resulting from Factor VIII or Factor IX deficiencies (Crystal, R. G. (1995) Science 270:404-410; Verma, I. M. and Somia, N. (1997) Nature 389:239-242)), (ii) express a conditionally lethal gene product (e.g., in the case of cancers which result from unregulated cell proliferation), or (iii) express a protein which affords protection against intracellular parasites (e.g., against human retroviruses, such as human immunodeficiency virus (HIV) (Baltimore, D. (1988) Nature 335:395-396; Poeschla, E. et al. (1996) Proc. Natl. Acad. Sci. USA. 93:11395-11399), hepatitis B or C virus (HBV, HCV); fungal parasites, such as Candida albicans and Paracoccidioides brasiliensis; and protozoan parasites such as Plasmodium falciparum and Trypanosoma cruzi). In the case where a genetic deficiency in sptm expression or regulation causes disease, the expression of sptm from an appropriate population of transduced cells may alleviate the clinical manifestations caused by the genetic deficiency.

[0218] In a further embodiment of the invention, diseases or disorders caused by deficiencies in sptm are treated by constructing mammalian expression vectors comprising sptm and introducing these vectors by mechanical means into sptm-deficient cells. Mechanical transfer technologies for use with cells in vivo or ex vitro include (i) direct DNA microinjection into individual cells, (ii) ballistic gold particle delivery, (iii) liposome-mediated transfection, (iv) receptor-mediated gene transfer, and (v) the use of DNA transposons (Morgan, R. A. and Anderson, W. F. (1993) Annu. Rev. Biochem 62:191-217; Ivics, Z. (1997) Cell 91:501-510; Boulay, J-L. and Récipon, H. (1998) Curr. Opin. Biotechnol. 9:445-450).

[0219] Expression vectors that may be effective for the expression of sptm include, but are not limited to, the PCDNA 3.1, EPITAG, PRCCMV2, PREP, PVAX vectors (Invitrogen, Carlsbad Calif.), PCMV-SCRIPT, PCMV-TAG, PEGSH/PERV (Stratagene, La Jolla Calif.), and PTET-OFF, PTET-ON, PTRE2, PTRE2-LUC, PTK-HYG (Clontech, Palo Alto Calif.). The sptm of the invention may be expressed using (i) a constitutively active promoter, (e.g., from cytomegalovirus (CMV), Rous sarcoma virus (RSV), SV40 virus, thymidine kinase (TK), or β-actin genes), (ii) an inducible promoter (e.g., the tetracycline-regulated promoter (Gossen, M. and Bujard, H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89:5547-5551; Gossen, M. et al., (1995) Science 268:1766-1769; Rossi, F. M. V. and Blau, H. M. (1998) Curr. Opin. Biotechnol. 9:451456), commercially available in the T-REX plasmid (Invitrogen); the ecdysone-inducible promoter (available in the plasmids PVGRXR and PIND; Invitrogen); the FK506/rapamycin inducible promoter; or the RU486/mifepristone inducible promoter (Rossi, F. M. V. and Blau, H. M. supra), or (iii) a tissue-specific promoter or the native promoter of the endogenous gene encoding SPTM from a normal individual.

[0220] Commercially available liposome transformation kits (e.g., the PERFECT LIPID TRANSFECTION KIT, available from Invitrogen) allow one with ordinary skill in the art to deliver polynucleotides to target cells in culture and require minimal effort to optimize experimental parameters. In the alternative, transformation is performed using the calcium phosphate method (Graham, F. L. and Eb, A. J. (1973) Virology 52:456-467), or by electroporation (Neumann, E. et al. (1982) EMBO J. 1:841-845). The introduction of DNA to primary cells requires modification of these standardized mammalian transfection protocols.

[0221] In another embodiment of the invention, diseases or disorders caused by genetic defects with respect to sptm expression are treated by constructing a retrovirus vector consisting of (i) sptm under the control of an independent promoter or the retrovirus long terminal repeat (LTR) promoter, (ii) appropriate RNA packaging signals, and (iii) a Rev-responsive element (RRE) along with additional retrovirus cis-acting RNA sequences and coding sequences required for efficient vector propagation. Retrovirus vectors (e.g., PFB and PFBNEO) are commercially available (Stratagene) and are based on published data (Riviere, I. et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92:6733-6737), incorporated by reference herein. The vector is propagated in an appropriate vector producing cell line (VPCL) that expresses an envelope gene with a tropism for receptors on the target cells or a promiscuous envelope protein such as VSVg (Armentano, D. et al. (1987) J. Virol. 61:1647-1650; Bender, M. A. et al. (1987) J. Virol. 61:1639-1646; Adam, M. A. and Miller, A. D. (1988) J. Virol. 62:3802-3806; Dull, T. et al. (1998) J. Virol. 72:8463-8471; Zufferey, R. et al. (1998) J. Virol. 72:9873-9880). U.S. Pat. No. 5,910,434 to Rigg (“Method for obtaining retrovirus packaging cell lines producing high transducing efficiency retroviral supernatant”) discloses a method for obtaining retrovirus packaging cell lines and is hereby incorporated by reference. Propagation of retrovirus vectors, transduction of a population of cells (e.g., CD4⁺ T-cells), and the return of transduced cells to a patient are procedures well known to persons skilled in the art of gene therapy and have been well documented (Ranga, U. et al. (1997) J. Virol. 71:7020-7029; Bauer, G. et al. (1997) Blood 89:2259-2267; Bonyhadi, M. L. (1997) J. Virol. 71:47074716; Ranga, U. et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95:1201-1206; Su, L. (1997) Blood 89:2283-2290).

[0222] In the alternative, an adenovirus-based gene therapy delivery system is used to deliver sptm to cells which have one or more genetic abnormalities with respect to the expression of sptm. The construction and packaging of adenovirus-based vectors are well known to those with ordinary skill in the art. Replication defective adenovirus vectors have proven to be versatile for importing genes encoding immunoregulatory proteins into intact islets in the pancreas (Csete, M. E. et al. (1995) Transplantation 27:263-268). Potentially useful adenoviral vectors are described in U.S. Pat. No. 5,707,618 to Armentano (“Adenovirus vectors for gene therapy”), hereby incorporated by reference. For adenoviral vectors, see also Antinozzi, P. A. et al. (1999) Annu. Rev. Nutr. 19:511-544 and Verma, I. M. and Somia, N. (1997) Nature 18:389:239-242, both incorporated by reference herein.

[0223] In another alternative, a herpes-based, gene therapy delivery system is used to deliver sptm to target cells which have one or more genetic abnormalities with respect to the expression of sptm. The use of herpes simplex virus (HSV)-based vectors may be especially valuable for introducing sptm to cells of the central nervous system, for which HSV has a tropism. The construction and packaging of herpes-based vectors are well known to those with ordinary skill in the art. A replication-competent herpes simplex virus (HSV) type 1-based vector has been used to deliver a reporter gene to the eyes of primates (Liu, X. et al. (1999) Exp. Eye Res. 169:385-395). The construction of a HSV-1 virus vector has also been disclosed in detail in U.S. Pat. No. 5,804,413 to DeLuca (“Herpes simplex virus strains for gene transfer”), which is hereby incorporated by reference. U.S. Pat. No. 5,804,413 teaches the use of recombinant HSV d92 which consists of a genome containing at least one exogenous gene to be transferred to a cell under the control of the appropriate promoter for purposes including human gene therapy. Also taught by this patent are the construction and use of recombinant HSV strains deleted for ICP4, ICP27 and ICP22. For HSV vectors, see also Goins, W. F. et al. 1999 J. Virol. 73:519-532 and Xu, H. et al., (1994) Dev. Biol. 163:152-161, hereby incorporated by reference. The manipulation of cloned herpesvirus sequences, the generation of recombinant virus following the transfection of multiple plasmids containing different segments of the large herpesvirus genomes, the growth and propagation of herpesvirus, and the infection of cells with herpesvirus are techniques well known to those of ordinary skill in the art.

[0224] In another alternative, an alphavirus (positive, single-stranded RNA virus) vector is used to deliver sptm to target cells. The biology of the prototypic alphavirus, Semliki Forest Virus (SFV), has been studied extensively and gene transfer vectors have been based on the SFV genome (Garoff, H. and Li, K-J. (1998) Curr. Opin. Biotech. 9:464-469). During alphavirus RNA replication, a subgenomic RNA is generated that normally encodes the viral capsid proteins. This subgenomic RNA replicates to higher levels than the full-length genomic RNA, resulting in the overproduction of capsid proteins relative to the viral proteins with enzymatic activity (e.g., protease and polymerase). Similarly, inserting sptm into the alphavirus genome in place of the capsid-coding region results in the production of a large number of sptm RNAs and the synthesis of high levels of SPTM in vector transduced cells. While alphavirus infection is typically associated with cell lysis within a few days, the ability to establish a persistent infection in hamster normal kidney cells (BHK-21) with a variant of Sindbis virus (SIN) indicates that the lytic replication of alphaviruses can be altered to suit the needs of the gene therapy application (Dryga, S. A. et al. (1997) Virology 228:74-83). The wide host range of alphaviruses will allow the introduction of sptm into a variety of cell types. The specific transduction of a subset of cells in a population may require the sorting of cells prior to transduction. The methods of manipulating infectious cDNA clones of alphaviruses, performing alphavirus cDNA and RNA transfections, and performing alphavirus infections, are well known to those with ordinary skill in the art.

[0225] Antibodies

[0226] Anti-SPTM antibodies may be used to analyze protein expression levels. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, and Fab fragments. For descriptions of and protocols of antibody technologies, see, e.g., Pound J. D. (1998) Immunochemical Protocols, Humana Press, Totowa, N.J.

[0227] The amino acid sequence encoded by the sptm of the Sequence Listing may be analyzed by appropriate software (e.g., LASERGENE NAVIGATOR software, DNASTAR) to determine regions of high immunogenicity. The optimal sequences for immunization are selected from the C-terminus, the N-terminus, and those intervening, hydrophilic regions of the polypeptide which are likely to be exposed to the external environment when the polypeptide is in its natural conformation. Analysis used to select appropriate epitopes is also described by Ausubel (1997, supra, Chapter 11.7). Peptides used for antibody induction do not need to have biological activity; however, they must be antigenic. Peptides used to induce specific antibodies may have an amino acid sequence consisting of at least five amino acids, preferably at least 10 amino acids, and most preferably at least 15 amino acids. A peptide which mimics an antigenic fragment of the natural polypeptide may be fused with another protein such as keyhole limpet hemocyanin (KLH; Sigma, St. Louis Mo.) for antibody production. A peptide encompassing an antigenic region may be expressed from an sptm, synthesized as described above, or purified from human cells.

[0228] Procedures well known in the art may be used for the production of antibodies. Various hosts including mice, goats, and rabbits, may be immunized by injection with a peptide. Depending on the host species, various adjuvants may be used to increase immunological response.

[0229] In one procedure, peptides about 15 residues in length may be synthesized using an ABI 431A peptide synthesizer (Applied Biosystems) using fmoc-chemistry and coupled to KLH (Sigma) by reaction with M-maleimidobenzoyl-N-hydroxysuccinimide ester (Ausubel, 1995, supra). Rabbits are immunized with the peptide-KLH complex in complete Freund's adjuvant. The resulting antisera are tested for antipeptide activity by binding the peptide to plastic, blocking with 1% bovine serum albumin (BSA), reacting with rabbit antisera, washing, and reacting with radioiodinated goat anti-rabbit IgG. Antisera with antipeptide activity are tested for anti-SPTM activity using protocols well known in the art, including ELISA, radioimmunoassay (RIA), and immunoblotting.

[0230] In another procedure, isolated and purified peptide may be used to immunize mice (about 100 μg of peptide) or rabbits (about 1 mg of peptide). Subsequently, the peptide is radioiodinated and used to screen the immunized animals' B-lymphocytes for production of antipeptide antibodies. Positive cells are then used to produce hybridomas using standard techniques. About 20 mg of peptide is sufficient for labeling and screening several thousand clones. Hybridomas of interest are detected by screening with radioiodinated peptide to identify those fusions producing peptide-specific monoclonal antibody. In a typical protocol, wells of a multi-well plate (FAST, Becton-Dickinson, Palo Alto, Calif.) are coated with affinity-purified, specific rabbit-anti-mouse (or suitable anti-species IgG) antibodies at 10 mg/ml. The coated wells are blocked with 1% BSA and washed and exposed to supernatants from hybridomas. After incubation, the wells are exposed to radiolabeled peptide at 1 mg/ml.

[0231] Clones producing antibodies bind a quantity of labeled peptide that is detectable above background. Such clones are expanded and subjected to 2 cycles of cloning. Cloned hybridomas are injected into pristane-treated mice to produce ascites, and monoclonal antibody is purified from the ascitic fluid by affinity chromatography on protein A (Amersham Pharmacia Biotech). Several procedures for the production of monoclonal antibodies, including in vitro production, are described in Pound (supra). Monoclonal antibodies with antipeptide activity are tested for anti-SPTM activity using protocols well known in the art, including ELISA, RIA, and immunoblotting.

[0232] Antibody fragments containing specific binding sites for an epitope may also be generated. For example, such fragments include, but are not limited to, the F(ab′)₂ fragments produced by pepsin digestion of the antibody molecule, and the Fab fragments generated by reducing the disulfide bridges of the F(ab′)₂ fragments. Alternatively, construction of Fab expression libraries in filamentous bacteriophage allows rapid and easy identification of monoclonal fragments with desired specificity (Pound, supra, Chaps. 45-47). Antibodies generated against polypeptide encoded by sptm can be used to purify and characterize full-length SPTM protein and its activity, binding partners, etc.

[0233] Assays Using Antibodies

[0234] Anti-SPTM antibodies may be used in assays to quantify the amount of SPTM found in a particular human cell. Such assays include methods utilizing the antibody and a label to detect expression level under normal or disease conditions. The peptides and antibodies of the invention may be used with or without modification or labeled by joining them, either covalently or noncovalently, with a reporter molecule.

[0235] Protocols for detecting and measuring protein expression using either polyclonal or monoclonal antibodies are well known in the art. Examples include ELISA, RIA, and fluorescent activated cell sorting (FACS). Such immunoassays typically involve the formation of complexes between the SPTM and its specific antibody and the measurement of such complexes. These and other assays are described in Pound (supra).

[0236] Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.

[0237] Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.

[0238] The disclosures of all patents, applications, and publications mentioned above and below, including U.S. Ser. No. 60/261,865, U.S. Ser. No. 60/262,599, U.S. Ser. No. 60/263,329, U.S. Ser. No. 60/262,209, U.S. Ser. No. 60/263,131, U.S. Ser. No. 60/262,208, U.S. Ser. No. 60/262,164, U.S. Ser. No. 60/263,063, U.S. Ser. No. 60/261,864, U.S. Ser. No. 60/262,760, U.S. Ser. No. 60/261,981, U.S. Ser. No. 60/263,070, U.S. Ser. No. 60/261,979, U.S. Ser. No. 60/263,066, U.S. Ser. No. 60/263,077, U.S. Ser. No. 60/263,076, U.S. Ser. No. 60/263,074, and U.S. Ser. No. 60/263,069, are hereby expressly incorporated by reference.

EXAMPLES

[0239] I. Construction of cDNA Libraries

[0240] RNA was purchased from CLONTECH Laboratories, Inc. (Palo Alto Calif.) or isolated from various tissues. Some tissues were homogenized and lysed in guanidinium isothiocyanate, while others were homogenized and lysed in phenol or in a suitable mixture of denaturants, such as TRIZOL (Life Technologies), a monophasic solution of phenol and guanidine isothiocyanate. The resulting lysates were centrifuged over CsCl cushions or extracted with chloroform RNA was precipitated with either isopropanol or sodium acetate and ethanol, or by other routine methods.

[0241] Phenol extraction and precipitation of RNA were repeated as necessary to increase RNA purity. In most cases, RNA was treated with DNase. For most libraries, poly(A+) RNA was isolated using oligo d(T)-coupled paramagnetic particles (Promega Corporation (Promega), Madison Wis.), OLIGOTEX latex particles (QIAGEN, Inc. (QIAGEN), Valencia Calif.), or an OLIGOTEX mRNA purification kit (QIAGEN). Alternatively, RNA was isolated directly from tissue lysates using other RNA isolation kits, e.g., the POLY(A)PURE mRNA purification kit (Ambion, Inc., Austin Tex.).

[0242] In some cases, Stratagene was provided with RNA and constructed the corresponding cDNA libraries. Otherwise, cDNA was synthesized and cDNA libraries were constructed with the UNIZAP vector system (Stratagene Cloning Systems, Inc. (Stratagene), La Jolla Calif.) or SUPERSCRIPT plasmid system (Life Technologies), using the recommended procedures or similar methods known in the art. (See, e.g., Ausubel, 1997, supra, Chapters 5.1 through 6.6.) Reverse transcription was initiated using oligo d(T) or random primers. Synthetic oligonucleotide adapters were ligated to double stranded cDNA, and the cDNA was digested with the appropriate restriction enzyme or enzymes. For most libraries, the cDNA was size-selected (300-1000 bp) using SEPHACRYL S1000, SEPHAROSE CL2B, or SEPHAROSE CL4B column chromatography (Amersham Pharmacia Biotech) or preparative agarose gel electrophoresis. cDNAs were ligated into compatible restriction enzyme sites of the polylinker of a suitable plasmid, e.g., PBLUESCRIPT plasmid (Stratagene), PSPORT1 plasmid (Life Technologies), PCDNA2.1 plasmid (Invitrogen, Carlsbad Calif.), PBK-CMV plasmid (Stratagene), PCR2-TOPOTA plasmid (Invitrogen), PCMV-ICIS plasmid (Stratagene), pIGEN (Incyte Genomics, Palo Alto Calif.), pRARE (Incyte Genomics), or pINCY (Incyte Genomics), or derivatives thereof. Recombinant plasmids were transformed into competent E. coli cells including XL1-Blue, XL1-BlueMRF, or SOLR from Stratagene or DH5α, DH10B, or ElectroMAX DH10B from Life Technologies.

[0243] II. Isolation of cDNA Clones

[0244] Plasmids were recovered from host cells by in vivo excision using the UNZAP vector system (Stratagene) or by cell lysis. Plasmids were purified using at least one of the following: the Magic or WIZARD Minipreps DNA purification system (Promega); the AGTC Miniprep purification kit (Edge BioSystems, Gaithersburg Md.); and the QIAWELL 8, QIAWELL 8 Plus, and QIAWELL 8 Ultra plasmid purification systems or the R.E.A.L. PREP 96 plasmid purification kit (QIAGEN). Following precipitation, plasmids were resuspended in 0.1 ml of distilled water and stored, with or without lyophilization, at 4° C.

[0245] Alternatively, plasmid DNA was amplified from host cell lysates using direct link PCR in a high-throughput format. (Rao, V. B. (1994) Anal. Biochem 216:1-14.) Host cell lysis and thermal cycling steps were carried out in a single reaction mixture. Samples were processed and stored in 384-well plates, and the concentration of amplified plasmid DNA was quantified fluorometrically using PICOGREEN dye (Molecular Probes, Inc. (Molecular Probes), Eugene Oreg.) and a FLUOROSKAN II fluorescence scanner (Labsystems Oy, Helsinki, Finland).

[0246] III. Sequencing and Analysis

[0247] cDNA sequencing reactions were processed using standard methods or high-throughput instrumentation such as the ABI CATALYST 800 thermal cycler (Applied Biosystems) or the PTC-200 thermal cycler (MJ Research) in conjunction with the HYDRA microdispenser (Robbins Scientific Corp., Sunnyvale Calif.) or the MICROLAB 2200 liquid transfer system (Hamilton). cDNA sequencing reactions were prepared using reagents provided by Amersham Pharmacia Biotech or supplied in ABI sequencing kits such as the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems). Electrophoretic separation of cDNA sequencing reactions and detection of labeled polynucleotides were carried out using the MEGABACE 1000 DNA sequencing system (Molecular Dynamics); the ABI PRISM 373 or 377 sequencing system (Applied Biosystems) in conjunction with standard ABI protocols and base calling software; or other sequence analysis systems known in the art. Reading frames within the cDNA sequences were identified using standard methods (reviewed in Ausubel, 1997, supra, Chapter 7.7). Some of the cDNA sequences were selected for extension using the techniques disclosed in Example VIII.

[0248] IV. Assembly and Analysis of Sequences

[0249] Component sequences from chromatograms were subject to PHRED analysis and assigned a quality score. The sequences having at least a required quality score were subject to various preprocessing editing pathways to eliminate, e.g., low quality 3′ ends, vector and linker sequences, polyA tails, Alu repeats, mitochondrial and ribosomal sequences, bacterial contamination sequences, and sequences smaller than 50 base pairs. In particular, low-information sequences and repetitive elements (e.g., dinucleotide repeats, Alu repeats, etc.) were replaced by “n's”, or masked, to prevent spurious matches.

[0250] Processed sequences were then subject to assembly procedures in which the sequences were assigned to gene bins (bins). Each sequence could only belong to one bin. Sequences in each gene bin were assembled to produce consensus sequences (templates). Subsequent new sequences were added to existing bins using BLASTN (v.1.4 WashU) and CROSSMATCH. Candidate pairs were identified as all BLAST hits having a quality score greater than or equal to 150. Alignments of at least 82% local identity were accepted into the bin. The component sequences from each bin were assembled using a version of PHRAP. Bins with several overlapping component sequences were assembled using DEEP PHRAP. The orientation (sense or antisense) of each assembled template was determined based on the number and orientation of its component sequences. Template sequences as disclosed in the sequence listing correspond to sense strand sequences (the “forward” reading frames), to the best determination. The complementary (antisense) strands are inherently disclosed herein. The component sequences which were used to assemble each template consensus sequence are listed in Table 3 along with their positions along the template nucleotide sequences.

[0251] Bins were compared against each other and those having local similarity of at least 82% were combined and reassembled. Reassembled bins having templates of insufficient overlap (less than 95% local identity) were re-split. Assembled templates were also subject to analysis by STITCHER/EXON MAPPER algorithms which analyze the probabilities of the presence of splice variants, alternatively spliced exons, splice junctions, differential expression of alternative spliced genes across tissue types or disease states, etc. These resulting bins were subject to several rounds of the above assembly procedures.

[0252] Once gene bins were generated based upon sequence alignments, bins were clone joined based upon clone information. If the 5′ sequence of one clone was present in one bin and the 3′ sequence from the same clone was present in a different bin, it was likely that the two bins actually belonged together in a single bin. The resulting combined bins underwent assembly procedures to regenerate the consensus sequences.

[0253] The final assembled templates were subsequently annotated using the following procedure. Template sequences were analyzed using BLASTN (v2.0, NCBI) versus gbpri (GenBank version 126). “Hits” were defined as an exact match having from 95% local identity over 200 base pairs through 100% local identity over 100 base pairs, or a homolog match having an E-value, i.e. a probability score, of ≦1×10⁻⁸. The hits were subject to frameshift FASTx versus GENPEPT (GenBank version 126). (See Table 6). In this analysis, a homolog match was defined as having an E-value of ≦1×10⁻⁸. The assembly method used above was described in “System and Methods for Analyzing Biomolecular Sequences,” U.S. Ser. No. 09/276,534, filed Mar. 25, 1999, and the LIFESEQ Gold user manual (Incyte) both incorporated by reference herein.

[0254] Following assembly, template sequences were subjected to motif, BLAST, and functional analyses, and categorized in protein hierarchies using methods described in, e.g., “Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data,” U.S. Pat. No. 6,023,659; “Relational Database for Storing Biomolecule Information,” U.S. Ser. No. 08/947,845, filed Oct. 9, 1997; “Project-Based Full-Length Biomolecular Sequence Database,” U.S. Pat. No. 5,953,727; and “Relational Database and System for Storing Information Relating to Biomolecular Sequences,” U.S. Ser. No. 09/034,807, filed Mar. 4, 1998, all of which are incorporated by reference herein.

[0255] The template sequences were further analyzed by translating each template in all three forward reading frames and searching each translation against the Pfam database of hidden Markov model-based protein families and domains using the HMMER software package (available to the public from Washington University School of Medicine, St. Louis Mo.). (See also World Wide Web site http://pfam.wustl.edu/ for detailed descriptions of Pfam protein domains and families.)

[0256] Additionally, the template sequences were translated in all three forward reading frames, and each translation was searched against hidden Markov models for signal peptides using the HMMER software package. Construction of hidden Markov models and their usage in sequence analysis has been described. (See, for example, Eddy, S. R. (1996) Curr. Opin. Str. Biol. 6:361-365.) Only those signal peptide hits with a cutoff score of 11 bits or greater are reported. A cutoff score of 11 bits or greater corresponds to at least about 91-94% true-positives in signal peptide prediction. Template sequences were also translated in all three forward reading frames, and each translation was searched against T a program that uses a hidden Markov model (HMM) to delineate transmembrane segments on protein sequences and determine orientation (Sonnhammer, E. L. et al. (1998) Proc. Sixth Intl. Conf. On Intelligent Systems for Mol. Biol., Glasgow et al., eds., The Am. Assoc. for Artificial Intelligence (AAAI) Press, Menlo Park, Calif., and MIT Press, Cambridge, Mass., pp. 175-182.) Regions of templates which, when translated, contain similarity to signal peptide or transmembrane consensus sequences are reported in Table 2.

[0257] Template sequences are further analyzed using the bioinformatics tools listed in Table 6, or using sequence analysis software known in the art such as MACDNASIS PRO software (Hitachi Software Engineering, South San Francisco Calif.) and LASERGENE software (DNASTAR). Template sequences may be further queried against public databases such as the GenBank rodent, mammalian, vertebrate, prokaryote, and eukaryote databases.

[0258] The template sequences were translated to derive the corresponding longest open reading frame as presented by the polypeptide sequences as reported in Table 5. Alternatively, a polypeptide of the invention may begin at any of the methionine residues within the full length translated polypeptide. Polypeptide sequences were subsequently analyzed by querying against the GenBank protein database (GENPEPT, (GenBank version 126)). Full length polynucleotide sequences are also analyzed using MACDNASIS PRO software (Hitachi Software Engineering, South San Francisco Calif.) and LASERGENE software (DNASTAR). Polynucleotide and polypeptide sequence alignments are generated using default parameters specified by the CLUSTAL algorithm as incorporated into the MEGALIGN multisequence alignment program (DNASTAR), which also calculates the percent identity between aligned sequences.

[0259] Table 5 shows sequences with homology to the polypeptides of the invention as identified by BLAST analysis against the GenBank protein (GENPEPT) database. Column 1 shows the polypeptide sequence identification number (SEQ ID NO:) for the polypeptide segments of the invention. Column 2 shows the reading frame used in the translation of the polynucleotide sequences encoding the polypeptide segments. Column 3 shows the length of the translated polypeptide segments. Columns 4 and 5 show the start and stop nucleotide positions of the polynucleotide sequences encoding the polypeptide segments. Column 6 shows the GenBank identification number (GI Number) of the nearest GenBank homolog. Column 7 shows the probability score for the match between each polypeptide and its GenBank homolog. Column 8 shows the annotation of the GenBank homolog.

[0260] V. Analysis of Polynucleotide Expression

[0261] Northern analysis is a laboratory technique used to detect the presence of a transcript of a gene and involves the hybridization of a labeled nucleotide sequence to a membrane on which RNAs from a particular cell type or tissue have been bound. (See, e.g., Sambrook, supra, ch. 7; Ausubel, 1995, supra, ch. 4 and 16.)

[0262] Analogous computer techniques applying BLAST were used to search for identical or related molecules in cDNA databases such as GenBank or LIFESEQ (Incyte Genomics). This analysis is much faster than multiple membrane-based hybridizations. In addition, the sensitivity of the computer search can be modified to determine whether any particular match is categorized as exact or similar. The basis of the search is the product score, which is defined as: $\frac{{BLAST}\quad {Score} \times {Percent}\quad {Identity}}{{5 \times {minimum}{\quad \quad}\left\{ {{{length}\left( {{Seq}.\quad 1} \right)},\quad {{length}\left( {{Seq}.\quad 2} \right)}} \right\}}\quad}$

[0263] The product score takes into account both the degree of similarity between two sequences and the length of the sequence match. The product score is a normalized value between 0 and 100, and is calculated as follows: the BLAST score is multiplied by the percent nucleotide identity and the product is divided by (5 times the length of the shorter of the two sequences). The BLAST score is calculated by assigning a score of +5 for every base that matches in a high-scoring segment pair (HSP), and −4 for every mismatch. Two sequences may share more than one HSP (separated by gaps). If there is more than one HSP, then the pair with the highest BLAST score is used to calculate the product score. The product score represents a balance between fractional overlap and quality in a BLAST alignment. For example, a product score of 100 is produced only for 100% identity over the entire length of the shorter of the two sequences being compared. A product score of 70 is produced either by 100% identity and 70% overlap at one end, or by 88% identity and 100% overlap at the other. A product score of 50 is produced either by 100% identity and 50% overlap at one end, or 79% identity and 100% overlap.

[0264] Alternatively, polynucleotide sequences encoding SPTM are analyzed with respect to the tissue sources from which they were derived. Polynucleotide sequences encoding SPTM were assembled, at least in part, with overlapping Incyte cDNA sequences. Each cDNA sequence is derived from a cDNA library constructed from a human tissue. Each human tissue is classified into one of the following organ/tissue categories: cardiovascular system; connective tissue; digestive system; embryonic structures; endocrine system; exocrine glands; genitalia, female; genitalia, male; germ cells; hemic and immune system; liver; musculoskeletal system; nervous system; pancreas; respiratory system; sense organs; skin; stomatognathic system; unclassified/mixed; or urinary tract. The number of libraries in each category for each polynucleotide sequence encoding SPTM is counted and divided by the total number of libraries across all categories for each polynucleotide sequence encoding SPTM. Similarly, each human tissue is classified into one of the following disease/condition categories: cancer, cell line, developmental, inflammation, neurological, trauma, cardiovascular, pooled, and other, and the number of libraries in each category for each polynucleotide sequence encoding SPTM is counted and divided by the total number of libraries across all categories for each polynucleotide sequence encoding SPTM. The resulting percentages reflect the tissue-specific and disease-specific expression of cDNA encoding SPTM. Percentage values of tissue-specific expression are reported in. cDNA sequences and cDNA library/tissue information are found in the LIFESEQ GOLD database (Incyte Genomics, Palo Alto Calif.).

[0265] VI. Tissue Distribution Profiling

[0266] A tissue distribution profile is determined for each template by compiling the cDNA library tissue classifications of its component cDNA sequences. Each component sequence, is derived from a cDNA library constructed from a human tissue. Each human tissue is classified into one of the following categories: cardiovascular system; connective tissue; digestive system; embryonic structures; endocrine system; exocrine glands; genitalia, female; genitalia, male; germ cells; hemic and immune system; liver; musculoskeletal system; nervous system; pancreas; respiratory system; sense organs; skin; stomatognathic system; unclassified/mixed; or urinary tract. Template sequences, component sequences, and cDNA library/tissue information are found in the LIFESQ GOLD database (Incyte Genomics, Palo Alto Calif.).

[0267] Table 4 shows the tissue distribution profile for the templates of the invention. For each template, the three most frequently observed tissue categories are shown in column 3, along with the percentage of component sequences belonging to each category. Only tissue categories with percentage values of ≧10% are shown. A tissue distribution of “widely distributed” in column 3 indicates percentage values of <10% in all tissue categories.

[0268] VII. Transcript Image Analysis

[0269] Transcript images are generated as described in Seilhamer et al., “Comparative Gene Transcript Analysis,” U.S. Pat. No. 5,840,484, incorporated herein by reference.

[0270] VIII. Extension of Polynucleotide Sequences and Isolation of a Full-Length cDNA

[0271] Oligonucleotide primers designed using an sptm of the Sequence Listing are used to extend the nucleic acid sequence. One primer is synthesized to initiate 5′ extension of the template, and the other primer, to initiate 3′ extension of the template. The initial primers may be designed using OLIGO 4.06 software (National Biosciences, Inc. (National Biosciences), Plymouth Minn.), or another appropriate program, to be about 22 to 30 nucleotides in length, to have a GC content of about 50% or more, and to anneal to the target sequence at temperatures of about 68° C. to about 72° C. Any stretch of nucleotides which would result in hairpin structures and primer-primer dimerizations are avoided. Selected human cDNA libraries are used to extend the sequence. If more than one extension is necessary or desired, additional or nested sets of primers are designed.

[0272] High fidelity amplification is obtained by PCR using methods well known in the art. PCR is performed in 96-well plates using the PTC-200 thermal cycler (MJ Research). The reaction mix contains DNA template, 200 nmol of each primer, reaction buffer containing Mg²⁺, (NH₄)₂SO₄, and β-mercaptoethanol, Taq DNA polymerase (Amersham Pharmacia Biotech), ELONGASE enzyme (Life Technologies), and Pfu DNA polymerase (Stratagene), with the following parameters for primer pair PCI A and PCI B: Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 60° C., 1 min; Step 4: 68° C., 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68° C., 5 min; Step 7: storage at 4° C. In the alternative, the parameters for primer pair T7 and SK+ are as follows: Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 57° C., 1 min; Step 4: 68° C., 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68° C., 5 min; Step 7: storage at 4° C.

[0273] The concentration of DNA in each well is determined by dispensing 100 μl PICOGREEN quantitation reagent (0.25% (v/v); Molecular Probes) dissolved in 1× Tris-EDTA (TE) and 0.5 μl of undiluted PCR product into each well of an opaque fluorimeter plate (Corning Incorporated (Corning), Corning N.Y.), allowing the DNA to bind to the reagent. The plate is scanned in a FLUOROSKAN II (Labsystems Oy) to measure the fluorescence of the sample and to quantify the concentration of DNA. A 5 μl to 10 μl aliquot of the reaction mixture is analyzed by electrophoresis on a 1% agarose mini-gel to determine which reactions are successful in extending the sequence.

[0274] The extended nucleotides are desalted and concentrated, transferred to 384-well plates, digested with CviJI cholera virus endonuclease (Molecular Biology Research, Madison Wis.), and sonicated or sheared prior to religation into pUC 18 vector (Amersham Pharmacia Biotech). For shotgun sequencing, the digested nucleotides are separated on low concentration (0.6 to 0.8%) agarose gels, fragments are excised, and agar digested with AGAR ACE (Promega). Extended clones are religated using T4 ligase (New England Biolabs, Inc., Beverly Mass.) into pUC 18 vector (Amersham Pharmacia Biotech), treated with Pfu DNA polymerase (Stratagene) to fill-in restriction site overhangs, and transfected into competent E. coli cells. Transformed cells are selected on antibiotic-containing media, individual colonies are picked and cultured overnight at 37° C. in 384-well plates in LB/2× carbenicillin liquid media.

[0275] The cells are lysed, and DNA is amplified by PCR using Taq DNA polymerase (Amersham Pharmacia Biotech) and Pfu DNA polymerase (Stratagene) with the following parameters: Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 60° C., 1 min; Step 4: 72° C., 2 min; Step 5: steps 2, 3, and 4 repeated 29 times; Step 6: 72° C., 5 min; Step 7: storage at 4° C. DNA is quantified by PICOGREEN reagent (Molecular Probes) as described above. Samples with low DNA recoveries are reamplified using the same conditions as described above. Samples are diluted with 20% dimethysulfoxide (1:2, v/v), and sequenced using DYENAMIC energy transfer sequencing primers and the DYENAMIC DIRECT kit (Amersham Pharmacia Biotech) or the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems).

[0276] In like manner, the sptm is used to obtain regulatory sequences (promoters, introns, and enhancers) using the procedure above, oligonucleotides designed for such extension, and an appropriate genomic library.

[0277] IX. Labeling of Probes and Southern Hybridization Analyses

[0278] Hybridization probes derived from the sptm of the Sequence Listing are employed for screening cDNAs, mRNAs, or genomic DNA. The labeling of probe nucleotides between 100 and 1000 nucleotides in length is specifically described, but essentially the same procedure may be used with larger cDNA fragments. Probe sequences are labeled at room temperature for 30 minutes using a T4 polynucleotide kinase, γ³²P-ATP, and 0.5× One-Phor-All Plus (Amersham Pharmacia Biotech) buffer and purified using a ProbeQuant G-50 Microcolumn (Amersham Pharmacia Biotech). The probe mixture is diluted to 10⁷ dpm/μg/ml hybridization buffer and used in a typical membrane-based hybridization analysis.

[0279] The DNA is digested with a restriction endonuclease such as Eco RV and is electrophoresed through a 0.7% agarose gel. The DNA fragments are transferred from the agarose to nylon membrane (NYTRAN Plus, Schleicher & Schuell, Inc., Keene N.H.) using procedures specified by the manufacturer of the membrane. Prehybridization is carried out for three or more hours at 68° C., and hybridization is carried out overnight at 68° C. To remove non-specific signals, blots are sequentially washed at room temperature under increasingly stringent conditions, up to 0.1× saline sodium citrate (SSC) and 0.5% sodium dodecyl sulfate. After the blots are placed in a PHOSPHORIMAGER cassette (Molecular Dynamics) or are exposed to autoradiography film, hybridization patterns of standard and experimental lanes are compared. Essentially the same procedure is employed when screening RNA.

[0280] X. Chromosome Mapping of sptm

[0281] The cDNA sequences which were used to assemble SEQ ID NO:1-75 are compared with sequences from the Incyte LIFESEQ database and public domain databases using BLAST and other implementations of the Smith-Waterman algorithm. Sequences from these databases that match SEQ ID NO:1-75 are assembled into clusters of contiguous and overlapping sequences using assembly algorithms such as PHRAP (Table 6). Radiation hybrid and genetic mapping data available from public resources such as the Stanford Human Genome Center (SHGC), Whitehead Institute for Genome Research (WIGR), and Généthon are used to determine if any of the clustered sequences have been previously mapped. Inclusion of a mapped sequence in a cluster will result in the assignment of all sequences of that cluster, including its particular SEQ ID NO:, to that map location. The genetic map locations of SEQ ID NO:1-75 are described as ranges, or intervals, of human chromosomes. The map position of an interval, in centiMorgans, is measured relative to the terminus of the chromosome's p-arm (The centiMorgan (cM) is a unit of measurement based on recombination frequencies between chromosomal markers. On average, 1 cM is roughly equivalent to 1 megabase (Mb) of DNA in humans, although this can vary widely due to hot and cold spots of recombination.) The cM distances are based on genetic markers mapped by Généthon which provide boundaries for radiation hybrid markers whose sequences were included in each of the clusters.

[0282] XI. Microarray Analysis

[0283] Probe Preparation from Tissue or Cell Samples

[0284] Total RNA is isolated from tissue samples using the guanidinium thiocyanate method and polyA⁺ RNA is purified using the oligo (dT) cellulose method. Each polyA⁺ RNA sample is reverse transcribed using MMLV reverse-transcriptase, 0.05 pg/μl oligo-dT primer (21mer), 1× first strand buffer, 0.03 units/μl RNase inhibitor, 500 μM dATP, 500 μM dGTP, 500 μM dTTP, 40 μM dCTP, 40 μM dCTP-Cy3 (BDS) or dCTP-Cy5 (Amersham Pharmacia Biotech). The reverse transcription reaction is performed in a 25 ml volume containing 200 ng polyA⁺ RNA with GEMBRIGHT kits (Incyte). Specific control polyA⁺ RNAs are synthesized by in vitro transcription from non-coding yeast genomic DNA (W. Lei, unpublished). As quantitative controls, the control mRNAs at 0.002 ng, 0.02 ng, 0.2 ng, and 2 ng are diluted into reverse transcription reaction at ratios of 1:100,000, 1:10,000, 1:1000, 1:100 (w/w) to sample mRNA respectively. The control mRNAs are diluted into reverse transcription reaction at ratios of 1:3, 3:1, 1:10, 10:1, 1:25, 25:1 (w/w) to sample mRNA differential expression patterns. After incubation at 37° C. for 2 hr, each reaction sample (one with Cy3 and another with Cy5 labeling) is treated with 2.5 ml of 0.5M sodium hydroxide and incubated for 20 minutes at 85° C. to the stop the reaction and degrade the RNA. Probes are purified using two successive CHROMA SPIN 30 gel filtration spin columns (CLONTECH Laboratories, Inc. (CLONTECH), Palo Alto Calif.) and after combining, both reaction samples are ethanol precipitated using 1 ml of glycogen (1 mg/ml), 60 ml sodium acetate, and 300 ml of 100% ethanol. The probe is then dried to completion using a SpeedVAC (Savant Instruments Inc., Holbrook N.Y.) and resuspended in 14 μl 5×SSC/0.2% SDS.

[0285] Microarray Preparation

[0286] Sequences of the present invention are used to generate array elements. Each array element is amplified from bacterial cells containing vectors with cloned cDNA inserts. PCR amplification uses primers complementary to the vector sequences flanking the cDNA insert. Array elements are amplified in thirty cycles of PCR from an initial quantity of 1-2 ng to a final quantity greater than 5 μg. Amplified array elements are then purified using SEPHACRYL-400 (Amersham Pharmacia Biotech).

[0287] Purified array elements are immobilized on polymer-coated glass slides. Glass microscope slides (Corning) are cleaned by ultrasound in 0.1% SDS and acetone, with extensive distilled water washes between and after treatments. Glass slides are etched in 4% hydrofluoric acid (VWR Scientific Products Corporation (VWR), West Chester, Pa.), washed extensively in distilled water, and coated with 0.05% aminopropyl silane (Sigma) in 95% ethanol. Coated slides are cured in a 110° C. oven.

[0288] Array elements are applied to the coated glass substrate using a procedure described in U.S. Pat. No. 5,807,522, incorporated herein by reference. 1 μl of the array element DNA, at an average concentration of 100 ng/μl, is loaded into the open capillary printing element by a high-speed robotic apparatus. The apparatus then deposits about 5 nl of array element sample per slide.

[0289] Microarrays are V-crosslinked using a STRATALNKER UV-crosslinker (Stratagene). Microarrays are washed at room temperature once in 0.2% SDS and three times in distilled water. Non-specific binding sites are blocked by incubation of microarrays in 0.2% casein in phosphate buffered saline (PBS) (Tropix, Inc., Bedford, Mass.) for 30 minutes at 60° C. followed by washes in 0.2% SDS and distilled water as before.

[0290] Hybridization

[0291] Hybridization reactions contain 9 μl of probe mixture consisting of 0.2 μg each of Cy3 and Cy5 labeled cDNA synthesis products in 5×SSC, 0.2% SDS hybridization buffer. The probe mixture is heated to 65° C. for 5 minutes and is aliquoted onto the microarray surface and covered with an 1.8 cm² coverslip. The arrays are transferred to a waterproof chamber having a cavity just slightly larger than a microscope slide. The chamber is kept at 100% humidity internally by the addition of 140 μl of 5×SSC in a corner of the chamber. The chamber containing the arrays is incubated for about 6.5 hours at 60° C. The arrays are washed for 10 min at 45° C. in a first wash buffer (1×SSC, 0.1% SDS), three times for 10 minutes each at 45° C. in a second wash buffer (0.1×SSC), and dried.

[0292] Detection

[0293] Reporter-labeled hybridization complexes are detected with a microscope equipped with an Innova 70 mixed gas 10 W laser (Coherent, Inc., Santa Clara Calif.) capable of generating spectral lines at 488 nm for excitation of Cy3 and at 632 nm for excitation of Cy5. The excitation laser light is focused on the array using a 20× microscope objective (Nikon, Inc., Melville N.Y.). The slide containing the array is placed on a computer-controlled X-Y stage on the microscope and raster-scanned past the objective. The 1.8 cm×1.8 cm array used in the present example is scanned with a resolution of 20 micrometers.

[0294] In two separate scans, a mixed gas multiline laser excites the two fluorophores sequentially. Emitted light is split, based on wavelength, into two photomultiplier tube detectors (PMT R1477, Hamamatsu Photonics Systems, Bridgewater N.J.) corresponding to the two fluorophores. Appropriate filters positioned between the array and the photomultiplier tubes are used to filter the signals. The emission maxima of the fluorophores used are 565 nm for Cy3 and 650 nm for Cy5. Each array is typically scanned twice, one scan per fluorophore using the appropriate filters at the laser source, although the apparatus is capable of recording the spectra from both fluorophores simultaneously.

[0295] The sensitivity of the scans is typically calibrated using the signal intensity generated by a cDNA control species added to the probe mix at a known concentration. A specific location on the array contains a complementary DNA sequence, allowing the intensity of the signal at that location to be correlated with a weight ratio of hybridizing species of 1:100,000. When two probes from different sources (e.g., representing test and control cells), each labeled with a different fluorophore, are hybridized to a single array for the purpose of identifying genes that are differentially expressed, the calibration is done by labeling samples of the calibrating cDNA with the two fluorophores and adding identical amounts of each to the hybridization mixture.

[0296] The output of the photomultiplier tube is digitized using a 12-bit RTI-835H analog-to-digital (A/D) conversion board (Analog Devices, Inc., Norwood, Mass.) installed in an IBM-compatible PC computer. The digitized data are displayed as an image where the signal intensity is mapped using a linear 20-color transformation to a pseudocolor scale ranging from blue (low signal) to red (high signal). The data is also analyzed quantitatively. Where two different fluorophores are excited and measured simultaneously, the data are first corrected for optical crosstalk (due to overlapping emission spectra) between the fluorophores using each fluorophore's emission spectrum.

[0297] A grid is superimposed over the fluorescence signal image such that the signal from each spot is centered in each element of the grid. The fluorescence signal within each element is then integrated to obtain a numerical value corresponding to the average intensity of the signal. The software used for signal analysis is the GEMTOOLS gene expression analysis program (Incyte).

[0298] XII. Complementary Nucleic Acids

[0299] Sequences complementary to the sptm are used to detect, decrease, or inhibit expression of the naturally occurring nucleotide. The use of oligonucleotides comprising from about 15 to 30 base pairs is typical in the art. However, smaller or larger sequence fragments can also be used. Appropriate oligonucleotides are designed from the sptm using OLIGO 4.06 software (National Biosciences) or other appropriate programs and are synthesized using methods standard in the art or ordered from a commercial supplier. To inhibit transcription, a complementary oligonucleotide is designed from the most unique 5′ sequence and used to prevent transcription factor binding to the promoter sequence. To inhibit translation, a complementary oligonucleotide is designed to prevent ribosomal binding and processing of the transcript.

[0300] XIII. Expression of SPTM

[0301] Expression and purification of SPTM is accomplished using bacterial or virus-based expression systems. For expression of SPTM in bacteria, DNA encoding SPTM is subcloned into an appropriate vector containing an antibiotic resistance gene and an inducible promoter that directs high levels of cDNA transcription. Examples of such promoters include, but are not limited to, the trp-lac (tac) hybrid promoter and the T5 or T7 bacteriophage promoter in conjunction with the lac operator regulatory element. Recombinant vectors are transformed into suitable bacterial hosts, e.g., BL21(DE3). Antibiotic resistant bacteria express SPTM upon induction with isopropyl beta-D-thiogalactopyranoside (IPTG). Expression of SPTM in eukaryotic cells is achieved by infecting insect or mammalian cell lines with recombinant Autographica californica nuclear polyhedrosis virus (AcMNPV), commonly known as baculovirus. The nonessential polyhedrin gene of baculovirus is replaced with cDNA encoding SPTM by either homologous recombination or bacterial-mediated transposition involving transfer plasmid intermediates. Viral infectivity is maintained and the strong polyhedrin promoter drives high levels of cDNA transcription. Recombinant baculovirus is used to infect Spodoptera frugiperda (Sf9) insect cells in most cases, or human hepatocytes, in some cases. Infection of the latter requires additional genetic modifications to baculovirus. (See e.g., Engelhard, supra; and Sandig, supra.)

[0302] In most expression systems, SPTM is synthesized as a fusion protein with, e.g., glutathione S-transferase (GST) or a peptide epitope tag, such as FLAG or 6-His, permitting rapid, single-step, affinity-based purification of recombinant fusion protein from crude cell lysates. GST, a 26-kilodalton enzyme from Schistosoma japonicum, enables the purification of fusion proteins on immobilized glutathione under conditions that maintain protein activity and antigenicity (Amersham Pharmacia Biotech). Following purification, the GST moiety can be proteolytically cleaved from SPTM at specifically engineered sites. FLAG, an 8-amino acid peptide, enables immunoaffinity purification using commercially available monoclonal and polyclonal anti-FLAG antibodies (Eastman Kodak Company, Rochester N.Y.). 6-His, a stretch of six consecutive histidine residues, enables purification on metal-chelate resins (QIAGEN). Methods for protein expression and purification are discussed in Ausubel (1995, supra, Chapters 10 and 16). Purified SPTM obtained by these methods can be used directly in the following activity assay.

[0303] XIV. Demonstration of SPTM Activity

[0304] An assay for SPTM activity measures the expression of SPTM on the cell surface. cDNA encoding SPTM is subcloned into an appropriate mammalian expression vector suitable for high levels of cDNA expression. The resulting construct is transfected into a nonhuman cell line such as NIH3T3. Cell surface proteins are labeled with biotin using methods known in the art. Immunoprecipitations are performed using SPTM-specific antibodies, and immunoprecipitated samples are analyzed using SDS-PAGE and immunoblotting techniques. The ratio of labeled immunoprecipitant to unlabeled immunoprecipitant is proportional to the amount of SPTM expressed on the cell surface.

[0305] Alternatively, an assay for SPTM activity measures the amount of SPTM in secretory, membrane-bound organelles. Transfected cells as described above are harvested and lysed. The lysate is fractionated using methods known to those of skill in the art, for example, sucrose gradient ultracentrifugation. Such methods allow the isolation of subcellular components such as the Golgi apparatus, ER, small membrane-bound vesicles, and other secretory organelles. Immunoprecipitations from fractionated and total cell lysates are performed using SPTM-specific antibodies, and immunoprecipitated samples are analyzed using SDS-PAGE and immunoblotting techniques. The concentration of SPTM in secretory organelles relative to SPTM in total cell lysate is proportional to the amount of SPTM in transit through the secretory pathway.

[0306] XV. Functional Assays

[0307] SPTM function is assessed by expressing sptm at physiologically elevated levels in mammalian cell culture systems. cDNA is subcloned into a mammalian expression vector containing a strong promoter that drives high levels of cDNA expression. Vectors of choice include pCMV SPORT (Life Technologies) and pCR3.1 (Invitrogen Corporation, Carlsbad Calif.), both of which contain the cytomegalovirus promoter. 5-10 μg of recombinant vector are transiently transfected into a human cell line, preferably of endothelial or hematopoietic origin, using either liposome formulations or electroporation. 1-2 μg of an additional plasmid containing sequences encoding a marker protein are co-transfected.

[0308] Expression of a marker protein provides a means to distinguish transfected cells from nontransfected cells and is a reliable predictor of cDNA expression from the recombinant vector. Marker proteins of choice include, e.g., Green Fluorescent Protein (GFP; CLONTECH), CD64, or a CD64-GFP fusion protein. Flow cytometry (FCM), an automated laser optics-based technique, is used to identify transfected cells expressing GFP or CD64-GFP and to evaluate the apoptotic state of the cells and other cellular properties.

[0309] FCM detects and quantifies the uptake of fluorescent molecules that diagnose events preceding or coincident with cell death. These events include changes in nuclear DNA content as measured by staining of DNA with propidium iodide; changes in cell size and granularity as measured by forward light scatter and 90 degree side light scatter; down-regulation of DNA synthesis as measured by decrease in bromodeoxyuridine uptake; alterations in expression of cell surface and intracellular proteins as measured by reactivity with specific antibodies; and alterations in plasma membrane composition as measured by the binding of fluorescein-conjugated Annexin V protein to the cell surface. Methods in flow cytometry are discussed in Ormerod, M. G. (1994) Flow Cytometry, Oxford, New York N.Y.

[0310] The influence of SPTM on gene expression can be assessed using highly purified populations of cells transfected with sequences encoding SPTM and either CD64 or CD64-GFP. CD64 and CD64-GFP are expressed on the surface of transfected cells and bind to conserved regions of human immunoglobulin G (IgG). Transfected cells are efficiently separated from nontransfected cells using magnetic beads coated with either human IgG or antibody against CD64 (DYNAL, Inc., Lake Success N.Y.). mRNA can be purified from the cells using methods well known by those of skill in the art. Expression of mRNA encoding SPTM and other genes of interest can be analyzed by northern analysis or microarray techniques.

[0311] XVI. Production of Antibodies

[0312] SPTM substantially purified using polyacrylamide gel electrophoresis (PAGE; see, e.g., Harrington, M. G. (1990) Methods Enzymol. 182:488495), or other purification techniques, is used to immunize rabbits and to produce antibodies using standard protocols.

[0313] Alternatively, the SPTM amino acid sequence is analyzed using LASERGENE software (DNASTAR) to determine regions of high immunogenicity, and a corresponding peptide is synthesized and used to raise antibodies by means known to those of skill in the art. Methods for selection of appropriate epitopes, such as those near the C-terminus or in hydrophilic regions are well described in the art. (See, e.g., Ausubel, 1995, supra, Chapter 11.)

[0314] Typically, peptides 15 residues in length are synthesized using an ABI 431A peptide synthesizer (Applied Biosystems) using fmoc-chemistry and coupled to KLH (Sigma) by reaction with N-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) to increase immunogenicity. (See, e.g., Ausubel, supra.) Rabbits are immunized with the peptide-KLH complex in complete Freund's adjuvant. Resulting antisera are tested for antipeptide activity by, for example, binding the peptide to plastic, blocking with 1% BSA, reacting with rabbit antisera, washing, and reacting with radioiodinated goat anti-rabbit IgG. Antisera with antipeptide activity are tested for anti-SPTM activity using protocols well known in the art, including ELISA, RIA, and immunoblotting.

[0315] XVII. Purification of Naturally Occurring SPTM Using Specific Antibodies

[0316] Naturally occurring or recombinant SPTM is substantially purified by immunoaffinity chromatography using antibodies specific for SPTM. An immunoaffinity column is constructed by covalently coupling anti-SPTM antibody to an activated chromatographic resin, such as CNBr-activated SEPHAROSE (Amersham Pharmacia Biotech). After the coupling, the resin is blocked and washed according to the manufacturer's instructions.

[0317] Media containing SPTM are passed over the immunoaffinity column, and the column is washed under conditions that allow the preferential absorbance of SPTM (e.g., high ionic strength buffers in the presence of detergent). The column is eluted under conditions that disrupt antibody/SPTM binding (e.g., a buffer of pH 2 to pH 3, or a high concentration of a chaotrope, such as urea or thiocyanate ion), and SPTM is collected.

[0318] XVIII. Identification of Molecules Which Interact with SPTM

[0319] SPTM, or biologically active fragments thereof, are labeled with ¹²⁵I Bolton-Hunter reagent. (See, e.g., Bolton, A. E. and W. M. Hunter (1973) Biochem J. 133:529-539.) Candidate molecules previously arrayed in the wells of a multi-well plate are incubated with the labeled SPTM, washed, and any wells with labeled SPTM complex are assayed. Data obtained using different concentrations of SPTM are used to calculate values for the number, affinity, and association of SPTM with the candidate molecules.

[0320] Alternatively, molecules interacting with SPTM are analyzed using the yeast two-hybrid system as described in Fields, S. and O. Song (1989) Nature 340:245-246, or using commercially available kits based on the two-hybrid system, such as the MATCHMAKER system (CLONTECH).

[0321] SPTM may also be used in the PATHCALLING process (CuraGen Corp., New Haven Conn.) which employs the yeast two-hybrid system in a high-throughput manner to determine all interactions between the proteins encoded by two large libraries of genes (Nandabalan, K. et al. (2000) U.S. Pat. No. 6,057,101).

[0322] All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims. TABLE 1 SEQ ID NO: Template ID SEQ ID NO: ORF ID 1 LI:418914.1:2001JAN12 76 LI:418914.1.orf1:2001JAN12 2 LI:246108.7:2001JAN12 77 LI:246108.7.orf3:2001JAN12 3 LI:204262.2:2001JAN12 78 LI:204262.2.orf1:2001JAN12 4 LI:331661.1:2001JAN12 79 LI:331661.1.orf1:2001JAN12 5 LI:335074.1:2001JAN12 80 LI:335074.1.orf1:2001JAN12 6 LI:154608.1:2001JAN12 81 LI:154608.1.orf2:2001JAN12 7 LI:462889.1:2001JAN12 82 LI:462889.1.orf2:2001JAN12 8 LI:236680.2:2001JAN12 83 LI:236680.2.orf2:2001JAN12 9 LI:228186.1:2001JAN12 84 LI:228186.1.orf2:2001JAN12 10 LI:721233.1:2001JAN12 85 LI:721233.1.orf1:2001JAN12 11 LI:291759.2:2001JAN12 86 LI:291759.2.orf2:2001JAN12 12 LI:292613.17:2001JAN12 87 LI:292613.17.orf1:2001JAN12 13 LI:412959.15:2001JAN12 88 LI:412959.15.orf3:2001JAN12 14 LI:482512.3:2001JAN12 89 LI:482512.3.orf1:2001JAN12 14 LI:482512.3:2001JAN12 90 LI:482512.3.orf2:2001JAN12 15 LI:413231.6:2001JAN12 91 LI:413231.6.orf1:2001JAN12 16 LI:203383.1:2001JAN12 92 LI:203383.1.orf1:2001JAN12 17 LI:133186.4:2001JAN12 93 LI:133186.4.orf3:2001JAN12 18 LI:238576.2:2001JAN12 94 LI:238576.2.orf1:2001JAN12 19 LI:903914.3:2001JAN12 95 LI:903914.3.orf2:2001JAN12 20 LI:150817.1:2001JAN12 96 LI:150817.1.orf2:2001JAN12 21 LI:219627.1:2001JAN12 97 LI:219627.1.orf3:2001JAN12 22 LI:197812.4:2001JAN12 98 LI:197812.4.orf3:2001JAN12 23 LI:101525.1:2001JAN12 99 LI:101525.1.orf2:2001JAN12 24 LI:891123.1:2001JAN12 100 LI:891123.1.orf3:2001JAN12 25 LI:813500.1:2001JAN12 101 LI:813500.1.orf1:2001JAN12 26 LI:1037251.1:2001JAN12 102 LI:1037251.1.orf1:2001JAN12 27 LI:2032187.1:2001JAN12 103 LI:2032187.1.orf2:2001JAN12 28 LI:347572.1:2001JAN12 104 LI:347572.1.orf3:2001JAN12 29 LI:007788.1:2001JAN12 105 LI:007788.1.orf1:2001JAN12 30 LI:336872.1:2001JAN12 106 LI:336872.1.orf2:2001JAN12 30 LI:336872.1:2001JAN12 107 LI:336872.1.orf3:2001JAN12 31 LI:1143291.1:2001JAN12 108 LI:1143291.1.orf2:2001JAN12 32 LI:093477.1:2001JAN12 109 LI:093477.1.orf1:2001JAN12 33 LI:222105.1:2001JAN12 110 LI:222105.1.orf2:2001JAN12 34 LI:816737.2:2001JAN12 111 LI:816737.2.orf3:2001JAN12 35 LI:475524.1:2001JAN12 112 LI:475524.1.orf2:2001JAN12 36 LI:383639.1:2001JAN12 113 LI:383639.1.orf1:2001JAN12 37 LI:814346.1:2001JAN12 114 LI:814346.1.orf2:2001JAN12 38 LI:898195.6:2001JAN12 115 LI:898195.6.orf2:2001JAN12 39 LI:210497.2:2001JAN12 116 LI:210497.2.orf3:2001JAN12 40 LI:110297.4:2001JAN12 117 LI:110297.4.orf2:2001JAN12 41 LI:2051312.1:2001JAN12 118 LI:2051312.1.orfl:2001JAN12 42 LI:350272.2:2001JAN12 119 LI:350272.2.orf3:2001JAN12 43 LI:1085472.4:2001JAN12 120 LI:1085472.4.ort1:2001JAN12 44 LI:1190272.1:2001JAN12 121 LI:1190272.1.orf2:2001JAN12 45 LI:1086797.1:2001JAN12 122 LI:1086797.1.orf1:2001JAN12 46 LI:1144466.1:2001JAN12 123 LI:1144466.1.orf1:2001JAN12 47 LI:1147914.1:2001JAN12 124 LI:1147914.1.orf3:2001JAN12 48 LI:758086.1:2001JAN12 125 LI:758086.1.orf2:2001JAN12 49 LI:765245.5:2001JAN12 126 LI:765245.5.orf3:2001JAN12 50 LI:335608.2:2001JAN12 127 LI:335608.2.orf3:2001JAN12 51 LI:405795.1:2001JAN12 128 LI:405795.1.orf3:2001JAN12 62 LI:014872.1:2001JAN12 129 LI:014872.1.orf3:2001JAN12 53 LI:239245,3:2001JAN12 130 LI:239245.3,orf3:2001JAN12 54 LI:142384.5:2001JAN12 131 LI:142384.5.orf3:2001JAN12 55 LI:2068768.1:2001JAN12 132 LI:2068768.1.orf3:2001JAN12 66 LI:2118074.1:2001JAN12 133 LI:2118074.1.orf3:2001JAN12 57 LI:1189068.4:2001JAN12 134 LI:1189068.4.orf2:2001JAN12 58 LI:2118704.1:2001JAN12 135 LI:2118704.1.orfl:2001JAN12 59 LI:03 1700.2:2001JAN12 136 LI:031700.2.orf3:2001JAN12 60 LI:2120122.1:2001JAN12 137 LI:2120122.1.orf1:2001JAN12 61 LI:816174.1:2001JAN12 138 LI:816174.1.orf1:2001JAN12 62 LI:1189569.11:2001JAN12 139 LI:1189569.11.orf2:2001JAN12 63 LI:413584.1:2001JAN12 140 LI:413584.1.orf1:2001JAN12 64 LI:791042.1:2001JAN12 141 LI:791042.1.orf2:2001JAN12 65 LI:1167140.1:2001JAN12 142 LI:1167140.1.orf3:2001JAN12 66 LI:054831.1:2001JAN12 143 LI:054831.1.orf2:2001JAN12 67 LI:1175083.1:2001JAN12 144 LI:1175083.1.orf2:2001JAN12 68 LI:2122897.2:2001JAN12 145 LI:2122897.2.orf2:2001JAN12 69 LI:2053195.3:2001JAN12 146 LI:2053195.3.orf3:2001JAN12 70 LI:439397.6:2001JAN12 147 LI:439397.6.orf2:2001JAN12 71 LI:816379.6:2001JAN12 148 LI:816379.6.orf2:2001JAN12 72 LI:2123452.4:2001JAN12 149 LI:2123452.4.orf3:2001JAN12 73 LI:474559.8:2001JAN12 150 LI:474559.8.orf3:2001JAN12 74 LI:1089871.1:2001JAN12 151 LI:1089871.1.orf3:2001JAN12 75 LI:289608.1:2001JAN12 152 LI:289608.1.orf3:2001JAN12

[0323] TABLE 2 SEQ ID NO: Template ID Start Stop Frame Domain Type Topology 1 LI:418914.1:2001JAN12 1 120 forward 1 TM Cytosolic 1 LI:418914.1:2001JAN12 121 143 forward 1 TM Transmembrane 1 LI:418914.1:2001JAN12 144 482 forward 1 TM Non-cytosolic 1 LI:418914.1:2001JAN12 483 505 forward 1 TM Transmembrane 1 LI:418914.1:2001JAN12 506 508 forward 1 TM Cytosolic 1 LI:418914.1:2001JAN12 1 115 forward 3 TM Cytosolic 1 LI:418914.1:2001JAN12 116 138 forward 3 TM Transmembrane 1 LI:418914.1:2001JAN12 139 142 forward 3 TM Non-cytosolic 1 LI:418914.1:2001JAN12 143 165 forward 3 TM Transmembrane 1 LI:418914.1:2001JAN12 166 322 forward 3 TM Cytosolic 1 LI:418914.1:2001JAN12 323 345 forward 3 TM Transmembrane 1 LI:418914.1:2001JAN12 346 359 forward 3 TM Non-cytosolic 1 LI:418914.1:2001JAN12 360 382 forward 3 TM Transmembrane 1 LI:418914.1:2001JAN12 383 388 forward 3 TM Cytosolic 1 LI:418914.1:2001JAN12 389 406 forward 3 TM Transmembrane 1 LI:418914.1:2001JAN12 407 420 forward 3 TM Non-cytosolic 1 LI:418914.1:2001JAN12 421 443 forward 3 TM Transmembrane 1 LI:418914.1:2001JAN12 444 507 forward 3 TM Cytosolic 2 LI:246108.7:2001JAN12 1 41 forward 1 TM Cytosolic 2 LI:246108.7:2001JAN12 42 59 forward 1 TM Transmembrane 2 LI:246108.7:2001JAN12 60 109 forward 1 TM Non-cytosolic 2 LI:246108.7:2001JAN12 110 132 forward 1 TM Transmembrane 2 LI:246108.7:2001JAN12 133 143 forward 1 TM Cytosolic 2 LI:246108.7:2001JAN12 144 166 forward 1 TM Transmembrane 2 LI:246108.7:2001JAN12 167 175 forward 1 TM Non-cytosolic 2 LI:246108.7:2001JAN12 176 198 forward 1 TM Transmembrane 2 LI:246108.7:2001JAN12 199 210 forward 1 TM Cytosolic 2 LI:246108.7:2001JAN12 211 233 forward 1 TM Transmembrane 2 LI:246108.7:2001JAN12 234 249 forward 1 TM Non-cytosolic 2 LI:246108.7:2001JAN12 1 19 forward 2 TM Cytosolic 2 LI:246108.7:2001JAN12 20 42 forward 2 TM Transmembrane 2 LI:246108.7:2001JAN12 43 56 forward 2 TM Non-cytosolic 2 LI:246108.7:2001JAN12 57 74 forward 2 TM Transmembrane 2 LI:246108.7:2001JAN12 75 86 forward 2 TM Cytosolic 2 LI:246108.7:2001JAN12 87 104 forward 2 TM Transmembrane 2 LI:246108.7:2001JAN12 105 113 forward 2 TM Non-cytosolic 2 LI:246108.7:2001JAN12 114 136 forward 2 TM Transmembrane 2 LI:246108.7:2001JAN12 137 142 forward 2 TM Cytosolic 2 LI:246108.7:2001JAN12 143 165 forward 2 TM Transmembrane 2 LI:246108.7:2001JAN12 166 184 forward 2 TM Non-cytosolic 2 LI:246108.7:2001JAN12 185 207 forward 2 TM Transmembrane 2 LI:246108.7:2001JAN12 208 249 forward 2 TM Cytosolic 2 LI:246108.7:2001JAN12 1 79 forward 3 TM Cytosolic 2 LI:246108.7:2001JAN12 80 102 forward 3 TM Transmembrane 2 LI:246108.7:2001JAN12 103 111 forward 3 TM Non-cytosolic 2 LI:246108.7:2001JAN12 112 131 forward 3 TM Transmembrane 2 LI:246108.7:2001JAN12 132 135 forward 3 TM Cytosolic 2 LI:246108.7:2001JAN12 136 158 forward 3 TM Transmembrane 2 LI:246108.7:2001JAN12 159 248 forward 3 TM Non-cytosolic 3 LI:204262.2:2001JAN12 1 144 forward 1 TM Cytosolic 3 LI:204262.2:2001JAN12 145 167 forward 1 TM Transmembrane 3 LI:204262.2:2001JAN12 168 220 forward 1 TM Non-cytosolic 3 LI:204262.2:2001JAN12 221 243 forward 1 TM Transmembrane 3 LI:204262.2:2001JAN12 244 374 forward 1 TM Cytosolic 3 LI:204262.2:2001JAN12 1 154 forward 2 TM Cytosolic 3 LI:204262.2:2001JAN12 155 177 forward 2 TM Transmembrane 3 LI:204262.2:2001JAN12 178 207 forward 2 TM Non-cytosolic 3 LI:204262.2:2001JAN12 208 230 forward 2 TM Transmembrane 3 LI:204262.2:2001JAN12 231 241 forward 2 TM Cytosolic 3 LI:204262.2:2001JAN12 242 264 forward 2 TM Transmembrane 3 LI:204262.2:2001JAN12 265 312 forward 2 TM Non-cytosolic 3 LI:204262.2:2001JAN12 313 332 forward 2 TM Transmembrane 3 LI:204262.2:2001JAN12 333 374 forward 2 TM Cytosolic 4 LI:331661.1:2001JAN12 1 554 forward 1 TM Non-cytosolic 4 LI:331661.1:2001JAN12 555 577 forward 1 TM Transmembrane 4 LI:331661.1:2001JAN12 578 589 forward 1 TM Cytosolic 5 LI:335074.1:2001JAN12 1 221 forward 1 TM Cytosolic 6 LI:154608.1:2001JAN12 1 40 forward 2 TM Cytosolic 6 LI:154608.1:2001JAN12 41 63 forward 2 TM Transmembrane 6 LI:154608.1:2001JAN12 64 196 forward 2 TM Non-cytosolic 6 LI:154608.1:2001JAN12 197 219 forward 2 TM Transmembrane 6 LI:154608.1:2001JAN12 220 252 forward 2 TM Cytosolic 7 LI:462889.1:2001JAN12 1 155 forward 3 TM Cytosolic 7 LI:462889.1:2001JAN12 156 178 forward 3 TM Transmembrane 7 LI:462889.1:2001JAN12 179 239 forward 3 TM Non-cytosolic 8 LI:236680.2:2001JAN12 1 4 forward 1 TM Non-cytosolic 8 LI:236680.2:2001JAN12 5 27 forward 1 TM Transmembrane 8 LI:236680.2:2001JAN12 28 47 forward 1 TM Cytosolic 8 LI:236680.2:2001JAN12 48 67 forward 1 TM Transmembrane 8 LI:236680.2:2001JAN12 68 777 forward 1 TM Non-cytosolic 8 LI:236680.2:2001JAN12 1 48 forward 2 TM Non-cytosolic 8 LI:236680.2:2001JAN12 49 71 forward 2 TM Transmembrane 8 LI:236680.2:2001JAN12 72 83 forward 2 TM Cytosolic 8 LI:236680.2:2001JAN12 84 106 forward 2 TM Transmembrane 8 LI:236680.2:2001JAN12 107 777 forward 2 TM Non-cytosolic 8 LI:236680.2:2001JAN12 1 19 forward 3 TM Cytosolic 8 LI:236680.2:2001JAN12 20 42 forward 3 TM Transmembrane 8 LI:236680.2:2001JAN12 43 777 forward 3 TM Non-cytosolic 9 LI:228186.1:2001JAN12 1 14 forward 1 TM Non-cytosolic 9 LI:228186.1:2001JAN12 15 37 forward 1 TM Transmembrane 9 LI:228186.1:2001JAN12 38 84 forward 1 TM Cytosolic 9 LI:228186.1:2001JAN12 85 107 forward 1 TM Transmembrane 9 LI:228186.1:2001JAN12 108 1670 forward 1 TM Non-cytosolic 9 LI:228186.1:2001JAN12 1 19 forward 2 TM Non-cytosolic 9 LI:228186.1:2001JAN12 20 39 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 40 51 forward 2 TM Cytosolic 9 LI:228186.1:2001JAN12 52 74 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 75 387 forward 2 TM Non-cytosolic 9 LI:228186.1:2001JAN12 388 410 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 411 447 forward 2 TM Cytosolic 9 LI:228186.1:2001JAN12 448 467 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 468 476 forward 2 TM Non-cytosolic 9 LI:228186.1:2001JAN12 477 499 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 500 511 forward 2 TM Cytosolic 9 LI:228186.1:2001JAN12 512 534 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 535 1231 forward 2 TM Non-cytosolic 9 LI:228186.1:2001JAN12 1232 1254 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 1255 1392 forward 2 TM Cytosolic 9 LI:228186.1:2001JAN12 1393 1415 forward 2 TM Transmembrane 9 LI:228186.1:2001JAN12 1416 1670 forward 2 TM Non-cytosolic 9 LI:228186.1:2001JAN12 1 21 forward 3 TM Cytosolic 9 LI:228186.1:2001JAN12 22 41 forward 3 TM Transmembrane 9 LI:228186.1:2001JAN12 42 55 forward 3 TM Non-cytosolic 9 LI:228186.1:2001JAN12 56 78 forward 3 TM Transmembrane 9 LI:228186.1:2001JAN12 79 84 forward 3 TM Cytosolic 9 LI:228186.1:2001JAN12 85 107 forward 3 TM Transmembrane 9 LI:228186.1:2001JAN12 108 1181 forward 3 TM Non-cytosolic 9 LI:228186.1:2001JAN12 1182 1204 forward 3 TM Transmembrane 9 LI:228186.1:2001JAN12 1205 1260 forward 3 TM Cytosolic 9 LI:228186.1:2001JAN12 1261 1283 forward 3 TM Transmembrane 9 LI:228186.1:2001JAN12 1284 1670 forward 3 TM Non-cytosolic 10 LI:721233.1:2001JAN12 1 175 forward 2 TM Cytosolic 10 LI:721233.1:2001JAN12 176 198 forward 2 TM Transmembrane 10 LI:721233.1:2001JAN12 199 217 forward 2 TM Non-cytosolic 11 LI:291759.2:2001JAN12 1 116 forward 1 TM Cytosolic 11 LI:291759.2:2001JAN12 117 139 forward 1 TM Transmembrane 11 LI:291759.2:2001JAN12 140 423 forward 1 TM Non-cytosolic 11 LI:291759.2:2001JAN12 1 192 forward 2 TM Cytosolic 11 LI:291759.2:2001JAN12 193 215 forward 2 TM Transmembrane 11 LI:291759.2:2001JAN12 216 423 forward 2 TM Non-cytosolic 12 LI:292613.17:2001JAN12 1 14 forward 1 TM Non-cytosolic 12 LI:292613.17:2001JAN12 15 33 forward 1 TM Transmembrane 12 LI:292613.17:2001JAN12 34 121 forward 1 TM Cytosolic 12 LI:292613.17:2001JAN12 1 56 forward 2 TM Cytosolic 12 LI:292613.17:2001JAN12 57 79 forward 2 TM Transmembrane 12 LI:292613.17:2001JAN12 80 120 forward 2 TM Non-cytosolic 12 LI:292613.17:2001JAN12 1 120 forward 3 TM Cytosolic 13 LI:412959.15:2001JAN12 1 52 forward 1 TM Non-cytosolic 13 LI:412959.15:2001JAN12 53 75 forward 1 TM Transmembrane 13 LI:412959.15:2001JAN12 76 95 forward 1 TM Cytosolic 13 LI:412959.15:2001JAN12 96 118 forward 1 TM Transmembrane 13 LI:412959.15:2001JAN12 119 137 forward 1 TM Non-cytosolic 13 LI:412959.15:2001JAN12 138 160 forward 1 TM Transmembrane 13 LI:412959.15:2001JAN12 161 164 forward 1 TM Cytosolic 13 LI:412959.15:2001JAN12 165 183 forward 1 TM Transmembrane 13 LI:412959.15:2001JAN12 184 187 forward 1 TM Non-cytosolic 13 LI:412959.15:2001JAN12 1 33 forward 2 TM Non-cytosolic 13 LI:412959.15:2001JAN12 34 56 forward 2 TM Transmembrane 13 LI:412959.15:2001JAN12 57 95 forward 2 TM Cytosolic 13 LI:412959.15:2001JAN12 96 118 forward 2 TM Transmembrane 13 LI:412959.15:2001JAN12 119 127 forward 2 TM Non-cytosolic 13 LI:412959.15:2001JAN12 128 145 forward 2 TM Transmembrane 13 LI:412959.15:2001JAN12 146 149 forward 2 TM Cytosolic 13 LI:412959.15:2001JAN12 150 169 forward 2 TM Transmembrane 13 LI:412959.15:2001JAN12 170 187 forward 2 TM Non-cytosolic 13 LI:412959.15:2001JAN12 1 125 forward 3 TM Cytosolic 13 LI:412959.15:2001JAN12 126 148 forward 3 TM Transmembrane 13 LI:412959.15:2001JAN12 149 187 forward 3 TM Non-cytosolic 14 LI:482512.3:2001JAN12 1 767 forward 2 TM Non-cytosolic 14 LI:482512.3:2001JAN12 768 790 forward 2 TM Transmembrane 14 LI:482512.3:2001JAN12 791 806 forward 2 TM Cytosolic 15 LI:413231.6:2001JAN12 1 231 forward 1 TM Non-cytosolic 15 LI:413231.6:2001JAN12 232 254 forward 1 TM Transmembrane 15 LI:413231.6:2001JAN12 255 274 forward 1 TM Cytosolic 15 LI:413231.6:2001JAN12 275 297 forward 1 TM Transmembrane 15 LI:413231.6:2001JAN12 298 332 forward 1 TM Non-cytosolic 16 LI:203383.1:2001JAN12 1 12 forward 1 TM Cytosolic 16 LI:203383.1:2001JAN12 13 32 forward 1 TM Transmembrane 16 LI:203383.1:2001JAN12 33 414 forward 1 TM Non-cytosolic 16 LI:203383.1:2001JAN12 1 12 forward 2 TM Cytosolic 16 LI:203383.1:2001JAN12 13 35 forward 2 TM Transmembrane 16 LI:203383.1:2001JAN12 36 413 forward 2 TM Non-cytosolic 16 LI:203383.1:2001JAN12 1 12 forward 3 TM Cytosolic 16 LI:203383.1:2001JAN12 13 35 forward 3 TM Transmembrane 16 LI:203383.1:2001JAN12 36 413 forward 3 TM Non-cytosolic 17 LI:133186.4:2001JAN12 1 25 forward 1 TM Non-cytosolic 17 LI:133186.4:2001JAN12 26 48 forward 1 TM Transmembrane 17 LI:133186.4:2001JAN12 49 52 forward 1 TM Cytosolic 17 LI:133186.4:2001JAN12 53 75 forward 1 TM Transmembrane 17 LI:133186.4:2001JAN12 76 89 forward 1 TM Non-cytosolic 17 LI:133186.4:2001JAN12 90 107 forward 1 TM Transmembrane 17 LI:133186.4:2001JAN12 108 119 forward 1 TM Cytosolic 17 LI:133186.4:2001JAN12 120 142 forward 1 TM Transmembrane 17 LI:133186.4:2001JAN12 143 192 forward 1 TM Non-cytosolic 17 LI:133186.4:2001JAN12 1 20 forward 2 TM Cytosolic 17 LI:133186.4:2001JAN12 21 43 forward 2 TM Transmembrane 17 LI:133186.4:2001JAN12 44 192 forward 2 TM Non-cytosolic 17 LI:133186.4:2001JAN12 1 61 forward 3 TM Non-cytosolic 17 LI:133186.4:2001JAN12 62 84 forward 3 TM Transmembrane 17 LI:133186.4:2001JAN12 85 191 forward 3 TM Cytosolic 18 LI:238576.2:2001JAN12 1 257 forward 1 TM Non-cytosolic 18 LI:238576.2:2001JAN12 258 280 forward 1 TM Transmembrane 18 LI:238576.2:2001JAN12 281 449 forward 1 TM Cytosolic 19 LI:903914.3:2001JAN12 1 607 forward 1 TM Non-cytosolic 19 LI:903914.3:2001JAN12 608 630 forward 1 TM Transmembrane 19 LI:903914.3:2001JAN12 631 917 forward 1 TM Cytosolic 19 LI:903914.3:2001JAN12 918 940 forward 1 TM Transmembrane 19 LI:903914.3:2001JAN12 941 1420 forward 1 TM Non-cytosolic 19 LI:903914.3:2001JAN12 1421 1443 forward 1 TM Transmembrane 19 LI:903914.3:2001JAN12 1444 1596 forward 1 TM Cytosolic 19 LI:903914.3:2001JAN12 1597 1619 forward 1 TM Transmembrane 19 LI:903914.3:2001JAN12 1620 1628 forward 1 TM Non-cytosolic 19 LI:903914.3:2001JAN12 1629 1651 forward 1 TM Transmembrane 19 LI:903914.3:2001JAN12 1652 1657 forward 1 TM Cytosolic 19 LI:903914.3:2001JAN12 1658 1680 forward 1 TM Transmembrane 19 LI:903914.3:2001JAN12 1681 2477 forward 1 TM Non-cytosolic 19 LI:903914.3:2001JAN12 1 313 forward 2 TM Non-cytosolic 19 LI:903914.3:2001JAN12 314 336 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 337 342 forward 2 TM Cytosolic 19 LI:903914.3:2001JAN12 343 362 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 363 366 forward 2 TM Non-cytosolic 19 LI:903914.3:2001JAN12 367 389 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 390 409 forward 2 TM Cytosolic 19 LI:903914.3:2001JAN12 410 432 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 433 446 forward 2 TM Non-cytosolic 19 LI:903914.3:2001JAN12 447 466 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 467 579 forward 2 TM Cytosolic 19 LI:903914.3:2001JAN12 580 598 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 599 607 forward 2 TM Non-cytosolic 19 LI:903914.3:2001JAN12 608 630 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 631 678 forward 2 TM Cytosolic 19 LI:903914.3:2001JAN12 679 701 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 702 845 forward 2 TM Non-cytosolic 19 LI:903914.3:2001JAN12 846 868 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 869 1071 forward 2 TM Cytosolic 19 LI:903914.3:2001JAN12 1072 1094 forward 2 TM Transmembrane 19 LI:903914.3:2001JAN12 1095 2476 forward 2 TM Non-cytosolic 19 LI:903914.3:2001JAN12 1 1157 forward 3 TM Non-cytosolic 19 LI:903914.3:2001JAN12 1158 1177 forward 3 TM Transmembrane 19 LI:903914.3:2001JAN12 1178 1419 forward 3 TM Cytosolic 19 LI:903914.3:2001JAN12 1420 1442 forward 3 TM Transmembrane 19 LI:903914.3:2001JAN12 1443 1456 forward 3 TM Non-cytosolic 19 LI:903914.3:2001JAN12 1457 1479 forward 3 TM Transmembrane 19 LI:903914.3:2001JAN12 1480 1499 forward 3 TM Cytosolic 19 LI:903914.3:2001JAN12 1500 1522 forward 3 TM Transmembrane 19 LI:903914.3:2001JAN12 1523 2476 forward 3 TM Non-cytosolic 20 LI:150817.1:2001JAN12 1 6 forward 1 TM Cytosolic 20 LI:150817.1:2001JAN12 7 29 forward 1 TM Transmembrane 20 LI:150817.1:2001JAN12 30 38 forward 1 TM Non-cytosolic 20 LI:150817.1:2001JAN12 39 61 forward 1 TM Transmembrane 20 LI:150817.1:2001JAN12 62 81 forward 1 TM Cytosolic 20 LI:150817.1:2001JAN12 82 104 forward 1 TM Transmembrane 20 LI:150817.1:2001JAN12 105 1471 forward 1 TM Non-cytosolic 20 LI:150817.1:2001JAN12 1 37 forward 3 TM Cytosolic 20 LI:150817.1:2001JAN12 38 60 forward 3 TM Transmembrane 20 LI:150817.1:2001JAN12 61 87 forward 3 TM Non-cytosolic 20 LI:150817.1:2001JAN12 88 110 forward 3 TM Transmembrane 20 LI:150817.1:2001JAN12 111 336 forward 3 TM Cytosolic 20 LI:150817.1:2001JAN12 337 359 forward 3 TM Transmembrane 20 LI:150817.1:2001JAN12 360 798 forward 3 TM Non-cytosolic 20 LI:150817.1:2001JAN12 799 821 forward 3 TM Transmembrane 20 LI:150817.1:2001JAN12 822 1024 forward 3 TM Cytosolic 20 LI:150817.1:2001JAN12 1025 1047 forward 3 TM Transmembrane 20 LI:150817.1:2001JAN12 1048 1471 forward 3 TM Non-cytosolic 21 LI:219627.1:2001JAN12 1 19 forward 1 TM Cytosolic 21 LI:219627.1:2001JAN12 20 42 forward 1 TM Transmembrane 21 LI:219627.1:2001JAN12 43 117 forward 1 TM Non-cytosolic 21 LI:219627.1:2001JAN12 118 140 forward 1 TM Transmembrane 21 LI:219627.1:2001JAN12 141 399 forward 1 TM Cytosolic 21 LI:219627.1:2001JAN12 400 419 forward 1 TM Transmembrane 21 LI:219627.1:2001JAN12 420 428 forward 1 TM Non-cytosolic 21 LI:219627.1:2001JAN12 429 451 forward 1 TM Transmembrane 21 LI:219627.1:2001JAN12 452 520 forward 1 TM Cytosolic 21 LI:219627.1:2001JAN12 521 543 forward 1 TM Transmembrane 21 LI:219627.1:2001JAN12 544 719 forward 1 TM Non-cytosolic 21 LI:219627.1:2001JAN12 1 523 forward 2 TM Non-cytosolic 21 LI:219627.1:2001JAN12 524 546 forward 2 TM Transmembrane 21 LI:219627.1:2001JAN12 547 676 forward 2 TM Cytosolic 21 LI:219627.1:2001JAN12 677 699 forward 2 TM Transmembrane 21 LI:219627.1:2001JAN12 700 719 forward 2 TM Non-cytosolic 21 LI:219627.1:2001JAN12 1 3 forward 3 TM Non-cytosolic 21 LI:219627.1:2001JAN12 4 20 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 21 26 forward 3 TM Cytosolic 21 LI:219627.1:2001JAN12 27 49 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 50 116 forward 3 TM Non-cytosolic 21 LI:219627.1:2001JAN12 117 139 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 140 223 forward 3 TM Cytosolic 21 LI:219627.1:2001JAN12 224 246 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 247 255 forward 3 TM Non-cytosolic 21 LI:219627.1:2001JAN12 256 278 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 279 509 forward 3 TM Cytosolic 21 LI:219627.1:2001JAN12 510 532 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 533 535 forward 3 TM Non-cytosolic 21 LI:219627.1:2001JAN12 536 558 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 559 665 forward 3 TM Cytosolic 21 LI:219627.1:2001JAN12 666 688 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 689 692 forward 3 TM Non-cytosolic 21 LI:219627.1:2001JAN12 693 715 forward 3 TM Transmembrane 21 LI:219627.1:2001JAN12 716 718 forward 3 TM Cytosolic 22 LI:197812.4:2001JAN12 1 14 forward 1 TM Non-cytosolic 22 LI:197812.4:2001JAN12 15 34 forward 1 TM Transmembrane 22 LI:197812.4:2001JAN12 35 107 forward 1 TM Cytosolic 22 LI:197812.4:2001JAN12 1 53 forward 2 TM Non-cytosolic 22 LI:197812.4:2001JAN12 54 76 forward 2 TM Transmembrane 22 LI:197812.4:2001JAN12 77 106 forward 2 TM Cytosolic 22 LI:197812.4:2001JAN12 1 52 forward 3 TM Cytosolic 22 LI:197812.4:2001JAN12 53 75 forward 3 TM Transmembrane 22 LI:197812.4:2001JAN12 76 106 forward 3 TM Non-cytosolic 23 LI:101525.1:2001JAN12 1 209 forward 2 TM Cytosolic 23 LI:101525.1:2001JAN12 210 232 forward 2 TM Transmembrane 23 LI:101525.1:2001JAN12 233 257 forward 2 TM Non-cytosolic 23 LI:101525.1:2001JAN12 258 280 forward 2 TM Transmembrane 23 LI:101525.1:2001JAN12 281 300 forward 2 TM Cytosolic 23 LI:101525.1:2001JAN12 301 318 forward 2 TM Transmembrane 23 LI:101525.1:2001JAN12 319 327 forward 2 TM Non-cytosolic 23 LI:101525.1:2001JAN12 328 350 forward 2 TM Transmembrane 23 LI:101525.1:2001JAN12 351 361 forward 2 TM Cytosolic 23 LI:101525.1:2001JAN12 362 379 forward 2 TM Transmembrane 23 LI:101525.1:2001JAN12 380 770 forward 2 TM Non-cytosolic 23 LI:101525.1:2001JAN12 1 209 forward 3 TM Cytosolic 23 LI:101525.1:2001JAN12 210 232 forward 3 TM Transmembrane 23 LI:101525.1:2001JAN12 233 769 forward 3 TM Non-cytosolic 24 LI:891123.1:2001JAN12 1 92 forward 1 TM Cytosolic 24 LI:891123.1:2001JAN12 93 115 forward 1 TM Transmembrane 24 LI:891123.1:2001JAN12 116 124 forward 1 TM Non-cytosolic 24 LI:891123.1:2001JAN12 125 147 forward 1 TM Transmembrane 24 LI:891123.1:2001JAN12 148 326 forward 1 TM Cytosolic 25 LI:813500.1:2001JAN12 1 388 forward 1 TM Non-cytosolic 25 LI:813500.1:2001JAN12 389 411 forward 1 TM Transmembrane 25 LI:813500.1:2001JAN12 412 691 forward 1 TM Cytosolic 25 LI:813500.1:2001JAN12 1 157 forward 3 TM Non-cytosolic 25 LI:813500.1:2001JAN12 158 180 forward 3 TM Transmembrane 25 LI:813500.1:2001JAN12 181 184 forward 3 TM Cytosolic 25 LI:813500.1:2001JAN12 185 207 forward 3 TM Transmembrane 25 LI:813500.1:2001JAN12 208 221 forward 3 TM Non-cytosolic 25 LI:813500.1:2001JAN12 222 244 forward 3 TM Transmembrane 25 LI:813500.1:2001JAN12 245 537 forward 3 TM Cytosolic 25 LI:813500.1:2001JAN12 538 560 forward 3 TM Transmembrane 25 LI:813500.1:2001JAN12 561 691 forward 3 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 1 59 forward 1 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 60 82 forward 1 TM Transmembrane 26 LI:1037251.1:2001JAN12 83 221 forward 1 TM Cytosolic 26 LI:1037251.1:2001JAN12 222 244 forward 1 TM Transmembrane 26 LI:1037251.1:2001JAN12 245 263 forward 1 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 264 286 forward 1 TM Transmembrane 26 LI:1037251.1:2001JAN12 287 428 forward 1 TM Cytosolic 26 LI:1037251.1:2001JAN12 429 451 forward 1 TM Transmembrane 26 LI:1037251.1:2001JAN12 452 614 forward 1 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 615 637 forward 1 TM Transmembrane 26 LI:1037251.1:2001JAN12 638 653 forward 1 TM Cytosolic 26 LI:1037251.1:2001JAN12 1 171 forward 2 TM Cytosolic 26 LI:1037251.1:2001JAN12 172 191 forward 2 TM Transmembrane 26 LI:1037251.1:2001JAN12 192 200 forward 2 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 201 223 forward 2 TM Transmembrane 26 LI:1037251.1:2001JAN12 224 267 forward 2 TM Cytosolic 26 LI:1037251.1:2001JAN12 268 290 forward 2 TM Transmembrane 26 LI:1037251.1:2001JAN12 291 425 forward 2 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 426 445 forward 2 TM Transmembrane 26 LI:1037251.1:2001JAN12 446 564 forward 2 TM Cytosolic 26 LI:1037251.1:2001JAN12 565 584 forward 2 TM Transmembrane 26 LI:1037251.1:2001JAN12 585 612 forward 2 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 613 635 forward 2 TM Transmembrane 26 LI:1037251.1:2001JAN12 636 652 forward 2 TM Cytosolic 26 LI:1037251.1:2001JAN12 1 98 forward 3 TM Cytosolic 26 LI:1037251.1:2001JAN12 99 121 forward 3 TM Transmembrane 26 LI:1037251.1:2001JAN12 122 262 forward 3 TM Non-cytosolic 26 LI:1037251.1:2001JAN12 263 285 forward 3 TM Transmembrane 26 LI:1037251.1:2001JAN12 286 428 forward 3 TM Cytosolic 26 LI:1037251.1:2001JAN12 429 451 forward 3 TM Transmembrane 26 LI:1037251.1:2001JAN12 452 652 forward 3 TM Non-cytosolic 27 LI:2032187.1:2001JAN12 1 14 forward 3 TM Non-cytosolic 27 LI:2032187.1:2001JAN12 15 36 forward 3 TM Transmembrane 27 LI:2032187.1:2001JAN12 37 37 forward 3 TM Cytosolic 27 LI:2032187.1:2001JAN12 38 60 forward 3 TM Transmembrane 27 LI:2032187.1:2001JAN12 61 480 forward 3 TM Non-cytosolic 28 LI:347572.1:2001JAN12 1 963 forward 2 TM Non-cytosolic 28 LI:347572.1:2001JAN12 964 986 forward 2 TM Transmembrane 28 LI:347572.1:2001JAN12 987 1221 forward 2 TM Cytosolic 28 LI:347572.1:2001JAN12 1 905 forward 3 TM Non-cytosolic 28 LI:347572.1:2001JAN12 906 925 forward 3 TM Transmembrane 28 LI:347572.1:2001JAN12 926 1221 forward 3 TM Cytosolic 29 LI:007788.1:2001JAN12 1 346 forward 1 TM Non-cytosolic 29 LI:007788.1:2001JAN12 347 366 forward 1 TM Transmembrane 29 LI:007788.1:2001JAN12 367 698 forward 1 TM Cytosolic 29 LI:007788.1:2001JAN12 1 344 forward 2 TM Cytosolic 29 LI:007788.1:2001JAN12 345 367 forward 2 TM Transmembrane 29 LI:007788.1:2001JAN12 368 697 forward 2 TM Non-cytosolic 29 LI:007788.1:2001JAN12 1 342 forward 3 TM Cytosolic 29 LI:007788.1:2001JAN12 343 365 forward 3 TM Transmembrane 29 LI:007788.1:2001JAN12 366 697 forward 3 TM Non-cytosolic 30 LI:336872.1:2001JAN12 1 406 forward 2 TM Non-cytosolic 30 LI:336872.1:2001JAN12 407 429 forward 2 TM Transmembrane 30 LI:336872.1:2001JAN12 430 580 forward 2 TM Cytosolic 31 LI:1143291.1:2001JAN12 1 554 forward 1 TM Non-cytosolic 31 LI:1143291.1:2001JAN12 555 577 forward 1 TM Transmembrane 31 LI:1143291.1:2001JAN12 578 623 forward 1 TM Cytosolic 31 LI:1143291.1:2001JAN12 624 643 forward 1 TM Transmembrane 31 LI:1143291.1:2001JAN12 644 647 forward 1 TM Non-cytosolic 32 LI:093477.1:2001JAN12 1 194 forward 1 TM Non-cytosolic 32 LI:093477.1:2001JAN12 195 217 forward 1 TM Transmembrane 32 LI:093477.1:2001JAN12 218 243 forward 1 TM Cytosolic 32 LI:093477.1:2001JAN12 244 263 forward 1 TM Transmembrane 32 LI:093477.1:2001JAN12 264 509 forward 1 TM Non-cytosolic 33 LI:222105.1:2001JAN12 1 759 forward 1 TM Non-cytosolic 33 LI:222105.1:2001JAN12 760 782 forward 1 TM Transmembrane 33 LI:222105.1:2001JAN12 783 825 forward 1 TM Cytosolic 33 LI:222105.1:2001JAN12 826 840 forward 1 TM Transmembrane 33 LI:222105.1:2001JAN12 841 859 forward 1 TM Non-cytosolic 33 LI:222105.1:2001JAN12 860 882 forward 1 TM Transmembrane 33 LI:222105.1:2001JAN12 883 905 forward 1 TM Cytosolic 33 LI:222105.1:2001JAN12 906 928 forward 1 TM Transmembrane 33 LI:222105.1:2001JAN12 929 947 forward 1 TM Non-cytosolic 33 LI:222105.1:2001JAN12 948 970 forward 1 TM Transmembrane 33 LI:222105.1:2001JAN12 971 981 forward 1 TM Cytosolic 33 LI:222105.1:2001JAN12 1 825 forward 2 TM Non-cytosolic 33 LI:222105.1:2001JAN12 826 840 forward 2 TM Transmembrane 33 LI:222105.1:2001JAN12 841 860 forward 2 TM Cytosolic 33 LI:222105.1:2001JAN12 861 883 forward 2 TM Transmembrane 33 LI:222105.1:2001JAN12 884 904 forward 2 TM Non-cytosolic 33 LI:222105.1:2001JAN12 905 927 forward 2 TM Transmembrane 33 LI:222105.1:2001JAN12 928 981 forward 2 TM Cytosolic 34 LI:816737.2:2001JAN12 1 753 forward 1 TM Non-cytosolic 34 LI:816737.2:2001JAN12 754 776 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 777 796 forward 1 TM Cytosolic 34 LI:816737.2:2001JAN12 797 819 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 820 906 forward 1 TM Non-cytosolic 34 LI:816737.2:2001JAN12 907 929 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 930 941 forward 1 TM Cytosolic 34 LI:816737.2:2001JAN12 942 964 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 965 1015 forward 1 TM Non-cytosolic 34 LI:816737.2:2001JAN12 1016 1038 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 1039 1067 forward 1 TM Cytosolic 34 LI:816737.2:2001JAN12 1068 1090 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 1091 1125 forward 1 TM Non-cytosolic 34 LI:816737.2:2001JAN12 1126 1148 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 1149 1167 forward 1 TM Cytosolic 34 LI:816737.2:2001JAN12 1168 1190 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 1191 1204 forward 1 TM Non-cytosolic 34 LI:816737.2:2001JAN12 1205 1227 forward 1 TM Transmembrane 34 LI:816737.2:2001JAN12 1228 1341 forward 1 TM Cytosolic 34 LI:816737.2:2001JAN12 1 901 forward 2 TM Non-cytosolic 34 LI:816737.2:2001JAN12 902 924 forward 2 TM Transmembrane 34 LI:816737.2:2001JAN12 925 1026 forward 2 TM Cytosolic 34 LI:816737.2:2001JAN12 1027 1046 forward 2 TM Transmembrane 34 LI:816737.2:2001JAN12 1047 1079 forward 2 TM Non-cytosolic 34 LI:816737.2:2001JAN12 1080 1102 forward 2 TM Transmembrane 34 LI:816737.2:2001JAN12 1103 1182 forward 2 TM Cytosolic 34 LI:816737.2:2001JAN12 1183 1205 forward 2 TM Transmembrane 34 LI:816737.2:2001JAN12 1206 1219 forward 2 TM Non-cytosolic 34 LI:816737.2:2001JAN12 1220 1242 forward 2 TM Transmembrane 34 LI:816737.2:2001JAN12 1243 1341 forward 2 TM Cytosolic 34 LI:816737.2:2001JAN12 1 302 forward 3 TM Cytosolic 34 LI:816737.2:2001JAN12 303 325 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 326 364 forward 3 TM Non-cytosolic 34 LI:816737.2:2001JAN12 365 387 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 388 666 forward 3 TM Cytosolic 34 LI:816737.2:2001JAN12 667 686 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 687 762 forward 3 TM Non-cytosolic 34 LI:816737.2:2001JAN12 763 785 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 786 899 forward 3 TM Cytosolic 34 LI:816737.2:2001JAN12 900 922 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 923 941 forward 3 TM Non-cytosolic 34 LI:816737.2:2001JAN12 942 960 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 961 966 forward 3 TM Cytosolic 34 LI:816737.2:2001JAN12 967 989 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 990 1024 forward 3 TM Non-cytosolic 34 LI:816737.2:2001JAN12 1025 1044 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 1045 1188 forward 3 TM Cytosolic 34 LI:816737.2:2001JAN12 1189 1211 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 1212 1245 forward 3 TM Non-cytosolic 34 LI:816737.2:2001JAN12 1246 1268 forward 3 TM Transmembrane 34 LI:816737.2:2001JAN12 1269 1340 forward 3 TM Cytosolic 35 LI:475524.1:2001JAN12 1 339 forward 3 TM Non-cytosolic 35 LI:475524.1:2001JAN12 340 362 forward 3 TM Transmembrane 35 LI:475524.1:2001JAN12 363 557 forward 3 TM Cytosolic 36 LI:383639.1:2001JAN12 1 172 forward 3 TM Cytosolic 36 LI:383639.1:2001JAN12 173 192 forward 3 TM Transmembrane 36 LI:383639.1:2001JAN12 193 206 forward 3 TM Non-cytosolic 36 LI:383639.1:2001JAN12 207 229 forward 3 TM Transmembrane 36 LI:383639.1:2001JAN12 230 240 forward 3 TM Cytosolic 36 LI:383639.1:2001JAN12 241 263 forward 3 TM Transmembrane 36 LI:383639.1:2001JAN12 264 466 forward 3 TM Non-cytosolic 36 LI:383639.1:2001JAN12 467 489 forward 3 TM Transmembrane 36 LI:383639.1:2001JAN12 490 500 forward 3 TM Cytosolic 36 LI:383639.1:2001JAN12 501 523 forward 3 TM Transmembrane 36 LI:383639.1:2001JAN12 524 971 forward 3 TM Non-cytosolic 37 LI:814346.1:2001JAN12 1 314 forward 2 TM Non-cytosolic 37 LI:814346.1:2001JAN12 315 337 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 338 348 forward 2 TM Cytosolic 37 LI:814346.1:2001JAN12 349 371 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 372 457 forward 2 TM Non-cytosolic 37 LI:814346.1:2001JAN12 458 477 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 478 483 forward 2 TM Cytosolic 37 LI:814346.1:2001JAN12 484 506 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 507 608 forward 2 TM Non-cytosolic 37 LI:814346.1:2001JAN12 609 631 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 632 767 forward 2 TM Cytosolic 37 LI:814346.1:2001JAN12 768 790 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 791 818 forward 2 TM Non-cytosolic 37 LI:814346.1:2001JAN12 819 841 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 842 853 forward 2 TM Cytosolic 37 LI:814346.1:2001JAN12 854 876 forward 2 TM Transmembrane 37 LI:814346.1:2001JAN12 877 924 forward 2 TM Non-cytosolic 37 LI:814346.1:2001JAN12 1 341 forward 3 TM Non-cytosolic 37 LI:814346.1:2001JAN12 342 364 forward 3 TM Transmembrane 37 LI:814346.1:2001JAN12 365 370 forward 3 TM Cytosolic 37 LI:814346.1:2001JAN12 371 393 forward 3 TM Transmembrane 37 LI:814346.1:2001JAN12 394 483 forward 3 TM Non-cytosolic 37 LI:814346.1:2001JAN12 484 506 forward 3 TM Transmembrane 37 LI:814346.1:2001JAN12 507 526 forward 3 TM Cytosolic 37 LI:814346.1:2001JAN12 527 549 forward 3 TM Transmembrane 37 LI:814346.1:2001JAN12 550 923 forward 3 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1 1117 forward 1 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1118 1140 forward 1 TM Transmembrane 38 LI:898195.6:2001JAN12 1141 1260 forward 1 TM Cytosolic 38 LI:898195.6:2001JAN12 1261 1283 forward 1 TM Transmembrane 38 LI:898195.6:2001JAN12 1284 1318 forward 1 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1319 1338 forward 1 TM Transmembrane 38 LI:898195.6:2001JAN12 1339 1384 forward 1 TM Cytosolic 38 LI:898195.6:2001JAN12 1385 1404 forward 1 TM Transmembrane 38 LI:898195.6:2001JAN12 1405 1418 forward 1 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1419 1441 forward 1 TM Transmembrane 38 LI:898195.6:2001JAN12 1442 1468 forward 1 TM Cytosolic 38 LI:898195.6:2001JAN12 1 905 forward 2 TM Non-cytosolic 38 LI:898195.6:2001JAN12 906 928 forward 2 TM Transmembrane 38 LI:898195.6:2001JAN12 929 969 forward 2 TM Cytosolic 38 LI:898195.6:2001JAN12 970 992 forward 2 TM Transmembrane 38 LI:898195.6:2001JAN12 993 1006 forward 2 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1007 1029 forward 2 TM Transmembrane 38 LI:898195.6:2001JAN12 1030 1118 forward 2 TM Cytosolic 38 LI:898195.6:2001JAN12 1119 1141 forward 2 TM Transmembrane 38 LI:898195.6:2001JAN12 1142 1263 forward 2 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1264 1286 forward 2 TM Transmembrane 38 LI:898195.6:2001JAN12 1287 1388 forward 2 TM Cytosolic 38 LI:898195.6:2001JAN12 1389 1411 forward 2 TM Transmembrane 38 LI:898195.6:2001JAN12 1412 1420 forward 2 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1421 1443 forward 2 TM Transmembrane 38 LI:898195.6:2001JAN12 1444 1468 forward 2 TM Cytosolic 38 LI:898195.6:2001JAN12 1 974 forward 3 TM Non-cytosolic 38 LI:898195.6:2001JAN12 975 997 forward 3 TM Transmembrane 38 LI:898195.6:2001JAN12 998 1120 forward 3 TM Cytosolic 38 LI:898195.6:2001JAN12 1121 1143 forward 3 TM Transmembrane 38 LI:898195.6:2001JAN12 1144 1152 forward 3 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1153 1175 forward 3 TM Transmembrane 38 LI:898195.6:2001JAN12 1176 1264 forward 3 TM Cytosolic 38 LI:898195.6:2001JAN12 1265 1284 forward 3 TM Transmembrane 38 LI:898195.6:2001JAN12 1285 1387 forward 3 TM Non-cytosolic 38 LI:898195.6:2001JAN12 1388 1410 forward 3 TM Transmembrane 38 LI:898195.6:2001JAN12 1411 1416 forward 3 TM Cytosolic 38 LI:898195.6:2001JAN12 1417 1439 forward 3 TM Transmembrane 38 LI:898195.6:2001JAN12 1440 1467 forward 3 TM Non-cytosolic 39 LI:210497.2:2001JAN12 1 138 forward 3 TM Cytosolic 40 LI:110297.4:2001JAN12 1 63 forward 1 TM Cytosolic 40 LI:110297.4:2001JAN12 64 86 forward 1 TM Transmembrane 40 LI:110297.4:2001JAN12 87 706 forward 1 TM Non-cytosolic 40 LI:110297.4:2001JAN12 707 724 forward 1 TM Transmembrane 40 LI:110297.4:2001JAN12 725 760 forward 1 TM Cytosolic 40 LI:110297.4:2001JAN12 761 783 forward 1 TM Transmembrane 40 LI:110297.4:2001JAN12 784 792 forward 1 TM Non-cytosolic 40 LI:110297.4:2001JAN12 793 815 forward 1 TM Transmembrane 40 LI:110297.4:2001JAN12 816 825 forward 1 TM Cytosolic 40 LI:110297.4:2001JAN12 1 129 forward 2 TM Cytosolic 40 LI:110297.4:2001JAN12 130 147 forward 2 TM Transmembrane 40 LI:110297.4:2001JAN12 148 156 forward 2 TM Non-cytosolic 40 LI:110297.4:2001JAN12 157 179 forward 2 TM Transmembrane 40 LI:110297.4:2001JAN12 180 601 forward 2 TM Cytosolic 40 LI:110297.4:2001JAN12 602 621 forward 2 TM Transmembrane 40 LI:110297.4:2001JAN12 622 625 forward 2 TM Non-cytosolic 40 LI:110297.4:2001JAN12 626 648 forward 2 TM Transmembrane 40 LI:110297.4:2001JAN12 649 761 forward 2 TM Cytosolic 40 LI:110297.4:2001JAN12 762 784 forward 2 TM Transmembrane 40 LI:110297.4:2001JAN12 785 798 forward 2 TM Non-cytosolic 40 LI:110297.4:2001JAN12 799 821 forward 2 TM Transmembrane 40 LI:110297.4:2001JAN12 822 825 forward 2 TM Cytosolic 40 LI:110297.4:2001JAN12 1 11 forward 3 TM Cytosolic 40 LI:110297.4:2001JAN12 12 29 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 30 62 forward 3 TM Non-cytosolic 40 LI:110297.4:2001JAN12 63 85 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 86 129 forward 3 TM Cytosolic 40 LI:110297.4:2001JAN12 130 152 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 153 291 forward 3 TM Non-cytosolic 40 LI:110297.4:2001JAN12 292 314 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 315 326 forward 3 TM Cytosolic 40 LI:110297.4:2001JAN12 327 349 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 350 363 forward 3 TM Non-cytosolic 40 LI:110297.4:2001JAN12 364 386 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 387 607 forward 3 TM Cytosolic 40 LI:110297.4:2001JAN12 608 630 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 631 732 forward 3 TM Non-cytosolic 40 LI:110297.4:2001JAN12 733 752 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 753 758 forward 3 TM Cytosolic 40 LI:110297.4:2001JAN12 759 781 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 782 790 forward 3 TM Non-cytosolic 40 LI:110297.4:2001JAN12 791 813 forward 3 TM Transmembrane 40 LI:110297.4:2001JAN12 814 824 forward 3 TM Cytosolic 41 LI:2051312.1:2001JAN12 1 46 forward 1 TM Cytosolic 41 LI:2051312.1:2001JAN12 47 69 forward 1 TM Transmembrane 41 LI:2051312.1:2001JAN12 70 542 forward 1 TM Non-cytosolic 41 LI:2051312.1:2001JAN12 1 36 forward 3 TM Cytosolic 41 LI:2051312.1:2001JAN12 37 59 forward 3 TM Transmembrane 41 LI:2051312.1:2001JAN12 60 541 forward 3 TM Non-cytosolic 42 LI:350272.2:2001JAN12 1 487 forward 1 TM Non-cytosolic 42 LI:350272.2:2001JAN12 488 510 forward 1 TM Transmembrane 42 LI:350272.2:2001JAN12 511 519 forward 1 TM Cytosolic 43 LI:1085472.4:2001JAN12 1 313 forward 1 TM Cytosolic 43 LI:1085472.4:2001JAN12 314 336 forward 1 TM Transmembrane 43 LI:1085472.4:2001JAN12 337 713 forward 1 TM Non-cytosolic 43 LI:1085472.4:2001JAN12 714 736 forward 1 TM Transmembrane 43 LI:1085472.4:2001JAN12 737 968 forward 1 TM Cytosolic 43 LI:1085472.4:2001JAN12 969 991 forward 1 TM Transmembrane 43 LI:1085472.4:2001JAN12 992 1199 forward 1 TM Non-cytosolic 43 LI:1085472.4:2001JAN12 1 1123 forward 2 TM Non-cytosolic 43 LI:1085472.4:2001JAN12 1124 1146 forward 2 TM Transmembrane 43 LI:1085472.4:2001JAN12 1147 1166 forward 2 TM Cytosolic 43 LI:1085472.4:2001JAN12 1167 1189 forward 2 TM Transmembrane 43 LI:1085472.4:2001JAN12 1190 1198 forward 2 TM Non-cytosolic 44 LI:1190272.1:2001JAN12 1 321 forward 1 TM Non-cytosolic 44 LI:1190272.1:2001JAN12 322 344 forward 1 TM Transmembrane 44 LI:1190272.1:2001JAN12 345 363 forward 1 TM Cytosolic 44 LI:1190272.1:2001JAN12 1 311 forward 3 TM Non-cytosolic 44 LI:1190272.1:2001JAN12 312 334 forward 3 TM Transmembrane 44 LI:1190272.1:2001JAN12 335 362 forward 3 TM Cytosolic 45 LI:1086797.1:2001JAN12 1 12 forward 1 TM Cytosolic 45 LI:1086797.1:2001JAN12 13 35 forward 1 TM Transmembrane 45 LI:1086797.1:2001JAN12 36 1202 forward 1 TM Non-cytosolic 45 LI:1086797.1:2001JAN12 1 12 forward 2 TM Cytosolic 45 LI:1086797.1:2001JAN12 13 35 forward 2 TM Transmembrane 45 LI:1086797.1:2001JAN12 36 1202 forward 2 TM Non-cytosolic 45 LI:1086797.1:2001JAN12 1 19 forward 3 TM Non-cytosolic 45 LI:1086797.1:2001JAN12 20 42 forward 3 TM Transmembrane 45 LI:1086797.1:2001JAN12 43 172 forward 3 TM Cytosolic 45 LI:1086797.1:2001JAN12 173 195 forward 3 TM Transmembrane 45 LI:1086797.1:2001JAN12 196 1013 forward 3 TM Non-cytosolic 45 LI:1086797.1:2001JAN12 1014 1036 forward 3 TM Transmembrane 45 LI:1086797.1:2001JAN12 1037 1202 forward 3 TM Cytosolic 46 LI:1144466.1:2001JAN12 1 690 forward 1 TM Non-cytosolic 46 LI:1144466.1:2001JAN12 691 710 forward 1 TM Transmembrane 46 LI:1144466.1:2001JAN12 711 723 forward 1 TM Cytosolic 46 LI:1144466.1:2001JAN12 1 690 forward 2 TM Non-cytosolic 46 LI:1144466.1:2001JAN12 691 710 forward 2 TM Transmembrane 46 LI:1144466.1:2001JAN12 711 723 forward 2 TM Cytosolic 47 LI:1147914.1:2001JAN12 1 71 forward 2 TM Cytosolic 47 LI:1147914.1:2001JAN12 72 94 forward 2 TM Transmembrane 47 LI:1147914.1:2001JAN12 95 464 forward 2 TM Non-cytosolic 48 LI:758086.1:2001JAN12 1 50 forward 1 TM Non-cytosolic 48 LI:758086.1:2001JAN12 51 73 forward 1 TM Transmembrane 48 LI:758086.1:2001JAN12 74 79 forward 1 TM Cytosolic 48 LI:758086.1:2001JAN12 80 97 forward 1 TM Transmembrane 48 LI:758086.1:2001JAN12 98 286 forward 1 TM Non-cytosolic 48 LI:758086.1:2001JAN12 287 309 forward 1 TM Transmembrane 48 LI:758086.1:2001JAN12 310 329 forward 1 TM Cytosolic 48 LI:758086.1:2001JAN12 330 352 forward 1 TM Transmembrane 48 LI:758086.1:2001JAN12 353 464 forward 1 TM Non-cytosolic 48 LI:758086.1:2001JAN12 1 382 forward 3 TM Non-cylosolic 48 LI:758086.1:2001JAN12 383 405 forward 3 TM Transmembrane 48 LI:758086.1:2001JAN12 406 437 forward 3 TM Cytosolic 48 LI:758086.1:2001JAN12 438 457 forward 3 TM Transmembrane 48 LI:758086.1:2001JAN12 458 463 forward 3 TM Non-cytosolic 49 LI:765245.5:2001JAN12 1 351 forward 1 TM Non-cytosolic 49 LI:765245.5:2001JAN12 352 374 forward 1 TM Transmembrane 49 LI:765245.5:2001JAN12 375 766 forward 1 TM Cytosolic 49 LI:765245.5:2001JAN12 1 352 forward 3 TM Non-cytosolic 49 LI:765245.5:2001JAN12 353 372 forward 3 TM Transmembrane 49 LI:765245.5:2001JAN12 373 384 forward 3 TM Cytosolic 49 LI:765245.5:2001JAN12 385 407 forward 3 TM Transmembrane 49 LI:765245.5:2001JAN12 408 765 forward 3 TM Non-cytosolic 50 LI:335608.2:2001JAN12 1 19 forward 2 TM Non-cytosolic 50 LI:335608.2:2001JAN12 20 42 forward 2 TM Transmembrane 50 LI:335608.2:2001JAN12 43 251 forward 2 TM Cytosolic 50 LI:335608.2:2001JAN12 252 269 forward 2 TM Transmembrane 50 LI:335608.2:2001JAN12 270 335 forward 2 TM Non-cytosolic 50 LI:335608.2:2001JAN12 336 358 forward 2 TM Transmembrane 50 LI:335608.2:2001JAN12 359 365 forward 2 TM Cytosolic 50 LI:335608.2:2001JAN12 1 19 forward 3 TM Non-cytosolic 50 LI:335608.2:2001JAN12 20 42 forward 3 TM Transmembrane 50 LI:335608.2:2001JAN12 43 53 forward 3 TM Cytosolic 50 LI:335608.2:2001JAN12 54 76 forward 3 TM Transmembrane 50 LI:335608.2:2001JAN12 77 251 forward 3 TM Non-cytosolic 50 LI:335608.2:2001JAN12 252 269 forward 3 TM Transmembrane 50 LI:335608.2:2001JAN12 270 291 forward 3 TM Cytosolic 50 LI:335608.2:2001JAN12 292 311 forward 3 TM Transmembrane 50 LI:335608.2:2001JAN12 312 323 forward 3 TM Non-cytosolic 50 LI:335608.2:2001JAN12 324 346 forward 3 TM Transmembrane 50 LI:335608.2:2001JAN12 347 365 forward 3 TM Cytosolic 51 LI:405795.1:2001JAN12 1 36 forward 1 TM Cytosolic 51 LI:405795.1:2001JAN12 37 59 forward 1 TM Transmembrane 51 LI:405795.1:2001JAN12 60 339 forward 1 TM Non-cytosolic 51 LI:405795.1:2001JAN12 340 362 forward 1 TM Transmembrane 51 LI:405795.1:2001JAN12 363 692 forward 1 TM Cytosolic 51 LI:405795.1:2001JAN12 693 715 forward 1 TM Transmembrane 51 LI:405795.1:2001JAN12 716 719 forward 1 TM Non-cytosolic 51 LI:405795.1:2001JAN12 720 742 forward 1 TM Transmembrane 51 LI:405795.1:2001JAN12 743 746 forward 1 TM Cytosolic 51 LI:405795.1:2001JAN12 1 139 forward 2 TM Non-cytosolic 51 LI:405795.1:2001JAN12 140 162 forward 2 TM Transmembrane 51 LI:405795.1:2001JAN12 163 316 forward 2 TM Cytosolic 51 LI:405795.1:2001JAN12 317 339 forward 2 TM Transmembrane 51 LI:405795.1:2001JAN12 340 418 forward 2 TM Non-cytosolic 51 LI:405795.1:2001JAN12 419 441 forward 2 TM Transmembrane 51 LI:405795.1:2001JAN12 442 699 forward 2 TM Cytosolic 51 LI:405795.1:2001JAN12 700 722 forward 2 TM Transmembrane 51 LI:405795.1:2001JAN12 723 745 forward 2 TM Non-cytosolic 51 LI:405795.1:2001JAN12 1 54 forward 3 TM Non-cytosolic 51 LI:405795.1:2001JAN12 55 77 forward 3 TM Transmembrane 51 LI:405795.1:2001JAN12 78 421 forward 3 TM Cytosolic 51 LI:405795.1:2001JAN12 422 444 forward 3 TM Transmembrane 51 LI:405795.1:2001JAN12 445 696 forward 3 TM Non-cytosolic 51 LI:405795.1:2001JAN12 697 719 forward 3 TM Transmembrane 51 LI:405795.1:2001JAN12 720 745 forward 3 TM Cytosolic 52 LI:014872.1:2001JAN12 1 44 forward 1 TM Cytosolic 52 LI:014872.1:2001JAN12 45 64 forward 1 TM Transmembrane 52 LI:014872.1:2001JAN12 65 97 forward 1 TM Non-cytosolic 52 LI:014872.1:2001JAN12 98 120 forward 1 TM Transmembrane 52 LI:014872.1:2001JAN12 121 453 forward 1 TM Cytosolic 53 LI:239245.3:2001JAN12 1 19 forward 1 TM Non-cytosolic 53 LI:239245.3:2001JAN12 20 42 forward 1 TM Transmembrane 53 LI:239245.3:2001JAN12 43 164 forward 1 TM Cytosolic 53 LI:239245.3:2001JAN12 165 187 forward 1 TM Transmembrane 53 LI:239245.3:2001JAN12 188 817 forward 1 TM Non-cytosolic 53 LI:239245.3:2001JAN12 818 840 forward 1 TM Transmembrane 53 LI:239245.3:2001JAN12 841 877 forward 1 TM Cytosolic 53 LI:239245.3:2001JAN12 1 810 forward 2 TM Non-cytosolic 53 LI:239245.3:2001JAN12 811 833 forward 2 TM Transmembrane 53 LI:239245.3:2001JAN12 834 877 forward 2 TM Cytosolic 53 LI:239245.3:2001JAN12 1 810 forward 3 TM Non-cytosolic 53 LI:239245.3:2001JAN12 811 833 forward 3 TM Transmembrane 53 LI:239245.3:2001JAN12 834 877 forward 3 TM Cytosolic 54 LI:142384.5:2001JAN12 1 574 forward 2 TM Non-cytosolic 54 LI:142384.5:2001JAN12 575 597 forward 2 TM Transmembrane 54 LI:142384.5:2001JAN12 598 725 forward 2 TM Cytosolic 54 LI:142384.5:2001JAN12 726 748 forward 2 TM Transmembrane 54 LI:142384.5:2001JAN12 749 752 forward 2 TM Non-cytosolic 54 LI:142384.5:2001JAN12 753 775 forward 2 TM Transmembrane 54 LI:142384.5:2001JAN12 776 995 forward 2 TM Cytosolic 54 LI:142384.5:2001JAN12 996 1015 forward 2 TM Transmembrane 54 LI:142384.5:2001JAN12 1016 1018 forward 2 TM Non-cytosolic 55 LI:2068768.1:2001JAN12 1 140 forward 2 TM Cytosolic 55 LI:2068768.1:2001JAN12 141 163 forward 2 TM Transmembrane 55 LI:2068768.1:2001JAN12 164 169 forward 2 TM Non-cytosolic 56 LI:2118074.1:2001JAN12 1 51 forward 3 TM Cytosolic 56 LI:2118074.1:2001JAN12 52 74 forward 3 TM Transmembrane 56 LI:2118074.1:2001JAN12 75 88 forward 3 TM Non-cytosolic 56 LI:2118074.1:2001JAN12 89 106 forward 3 TM Transmembrane 56 LI:2118074.1:2001JAN12 107 145 forward 3 TM Cytosolic 56 LI:2118074.1:2001JAN12 146 168 forward 3 TM Transmembrane 56 LI:2118074.1:2001JAN12 169 178 forward 3 TM Non-cytosolic 57 LI:1189068.4:2001JAN12 1 562 forward 3 TM Non-cytosolic 57 LI:1189068.4:2001JAN12 563 585 forward 3 TM Transmembrane 57 LI:1189068.4:2001JAN12 586 654 forward 3 TM Cytosolic 58 LI:2118704.1:2001JAN12 1 33 forward 3 TM Non-cytosolic 58 LI:2118704.1:2001JAN12 34 56 forward 3 TM Transmembrane 58 LI:2118704.1:2001JAN12 57 60 forward 3 TM Cytosolic 58 LI:2118704.1:2001JAN12 61 83 forward 3 TM Transmembrane 58 LI:2118704.1:2001JAN12 84 339 forward 3 TM Non-cytosolic 59 LI:031700.2:2001JAN12 1 237 forward 1 TM Cytosolic 59 LI:031700.2:2001JAN12 238 260 forward 1 TM Transmembrane 59 LI:031700.2:2001JAN12 261 269 forward 1 TM Non-cytosolic 59 LI:031700.2:2001JAN12 270 292 forward 1 TM Transmembrane 59 LI:031700.2:2001JAN12 293 389 forward 1 TM Cytosolic 59 LI:031700.2:2001JAN12 390 412 forward 1 TM Transmembrane 59 LI:031700.2:2001JAN12 413 847 forward 1 TM Non-cytosolic 59 LI:031700.2:2001JAN12 1 99 forward 2 TM Non-cytosolic 59 LI:031700.2:2001JAN12 100 119 forward 2 TM Transmembrane 59 LI:031700.2:2001JAN12 120 251 forward 2 TM Cytosolic 59 LI:031700.2:2001JAN12 252 271 forward 2 TM Transmembrane 59 LI:031700.2:2001JAN12 272 274 forward 2 TM Non-cytosolic 59 LI:031700.2:2001JAN12 275 294 forward 2 TM Transmembrane 59 LI:031700.2:2001JAN12 295 388 forward 2 TM Cytosolic 59 LI:031700.2:2001JAN12 389 411 forward 2 TM Transmembrane 59 LI:031700.2:2001JAN12 412 420 forward 2 TM Non-cytosolic 59 LI:031700.2:2001JAN12 421 443 forward 2 TM Transmembrane 59 LI:031700.2:2001JAN12 444 488 forward 2 TM Cytosolic 59 LI:031700.2:2001JAN12 489 508 forward 2 TM Transmembrane 59 LI:031700.2:2001JAN12 509 847 forward 2 TM Non-cytosolic 59 LI:031700.2:2001JAN12 1 4 forward 3 TM Non-cytosolic 59 LI:031700.2:2001JAN12 5 22 forward 3 TM Transmembrane 59 LI:031700.2:2001JAN12 23 97 forward 3 TM Cytosolic 59 LI:031700.2:2001JAN12 98 120 forward 3 TM Transmembrane 59 LI:031700.2:2001JAN12 121 245 forward 3 TM Non-cytosolic 59 LI:031700.2:2001JAN12 246 268 forward 3 TM Transmembrane 59 LI:031700.2:2001JAN12 269 274 forward 3 TM Cytosolic 59 LI:031700.2:2001JAN12 275 294 forward 3 TM Transmembrane 59 LI:031700.2:2001JAN12 295 846 forward 3 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 1 25 forward 1 TM Cytosolic 60 LI:2120122.1:2001JAN12 26 48 forward 1 TM Transmembrane 60 LI:2120122.1:2001JAN12 49 267 forward 1 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 268 287 forward 1 TM Transmembrane 60 LI:2120122.1:2001JAN12 288 299 forward 1 TM Cytosolic 60 LI:2120122.1:2001JAN12 300 322 forward 1 TM Transmembrane 60 LI:2120122.1:2001JAN12 323 350 forward 1 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 351 373 forward 1 TM Transmembrane 60 LI:2120122.1:2001JAN12 374 443 forward 1 TM Cytosolic 60 LI:2120122.1:2001JAN12 444 466 forward 1 TM Transmembrane 60 LI:2120122.1:2001JAN12 467 470 forward 1 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 471 493 forward 1 TM Transmembrane 60 LI:2120122.1:2001JAN12 494 505 forward 1 TM Cytosolic 60 LI:2120122.1:2001JAN12 506 528 forward 1 TM Transmembrane 60 LI:2120122.1:2001JAN12 529 586 forward 1 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 1 122 forward 2 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 123 142 forward 2 TM Transmembrane 60 LI:2120122.1:2001JAN12 143 148 forward 2 TM Cytosolic 60 LI:2120122.1:2001JAN12 149 171 forward 2 TM Transmembrane 60 LI:2120122.1:2001JAN12 172 462 forward 2 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 463 485 forward 2 TM Transmembrane 60 LI:2120122.1:2001JAN12 486 586 forward 2 TM Cytosolic 60 LI:2120122.1:2001JAN12 1 23 forward 3 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 24 46 forward 3 TM Transmembrane 60 LI:2120122.1:2001JAN12 47 65 forward 3 TM Cytosolic 60 LI:2120122.1:2001JAN12 66 85 forward 3 TM Transmembrane 60 LI:2120122.1:2001JAN12 86 254 forward 3 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 255 277 forward 3 TM Transmembrane 60 LI:2120122.1:2001JAN12 278 425 forward 3 TM Cytosolic 60 LI:2120122.1:2001JAN12 426 448 forward 3 TM Transmembrane 60 LI:2120122.1:2001JAN12 449 467 forward 3 TM Non-cytosolic 60 LI:2120122.1:2001JAN12 468 490 forward 3 TM Transmembrane 60 LI:2120122.1:2001JAN12 491 496 forward 3 TM Cytosolic 60 LI:2120122.1:2001JAN12 497 515 forward 3 TM Transmembrane 60 LI:2120122.1:2001JAN12 516 585 forward 3 TM Non-cytosolic 61 LI:816174.1:2001JAN12 1 277 forward 3 TM Non-cytosolic 61 LI:816174.1:2001JAN12 278 300 forward 3 TM Transmembrane 61 LI:816174.1:2001JAN12 301 344 forward 3 TM Cytosolic 62 LI:1189569.11:2001JAN12 1 12 forward 1 TM Cytosolic 62 LI:1189569.11:2001JAN12 13 35 forward 1 TM Transmembrane 62 LI:1189569.11:2001JAN12 36 305 forward 1 TM Non-cytosolic 62 LI:1189569.11:2001JAN12 1 184 forward 2 TM Non-cytosolic 62 LI:1189569.11:2001JAN12 185 207 forward 2 TM Transmembrane 62 LI:1189569.11:2001JAN12 208 304 forward 2 TM Cytosolic 63 LI:413584.1:2001JAN12 1 4 forward 2 TM Non-cytosolic 63 LI:413584.1:2001JAN12 5 24 forward 2 TM Transmembrane 63 LI:413584.1:2001JAN12 25 72 forward 2 TM Cytosolic 63 LI:413584.1:2001JAN12 73 95 forward 2 TM Transmembrane 63 LI:413584.1:2001JAN12 96 445 forward 2 TM Non-cytosolic 64 LI:791042.1:2001JAN12 1 392 forward 2 TM Non-cytosolic 64 LI:791042.1:2001JAN12 393 415 forward 2 TM Transmembrane 64 LI:791042.1:2001JAN12 416 434 forward 2 TM Cytosolic 64 LI:791042.1:2001JAN12 435 457 forward 2 TM Transmembrane 64 LI:791042.1:2001JAN12 458 487 forward 2 TM Non-cytosolic 65 LI:1167140.1:2001JAN12 1 444 forward 1 TM Non-cytosolic 65 LI:1167140.1:2001JAN12 445 467 forward 1 TM Transmembrane 65 LI:1167140.1:2001JAN12 468 519 forward 1 TM Cytosolic 65 LI:1167140.1:2001JAN12 1 444 forward 2 TM Non-cytosolic 65 LI:1167140.1:2001JAN12 445 467 forward 2 TM Transmembrane 65 LI:1167140.1:2001JAN12 468 519 forward 2 TM Cytosolic 65 LI:1167140.1:2001JAN12 1 367 forward 3 TM Non-cytosolic 65 LI:1167140.1:2001JAN12 368 387 forward 3 TM Transmembrane 65 LI:1167140.1:2001JAN12 388 423 forward 3 TM Cytosolic 65 LI:1167140.1:2001JAN12 424 446 forward 3 TM Transmembrane 65 LI:1167140.1:2001JAN12 447 450 forward 3 TM Non-cytosolic 65 LI:1167140.1:2001JAN12 451 473 forward 3 TM Transmembrane 65 LI:1167140.1:2001JAN12 474 485 forward 3 TM Cytosolic 65 LI:1167140.1:2001JAN12 486 508 forward 3 TM Transmembrane 65 LI:1167140.1:2001JAN12 509 518 forward 3 TM Non-cytosolic 66 LI:054831.1:2001JAN12 1 3 forward 2 TM Non-cytosolic 66 LI:054831.1:2001JAN12 4 21 forward 2 TM Transmembrane 66 LI:054831.1:2001JAN12 22 51 forward 2 TM Cytosolic 66 LI:054831.1:2001JAN12 52 74 forward 2 TM Transmembrane 66 LI:054831.1:2001JAN12 75 603 forward 2 TM Non-cytosolic 67 LI:1175083.1:2001JAN12 1 326 forward 3 TM Non-cytosolic 67 LI:1175083.1:2001JAN12 327 349 forward 3 TM Transmembrane 67 LI:1175083.1:2001JAN12 350 354 forward 3 TM Cytosolic 68 LI:2122897.2:2001JAN12 1 402 forward 2 TM Non-cytosolic 68 LI:2122897.2:2001JAN12 403 425 forward 2 TM Transmembrane 68 LI:2122897.2:2001JAN12 426 467 forward 2 TM Cytosolic 68 LI:2122897.2:2001JAN12 1 391 forward 3 TM Non-cytosolic 68 LI:2122897.2:2001JAN12 392 414 forward 3 TM Transmembrane 68 LI:2122897.2:2001JAN12 415 466 forward 3 TM Cytosolic 69 LI:2053195.3:2001JAN12 1 9 forward 3 TM Non-cytosolic 69 LI:2053195.3:2001JAN12 10 28 forward 3 TM Transmembrane 69 LI:2053195.3:2001JAN12 29 101 forward 3 TM Cytosolic 70 LI:439397.6:2001JAN12 1 407 forward 3 TM Non-cytosolic 70 LI:439397.6:2001JAN12 408 430 forward 3 TM Transmembrane 70 LI:439397.6:2001JAN12 431 453 forward 3 TM Cytosolic 71 LI:816379.6:2001JAN12 1 129 forward 1 TM Cytosolic 71 LI:816379.6:2001JAN12 130 147 forward 1 TM Transmembrane 71 LI:816379.6:2001JAN12 148 150 forward 1 TM Non-cytosolic 71 LI:816379.6:2001JAN12 151 173 forward 1 TM Transmembrane 71 LI:816379.6:2001JAN12 174 211 forward 1 TM Cytosolic 71 LI:816379.6:2001JAN12 212 234 forward 1 TM Transmembrane 71 LI:816379.6:2001JAN12 235 633 forward 1 TM Non-cytosolic 71 LI:816379.6:2001JAN12 634 653 forward 1 TM Transmembrane 71 LI:816379.6:2001JAN12 654 659 forward 1 TM Cytosolic 71 LI:816379.6:2001JAN12 660 682 forward 1 TM Transmembrane 71 LI:816379.6:2001JAN12 683 734 forward 1 TM Non-cytosolic 71 LI:816379.6:2001JAN12 1 37 forward 2 TM Non-cytosolic 71 LI:816379.6:2001JAN12 38 60 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 61 79 forward 2 TM Cytosolic 71 LI:816379.6:2001JAN12 80 102 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 103 144 forward 2 TM Non-cytosolic 71 LI:816379.6:2001JAN12 145 167 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 168 212 forward 2 TM Cytosolic 71 LI:816379.6:2001JAN12 213 232 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 233 289 forward 2 TM Non-cytosolic 71 LI:816379.6:2001JAN12 290 307 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 308 394 forward 2 TM Cytosolic 71 LI:816379.6:2001JAN12 395 414 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 415 418 forward 2 TM Non-cytosolic 71 LI:816379.6:2001JAN12 419 441 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 442 447 forward 2 TM Cytosolic 71 LI:816379.6:2001JAN12 448 470 forward 2 TM Transmembrane 71 LI:816379.6:2001JAN12 471 734 forward 2 TM Non-cytosolic 71 LI:816379.6:2001JAN12 1 39 forward 3 TM Non-cytosolic 71 LI:816379.6:2001JAN12 40 62 forward 3 TM Transmembrane 71 LI:816379.6:2001JAN12 63 132 forward 3 TM Cytosolic 71 LI:816379.6:2001JAN12 133 155 forward 3 TM Transmembrane 71 LI:816379.6:2001JAN12 156 281 forward 3 TM Non-cytosolic 71 LI:816379.6:2001JAN12 282 304 forward 3 TM Transmembrane 71 LI:816379.6:2001JAN12 305 399 forward 3 TM Cytosolic 71 LI:816379.6:2001JAN12 400 422 forward 3 TM Transmembrane 71 LI:816379.6:2001JAN12 423 436 forward 3 TM Non-cytosolic 71 LI:816379.6:2001JAN12 437 459 forward 3 TM Transmembrane 71 LI:816379.6:2001JAN12 460 629 forward 3 TM Cytosolic 71 LI:816379.6:2001JAN12 630 652 forward 3 TM Transmembrane 71 LI:816379.6:2001JAN12 653 734 forward 3 TM Non-cytosolic 72 LI:2123452.4:2001JAN12 1 36 forward 1 TM Non-cytosolic 72 LI:2123452.4:2001JAN12 37 59 forward 1 TM Transmembrane 72 LI:2123452.4:2001JAN12 60 60 forward 1 TM Cytosolic 72 LI:2123452.4:2001JAN12 61 78 forward 1 TM Transmembrane 72 LI:2123452.4:2001JAN12 79 87 forward 1 TM Non-cytosolic 72 LI:2123452.4:2001JAN12 88 110 forward 1 TM Transmembrane 72 LI:2123452.4:2001JAN12 111 156 forward 1 TM Cytosolic 72 LI:2123452.4:2001JAN12 1 28 forward 2 TM Cytosolic 72 LI:2123452.4:2001JAN12 29 51 forward 2 TM Transmembrane 72 LI:2123452.4:2001JAN12 52 65 forward 2 TM Non-cytosolic 72 LI:2123452.4:2001JAN12 66 88 forward 2 TM Transmembrane 72 LI:2123452.4:2001JAN12 89 156 forward 2 TM Cytosolic 73 LI:474559.8:2001JAN12 1 110 forward 1 TM Non-cytosolic 73 LI:474559.8:2001JAN12 111 133 forward 1 TM Transmembrane 73 LI:474559.8:2001JAN12 134 215 forward 1 TM Cytosolic 73 LI:474559.8:2001JAN12 1 175 forward 2 TM Cytosolic 73 LI:474559.8:2001JAN12 176 198 forward 2 TM Transmembrane 73 LI:474559.8:2001JAN12 199 215 forward 2 TM Non-cytosolic 73 LI:474559.8:2001JAN12 1 215 forward 3 TM Cytosolic 74 LI:1089871.1:2001JAN12 1 218 forward 2 TM Cytosolic 74 LI:1089871.1:2001JAN12 219 241 forward 2 TM Transmembrane 74 LI:1089871.1:2001JAN12 242 282 forward 2 TM Non-cytosolic 74 LI:1089871.1:2001JAN12 283 305 forward 2 TM Transmembrane 74 LI:1089871.1:2001JAN12 306 380 forward 2 TM Cytosolic 74 LI:1089871.1:2001JAN12 381 400 forward 2 TM Transmembrane 74 LI:1089871.1:2001JAN12 401 437 forward 2 TM Non-cytosolic 74 LI:1089871.1:2001JAN12 438 460 forward 2 TM Transmembrane 74 LI:1089871.1:2001JAN12 461 614 forward 2 TM Cytosolic 74 LI:1089871.1:2001JAN12 615 637 forward 2 TM Transmembrane 74 LI:1089871.1:2001JAN12 638 760 forward 2 TM Non-cytosolic 74 LI:1089871.1:2001JAN12 1 221 forward 3 TM Cytosolic 74 LI:1089871.1:2001JAN12 222 244 forward 3 TM Transmembrane 74 LI:1089871.1:2001JAN12 245 271 forward 3 TM Non-cytosolic 74 LI:1089871.1:2001JAN12 272 289 forward 3 TM Transmembrane 74 LI:1089871.1:2001JAN12 290 437 forward 3 TM Cytosolic 74 LI:1089871.1:2001JAN12 438 460 forward 3 TM Transmembrane 74 LI:1089871.1:2001JAN12 461 760 forward 3 TM Non-cytosolic 75 LI:289608.1:2001JAN12 1 148 forward 2 TM Cytosolic 75 LI:289608.1:2001JAN12 149 171 forward 2 TM Transmembrane 75 LI:289608.1:2001JAN12 172 180 forward 2 TM Non-cytosolic 75 LI:289608.1:2001JAN12 181 203 forward 2 TM Transmembrane 75 LI:289608.1:2001JAN12 204 220 forward 2 TM Cytosolic 75 LI:289608.1:2001JAN12 1 184 forward 3 TM Non-cytosolic 75 LI:289608.1:2001JAN12 185 207 forward 3 TM Transmembrane 75 LI:289608.1:2001JAN12 208 219 forward 3 TM Cytosolic

[0324] TABLE 3 SEQ ID NO: Template ID Component ID Start Stop 1 LI:418914.1:2001JAN12 4029796F6 268 553 1 LI:418914.1:2001JAN12 4029796H1 268 524 1 LI:418914.1:2001JAN12 g4988429 303 758 1 LI:418914.1:2001JAN12 g1101061 352 513 1 LI:418914.1:2001JAN12 g5633945 359 758 1 LI:418914.1:2001JAN12 g3078225 383 758 1 LI:418914.1:2001JAN12 71259473V1 1063 1416 1 LI:418914.1:2001JAN12 5998440H1 1107 1416 1 LI:418914.1:2001JAN12 5051546T6 1218 1423 1 LI:418914.1:2001JAN12 5834482H1 1349 1507 1 LI:418914.1:2001JAN12 5834482T6 1349 1525 1 LI:418914.1:2001JAN12 7586321H2 646 1257 1 LI:418914.1:2001JAN12 5051546F6 819 1234 1 LI:418914.1:2001JAN12 5051546H1 819 1046 1 LI:418914.1:2001JAN12 8066123J1 833 1401 1 LI:418914.1:2001JAN12 4659880H1 32 279 1 LI:418914.1:2001JAN12 g1126083 166 544 1 LI:418914.1:2001JAN12 4029796T6 261 527 1 LI:418914.1:2001JAN12 5726505H1 1 383 1 LI:418914.1:2001JAN12 046079H1 22 158 2 LI:246108.7:2001JAN12 g1696312 457 748 2 LI:246108.7:2001JAN12 g2194270 434 744 2 LI:246108.7:2001JAN12 3852492T6 196 723 2 LI:246108.7:2001JAN12 6888706J1 48 648 2 LI:246108.7:2001JAN12 3852492F6 148 617 2 LI:246108.7:2001JAN12 3852492H1 149 429 2 LI:246108.7:2001JAN12 g2194338 1 339 3 LI:20426Z.2:2001JAN12 g1267547 815 1122 3 LI:204262.2:2001JAN12 g3037719 822 1113 3 LI:204262.2:2001JAN12 g3330198 830 1115 3 LI:204262.2:2001JAN12 g762085 832 1089 3 LI:204262.2:2001JAN12 g5663772 840 1111 3 LI:204262.2:2001JAN12 g2054071 842 1132 3 LI:204262.2:2001JAN12 g2838446 845 1109 3 LI:204262.2:2001JAN12 g921316 850 1119 3 LI:204262.2:2001JAN12 g921478 856 1090 3 LI:204262.2:2001JAN12 g6401369 869 1115 3 LI:204262.2:2001JAN12 3009683H1 875 1022 3 LI:204262.2:2001JAN12 g5863680 882 1115 3 LI:204262.2:2001JAN12 g5904949 5 398 3 LI:204262.2:2001JAN12 6886754J1 8 371 3 LI:204262.2:2001JAN12 2651027H1 14 269 3 LI:204262.2:2001JAN12 2864552H1 13 311 3 LI:204262.2:2001JAN12 3798411H1 18 295 3 LI:204262.2:2001JAN12 3056428H1 24 239 3 LI:204262.2:2001JAN12 g5325960 165 407 3 LI:204262.2:2001JAN12 4405093H1 177 423 3 LI:204262.2:2001JAN12 7710231H1 197 785 3 LI:204262.2:2001JAN12 1316952H1 200 392 3 LI:204262.2:2001JAN12 5697164H1 208 392 3 LI:204262.2:2001JAN12 g1933501 302 392 3 LI:204262.2:2001JAN12 3085446H1 317 591 3 LI:204262.2:2001JAN12 4370458H1 379 483 3 LI:204262.2:2001JAN12 2429647H1 398 626 3 LI:204262.2:2001JAN12 g1301433 397 758 3 LI:204262.2:2001JAN12 1907484H1 399 658 3 LI:204262.2:2001JAN12 4407466H1 399 654 3 LI:204262.2:2001JAN12 1891084H1 399 662 3 LI:204262.2:2001JAN12 1907484F6 399 721 3 LI:204262.2:2001JAN12 5905191H1 409 558 3 LI:204262.2:2001JAN12 2905068H1 409 609 3 LI:204262.2:2001JAN12 8180656H1 409 840 3 LI:204262.2:2001JAN12 3669938H1 410 707 3 LI:204262.2:2001JAN12 3168274H1 415 695 3 LI:204262.2:2001JAN12 4370372H1 415 647 3 LI:204262.2:2001JAN12 1704319H1 414 623 3 LI:204262.2:2001JAN12 2113619H1 415 640 3 LI:204262.2:2001JAN12 663536H1 415 645 3 LI:204262.2:2001JAN12 3334434H1 409 540 3 LI:204262.2:2001JAN12 1955142H1 415 609 3 LI:204262.2:2001JAN12 2114652H1 419 688 3 LI:204262.2:2001JAN12 7077958H1 1 378 3 LI:204262.2:2001JAN12 2906317F6 1 373 3 LI:204262.2:2001JAN12 2906317H1 1 306 3 LI:204262.2:2001JAN12 2905586H1 3 269 3 LI:204262.2:2001JAN12 g7317508 4 384 3 LI:204262.2:2001JAN12 6450961H1 5 586 3 LI:204262.2:2001JAN12 2733223H1 483 763 3 LI:204262.2:2001JAN12 5490990H1 483 770 3 LI:20426Z.2:2001JAN12 4367028H1 493 738 3 LI:204262.2:2001JAN12 4368445H1 493 772 3 LI:204262.2:2001JAN12 4376291H1 499 755 3 LI:204262.2:2001JAN12 3427865H1 530 791 3 LI:204262.2:2001JAN12 6206254H1 530 1098 3 LI:204262.2:2001JAN12 g2054234 543 866 3 LI:204262.2:2001JAN12 5789606H1 546 837 3 LI:204262.2:2001JAN12 5795364H1 546 828 3 LI:204262.2:2001JAN12 g4533121 547 1019 3 LI:204262.2:2001JAN12 g847490 562 832 3 LI:204262.2:2001JAN12 g921174 563 873 3 LI:204262.2:2001JAN12 g921384 563 869 3 LI:204262.2:2001JAN12 6517347H1 577 1072 3 LI:204262.2:2001JAN12 190748416 591 981 3 LI:204262.2:2001JAN12 6713444H1 595 1006 3 LI:204262.2:2001JAN12 1569057H1 595 804 3 LI:204262.2:2001JAN12 6715344F8 609 1017 3 LI:204262.2:2001JAN12 g7278310 610 1017 3 LI:204262.2:2001JAN12 2905921H1 614 893 3 LI:204262.2:2001JAN12 g5370364 617 1027 3 LI:204262.2:2001JAN12 6715344F6 616 1006 3 LI:204262.2:2001JAN12 g5740750 617 1022 3 LI:204262.2:2001JAN12 g5510928 618 1017 3 LI:204262.2:2001JAN12 g3744370 626 1022 3 LI:204262.2:2001JAN12 1400614H1 627 860 3 LI:204262.2:2001JAN12 1396990H1 627 866 3 LI:204262.2:2001JAN12 1397508H1 627 870 3 LI:204262.2:2001JAN12 7710231J1 637 1123 3 LI:204262.2:2001JAN12 g4291140 644 1114 3 LI:204262.2:2001JAN12 g5425821 647 1113 3 LI:204262.2:2001JAN12 g5235945 661 1117 3 LI:204262.2:2001JAN12 g4533235 663 1118 3 LI:204262.2:2001JAN12 1333591H1 663 904 3 LI:204262.2:2001JAN12 g4524193 665 1116 3 LI:204262.2:2001JAN12 g8361553 665 1114 3 LI:204262.2:2001JAN12 g6835880 666 1117 3 LI:204262.2:2001JAN12 g4524592 667 1022 3 LI:204262.2:2001JAN12 g5675646 673 1129 3 LI:204262.2:2001JAN12 g5396644 679 1114 3 LI:204262.2:2001JAN12 2905087H1 419 689 3 LI:204262.2:2001JAN12 901294H1 419 717 3 LI:204262.2:2001JAN12 901294R1 419 909 3 LI:204262.2:2001JAN12 3986655H1 421 690 3 LI:204262.2:2001JAN12 g1955172 424 751 3 LI:204262.2:2001JAN12 2908149H1 421 713 3 LI:204262.2:2001JAN12 2904727H1 432 731 3 LI:204262.2:2001JAN12 3762093T6 436 1046 3 LI:204262.2:2001JAN12 3590473H1 452 751 3 LI:204262.2:2001JAN12 g1301395 469 692 3 LI:204262.2:2001JAN12 5101734H1 479 720 3 LI:204262.2:2001JAN12 g5744485 881 1114 3 LI:204262.2:2001JAN12 3513391H1 884 1104 3 LI:204262.2:2001JAN12 625181H1 892 1114 3 LI:204262.2:2001JAN12 g1264641 910 1115 3 LI:204262.2:2001JAN12 g6946728 917 1022 3 LI:204262.2:2001JAN12 5595731H1 1020 1112 3 LI:204262.2:2001JAN12 g2753547 742 932 3 LI:204262.2:2001JAN12 g2902957 742 888 3 LI:204262.2:2001JAN12 g1489513 745 1114 3 LI:204262.2:2001JAN12 g2834856 745 1114 3 LI:204262.2:2001JAN12 g3754537 754 1119 3 LI:204262.2:2001JAN12 g6041209 759 1114 3 LI:204262.2:2001JAN12 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5067002H1 1839 2062 8 LI:236680.2:2001JAN12 g4764199 1849 2325 8 LI:236680.2:2001JAN12 g5675041 1854 2325 8 LI:236680.2:2001JAN12 g1289941 1854 2333 8 LI:236680.2:2001JAN12 g3594344 1855 2327 8 LI:236680.2:2001JAN12 g1886363 1854 2284 8 LI:236680.2:2001JAN12 g1071482 1859 2169 8 LI:236680.2:2001JAN12 2614306T6 1868 2285 8 LI:236680.2:2001JAN12 6123995H1 1874 2220 8 LI:236680.2:2001JAN12 6124095H1 1874 2319 8 LI:236680.2:2001JAN12 g4308115 1878 2322 8 LI:236680.2:2001JAN12 4120305H1 1884 2157 8 LI:236680.2:2001JAN12 2285547H1 1889 2158 8 LI:236680.2:2001JAN12 92903185 1891 2322 8 LI:236680.2:2001JAN12 2717291H1 1899 2156 8 LI:236680.2:2001JAN12 1511984T6 1902 2283 8 LI:236680.2:2001JAN12 g2902705 1903 2319 8 LI:236680.2:2001JAN12 2121490H1 1903 2190 8 LI:236680.2:2001JAN12 6891191H1 1906 2273 8 LI:236680.2:2001JAN12 1531659H1 1907 2125 8 LI:236680.2:2001JAN12 g2901559 1916 2317 8 LI:236680.2:2001JAN12 g1927650 1922 2327 8 LI:236680.2:2001JAN12 g1779557 1920 2322 8 LI:236680.2:2001JAN12 764247H1 1923 2225 8 LI:236680.2:2001JAN12 4909776H1 1922 2211 8 LI:236680.2:2001JAN12 g3246364 1924 2328 8 LI:236680.2:2001JAN12 g6034682 1924 2322 8 LI:236680.2:2001JAN12 g3400920 1928 2322 8 LI:236680.2:2001JAN12 g3921126 1931 2323 8 LI:236680.2:2001JAN12 g2184277 1931 2322 8 LI:236680.2:2001JAN12 g2789087 1931 2322 8 LI:236680.2:2001JAN12 5266178H1 1942 2100 8 LI:236680.2:2001JAN12 5268752H1 1943 2238 8 LI:236680.2:2001JAN12 g6034690 1950 2322 8 LI:236680.2:2001JAN12 g1071376 1960 2318 8 LI:236680.2:2001JAN12 g1190233 1962 2318 8 LI:236680.2:2001JAN12 g3134236 1962 2317 8 LI:236680.2:2001JAN12 g1921221 1962 2313 8 LI:236680.2:2001JAN12 4024449H1 1964 2154 8 LI:236680.2:2001JAN12 6449287H1 1970 2317 8 LI:236680.2:2001JAN12 4029205H1 1975 2241 8 LI:236680.2:2001JAN12 6446287H1 1974 2317 8 LI:236680.2:2001JAN12 1384614H1 1985 2247 8 LI:236680.2:2001JAN12 g2154287 1988 2314 8 LI:236680.2:2001JAN12 g1312625 1444 1937 8 LI:236680.2:2001JAN12 4400655H1 1445 1724 8 LI:236680.2:2001JAN12 g5109483 1451 1887 8 LI:236680.2:2001JAN12 5714792H1 1457 1769 8 LI:236680.2:2001JAN12 6706664H1 1469 1957 8 LI:236680.2:2001JAN12 5429194H1 1469 1757 8 LI:236680.2:2001JAN12 g2229268 1490 1902 8 LI:236680.2:2001JAN12 415958H1 1491 1737 8 LI:236680.2:2001JAN12 6756226H1 1501 2209 8 LI:236680.2:2001JAN12 200080H1 1512 1827 8 LI:236680.2:2001JAN12 200081H1 1512 1828 8 LI:236680.2:2001JAN12 5611292H1 1518 1799 8 LI:236680.2:2001JAN12 g1191362 1524 1680 8 LI:236680.2:2001JAN12 7336684H1 1563 1916 8 LI:236680.2:2001JAN12 2314511H1 1585 1833 8 LI:236680.2:2001JAN12 g6702138 1580 1892 8 LI:236680.2:2001JAN12 g3202284 1583 1896 8 LI:236680.2:2001JAN12 724515R1 1585 2156 8 LI:236680.2:2001JAN12 724515H1 1585 1825 8 LI:236680.2:2001JAN12 g6992823 1589 1892 8 LI:236680.2:2001JAN12 2886039H1 1613 1884 8 LI:236680.2:2001JAN12 2874078H1 1618 1916 8 LI:236680.2:2001JAN12 3702979H1 1619 1916 8 LI:236680.2:2001JAN12 2665478H1 1621 1887 8 LI:236680.2:2001JAN12 2370703H1 1622 1885 8 LI:236680.2:2001JAN12 5913623H1 1623 1931 8 LI:236680.2:2001JAN12 1915623H1 1625 1843 8 LI:236680.2:2001JAN12 5264651H2 1638 1907 8 LI:236680.2:2001JAN12 3825094H1 1645 1890 8 LI:236680.2:2001JAN12 993892T1 1707 1851 8 LI:236680.2:2001JAN12 497542H1 1724 1887 8 LI:236680.2:2001JAN12 g3253828 1725 2161 8 LI:236680.2:2001JAN12 2925528H1 1738 1906 8 LI:236680.2:2001JAN12 2244966H1 1743 1998 8 LI:236680.2:2001JAN12 4320814H1 1748 2035 8 LI:236680.2:2001JAN12 5303358H1 1758 1980 8 LI:236680.2:2001JAN12 3387208H1 1758 1976 8 LI:236680.2:2001JAN12 g2705585 1786 2314 8 LI:236680.2:2001JAN12 g1957960 1801 2285 8 LI:236680.2:2001JAN12 5901612H1 1806 2120 8 LI:236680.2:2001JAN12 1832942H1 1806 2088 8 LI:236680.2:2001JAN12 5894013HI 1806 1916 8 LI:236680.2:2001JAN12 g3433338 2095 2287 8 LI:236680.2:2001JAN12 5067691H1 2096 2326 8 LI:236680.2:2001JAN12 1916921H1 2136 2328 8 LI:236680.2:2001JAN12 2599527T6 2146 2285 8 LI:236680.2:2001JAN12 2560611H1 2169 2322 8 LI:236680.2:2001JAN12 g1241937 2178 2317 8 LI:236680.2:2001JAN12 2330769H1 2255 2326 8 LI:236680.2:2001JAN12 4773732H1 2264 2322 8 LI:236680.2:2001JAN12 g2805069 1417 1903 8 LI:236680.2:2001JAN12 3235380H1 1428 1698 8 LI:236680.2:2001JAN12 571475H1 1440 1661 8 LI:236680.2:2001JAN12 440467H1 1351 1489 8 LI:236680.2:2001JAN12 1948625H1 1353 1613 8 LI:236680.2:2001JAN12 5536452H1 1365 1521 8 LI:236680.2:2001JAN12 056288H1 1363 1535 8 LI:236680.2:2001JAN12 g1810092 1366 1580 8 LI:236680.2:2001JAN12 3486974H1 1370 1635 8 LI:236680.2:2001JAN12 1848282H1 1373 1651 8 LI:236680.2:2001JAN12 6881552H1 1377 1896 8 LI:236680.2:2001JAN12 053537H1 1378 1577 8 LI:236680.2:2001JAN12 413100H1 1380 1595 8 LI:236680.2:2001JAN12 6411776H1 1397 1926 8 LI:236680.2:2001JAN12 5946170H1 1409 1655 8 LI:236680.2:2001JAN12 3557711H1 1351 1632 8 LI:236680.2:2001JAN12 3159474H1 1351 1618 8 LI:236680.2:2001JAN12 4707470H1 1351 1599 8 LI:236680.2:2001JAN12 437494H1 1351 1558 8 LI:236680.2:2001JAN12 g2011273 1351 1541 8 LI:236680.2:2001JAN12 5376179H1 1351 1520 8 LI:236680.2:2001JAN12 g3039383 1312 1674 8 LI:236680.2:2001JAN12 g3429533 1312 1702 8 LI:236680.2:2001JAN12 g3048130 1313 1599 8 LI:236680.2:2001JAN12 1390588H1 1312 1436 8 LI:236680.2:2001JAN12 g1885716 1307 1722 8 LI:236680.2:2001JAN12 2075665H1 1308 1597 8 LI:236680.2:2001JAN12 2293582H1 1308 1585 8 LI:236680.2:2001JAN12 4707390H1 1310 1585 8 LI:236680.2:2001JAN12 4342282H1 1314 1517 8 LI:236680.2:2001JAN12 201900416 1336 1860 8 LI:236680.2:2001JAN12 6076309H1 1336 1598 8 LI:236680.2:2001JAN12 6034056H1 1338 2016 8 LI:236680.2:2001JAN12 g1313848 1346 1841 8 LI:236680.2:2001JAN12 5805420H1 1339 1667 8 LI:236680.2:2001JAN12 2222252H1 1341 1624 8 LI:236680.2:2001JAN12 6040024H1 1346 1986 8 LI:236680.2:2001JAN12 g1921327 1350 1669 8 LI:236680.2:2001JAN12 5854844H1 1346 1644 8 LI:236680.2:2001JAN12 6267478H1 1351 1892 8 LI:236680.2:2001JAN12 4082468H1 1248 1545 8 LI:236680.2:2001JAN12 174345016 1249 1861 8 LI:236680.2:2001JAN12 2101426H1 1253 1534 8 LI:236680.2:2001JAN12 1700062H1 1264 1489 8 LI:236680.2:2001JAN12 1698445H1 1264 1317 8 LI:236680.2:2001JAN12 2955049H1 1265 1515 8 LI:236680.2:2001JAN12 34196716 1267 1861 8 LI:236680.2:2001JAN12 g2107080 1271 1661 8 LI:236680.2:2001JAN12 881668H1 1282 1553 8 LI:236680.2:2001JAN12 g2237266 2000 2323 8 LI:236680.2:2001JAN12 4081922H1 1247 1559 8 LI:236680.2:2001JAN12 3442789H1 2187 2322 8 LI:236680.2:2001JAN12 g2881308 2217 2317 8 LI:236680.2:2001JAN12 4907175H2 2233 2307 8 LI:236680.2:2001JAN12 g1238176 2242 2343 9 LI:228186.1:2001JAN12 2578858F6 3757 4250 9 LI:228186.1:2001JAN12 2578858H1 3757 4017 9 LI:228186.1:2001JAN12 g2183340 3767 4181 9 LI:228186.1:2001JAN12 g6716882 3769 4179 9 LI:228186.1:2001JAN12 g2783648 3788 4185 9 LI:228186.1:2001JAN12 g3674771 3791 4186 9 LI:228186.1:2001JAN12 1466016H1 3790 3973 9 LI:228186.1:2001JAN12 g3418449 3819 4179 9 LI:228186.1:2001JAN12 g4988753 3819 4180 9 LI:228186.1:2001JAN12 55037512H1 3841 4180 9 LI:228186.1:2001JAN12 g5234992 3842 4180 9 LI:228186.1:2001JAN12 g824803 3848 4273 9 LI:228186.1:2001JAN12 g5635255 3863 4128 9 LI:228186.1:2001JAN12 2117539H1 3866 4102 9 LI:228186.1:2001JAN12 5067110H1 3881 4160 9 LI:228186.1:2001JAN12 g4152912 3903 4180 9 LI:228186.1:2001JAN12 1572173T6 3915 4137 9 LI:228186.1:2001JAN12 2752418H1 3923 4171 9 LI:228186.1:2001JAN12 5697802H1 3927 4180 9 LI:228186.1:2001JAN12 2181068H1 3989 4179 9 LI:228186.1:2001JAN12 2729487T6 3990 4136 9 LI:228186.1:2001JAN12 g4739655 4009 4182 9 LI:228186.1:2001JAN12 g7277624 4009 4182 9 LI:228186.1:2001JAN12 g4740529 4009 4179 9 LI:228186.1:2001JAN12 3229045H1 4017 4181 9 LI:228186.1:2001JAN12 g4082575 4069 4171 9 LI:228186.1:2001JAN12 g4082569 4092 4171 9 LI:228186.1:2001JAN12 g4148819 4092 4161 9 LI:228186.1:2001JAN12 1209337H1 4110 4179 9 LI:228186.1:2001JAN12 2101282H1 4211 4427 9 LI:228186.1:2001JAN12 4227560H1 4257 4545 9 LI:228186.1:2001JAN12 7109046H1 4266 4806 9 LI:228186.1:2001JAN12 6535226H1 4275 4724 9 LI:228186.1:2001JAN12 3146996H1 4286 4551 9 LI:228186.1:2001JAN12 g1275619 4326 4781 9 LI:228186.1:2001JAN12 g692290 4326 4581 9 LI:228186.1:2001JAN12 2285278T6 4367 4967 9 LI:228186.1:2001JAN12 2355972F6 4387 4786 9 LI:228186.1:2001JAN12 2355972H1 4387 4613 9 LI:228186.1:2001JAN12 g6991850 4425 5011 9 LI:228186.1:2001JAN12 2578858T6 4515 4969 9 LI:228186.1:2001JAN12 542452T6 4516 4952 9 LI:228186.1:2001JAN12 542452R6 4516 4910 9 LI:228186.1:2001JAN12 542452H1 4516 4816 9 LI:228186.1:2001JAN12 g3431234 4521 5006 9 LI:228186.1:2001JAN12 2355972T6 4524 4968 9 LI:228186.1:2001JAN12 g3307941 4564 5012 9 LI:228186.1:2001JAN12 g4738418 4584 5011 9 LI:228186.1:2001JAN12 g3418990 4585 5011 9 LI:228186.1:2001JAN12 g5812478 4605 5011 9 LI:228186.1:2001JAN12 g4006328 4607 5011 9 LI:228186.1:2001JAN12 g768507 4623 5001 9 LI:228186.1:2001JAN12 3905873H1 4620 4870 9 LI:228186.1:2001JAN12 g2714597 4624 5011 9 LI:228186.1:2001JAN12 190176H1 4638 4866 9 LI:228186.1:2001JAN12 g1502034 4642 5011 9 LI:228186.1:2001JAN12 917566H1 4648 4740 9 LI:228186.1:2001JAN12 g2952679 4650 5017 9 LI:228186.1:2001JAN12 g692251 4660 5014 9 LI:228186.1:2001JAN12 g6835507 4660 5011 9 LI:228186.1:2001JAN12 g824186 4671 4999 9 LI:228186.1:2001JAN12 g566892 4699 5011 9 LI:228186.1:2001JAN12 g2669944 4710 5012 9 LI:228186.1:2001JAN12 g876930 4719 5001 9 LI:228186.1:2001JAN12 1357315T6 4725 4972 9 LI:228186.1:2001JAN12 6583355T1 3493 4089 9 LI:228186.1:2001JAN12 2285278R6 3496 3883 9 LI:228186.1:2001JAN12 2285278H1 3496 3739 9 LI:228186.1:2001JAN12 5947052H1 3499 3659 9 LI:228186.1:2001JAN12 667861T6 3514 4136 9 LI:228186.1:2001JAN12 2501382H1 3538 3766 9 LI:228186.1:2001JAN12 952741R1 3554 4080 9 LI:228186.1:2001JAN12 952741H1 3554 3817 9 LI:228186.1:2001JAN12 3055946H1 3566 3837 9 LI:228186.1:2001JAN12 2937765T6 3579 4165 9 LI:228186.1:2001JAN12 3525403H1 3583 3833 9 LI:228186.1:2001JAN12 700438R6 3605 3998 9 LI:228186.1:2001JAN12 700438H1 3605 3860 9 LI:228186.1:2001JAN12 699637H1 3605 3805 9 LI:228186.1:2001JAN12 700438T6 3605 4140 9 LI:228186.1:2001JAN12 1572292T6 3617 4139 9 LI:228186.1:2001JAN12 157244416 3617 4140 9 LI:228186.1:2001JAN12 5723113H1 3667 4223 9 LI:228186.1:2001JAN12 5723215H1 3667 4096 9 LI:228186.1:2001JAN12 3779008H1 3675 3979 9 LI:228186.1:2001JAN12 5649315H1 3699 3959 9 LI:228186.1:2001JAN12 g4390668 3708 4182 9 LI:228186.1:2001JAN12 g5231487 3715 4179 9 LI:228186.1:2001JAN12 g6709352 3720 4180 9 LI:228186.1:2001JAN12 g5526660 3724 4183 9 LI:228186.1:2001JAN12 g4175746 3739 4183 9 LI:228186.1:2001JAN12 727019H1 3740 4045 9 LI:228186.1:2001JAN12 g6132296 3745 4181 9 LI:228186.1:2001JAN12 568776H1 3749 4015 9 LI:228186.1:2001JAN12 g5444612 3750 4179 9 LI:228186.1:2001JAN12 g6028408 3750 4179 9 LI:228186.1:2001JAN12 70012310D1 2982 3368 9 LI:228186.1:2001JAN12 70004276D1 2982 3380 9 LI:228186.1:2001JAN12 70006106D1 2981 3222 9 LI:228186.1:2001JAN12 2937765H1 3008 3296 9 LI:228186.1:2001JAN12 2937765F6 3008 3503 9 LI:228186.1:2001JAN12 2863195H1 3111 3383 9 LI:228186.1:2001JAN12 8179891H1 3119 3612 9 LI:228186.1:2001JAN12 70001338D1 3123 3221 9 LI:228186.1:2001JAN12 70008533D1 3132 3221 9 LI:228186.1:2001JAN12 5867485H1 3134 3403 9 LI:228186.1:2001JAN12 781214H1 1607 1791 9 LI:228186.1:2001JAN12 g3900472 1677 1791 9 LI:228186.1:2001JAN12 667861R6 1716 2283 9 LI:228186.1:2001JAN12 667861H1 1716 1791 9 LI:228186.1:2001JAN12 666910H1 1716 1791 9 LI:228186.1:2001JAN12 3347266H1 2070 2332 9 LI:228186.1:2001JAN12 7733338J2 2100 2404 9 LI:228186.1:2001JAN12 1387055H1 2100 2221 9 LI:228186.1:2001JAN12 4434739H1 2100 2194 9 LI:228186.1:2001JAN12 7666362H1 2100 2267 9 LI:228186.1:2001JAN12 1316454F6 2100 2257 9 LI:228186.1:2001JAN12 1316454H1 2100 2216 9 LI:228186.1:2001JAN12 4226489H1 2150 2413 9 LI:228186.1:2001JAN12 2623306H1 2153 2414 9 LI:228186.1:2001JAN12 6023585H1 2170 2440 9 LI:228186.1:2001JAN12 7320012H1 2186 2709 9 LI:228186.1:2001JAN12 7734147J2 2209 2811 9 LI:228186.1:2001JAN12 4919037H2 2217 2496 9 LI:228186.1:2001JAN12 3328979H1 2257 2472 9 LI:228186.1:2001JAN12 1574559H1 2266 2489 9 LI:228186.1:2001JAN12 1574592H1 2266 2379 9 LI:228186.1:2001JAN12 1001336R1 2273 2792 9 LI:228186.1:2001JAN12 1001336H1 2273 2507 9 LI:228186.1:2001JAN12 8184932H1 2312 2938 9 LI:228186.1:2001JAN12 3698252H1 2331 2639 9 LI:228186.1:2001JAN12 793092H1 2338 2537 9 LI:228186.1:2001JAN12 8168102J1 2414 3052 9 LI:228186.1:2001JAN12 8168102H1 2416 3052 9 LI:228186.1:2001JAN12 70004803D1 2498 2711 9 LI:228186.1:2001JAN12 70008848D1 2510 2979 9 LI:228186.1:2001JAN12 70006448D1 2516 3099 9 LI:228186.1:2001JAN12 3491173F6 2516 3153 9 LI:228186.1:2001JAN12 70009419D1 2516 3026 9 LI:228186.1:2001JAN12 70008962D1 2516 3008 9 LI:228186.1:2001JAN12 70005299D1 2516 3103 9 LI:228186.1:2001JAN12 70002134D1 2516 2980 9 LI:228186.1:2001JAN12 70004120D1 2516 2878 9 LI:228186.1:2001JAN12 3491173H1 2517 2823 9 LI:228186.1:2001JAN12 7344433H1 2526 3086 9 LI:228186.1:2001JAN12 70010456D1 2546 2980 9 LI:228186.1:2001JAN12 2098590R6 2551 3125 9 LI:228186.1:2001JAN12 2098590H1 2551 2800 9 LI:228186.1:2001JAN12 5533049H1 2564 2758 9 LI:228186.1:2001JAN12 70004533D1 2577 3123 9 LI:228186.1:2001JAN12 70006324D1 2577 3103 9 LI:228186.1:2001JAN12 70011507D1 2577 3073 9 LI:228186.1:2001JAN12 70006718D1 2577 2971 9 LI:228186.1:2001JAN12 70007092D1 2577 2938 9 LI:228186.1:2001JAN12 7733338H2 2614 3174 9 LI:228186.1:2001JAN12 7124234H1 2603 3140 9 LI:228186.1:2001JAN12 70008418D1 2643 3221 9 LI:228186.1:2001JAN12 3491173T6 2667 3388 9 LI:228186.1:2001JAN12 70002534D1 2679 3210 9 LI:228186.1:2001JAN12 70005595D1 2679 3199 9 LI:228186.1:2001JAN12 70008578D1 2679 3161 9 LI:228186.1:2001JAN12 2889251H1 2682 2971 9 LI:228186.1:2001JAN12 70011779D1 2680 3073 9 LI:228186.1:2001JAN12 2889309F6 2682 3066 9 LI:228186.1:2001JAN12 2889309H1 2682 2983 9 LI:228186.1:2001JAN12 70006774D1 2712 3121 9 LI:228186.1:2001JAN12 70003888D1 2712 3320 9 LI:228186.1:2001JAN12 70006280D1 2712 3330 9 LI:228186.1:2001JAN12 70006292D1 2712 3222 9 LI:228186.1:2001JAN12 70001797D1 2712 3221 9 LI:228186.1:2001JAN12 70008495D1 2712 3177 9 LI:228186.1:2001JAN12 70001207D1 2712 3164 9 LI:228186.1:2001JAN12 70002332D1 2713 3315 9 LI:228186.1:2001JAN12 70007897D1 2713 3313 9 LI:228186.1:2001JAN12 70005965D1 2713 3221 9 LI:228186.1:2001JAN12 70006228D1 2713 3221 9 LI:228186.1:2001JAN12 70006597D1 2713 3141 9 LI:228186.1:2001JAN12 70002365D1 2736 3326 9 LI:228186.1:2001JAN12 3832785H1 2760 3069 9 LI:228186.1:2001JAN12 70005365D1 2824 3329 9 LI:228186.1:2001JAN12 3038130H1 2839 3096 9 LI:228186.1:2001JAN12 3038185H1 2839 3072 9 LI:228186.1:2001JAN12 2889309T6 2859 3026 9 LI:228186.1:2001JAN12 3493336T6 2904 3382 9 LI:228186.1:2001JAN12 70004085D1 2981 3222 9 LI:228186.1:2001JAN12 70002244D1 2982 3559 9 LI:228186.1:2001JAN12 70006170D1 2982 3561 9 LI:228186.1:2001JAN12 7453509H1 1 589 9 LI:228186.1:2001JAN12 706431H1 104 364 9 LI:228186.1:2001JAN12 552849R6 209 716 9 LI:228186.1:2001JAN12 552849H1 209 439 9 LI:228186.1:2001JAN12 2729487H1 294 539 9 LI:228186.1:2001JAN12 6913225J1 335 888 9 LI:228186.1:2001JAN12 g2153761 479 913 9 LI:228186.1:2001JAN12 7339459H1 537 1030 9 LI:228186.1:2001JAN12 1255495T6 565 1081 9 LI:228186.1:2001JAN12 1837462F6 635 1091 9 LI:228186.1:2001JAN12 1837462H1 636 890 9 LI:228186.1:2001JAN12 g4395197 729 1123 9 LI:228186.1:2001JAN12 3097532H1 802 1107 9 LI:228186.1:2001JAN12 g915974 1030 1354 9 LI:228186.1:2001JAN12 g1524460 1051 1237 9 LI:228186.1:2001JAN12 g2153706 1068 1440 9 LI:228186.1:2001JAN12 5711878H1 1110 1383 9 LI:228186.1:2001JAN12 1837462T6 1129 1755 9 LI:228186.1:2001JAN12 1544854R6 1167 1485 9 LI:228186.1:2001JAN12 1544854H1 1167 1353 9 LI:228186.1:2001JAN12 1544854T6 1192 1710 9 LI:228186.1:2001JAN12 552849T6 1198 1396 9 LI:228186.1:2001JAN12 g5664103 1290 1756 9 LI:228186.1:2001JAN12 g6196828 1332 1754 9 LI:228186.1:2001JAN12 g6401446 1354 1756 9 LI:228186.1:2001JAN12 g1523710 1390 1753 9 LI:228186.1:2001JAN12 g3329948 1498 1757 9 LI:228186.1:2001JAN12 g4222632 4725 5012 9 LI:228186.1:2001JAN12 g5232252 4725 4991 9 LI:228186.1:2001JAN12 g824804 4731 5011 9 LI:228186.1:2001JAN12 1357315F6 4732 5011 9 LI:228186.1:2001JAN12 1357315H1 4732 4988 9 LI:228186.1:2001JAN12 g671294 4768 4991 9 LI:228186.1:2001JAN12 g5633555 4804 4924 9 LI:228186.1:2001JAN12 g1241956 4868 5012 9 LI:228186.1;2001JAN12 3553562H1 3315 3591 9 LI:228186.1:2001JAN12 g574651 3356 3702 9 LI:228186.1:2001JAN12 g876929 3357 3678 9 LI:228186.1:2001JAN12 g772754 3371 3657 9 LI:228186.1:2001JAN12 g768508 3392 3762 9 LI:228186.1:2001JAN12 3557642H1 3395 3671 9 LI:228186.1:2001JAN12 3737557R1 3431 3741 9 LI:228186.1:2001JAN12 597044H1 3134 3375 9 LI:228186.1:2001JAN12 5393122H1 3142 3403 9 LI:228186.1:2001JAN12 4068833H1 3142 3409 9 LI:228186.1:2001JAN12 5580464H1 3153 3393 9 LI:228186.1:2001JAN12 4238877H1 3154 3433 9 LI:228186.1:2001JAN12 1572292F6 3159 3595 9 LI:228186.1:2001JAN12 1572292H1 3159 3357 9 LI:228186.1:2001JAN12 1232738H1 3162 3399 9 LI:228186.1:2001JAN12 4857088H1 3223 3480 9 LI:228186.1:2001JAN12 4273286H1 3255 3535 9 LI:228186.1:2001JAN12 3449302HI 3285 3541 9 LI:228186.1:2001JAN12 5608885H1 3309 3571 9 LI:228186.1:2001JAN12 5607886H1 3309 3551 10 LI:721233.1:2001JAN12 6271332H2 1 571 10 LI:721233.1:2001JAN12 6271332F8 16 652 10 LI:721233.1:2001JAN12 6271332T8 59 643 11 LI:291759.2:2001JAN12 g1210479 114 173 11 LI:291759.2:2001JAN12 g835196 114 178 11 LI:291759.2:2001JAN12 5773096H1 117 534 11 LI:291759.2:2001JAN12 3506266H1 118 405 11 LI:291759.2:2001JAN12 3678854H1 119 196 11 LI:291759.2:2001JAN12 g1314909 125 572 11 LI:291759.2:2001JAN12 309322H1 131 370 11 LI:291759.2:2001JAN12 6456256H1 155 653 11 LI:291759.2:2001JAN12 6456209H1 159 653 11 LI:291759.2:2001JAN12 6456309H1 183 632 11 LI:291759.2:2001JAN12 917190H1 220 551 11 LI:291759.2:2001JAN12 g1753322 250 327 11 LI:291759.2:2001JAN12 2654790T6 277 874 11 LI:291759.2:2001JAN12 4298445H1 291 560 11 LI:291759.2:2001JAN12 7733027H2 552 1131 11 LI:291759.2:2001JAN12 7110866H1 567 654 11 LI:291759.2:2001JAN12 2936830H1 632 906 11 LI:291759.2:2001JAN12 2611540H1 626 680 11 LI:291759.2:2001JAN12 4636570H1 637 891 11 LI:291759.2:2001JAN12 2994056H1 642 920 11 LI:291759.2:2001JAN12 g7043884 652 927 11 LI:291759.2:2001JAN12 g1189956 635 905 11 LI:291752.2:2001JAN12 g3422670 638 904 11 LI:291759.2:2001JAN12 1961123T6 639 869 11 LI:291759.2:2001JAN12 g7318146 646 910 11 LI:291759.2:2001JAN12 2736026T6 646 868 11 LI:291759.2:2001JAN12 g3095265 647 910 11 LI:291759.2:2001JAN12 5759842H1 647 710 11 LI:291759.2:2001JAN12 g1379309 648 910 11 LI:291759.2:2001JAN12 g2278758 648 910 11 LI:291759.2:2001JAN12 1371310H1 649 805 11 LI:291759.2:2001JAN12 g5671213 584 840 11 LI:291759.2:2001JAN12 g2741292 587 846 11 LI:291759.2:2001JAN12 g4988210 587 841 11 LI:291759.2:2001JAN12 g1817486 587 842 11 LI:291759.2:2001JAN12 g7150329 587 837 11 LI:291759.2:2001JAN12 g4998453 587 837 11 LI:291759.2:2001JAN12 g1313377 587 837 11 LI:291759.2:2001JAN12 g1192583 587 837 11 LI:291759.2:2001JAN12 1508944F6 749 1002 11 LI:291759.2:2001JAN12 1508944T6 587 823 11 LI:291759.2:2001JAN12 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LI:291759.2:2001JAN12 910870H1 13 201 11 LI:291759.2:2001JAN12 1681732T7 14 165 11 LI:291759.2:2001JAN12 1681732T6 14 164 11 LI:291759.2:2001JAN12 g2022753 12 197 11 LI:291759.2:2001JAN12 2413084H1 832 1002 11 LI:291759.2:2001JAN12 6883666J1 779 1172 11 LI:291759.2:2001JAN12 1927072H1 1 54 11 LI:291759.2:2001JAN12 g4217544 1 54 11 LI:291759.2:2001JAN12 g1981790 867 1155 11 LI:291759.2:2001JAN12 5298489H1 1 54 11 LI:291759.2:2001JAN12 2671094F6 924 1167 11 LI:291752.2:2001JAN12 2671094T6 924 1438 11 LI:291752.2:2001JAN12 2671094H1 924 1165 11 LI:291752.2:2001JAN12 g1995827 941 1027 11 LI:291759.2:2001JAN12 2736026F6 941 1237 11 LI:291759.2:2001JAN12 2736026H1 941 1070 11 LI:291759.2:2001JAN12 5476134H1 961 1178 11 LI:291759.2:2001JAN12 5477477H1 961 1178 11 LI:291759.2:2001JAN12 5479864H1 961 1229 11 LI:291759.2:2001JAN12 5478264H1 961 1110 11 LI:291759.2:2001JAN12 4692078H1 973 1129 11 LI:291759.2:2001JAN12 g1186868 1013 1173 11 LI:291759.2:2001JAN12 g1186747 1013 1188 11 LI:291759.2:2001JAN12 5103848H1 1029 1245 11 LI:291759.2:2001JAN12 4772463H1 1052 1246 11 LI:291759.2:2001JAN12 1961123H1 1066 1246 11 LI:291759.2:2001JAN12 1961123R6 1066 1246 11 LI:291759.2:2001JAN12 6180072H1 351 643 11 LI:291759.2:2001JAN12 2738251F6 409 936 11 LI:291759.2:2001JAN12 2738251H1 409 674 11 LI:291759.2:2001JAN12 g1860299 413 683 11 LI:291759.2:2001JAN12 3352689H1 421 613 11 LI:291759.2:2001JAN12 g3280105 448 920 11 LI:291759.2:2001JAN12 g5636736 448 915 11 LI:291759.2:2001JAN12 g1243075 450 672 11 LI:291759.2:2001JAN12 2681533H1 433 723 11 LI:291759.2:2001JAN12 g4175465 440 886 11 LI:291759.2:2001JAN12 515771H1 531 669 11 LI:291759.2:2001JAN12 g1997928 1 269 11 LI:291759.2:2001JAN12 7733027J2 16 661 11 LI:291759.2:2001JAN12 g835195 67 392 11 LI:291759.2:2001JAN12 g856172 107 392 11 LI:291759.2:2001JAN12 2654790F6 114 520 11 LI:291759.2:2001JAN12 6883666H1 114 462 11 LI:291759.2:2001JAN12 7597338H1 114 459 11 LI:291759.2:2001JAN12 8194536J1 114 412 11 LI:291759.2:2001JAN12 2328960R6 114 330 11 LI:291759.2:2001JAN12 2654790H1 114 291 11 LI:291759.2:2001JAN12 2328960H1 114 246 11 LI:291759.2:2001JAN12 4996248H1 114 217 11 LI:291759.2:2001JAN12 5610314H1 114 211 11 LI:291759.2:2001JAN12 g856075 114 206 11 LI:291759.2:2001JAN12 7982183H1 1103 1246 11 LI:291759.2:2001JAN12 3475555H1 1116 1270 11 LI:291759.2:2001JAN12 291454H1 1128 1246 11 LI:291759.2:2001JAN12 2009374H1 1168 1246 12 LI:292613.17:2001JAN12 994833R6 1 309 12 LI:292613.17:2001JAN12 994833H1 1 124 12 LI:292613.17:2001JAN12 994833T6 1 363 12 LI:292613.17:2001JAN12 4149665F6 1 355 12 LI:292613.17:2001JAN12 4149665H1 1 228 12 LI:292613.17:2001JAN12 1507329H1 46 170 12 LI:292613.17:2001JAN12 3144082H1 62 276 12 LI:292613.17:2001JAN12 3143359H1 62 224 12 LI:292613.17:2001JAN12 4851779H1 249 508 13 LI:412959.15:2001JAN12 2674048F6 1 330 13 LI:412959.15:2001JAN12 2674048H1 1 211 13 LI:412959.15:2001JAN12 2330307R6 29 493 13 LI:412959.15:2001JAN12 2330307H1 29 304 13 LI:412959.15:2001JAN12 1739552H1 29 95 13 LI:412959.15:2001JAN12 2550691H1 49 290 13 LI:412959.15:2001JAN12 5205237H2 113 370 13 LI:412959.15:2001JAN12 5205237F6 113 406 13 LI:412959.15:2001JAN12 5799259H1 178 406 13 LI:412959.15:2001JAN12 5646172H1 199 293 13 LI:412959.15:2001JAN12 955847H1 325 563 14 LI:482512.3:2001JAN12 g873524 2221 2415 14 LI:482512.3:2001JAN12 g4328019 2156 2401 14 LI:482512.3:2001JAN12 5835727H1 2100 2384 14 LI:482512.3:2001JAN12 g3835121 2159 2400 14 LI:482512.3:2001JAN12 809937R1 2105 2405 14 LI:482512.3:2001JAN12 80993711 2105 2362 14 LI:482512.3:2001JAN12 809937H1 2105 2397 14 LI:482512.3:2001JAN12 g3736000 2108 2405 14 LI:482512.3:2001JAN12 1753767H1 2110 2351 14 LI:482512.3:2001JAN12 1754121H1 2110 2351 14 LI:482512.3:2001JAN12 2371576H1 1856 2086 14 LI:482512.3:2001JAN12 1496803H1 1856 2073 14 LI:482512.3:2001JAN12 4530169H1 1869 2129 14 LI:482512.3:2001JAN12 g2115734 1879 2387 14 LI:482512.3:2001JAN12 8262183J1 1887 2385 14 LI:482512.3:2001JAN12 g2556760 1904 2402 14 LI:482512.3:2001JAN12 g3245066 1905 2405 14 LI:482512.3:2001JAN12 2457752T6 1904 2360 14 LI:482512.3:2001JAN12 g2553409 1907 2401 14 LI:482512.3:2001JAN12 g1718873 1908 2227 14 LI:482512.3:2001JAN12 g1860643 1908 2281 14 LI:482512.3:2001JAN12 g4524169 1915 2400 14 LI:482512.3:2001JAN12 g2115481 1917 2410 14 LI:482512.3:2001JAN12 g3109337 1918 2409 14 LI:482512.3:2001JAN12 g3433865 1925 2402 14 LI:482512.3:2001JAN12 g4196841 1941 2402 14 LI:482512.3:2001JAN12 g4189929 1948 2401 14 LI:482512.3:2001JAN12 g3308018 1952 2405 14 LI:482512.3:2001JAN12 g6131965 1952 2407 14 LI:482512.3:2001JAN12 g4372573 1952 2400 14 LI:482512.3:2001JAN12 6203722H2 1953 2400 14 LI:482512.3:2001JAN12 g6131971 1956 2407 14 LI:482512.3:2001JAN12 g1138274 1966 2400 14 LI:482512.3:2001JAN12 g5632175 1965 2400 14 LI:482512.3:2001JAN12 3602394H1 1965 2250 14 LI:482512.3:2001JAN12 5755635H1 1817 1901 14 LI:482512.3:2001JAN12 5314801H1 1827 2078 14 LI:482512.3:2001JAN12 5314701H1 1827 1985 14 LI:482512.3:2001JAN12 5585639H1 1828 2052 14 LI:482512.3:2001JAN12 5661181H1 1848 2086 14 LI:482512.3:2001JAN12 002115H1 1851 2306 14 LI:482512.3:2001JAN12 3784573H1 1853 2168 14 LI:482512.3:2001JAN12 873570H1 2261 2405 14 LI:482512.3:2001JAN12 4542494H1 2311 2405 14 LI:482512.3:2001JAN12 3075723H1 2326 2400 14 LI:482512.3;2001JAN12 940889H1 2348 2405 14 LI:482512.3:2001JAN12 1380644H1 2019 2283 14 LI:482512.3:2001JAN12 g1148949 2016 2400 14 LI:482512.3:2001JAN12 g1118371 2018 2402 14 LI:482512.3:2001JAN12 1380645H1 2019 2281 14 LI:482512.3:2001JAN12 1384594H1 2019 2260 14 LI:482512.3:2001JAN12 g1421883 2020 2405 14 LI:482512.3:2001JAN12 g1664147 2021 2401 14 LI:482512.3:2001JAN12 945748H1 2023 2185 14 LI:482512.3:2001JAN12 3839205H1 2024 2339 14 LI:482512.3:2001JAN12 g3178370 2026 2411 14 LI:482512.3:2001JAN12 g1398466 1981 2404 14 LI:482512.3:2001JAN12 5663784H1 1984 2274 14 LI:482512.3:2001JAN12 g2618247 1995 2401 14 LI:482512.3:2001JAN12 g2834644 1995 2401 14 LI:482512.3:2001JAN12 g1754374 1996 2404 14 LI:482512.3:2001JAN12 g3246099 1999 2410 14 LI:482512.3:2001JAN12 g4107748 2000 2401 14 LI:482512.3:2001JAN12 g1718874 2002 2402 14 LI:482512.3:2001JAN12 g1861028 2004 2402 14 LI:482512.3:2001JAN12 g1955011 2009 2378 14 LI:482512.3:2001JAN12 2017265H1 2015 2160 14 LI:482512.3:2001JAN12 g927843 1487 1645 14 LI:482512.3:2001JAN12 3944613H1 1490 1645 14 LI:482512.3:2001JAN12 g1057615 1490 1632 14 LI:482512.3:2001JAN12 g711667 1496 1653 14 LI:482512.3:2001JAN12 g763648 1497 1598 14 LI:482512.3:2001JAN12 5699665H1 1500 1675 14 LI:482512.3:2001JAN12 g2714398 1504 1653 14 LI:482512.3:2001JAN12 g668934 1505 1598 14 LI:482512.3:2001JAN12 2456911H1 1531 1598 14 LI:482512.3:2001JAN12 g3146519 1534 1598 14 LI:482512.3:2001JAN12 g709509 1536 1598 14 LI:482512.3:2001JAN12 1384064H1 1579 1645 14 LI:482512.3:2001JAN12 6559028H1 1813 2383 14 LI:482512.3:2001JAN12 g1146774 1812 2174 14 LI:482512.3:2001JAN12 1518980T7 1816 2309 14 LI:482512.3:2001JAN12 6949010H1 1817 2288 14 LI:482512.3:2001JAN12 2325041H1 1817 1948 14 LI:482512.3:2001JAN12 5755636H1 1816 2045 14 LI:482512.3:2001JAN12 1855715F6 1817 2110 14 LI:482512.3:2001JAN12 5263754H1 1817 2051 14 LI:482512.3:2001JAN12 1855715H1 1817 1879 14 LI:482512.3:2001JAN12 g3277379 1429 1598 14 LI:482512.3:2001JAN12 6948396H1 1433 1566 14 LI:482512.3:2001JAN12 g2754313 1438 1598 14 LI:482512.3:2001JAN12 g3659102 1441 1653 14 LI:482512.3:2001JAN12 2544736H1 1441 1639 14 LI:482512.3:2001JAN12 2761382H1 1442 1667 14 LI:482512.3:2001JAN12 g2714655 1441 1645 14 LI:482512.3:2001JAN12 g3802581 1446 1631 14 LI:482512.3:2001JAN12 1991282H1 1447 1639 14 LI:482512.3:2001JAN12 g985287 1447 1598 14 LI:482512.3:2001JAN12 6700167H1 1451 1892 14 LI:482512.3:2001JAN12 6558151H1 1453 1975 14 LI:482512.3:2001JAN12 g1042434 1452 1598 14 LI:482512.3:2001JAN12 g747038 1457 1645 14 LI:482512.3:2001JAN12 4638167H1 1462 1644 14 LI:482512.3:2001JAN12 3810276H1 1480 1598 14 LI:482512.3:2001JAN12 g1383051 1485 1645 14 LI:482512.3:2001JAN12 g2713364 1484 1613 14 LI:482512.3:2001JAN12 g2593948 2164 2327 14 LI:482512.3:2001JAN12 g1625916 1980 2401 14 LI:482512.3:2001JAN12 g2742370 2191 2405 14 LI:482512.3:2001JAN12 2503846H1 2201 2400 14 LI:482512.3:2001JAN12 g1550293 938 1029 14 LI:482512.3:2001JAN12 g873523 940 1267 14 LI:482512.3:2001JAN12 g875484 940 1278 14 LI:482512.3:2001JAN12 3140312H1 940 1217 14 LI:482512.3:2001JAN12 046678H1 962 1243 14 LI:482512.3:2001JAN12 043864H1 963 1277 14 LI:482512.3:2001JAN12 1916774H1 974 1277 14 LI:482512.3:2001JAN12 g1392105 980 1489 14 LI:482512.3:2001JAN12 g1685835 982 1387 14 LI:482512.3:2001JAN12 4155543H1 1006 1254 14 LI:482512.3:2001JAN12 6951737H1 1007 1244 14 LI:482512.3:2001JAN12 3844826H1 1014 1320 14 LI:482512.3:2001JAN12 3257104H1 1036 1316 14 LI:482512.3:2001JAN12 3979735H1 1047 1361 14 LI:482512.3:2001JAN12 5068828H1 1048 1348 14 LI:482512.3:2001JAN12 g675099 1061 1479 14 LI:482512.3:2001JAN12 g706514 1061 1458 14 LI:482512.3:2001JAN12 2185344H1 1075 1386 14 LI:482512.3:2001JAN12 589365H1 1075 1335 14 LI:482512.3:2001JAN12 5031411H1 1076 1375 14 LI:482512.3:2001JAN12 4087425H1 1086 1394 14 LI:482512.3:2001JAN12 g2433835 1102 1526 14 LI:482512.3:2001JAN12 7244978H1 1115 1673 14 LI:482512.3:2001JAN12 045891H1 1119 1388 14 LI:482512.3:2001JAN12 5260860H1 1119 1369 14 LI:482512.3:2001JAN12 1305950T6 1120 1631 14 LI:482512.3:2001JAN12 4624991H1 1121 1390 14 LI:482512.3:2001JAN12 3516303H1 1125 1398 14 LI:482512.3:2001JAN12 306079H1 1139 1363 14 LI:482512.3:2001JAN12 307499H1 1140 1524 14 LI:482512.3:2001JAN12 g5110580 1143 1515 14 LI:482512.3:2001JAN12 5962610H1 1170 1657 14 LI:482512.3:2001JAN12 7232448H1 1168 1598 14 LI:482512.3:2001JAN12 5974019H1 1189 1645 14 LI:482512.3:2001JAN12 4626361H1 1189 1460 14 LI:482512.3:2001JAN12 4637075H1 1195 1460 14 LI:482512.3:2001JAN12 6977977H1 1214 1632 14 LI:482512.3:2001JAN12 6726370H1 1215 1598 14 LI:482512.3:2001JAN12 6820986H1 1223 1598 14 LI:482512.3:2001JAN12 2182014H1 1230 1517 14 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LI:482512.3:2001JAN12 4182102H1 1399 1639 14 LI:482512.3:2001JAN12 g1736048 1401 1598 14 LI:482512.3:2001JAN12 3414387H1 1405 1638 14 LI:482512.3:2001JAN12 3618923H1 1407 1686 14 LI:482512.3:2001JAN12 g1550465 1407 1644 14 LI:482512.3:2001JAN12 3618907H1 1406 1639 14 LI:482512.3:2001JAN12 g2219112 1408 1598 14 LI:482512.3:2001JAN12 g880239 1420 1598 14 LI:482512.3:2001JAN12 g717966 1426 1645 14 LI:482512.3:2001JAN12 4557378H1 1424 1639 14 LI:482512.3:2001JAN12 g3277736 1427 1515 14 LI:482512.3:2001JAN12 g991594 1428 1646 14 LI:482512.3:2001JAN12 g696806 828 1200 14 LI:482512.3:2001JAN12 7333420H1 842 1480 14 LI:482512.3:2001JAN12 6173218H1 845 1162 14 LI:482512.3:2001JAN12 g1151824 849 1344 14 LI:482512.3:2001JAN12 2400804H1 861 1113 14 LI:482512.3:2001JAN12 g763702 873 1148 14 LI:482512.3:2001JAN12 1894128H1 877 1121 14 LI:482512.3:2001JAN12 2401675H1 877 1118 14 LI:482512.3:2001JAN12 4718965H1 885 1163 14 LI:482512.3:2001JAN12 g1550279 903 1047 14 LI:482512.3:2001JAN12 085340H1 926 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18 LI:238576.2:2001JAN12 71301830V1 661 1344 18 LI:238576.2:2001JAN12 3866748H1 662 961 18 LI:238576.2:2001JAN12 3501407H1 662 995 18 LI:238576.2:2001JAN12 g891119 668 951 18 LI:238576.2:2001JAN12 7062009H1 673 1090 18 LI:238576.2:2001JAN12 6401339H1 369 652 18 LI:238576.2:2001JAN12 3483783H1 373 645 18 LI:238576.2:2001JAN12 3375342H1 370 620 18 LI:238576.2:2001JAN12 5473124H1 376 544 18 LI:238576.2:2001JAN12 5607966H1 375 647 18 LI:238576.2:2001JAN12 5610077H1 375 621 18 LI:238576.2:2001JAN12 4302082H1 378 648 18 LI:238576.2:2001JAN12 516261R1 385 1026 18 LI:238576.2:2001JAN12 516261H1 385 622 18 LI:238576.2:2001JAN12 g2110639 799 1249 18 LI:238576.2:2001JAN12 70832396V1 797 979 18 LI:238576.2:2001JAN12 1653928H1 809 1077 18 LI:238576.2:2001JAN12 71300941V1 814 1335 18 LI:238576.2:2001JAN12 70943453V1 814 979 18 LI:238576.2:2001JAN12 g2953761 815 1336 18 LI:238576.2:2001JAN12 g3933979 822 1336 18 LI:238576.2:2001JAN12 659592H1 820 1113 18 LI:238576.2:2001JAN12 g3674153 826 1333 18 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LI:903914.3:2001JAN12 1743366H1 7299 7423 19 LI:903914.3:2001JAN12 1741327H1 7299 7423 19 LI:903914.3:2001JAN12 g6047724 7303 7431 19 LI:903914.3:2001JAN12 7668337H1 4855 5451 19 LI:903914.3:2001JAN12 4492309H1 7248 7419 19 LI:903914.3:2001JAN12 322278H1 7253 7424 19 LI:903914.3:2001JAN12 1549589H1 7257 7423 19 LI:903914.3:2001JAN12 1241062H1 7265 7419 19 LI:903914.3:2001JAN12 71083931V1 1875 2464 19 LI:903914.3:2001JAN12 g4186397 1872 2317 19 LI:903914.3:2001JAN12 2294257H1 1871 2111 19 LI:903914.3:2001JAN12 g1320521 1875 2279 19 LI:903914.3:2001JAN12 71083872V1 1875 2525 19 LI:903914.3:2001JAN12 71081902V1 1875 2443 19 LI:903914.3:2001JAN12 71254175V1 1875 2443 19 LI:903914.3:2001JAN12 71254028V1 1875 2432 19 LI:903914.3:2001JAN12 1367647R1 1875 2432 19 LI:903914.3:2001JAN12 71084015V1 1875 2413 19 LI:903914.3:2001JAN12 71084008V1 1875 2413 19 LI:903914.3:2001JAN12 71082302V1 1875 2321 19 LI:903914.3:2001JAN12 1989169H1 1875 2138 19 LI:903914.3:2001JAN12 1367647H1 1875 2087 19 LI:903914.3:2001JAN12 71253020V1 1875 2441 19 LI:903914.3:2001JAN12 1367647R6 1876 2494 19 LI:903914.3:2001JAN12 5273285H1 1885 2137 19 LI:903914.3:2001JAN12 3156244H1 1891 2174 19 LI:903914.3:2001JAN12 3678891H1 1893 1960 19 LI:903914.3:2001JAN12 385798H1 1908 2114 19 LI:903914.3:2001JAN12 2730331T6 1920 2572 19 LI:903914.3:2001JAN12 5699726H1 1920 2156 19 LI:903914.3:2001JAN12 71253961V1 1926 2547 19 LI:903914.3:2001JAN12 4556124H1 1926 2202 19 LI:903914.3:2001JAN12 2297603H2 1926 2111 19 LI:903914.3:2001JAN12 4020232T8 1980 2445 19 LI:903914.3:2001JAN12 4940639H1 1981 2283 19 LI:903914.3:2001JAN12 70776485V1 1988 2619 19 LI:903914.3:2001JAN12 2043303H1 1990 2282 19 LI:903914.3:2001JAN12 1909733H1 1991 2241 19 LI:903914.3:2001JAN12 6858206H1 2023 2370 19 LI:903914.3:2001JAN12 71081796V1 2026 2627 19 LI:903914.3:2001JAN12 5607490H1 2033 2290 19 LI:903914.3:2001JAN12 6363903H1 2037 2359 19 LI:903914.3:2001JAN12 4020232T9 2042 2511 19 LI:903914.3:2001JAN12 3247024H1 2046 2300 19 LI:903914.3:2001JAN12 2170128H1 2047 2300 19 LI:903914.3:2001JAN12 2372535H1 2053 2294 19 LI:903914.3:2001JAN12 3492337T6 2063 2582 19 LI:903914.3:2001JAN12 g1856248 2075 2525 19 LI:903914.3:2001JAN12 1569651T6 2077 2582 19 LI:903914.3:2001JAN12 1600963T6 2080 2581 19 LI:903914.3:2001JAN12 1243240H1 2086 2351 19 LI:903914.3:2001JAN12 1569651H1 2087 2304 19 LI:903914.3:2001JAN12 1569651F6 2087 2469 19 LI:903914.3:2001JAN12 1990456T6 2096 2580 19 LI:903914.3:2001JAN12 928796R1 2103 2590 19 LI:903914.3:2001JAN12 928796H1 2103 2438 19 LI:903914.3:2001JAN12 2118967H1 2117 2256 19 LI:903914.3:2001JAN12 g1734431 2119 2554 19 LI:903914.3:2001JAN12 3432729H1 2118 2395 19 LI:903914.3:2001JAN12 6123901H1 2129 2619 19 LI:903914.3:2001JAN12 g5454395 2130 2619 19 LI:903914.3:2001JAN12 g2321072 2136 2621 19 LI:903914.3:2001JAN12 2547870T6 2138 2581 19 LI:903914.3:2001JAN12 5447240H1 2140 2422 19 LI:903914.3:2001JAN12 g3427014 2144 2619 19 LI:903914.3:2001JAN12 5021831H1 2145 2435 19 LI:903914.3:2001JAN12 g6702158 2158 2619 19 LI:903914.3:2001JAN12 g5933209 2159 2619 19 LI:903914.3:2001JAN12 3958117H2 2172 2479 19 LI:903914.3:2001JAN12 g3110006 2177 2622 19 LI:903914.3:2001JAN12 g5234760 2181 2625 19 LI:903914.3:2001JAN12 g4450748 2190 2620 19 LI:903914.3:2001JAN12 g2914785 2205 2625 19 LI:903914.3:2001JAN12 g3961892 2208 2624 19 LI:903914.3:2001JAN12 805133H1 2211 2421 19 LI:903914.3:2001JAN12 70778718V1 1792 2420 19 LI:903914.3:2001JAN12 4554732H1 1793 2051 19 LI:903914.3:2001JAN12 g827323 1808 2043 19 LI:903914.3:2001JAN12 961934R1 1810 2234 19 LI:903914.3:2001JAN12 961934H1 1810 2087 19 LI:903914.3:2001JAN12 g1641446 1812 2044 19 LI:903914.3:2001JAN12 2293990H1 1818 1994 19 LI:903914.3:2001JAN12 835913H1 1821 2137 19 LI:903914.3:2001JAN12 1446465H1 1828 2070 19 LI:903914.3:2001JAN12 553648H1 1829 2071 19 LI:903914.3:2001JAN12 5393691H1 1830 2015 19 LI:903914.3:2001JAN12 421754H1 1830 1991 19 LI:903914.3:2001JAN12 6121866H1 1841 2048 19 LI:903914.3:2001JAN12 6126337H1 1841 2318 19 LI:903914.3:2001JAN12 4020232F8 1841 2280 19 LI:903914.3:2001JAN12 70778271V1 1841 2137 19 LI:903914.3:2001JAN12 70777566V1 1841 2122 19 LI:903914.3:2001JAN12 1990456F6 1841 2172 19 LI:903914.3:2001JAN12 4707821H1 1841 2077 19 LI:903914.3:2001JAN12 3000426H1 1841 2056 19 LI:903914.3:2001JAN12 4245793H1 1841 2037 19 LI:903914.3:2001JAN12 3003976H1 1841 2038 19 LI:903914.3:2001JAN12 2394666F6 1841 2034 19 LI:903914.3:2001JAN12 3580094H1 1841 2006 19 LI:903914.3:2001JAN12 2394666H1 1841 2003 19 LI:903914.3:2001JAN12 3272189H1 1841 1949 19 LI:903914.3:2001JAN12 4020531H1 1841 1989 19 LI:903914.3:2001JAN12 5347105H1 1841 1924 19 LI:903914.3:2001JAN12 2108566H1 1841 1917 19 LI:903914.3:2001JAN12 1990489H1 1841 1900 19 LI:903914.3:2001JAN12 3236769H1 1841 1899 19 LI:903914.3:2001JAN12 999733H1 1841 1959 19 LI:903914.3:2001JAN12 2905432H1 1841 1943 19 LI:903914.3:2001JAN12 6977235H1 1852 2416 19 LI:903914.3:2001JAN12 4205750H1 1851 2103 19 LI:903914.3:2001JAN12 2135434H1 1856 2114 19 LI:903914.3:2001JAN12 2442345H1 1866 2088 19 LI:903914.3:2001JAN12 4187650H1 1869 2188 19 LI:903914.3:2001JAN12 71252927V1 1875 2441 19 LI:903914.3:2001JAN12 70777216V1 1871 2523 19 LI:903914.3:2001JAN12 g2337025 7241 7419 19 LI:903914.3:2001JAN12 3907813H1 6327 6462 19 LI:903914.3:2001JAN12 2361452H1 4448 4692 19 LI:903914.3:2001JAN12 2361452R6 4451 4894 19 LI:903914.3:2001JAN12 g2023458 4467 4818 19 LI:903914.3:2001JAN12 3765601H1 4474 4767 19 LI:903914.3:2001JAN12 1527196H1 4496 4696 19 LI:903914.3:2001JAN12 7176537H1 4559 5141 19 LI:903914.3:2001JAN12 6400391H1 4577 4846 19 LI:903914.3:2001JAN12 g1975591 4619 4980 19 LI:903914.3:2001JAN12 6884909H1 4628 5099 19 LI:903914.3:2001JAN12 3769529H1 4679 4988 19 LI:903914.3:2001JAN12 7401247H1 4681 5238 19 LI:903914.3:2001JAN12 6784595H2 4690 5300 19 LI:903914.3:2001JAN12 6153049H1 4716 5009 19 LI:903914.3:2001JAN12 7760529J1 4742 5215 19 LI:903914.3:2001JAN12 4289851H1 4721 5013 19 LI:903914.3:2001JAN12 71060744V1 4728 5446 19 LI:903914.3:2001JAN12 g2021897 4739 5058 19 LI:903914.3:2001JAN12 3491063H1 4757 4935 19 LI:903914.3:2001JAN12 g1067589 4794 5143 19 LI:903914.3:2001JAN12 71060148V1 4809 5408 19 LI:903914.3:2001JAN12 916113H1 4809 5107 19 LI:903914.3:2001JAN12 917254H1 4787 4896 19 LI:903914.3:2001JAN12 8005801H1 4842 5510 19 LI:903914.3:2001JAN12 g3924026 2267 2622 19 LI:903914.3:2001JAN12 g5635220 2282 2619 19 LI:903914.3:2001JAN12 g1856164 2307 2619 19 LI:903914.3:2001JAN12 5021831T1 2315 2570 19 LI:903914.3:2001JAN12 g4123822 2320 2628 19 LI:903914.3:2001JAN12 3733681H1 2322 2504 19 LI:903914.3:2001JAN12 4219064T6 2337 2580 19 LI:903914.3:2001JAN12 4219064H1 2344 2497 19 LI:903914.3:2001JAN12 4219064F6 2344 2619 19 LI:903914.3:2001JAN12 g838434 2346 2620 19 LI:903914.3:2001JAN12 g722865 2349 2619 19 LI:903914.3:2001JAN12 5376422H1 2355 2578 19 LI:903914.3:2001JAN12 669580H1 2358 2619 19 LI:903914.3:2001JAN12 3122606H1 2363 2619 19 LI:903914.3:2001JAN12 5376420H1 2375 2578 19 LI:903914.3:2001JAN12 1493091H1 2387 2609 19 LI:903914.3:2001JAN12 507804H1 2392 2608 19 LI:903914.3:2001JAN12 g1740280 2417 2619 19 LI:903914.3:2001JAN12 g1265510 2417 2625 19 LI:903914.3:2001JAN12 g2752889 2444 2719 19 LI:903914.3:2001JAN12 g1990734 2443 2619 19 LI:903914.3:2001JAN12 1267265F1 2468 2708 19 LI:903914.3:2001JAN12 1267265H1 2468 2619 19 LI:903914.3:2001JAN12 7689215J1 2475 2886 19 LI:903914.3:2001JAN12 8065006J2 2480 2709 19 LI:903914.3:2001JAN12 717562H1 2502 2739 19 LI:903914.3:2001JAN12 g4325422 2519 2620 19 LI:903914.3:2001JAN12 g2191530 2533 2708 19 LI:903914.3:2001JAN12 g4087661 2557 2713 19 LI:903914.3:2001JAN12 6811344H1 2643 2891 19 LI:903914.3:2001JAN12 6811344J1 2644 2891 19 LI:903914.3:2001JAN12 851686R7 2656 2883 19 LI:903914.3:2001JAN12 851686H1 2656 2745 19 LI:903914.3:2001JAN12 7948951H1 2822 3461 19 LI:903914.3:2001JAN12 8103227J1 3123 3549 19 LI:903914.3:2001JAN12 7949060J1 3134 3549 19 LI:903914.3:2001JAN12 7951116J1 3134 3549 19 LI:903914.3:2001JAN12 8103227H1 3134 3549 19 LI:903914.3:2001JAN12 7949060H1 3145 3549 19 LI:903914.3:2001JAN12 7951116H1 3145 3549 19 LI:903914.3:2001JAN12 8104015J1 3150 3549 19 LI:903914.3:2001JAN12 8107232J1 3156 3549 19 LI:903914.3:2001JAN12 8104015H1 3161 3549 19 LI:903914.3:2001JAN12 8107232H1 3171 3549 19 LI:903914.3:2001JAN12 7949810J1 3190 3517 19 LI:903914.3:2001JAN12 7348048H1 3191 3612 19 LI:903914.3:2001JAN12 6766063J1 3194 3451 19 LI:903914.3:2001JAN12 5045589F6 3323 3851 19 LI:903914.3:2001JAN12 5045589H1 3323 3583 19 LI:903914.3:2001JAN12 7201185H2 3431 3872 19 LI:903914.3:2001JAN12 381610H1 3494 3777 19 LI:903914.3:2001JAN12 7324617H1 3549 3994 19 LI:903914.3:2001JAN12 7281557H1 3678 4148 19 LI:903914.3:2001JAN12 7230032H1 3700 4281 19 LI:903914.3:2001JAN12 7623635J1 3709 4216 19 LI:903914.3:2001JAN12 g1999864 3784 4164 19 LI:903914.3:2001JAN12 2730331H1 3893 3961 19 LI:903914.3:2001JAN12 7005732H1 3930 4500 19 LI:903914.3:2001JAN12 7376940H1 3989 4617 19 LI:903914.3:2001JAN12 7377084H1 3989 4459 19 LI:903914.3:2001JAN12 6984452H1 4080 4494 19 LI:903914.3:2001JAN12 6987957H1 4087 4505 19 LI:903914.3:2001JAN12 6450205H1 4172 4722 19 LI:903914.3:2001JAN12 71058745V1 4216 4813 19 LI:903914.3:2001JAN12 2849931F6 4216 4706 19 LI:903914.3:2001JAN12 2849931H1 4216 4429 19 LI:903914.3:2001JAN12 71059917V1 4216 4650 19 LI:903914.3:2001JAN12 g2243551 4248 4549 19 LI:903914.3:2001JAN12 3234057H2 4330 4597 19 LI:903914.3:2001JAN12 3234057F6 4330 5005 19 LI:903914.3:2001JAN12 7262938H1 4370 4982 19 LI:903914.3:2001JAN12 70775868V1 1772 2171 19 LI:903914.3:2001JAN12 3686071H1 7045 7346 19 LI:903914.3:2001JAN12 4547442H1 7051 7306 19 LI:903914.3:2001JAN12 7055567H1 7053 7423 19 LI:903914.3:2001JAN12 g889248 7059 7431 19 LI:903914.3:2001JAN12 1678124H1 7053 7298 19 LI:903914.3:2001JAN12 5875620H1 7061 7370 19 LI:903914.3:2001JAN12 g3694594 7073 7419 19 LI:903914.3:2001JAN12 g1123906 7083 7419 19 LI:903914.3:2001JAN12 4975315F6 7091 7419 19 LI:903914.3:2001JAN12 5266215H1 7092 7371 19 LI:903914.3:2001JAN12 g4452193 7099 7431 19 LI:903914.3:2001JAN12 g1186276 7107 7423 19 LI:903914.3:2001JAN12 5183196H1 7118 7336 19 LI:903914.3:2001JAN12 g856705 7127 7406 19 LI:903914.3:2001JAN12 677740H1 7131 7412 19 LI:903914.3:2001JAN12 676808H1 7131 7400 19 LI:903914.3:2001JAN12 g1013661 7140 7419 19 LI:903914.3:2001JAN12 2100964H1 7146 7414 19 LI:903914.3:2001JAN12 2540050H1 7150 7424 19 LI:903914.3:2001JAN12 g2252387 7150 7437 19 LI:903914.3:2001JAN12 930677H1 7158 7419 19 LI:903914.3:2001JAN12 930330R1 7158 7419 19 LI:903914.3:2001JAN12 930330H1 7158 7419 19 LI:903914.3:2001JAN12 930654T1 7158 7361 19 LI:903914.3:2001JAN12 930685H1 7158 7263 19 LI:903914.3:2001JAN12 2864854H1 7162 7388 19 LI:903914.3:2001JAN12 868707H1 7167 7423 19 LI:903914.3:2001JAN12 g1267192 7186 7432 19 LI:903914.3:2001JAN12 g562665 7193 7423 19 LI:903914.3:2001JAN12 6375970H1 7194 7392 19 LI:903914.3:2001JAN12 1399324H1 7201 7423 19 LI:903914.3:2001JAN12 1849865H1 7206 7423 19 LI:903914.3:2001JAN12 1849865F6 7206 7418 19 LI:903914.3:2001JAN12 1849865T6 7211 7351 19 LI:903914.3:2001JAN12 3230786H1 7213 7428 19 LI:903914.3:2001JAN12 g5454895 7217 7426 19 LI:903914.3:2001JAN12 g3846473 7224 7419 19 LI:903914.3:2001JAN12 6376346H1 7226 7424 19 LI:903914.3:2001JAN12 g2769135 7225 7423 19 LI:903914.3:2001JAN12 2361452T6 7229 7379 19 LI:903914.3:2001JAN12 g2321435 7238 7417 19 LI:903914.3:2001JAN12 1841486T6 6949 7370 19 LI:903914.3:2001JAN12 1848885H1 6953 7231 19 LI:903914.3:2001JAN12 3872091H1 6957 7160 19 LI:903914.3:2001JAN12 5834344H1 6958 7205 19 LI:903914.3:2001JAN12 3290474H1 6963 7238 19 LI:903914.3:2001JAN12 4020315H1 6966 7275 19 LI:903914.3:2001JAN12 g1264969 6969 7423 19 LI:903914.3:2001JAN12 5352320H1 6971 7233 19 LI:903914.3:2001JAN12 g1613949 6974 7423 19 LI:903914.3:2001JAN12 4131669H2 6972 7263 19 LI:903914.3:2001JAN12 g4307819 6975 7423 19 LI:903914.3:2001JAN12 g4307497 6975 7423 19 LI:903914.3:2001JAN12 g2941476 6978 7474 19 LI:903914.3:2001JAN12 g4307784 6984 7423 19 LI:903914.3:2001JAN12 g5113443 6987 7419 19 LI:903914.3:2001JAN12 g5656968 6989 7429 19 LI:903914.3:2001JAN12 3880474H1 6993 7269 19 LI:903914.3:2001JAN12 2763034H1 6997 7257 19 LI:903914.3:2001JAN12 4697488H1 6999 7259 19 LI:903914.3:2001JAN12 g2750785 6998 7378 19 LI:903914.3:2001JAN12 2675323R6 7002 7429 19 LI:903914.3:2001JAN12 2153952H1 7003 7306 19 LI:903914.3:2001JAN12 g3092434 7004 7421 19 LI:903914.3:2001JAN12 g856676 7016 7402 19 LI:903914.3:2001JAN12 g4453071 7011 7419 19 LI:903914.3:2001JAN12 5170747H1 7009 7246 19 LI:903914.3:2001JAN12 3282064H1 7013 7286 19 LI:903914.3:2001JAN12 g4307777 7026 7422 19 LI:903914.3:2001JAN12 g5591161 7035 7427 19 LI:903914.3:2001JAN12 1740132H1 7036 7312 19 LI:903914.3:2001JAN12 g3179611 7042 7423 19 LI:903914.3:2001JAN12 1837438H1 7042 7325 19 LI:903914.3:2001JAN12 2440653H1 7042 7312 19 LI:903914.3:2001JAN12 6295816H1 6650 6902 19 LI:903914.3:2001JAN12 5771396H1 6660 7230 19 LI:903914.3:2001JAN12 3936291H1 6670 6952 19 LI:903914.3:2001JAN12 3937028H1 6670 6948 19 LI:903914.3:2001JAN12 606531H1 6691 6968 19 LI:903914.3:2001JAN12 684224H1 6691 6944 19 LI:903914.3:2001JAN12 3697493H1 6706 6991 19 LI:903914.3:2001JAN12 6612638H1 6706 6876 19 LI:903914.3:2001JAN12 5376226H1 6710 6970 19 LI:903914.3:2001JAN12 5377950H1 6715 6988 19 LI:903914.3:2001JAN12 1820719H1 6750 6985 19 LI:903914.3:2001JAN12 3784681H1 6754 7056 19 LI:903914.3:2001JAN12 4718760H1 6758 7033 19 LI:903914.3:2001JAN12 5757047H1 6762 7019 19 LI:903914.3:2001JAN12 7629775H1 6766 7420 19 LI:903914.3:2001JAN12 5205018H2 6766 7028 19 LI:903914.3:2001JAN12 1942527H1 6777 7024 19 LI:903914.3:2001JAN12 1997860T6 6798 7381 19 LI:903914.3:2001JAN12 671353H1 6801 7075 19 LI:903914.3:2001JAN12 362876F1 6804 7423 19 LI:903914.3:2001JAN12 2849931T6 6804 7380 19 LI:903914.3:2001JAN12 4058866H1 6806 6917 19 LI:903914.3:2001JAN12 4464979H1 6820 7058 19 LI:903914.3:2001JAN12 6052006J1 6826 7411 19 LI:903914.3:2001JAN12 5949433H1 6843 7200 19 LI:903914.3:2001JAN12 2043101H1 6856 7140 19 LI:903914.3:2001JAN12 g1641771 6854 7207 19 LI:903914.3:2001JAN12 3945569H1 6877 7113 19 LI:903914.3:2001JAN12 4657370H1 6883 7199 19 LI:903914.3:2001JAN12 1721643T6 6886 7384 19 LI:903914.3:2001JAN12 3766583T6 6893 7369 19 LI:903914.3:2001JAN12 71060681V1 6906 7449 19 LI:903914.3:2001JAN12 4190034H1 6912 7212 19 LI:903914.3:2001JAN12 1860946H1 6927 7144 19 LI:903914.3:2001JAN12 432051H1 6932 7253 19 LI:903914.3:2001JAN12 g2933159 6936 7423 19 LI:903914.3:2001JAN12 g7458418 6938 7426 19 LI:903914.3:2001JAN12 g5057082 6941 7422 19 LI:903914.3:2001JAN12 g4969803 6948 7310 19 LI:903914.3:2001JAN12 71059046V1 6327 6709 19 LI:903914.3:2001JAN12 71059950V1 6327 6694 19 LI:903914.3:2001JAN12 71059405V1 6327 6676 19 LI:903914.3:2001JAN12 6559733H1 6327 6625 19 LI:903914.3:2001JAN12 6523975H1 6327 6597 19 LI:903914.3:2001JAN12 6520304H1 6327 6591 19 LI:903914.3:2001JAN12 4312672H1 6327 6571 19 LI:903914.3:2001JAN12 4915157H1 6327 6562 19 LI:903914.3:2001JAN12 4847991H1 6327 6447 19 LI:903914.3:2001JAN12 4151259H1 6340 6615 19 LI:903914.3:2001JAN12 2269914H1 6340 6597 19 LI:903914.3:2001JAN12 3811276H1 6336 6632 19 LI:903914.3:2001JAN12 6437451H1 6353 6803 19 LI:903914.3:2001JAN12 849332R1 6354 6955 19 LI:903914.3:2001JAN12 4528371H1 6360 6631 19 LI:903914.3:2001JAN12 4314581H1 6359 6636 19 LI:903914.3:2001JAN12 2437184H1 6360 6611 19 LI:903914.3:2001JAN12 2945963H1 6361 6688 19 LI:903914.3:2001JAN12 1841486R6 6387 6669 19 LI:903914.3:2001JAN12 1841486H1 6387 6662 19 LI:903914.3:2001JAN12 g1295442 6403 6960 19 LI:903914.3:2001JAN12 4214148H1 6411 6661 19 LI:903914.3:2001JAN12 4291340H1 6425 6522 19 LI:903914.3:2001JAN12 4019764H1 6431 6701 19 LI:903914.3:2001JAN12 5876161H1 6444 6701 19 LI:903914.3:2001JAN12 2413803H1 6450 6712 19 LI:903914.3:2001JAN12 7238106H1 6457 7035 19 LI:903914.3:2001JAN12 2470355H1 6468 6741 19 LI:903914.3:2001JAN12 817310R1 6472 7059 19 LI:903914.3:2001JAN12 993250H1 6486 6766 19 LI:903914.3:2001JAN12 5877179H1 6496 6790 19 LI:903914.3:2001JAN12 1432655R1 6500 7027 19 LI:903914.3:2001JAN12 1432655H1 6500 6758 19 LI:903914.3:2001JAN12 362876R1 6509 6983 19 LI:903914.3:2001JAN12 6295840H1 6514 6747 19 LI:903914.3:2001JAN12 5857931H1 6514 6813 19 LI:903914.3:2001JAN12 6292532H1 6514 6697 19 LI:903914.3:2001JAN12 5686608H1 6518 6836 19 LI:903914.3:2001JAN12 749001R1 6526 7074 19 LI:903914.3:2001JAN12 60133426V1 6536 6618 19 LI:903914.3:2001JAN12 60133428V1 6536 6739 19 LI:903914.3:2001JAN12 60133431V1 6536 6699 19 LI:903914.3:2001JAN12 1390750H1 6543 6750 19 LI:903914.3:2001JAN12 5433174H1 6566 6759 19 LI:903914.3:2001JAN12 2804231H1 6567 6834 19 LI:903914.3:2001JAN12 2628869H1 6567 6813 19 LI:903914.3:2001JAN12 4060925H1 6581 6743 19 LI:903914.3:2001JAN12 319948H1 6597 6999 19 LI:903914.3:2001JAN12 1306876H1 6596 6842 19 LI:903914.3:2001JAN12 5096421H1 6600 6834 19 LI:903914.3:2001JAN12 4024956H1 6605 6903 19 LI:903914.3:2001JAN12 3245265H1 6604 6881 19 LI:903914.3:2001JAN12 6064342H1 6605 6912 19 LI:903914.3:2001JAN12 5531985H1 6605 6878 19 LI:903914.3:2001JAN12 1853136H1 6613 6889 19 LI:903914.3:2001JAN12 5351404H1 6645 6918 19 LI:903914.3:2001JAN12 1924306H1 2251 2471 19 LI:903914.3:2001JAN12 3942245H1 6327 6425 19 LI:903914.3:2001JAN12 5665804H1 6327 6398 19 LI:903914.3:2001JAN12 7229817H1 6327 6801 19 LI:903914.3:2001JAN12 7233211H1 6327 6728 19 LI:903914.3:2001JAN12 6059834H1 5891 6060 19 LI:903914.3:2001JAN12 701473H1 2213 2489 19 LI:903914.3:2001JAN12 g2674759 2215 2697 19 LI:903914.3:2001JAN12 4979871H1 1500 1573 19 LI:903914.3:2001JAN12 3706347H1 1509 1573 19 LI:903914.3:2001JAN12 2730331F6 1593 2015 19 LI:903914.3:2001JAN12 660904H1 1740 1921 19 LI:903914.3:2001JAN12 3044527H1 6327 6458 19 LI:903914.3:2001JAN12 5848222H1 6327 6474 19 LI:903914.3:2001JAN12 71064557V1 5953 6377 19 LI:903914.3:2001JAN12 4569837H1 5966 6060 19 LI:903914.3:2001JAN12 2893660H1 5974 6060 19 LI:903914.3:2001JAN12 71058037V1 5997 6587 19 LI:903914.3:2001JAN12 7701709H1 6128 6790 19 LI:903914.3:2001JAN12 1839135H1 6134 6401 19 LI:903914.3:2001JAN12 2252132H1 6165 6394 19 LI:903914.3:2001JAN12 5720531H1 6296 6812 19 LI:903914.3:2001JAN12 449352H1 6310 6553 19 LI:903914.3:2001JAN12 1386956H1 6315 6566 19 LI:903914.3:2001JAN12 g2026407 6321 6571 19 LI:903914.3:2001JAN12 5800119H1 6324 6828 19 LI:903914.3:2001JAN12 5662508H1 6323 6609 19 LI:903914.3:2001JAN12 6052006H1 6327 6561 19 LI:903914.3:2001JAN12 6520204H1 6327 6518 19 LI:903914.3:2001JAN12 3021455H1 6327 6518 19 LI:903914.3:2001JAN12 71058395V1 5904 6592 19 LI:903914.3:2001JAN12 g3427623 5902 6060 19 LI:903914.3:2001JAN12 5429571H1 5917 6060 19 LI:903914.3:2001JAN12 2708592H1 5918 6060 19 LI:903914.3:2001JAN12 5868759H1 5919 6060 19 LI:903914.3:2001JAN12 2707536H1 5919 6060 19 LI:903914.3:2001JAN12 5868791H1 5920 6060 19 LI:903914.3:2001JAN12 3126247H1 5949 6060 19 LI:903914.3:2001JAN12 3982986H1 6327 6429 19 LI:903914.3:2001JAN12 g4392853 7309 7419 19 LI:903914.3:2001JAN12 g1013261 2252 2619 19 LI:903914.3:2001JAN12 g2874443 2217 2708 19 LI:903914.3:2001JAN12 4414572H1 2245 2503 19 LI:903914.3:2001JAN12 3750656H1 2249 2507 19 LI:903914.3:2001JAN12 g2216495 2216 2622 19 LI:903914.3:2001JAN12 g3742849 2214 2619 19 LI:903914.3:2001JAN12 g1119073 2214 2619 19 LI:903914.3:2001JAN12 6219841H2 2214 2586 19 LI:903914.3:2001JAN12 1006299H1 1146 1433 19 LI:903914.3:2001JAN12 068728H1 1160 1277 19 LI:903914.3:2001JAN12 5687390H1 1168 1423 19 LI:903914.3:2001JAN12 2547870F6 1191 1593 19 LI:903914.3:2001JAN12 8104052J1 1191 1573 19 LI:903914.3:2001JAN12 2547870H1 1191 1453 19 LI:903914.3:2001JAN12 8104052H1 1202 1573 19 LI:903914.3:2001JAN12 1729036H1 1219 1434 19 LI:903914.3:2001JAN12 70778720V1 1242 1569 19 LI:903914.3:2001JAN12 3142223H1 1259 1540 19 LI:903914.3:2001JAN12 70775698V1 1284 1573 19 LI:903914.3:2001JAN12 70776846V1 1303 1573 19 LI:903914.3:2001JAN12 70777640V1 1305 1947 19 LI:903914.3:2001JAN12 678366H1 1306 1591 19 LI:903914.3:2001JAN12 7647608J1 1323 1951 19 LI:903914.3:2001JAN12 4519410H1 1348 1573 19 LI:903914.3:2001JAN12 70781069V1 1377 1573 19 LI:903914.3:2001JAN12 70781021V1 1385 1573 19 LI:903914.3:2001JAN12 70779022V1 1388 1982 19 LI:903914.3:2001JAN12 70777204V1 1427 1997 19 LI:903914.3:2001JAN12 70777316V1 1437 1898 19 LI:903914.3:2001JAN12 5265270H2 1445 1573 19 LI:903914.3:2001JAN12 3720239H1 1482 1573 19 LI:903914.3:2001JAN12 116920R1 1486 1568 19 LI:903914.3:2001JAN12 116920H1 1486 1573 19 LI:903914.3:2001JAN12 7999947H1 1 479 19 LI:903914.3:2001JAN12 8004063H1 229 759 19 LI:903914.3:2001JAN12 g2191602 294 758 19 LI:903914.3:2001JAN12 5540783H1 351 468 19 LI:903914.3:2001JAN12 359504H1 391 583 19 LI:903914.3:2001JAN12 359504R6 391 762 19 LI:903914.3:2001JAN12 5909276H1 503 799 19 LI:903914.3:2001JAN12 1003345H1 664 937 19 LI:903914.3:2001JAN12 6925495H1 839 1108 19 LI:903914.3:2001JAN12 70779035V1 854 1382 19 LI:903914.3:2001JAN12 3492337F6 854 1124 19 LI:903914.3:2001JAN12 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LI:150817.1:2001JAN12 70657138V1 514 969 20 LI:150817.1:2001JAN12 70659173V1 604 1148 20 LI:150817.1:2001JAN12 70660195V1 697 1306 20 LI:150817.1:2001JAN12 70658942V1 707 1217 20 LI:150817.1:2001JAN12 70655575V1 718 1205 20 LI:150817.1:2001JAN12 70660329V1 741 1315 20 LI:150817.1:2001JAN12 70656696V1 775 1319 20 LI:150817.1:2001JAN12 70665015V1 783 1322 20 LI:150817.1:2001JAN12 70646875V1 786 1322 20 LI:150817.1:2001JAN12 70655650V1 842 1334 20 LI:150817.1:2001JAN12 70660055V1 860 1319 20 LI:150817.1:2001JAN12 70659977V1 881 1322 20 LI:150817.1:2001JAN12 70659456V1 931 1305 20 LI:150817.1:2001JAN12 70658365V1 988 1322 20 LI:150817.1:2001JAN12 1943823T6 1013 1313 20 LI:150817.1:2001JAN12 70655792V1 1025 1313 20 LI:150817.1:2001JAN12 70660911V1 1115 1313 20 LI:150817.1:2001JAN12 70657216V1 1208 1819 20 LI:150817.1:2001JAN12 70659311V1 1236 1788 20 LI:150817.1:2001JAN12 70656288V1 1241 1752 20 LI:150817.1:2001JAN12 70659276V1 1631 1867 20 LI:150817.1:2001JAN12 70660598V1 1643 1972 20 LI:150817.1:2001JAN12 70658469V1 1642 2192 20 LI:150817.1:2001JAN12 70660035V1 1643 1867 20 LI:150817.1:2001JAN12 70657033V1 1646 1996 20 LI:150817.1:2001JAN12 70660918V1 1646 1986 20 LI:150817.1:2001JAN12 70660689V1 1646 1899 20 LI:150817.1:2001JAN12 70656049V1 1741 2055 20 LI:150817.1:2001JAN12 70657104V1 1817 2445 20 LI:150817.1:2001JAN12 70657113V1 1925 2531 20 LI:150817.1:2001JAN12 70656974V1 1982 2142 20 LI:150817.1:2001JAN12 70660750V1 2088 2752 20 LI:150817.1:2001JAN12 70655811V1 2092 2644 20 LI:150817.1:2001JAN12 70660590V1 2124 2642 20 LI:150817.1:2001JAN12 70658522V1 2156 2706 20 LI:150817.1:2001JAN12 70658749V1 2211 2881 20 LI:150817.1:2001JAN12 70657879V1 2216 2770 20 LI:150817.1:2001JAN12 70659980V1 2216 2706 20 LI:150817.1:2001JAN12 70658750V1 2227 2706 20 LI:150817.1:2001JAN12 70660410V1 2330 2706 20 LI:150817.1:2001JAN12 70657215V1 2471 3064 20 LI:150817.1:2001JAN12 70658900V1 2496 2887 20 LI:150817.1:2001JAN12 70666665V1 2525 2837 20 LI:150817.1:2001JAN12 70660097V1 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70658626V1 3857 4415 20 LI:150817.1:2001JAN12 70658812V1 3960 4415 21 LI:219627.1:2001JAN12 70789358V1 1393 1804 21 LI:219627.1:2001JAN12 70788326V1 1531 2095 21 LI:219627.1:2001JAN12 70790250V1 1612 2077 21 LI:219627.1:2001JAN12 70788017V1 1571 2067 21 LI:219627.1:2001JAN12 70791462V1 2006 2158 21 LI:219627.1:2001JAN12 70790742V1 1384 2155 21 LI:219627.1:2001JAN12 70792302V1 1445 2142 21 LI:219627.1:2001JAN12 70788748V1 1485 2107 21 LI:219627.1:2001JAN12 70792649V1 905 1371 21 LI:219627.1:2001JAN12 70792154V1 747 1357 21 LI:219627.1:2001JAN12 70789945V1 775 1346 21 LI:219627.1:2001JAN12 70789514V1 757 1310 21 LI:219627.1:2001JAN12 70792971V1 914 1304 21 LI:219627.1:2001JAN12 70790749V1 759 1298 21 LI:219627.1:2001JAN12 70791220V1 576 1207 21 LI:219627.1:2001JAN12 70788290V1 952 1130 21 LI:219627.1:2001JAN12 70791665V1 905 1131 21 LI:219627.1:2001JAN12 70787851V1 531 1083 21 LI:219627.1:2001JAN12 70789143V1 608 1082 21 LI:219627.1:2001JAN12 g2158893 600 1037 21 LI:219627.1:2001JAN12 70788396V1 803 1000 21 LI:219627.1:2001JAN12 70789866V1 383 935 21 LI:219627.1:2001JAN12 70789214V1 714 917 21 LI:219627.1:2001JAN12 4031871F6 383 771 21 LI:219627.1:2001JAN12 4031871H1 383 625 21 LI:219627.1:2001JAN12 g5340544 97 536 21 LI:219627.1:2001JAN12 g3146729 300 503 21 LI:219627.1:2001JAN12 70790411V1 1068 1584 21 LI:219627.1:2001JAN12 70788322V1 1034 1579 21 LI:219627.1:2001JAN12 70792873V1 1022 1534 21 LI:219627.1:2001JAN12 g3057511 1331 1519 21 LI:219627.1:2001JAN12 g5441098 1064 1519 21 LI:219627.1:2001JAN12 70787956V1 977 1504 21 LI:219627.1:2001JAN12 70790407V1 970 1475 21 LI:219627.1:2001JAN12 70788313V1 909 1466 21 LI:219627.1:2001JAN12 70787561V1 884 1449 21 LI:219627.1:2001JAN12 70790141V1 893 1392 21 LI:219627.1:2001JAN12 70788429V1 847 1383 21 LI:219627.1:2001JAN12 g2158894 915 1379 21 LI:219627.1:2001JAN12 70792054V1 802 1373 21 LI:219627.1:2001JAN12 70788620V1 1065 1655 21 LI:219627.1:2001JAN12 70788818V1 1303 1669 21 LI:219627.1:2001JAN12 70792338V1 1105 1669 21 LI:219627.1:2001JAN12 70790643V1 1610 1669 21 LI:219627.1:2001JAN12 70789004V1 1183 1669 21 LI:219627.1:2001JAN12 70789678V1 1440 1669 21 LI:219627.1:2001JAN12 70789318V1 1516 1669 21 LI:219627.1:2001JAN12 70788994V1 1232 1669 21 LI:219627.1:2001JAN12 70793045V1 1206 1658 21 LI:219627.1:2001JAN12 70791928V1 1297 1670 21 LI:219627.1:2001JAN12 70790374V1 1389 1669 21 LI:219627.1:2001JAN12 70793231V1 1344 1677 21 LI:219627.1:2001JAN12 70792560V1 1548 1669 21 LI:219627.1:2001JAN12 70790741V1 1191 1693 21 LI:219627.1:2001JAN12 70790021V1 1316 1677 21 LI:219627.1:2001JAN12 g2903300 188 472 21 LI:219627.1:2001JAN12 g6073244 1 438 22 LI:197812.4:2001JAN12 6845095F8 1 321 22 LI:197812.4:2001JAN12 6845095H1 1 338 22 LI:197812.4:2001JAN12 6845095T8 1 238 23 LI:101525.1:2001JAN12 71032233V1 1596 2032 23 LI:101525.1:2001JAN12 70973792V1 1596 2032 23 LI:101525.1:2001JAN12 70973476V1 1650 2184 23 LI:101525.1:2001JAN12 70971931V1 1715 2243 23 LI:101525.1:2001JAN12 70974856V1 1754 2320 23 LI:101525.1:2001JAN12 70974126V1 1777 2198 23 LI:101525.1:2001JAN12 70974960V1 1883 2402 23 LI:101525.1:2001JAN12 71291604V1 785 1291 23 LI:101525.1:2001JAN12 70974489V1 876 1291 23 LI:101525.1:2001JAN12 70972101V1 883 1325 23 LI:101525.1:2001JAN12 70971439V1 902 1291 23 LI:101525.1:2001JAN12 70973738V1 955 1291 23 LI:101525.1:2001JAN12 g2268726 958 1221 23 LI:101525.1:2001JAN12 71292025V1 1038 1291 23 LI:101525.1:2001JAN12 71290752V1 1039 1293 23 LI:101525.1:2001JAN12 70972211V1 1050 1291 23 LI:101525.1:2001JAN12 70974879V1 1124 1258 23 LI:101525.1:2001JAN12 70973578V1 1155 1823 23 LI:101525.1:2001JAN12 71290943V1 1228 1687 23 LI:101525.1:2001JAN12 71291628V1 1593 2001 23 LI:101525.1:2001JAN12 70973404V1 1588 2216 23 LI:101525.1:2001JAN12 70974980V1 1592 1963 23 LI:101525.1:2001JAN12 71290746V1 1591 1919 23 LI:101525.1:2001JAN12 71291848V1 1592 1931 23 LI:101525.1:2001JAN12 2866445H1 1 294 23 LI:101525.1:2001JAN12 2866445F6 1 470 23 LI:101525.1:2001JAN12 5523470F6 147 549 23 LI:101525.1:2001JAN12 5523470H1 147 372 23 LI:101525.1:2001JAN12 71291594V1 236 880 23 LI:101525.1:2001JAN12 70973566V1 287 933 23 LI:101525.1:2001JAN12 8122508H1 348 953 23 LI:101525.1:2001JAN12 8121078H1 348 821 23 LI:101525.1:2001JAN12 8121568H1 348 967 23 LI:101525.1:2001JAN12 71291773V1 630 1090 23 LI:101525.1:2001JAN12 70972946V1 2057 2311 23 LI:101525.1:2001JAN12 70973242V1 2168 2717 23 LI:101525.1:2001JAN12 g7038453 2194 2311 23 LI:101525.1:2001JAN12 71032294V1 2219 2311 24 LI:891123.1:2001JAN12 5317671T8 177 619 24 LI:891123.1:2001JAN12 6387528H1 197 479 24 LI:891123.1:2001JAN12 71927257V1 475 978 24 LI:891123.1:2001JAN12 70613467V1 1 701 24 LI:891123.1:2001JAN12 71663758V1 150 470 25 LI:813500.1:2001JAN12 776875R6 1577 2060 25 LI:813500.1:2001JAN12 841791R6 1577 2074 25 LI:813500.1:2001JAN12 776875T6 1577 2017 25 LI:813500.1:2001JAN12 769578T6 1577 2017 25 LI:813500.1:2001JAN12 758083T6 1577 2016 25 LI:813500.1:2001JAN12 838871R1 1577 1988 25 LI:813500.1:2001JAN12 838897H1 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LI:1037251.1:2001JAN12 7603548J1 333 896 26 LI:1037251.1:2001JAN12 8045689H1 377 1013 26 LI:1037251.1:2001JAN12 7367091H1 580 1157 26 LI:1037251.1:2001JAN12 8096224H1 854 1311 26 LI:1037251.1:2001JAN12 8095595H1 958 1517 26 LI:1037251.1:2001JAN12 6444487F8 1013 1621 26 LI:1037251.1:2001JAN12 7581788H1 1021 1460 26 LI:1037251.1:2001JAN12 7714966J1 1039 1314 26 LI:1037251.1:2001JAN12 7597602H1 1097 1609 26 LI:1037251.1:2001JAN12 7951081H1 1113 1309 26 LI:1037251.1:2001JAN12 7102957R8 1184 1628 26 LI:1037251.1:2001JAN12 7701607H1 1338 1745 26 LI:1037251.1:2001JAN12 7701607J1 1332 1929 26 LI:1037251.1:2001JAN12 g7280119 1332 1681 26 LI:1037251.1:2001JAN12 7458852H1 1366 1892 26 LI;1037251.1:2001JAN12 g6655995 1368 1800 26 LI:1037251.1:2001JAN12 7126809F8 1385 1950 26 LI:1037251.1:2001JAN12 7969583H1 1443 1959 26 LI:1037251.1:2001JAN12 7614391H1 1546 1948 26 LI:1037251.1:2001JAN12 g7455649 1559 1949 26 LI:1037251.1:2001JAN12 g5810040 1570 1897 26 LI:1037251.1:2001JAN12 g7039869 1580 1949 26 LI:1037251.1:2001JAN12 7589244H2 1686 1948 26 LI:1037251.1:2001JAN12 g6641269 1807 1912 26 LI:1037251.1:2001JAN12 7658341J1 1 419 26 LI:1037251.1:2001JAN12 7579302H1 23 524 27 LI:2032187.1:2001JAN12 7958638J1 293 966 27 LI:2032187.1:2001JAN12 7705503H1 464 946 27 LI:2032187.1:2001JAN12 8211563H1 684 1442 27 LI:2032187.1:2001JAN12 71884877V1 402 922 27 LI:2032187.1:2001JAN12 8273937T1 732 1395 27 LI:2032187.1:2001JAN12 71894564V1 642 1364 27 LI:2032187.1:2001JAN12 71893737V1 561 1360 27 LI:2032187.1:2001JAN12 71891279V1 541 1265 27 LI:2032187.1:2001JAN12 71893377V1 389 1089 27 LI:2032187.1:2001JAN12 71891061V1 338 985 27 LI:2032187.1:2001JAN12 71893504V1 286 991 27 LI:2032187.1:2001JAN12 71894109V1 126 833 27 LI:2032187.1:2001JAN12 71893826V1 44 822 27 LI:2032187.1:2001JAN12 71892181V1 126 784 27 LI:2032187.1:2001JAN12 71894843V1 133 786 27 LI:2032187.1:2001JAN12 71893566V1 1 680 27 LI:2032187.1:2001JAN12 71890772V1 1 659 27 LI:2032187.1:2001JAN12 71886767V1 389 628 28 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28 LI:347572.1:2001JAN12 71872491V1 1377 2044 28 LI:347572.1:2001JAN12 71872623V1 1377 2043 28 LI:347572.1:2001JAN12 70555528V1 1380 2090 28 LI:347572.1:2001JAN12 70556961V1 774 1485 28 LI:347572.1:2001JAN12 71876167V1 790 964 28 LI:347572.1:2001JAN12 71874464V1 755 1473 28 LI:347572.1:2001JAN12 71158362V1 1823 2595 28 LI:347572.1:2001JAN12 70557446V1 1826 2467 28 LI:347572.1:2001JAN12 71874757V1 1336 1709 28 LI:347572.1:2001JAN12 70326574D1 1340 1801 28 LI:347572.1:2001JAN12 7629109J1 1346 1737 28 LI:347572.1:2001JAN12 7629109H1 1346 1737 28 LI:347572.1:2001JAN12 70555309V1 1357 1983 28 LI:347572.1:2001JAN12 70555879V1 757 1373 28 LI:347572.1:2001JAN12 71304118V1 1821 2451 28 LI:347572.1:2001JAN12 3279857H1 1798 2085 28 LI:347572.1:2001JAN12 7187319IV1 1322 1929 28 LI:347572.1:2001JAN12 71875680V1 1794 2027 28 LI:347572.1:2001JAN12 70556404V1 1557 2115 28 LI:347572.1:2001JAN12 71873172V1 1307 2068 28 LI:347572.1:2001JAN12 71873872V1 1292 2038 28 LI:347572.1:2001JAN12 71874274V1 1559 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LI:347572.1:2001JAN12 71873016V1 897 1590 28 LI:347572.1:2001JAN12 6785373H1 907 1509 28 LI:347572.1:2001JAN12 70555300V1 730 1307 28 LI:347572.1:2001JAN12 70554782V1 738 1431 28 LI:347572.1:2001JAN12 1582746H1 3313 3567 28 LI:347572.1:2001JAN12 g7317002 3442 3605 28 LI:347572.1:2001JAN12 g4739984 3524 3605 28 LI:347572.1:2001JAN12 4179741T9 2966 3534 28 LI:347572.1:2001JAN12 70556579V1 2952 3281 28 LI:347572.1:2001JAN12 71303602V1 2958 3644 28 LI:347572.1:2001JAN12 g2099950 3219 3458 28 LI:347572.1:2001JAN12 g2051100 2977 3283 28 LI:347572.1:2001JAN12 6075277H1 2981 3189 28 LI:347572.1:2001JAN12 g7278026 3250 3605 28 LI:347572.1:2001JAN12 1426361F6 3012 3472 28 LI:347572.1:2001JAN12 g5664324 3250 3605 28 LI:347572.1:2001JAN12 1426357H1 3012 3216 28 LI:347572.1:2001JAN12 71131546V1 3021 3329 28 LI:347572.1:2001JAN12 5536040H1 3065 3300 28 LI:347572.1:2001JAN12 1501621T6 3108 3622 28 LI:347572.1:2001JAN12 71158019V1 3113 3605 28 LI:347572.1:2001JAN12 4050931H1 3132 3454 28 LI:347572.1:2001JAN12 70326238D1 3143 3605 28 LI:347572.1:2001JAN12 4179553T9 3155 3518 28 LI:347572.1:2001JAN12 71156430V1 3157 3605 28 LI:347572.1:2001JAN12 g4665411 3160 3605 28 LI:347572.1:2001JAN12 g6658497 3170 3661 28 LI:347572.1:2001JAN12 4172634T6 3179 3615 28 LI:347572.1:2001JAN12 g2099982 3184 3605 28 LI:347572.1:2001JAN12 2770719Hl 3210 3499 28 LI:347572.1:2001JAN12 g5452554 3275 3664 28 LI:347572.1:2001JAN12 2770719F6 3210 3421 28 LI:347572.1:2001JAN12 g2077519 3217 3605 28 LI:347572.1:2001JAN12 2925464F6 16 570 28 LI:347572.1:2001JAN12 4179240H1 17 287 28 LI:347572.1:2001JAN12 4874914H1 4 263 28 LI:347572.1:2001JAN12 4179741H1 4 294 28 LI:347572.1:2001JAN12 6785591H1 12 524 28 LI:347572.1:2001JAN12 6830659J1 1782 2441 28 LI:347572.1:2001JAN12 71874444V1 1213 1849 28 LI:347572.1:2001JAN12 g5850365 1212 1592 28 LI:347572.1:2001JAN12 g5865429 1217 1537 28 LI:347572.1:2001JAN12 71872572V1 1247 1920 28 LI:347572.1:2001JAN12 71874921V1 1267 1914 28 LI:347572.1:2001JAN12 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LI:007788.1:2001JAN12 71426610V1 375 481 29 LI:007788.1:2001JAN12 71436995V1 540 1112 29 LI:007788.1:2001JAN12 71440391V1 253 822 29 LI:007788.1:2001JAN12 71438372V1 282 1156 29 LI:007788.1:2001JAN12 71432321V1 294 791 29 LI:007788.1:2001JAN12 71440960V1 315 961 29 LI:007788.1:2001JAN12 71432360V1 350 888 29 LI:007788.1:2001JAN12 71442282V1 366 876 29 LI:007788.1:2001JAN12 71441217V1 160 681 29 LI:007788.1:2001JAN12 71422030V1 251 503 29 LI:007788.1:2001JAN12 71454158V1 719 906 29 LI:007788.1:2001JAN12 71443151V1 720 1085 29 LI:007788.1:2001JAN12 71448621V1 689 1145 29 LI:007788.1:2001JAN12 71443729V1 693 1314 29 LI:007788.1:2001JAN12 71443176V1 715 1061 29 LI:007788.1:2001JAN12 71420002V1 1304 1568 29 LI:007788.1:2001JAN12 71423336V1 1313 1535 29 LI:007788.1:2001JAN12 71434893V1 1319 2016 29 LI:007788.1:2001JAN12 71461970V1 141 410 29 LI:007788.1:2001JAN12 g1886530 1 272 29 LI:007788.1:2001JAN12 71440642V1 532 1047 29 LI:007788.1:2001JAN12 71433158V1 407 960 29 LI:007788.1:2001JAN12 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LI:007788.1:2001JAN12 71433281V1 1212 1655 29 LI:007788.1:2001JAN12 71429319V1 1282 1515 29 LI:007788.1:2001JAN12 71438954V1 1142 1718 29 LI:007788.1:2001JAN12 71440857V1 1148 1649 29 LI:007788.1:2001JAN12 71439354V1 1150 1655 29 LI:007788.1:2001JAN12 71441496V1 1150 1652 29 LI:007788.1:2001JAN12 71440905V1 1149 1632 29 LI:007788.1:2001JAN12 2844842T6 1191 1652 29 LI:007788.1:2001JAN12 71433422V1 1208 1648 29 LI:007788.1:2001JAN12 71438640V1 1377 1541 29 LI:007788.1:2001JAN12 71441467V1 1361 1976 29 LI:007788.1:2001JAN12 71436418V1 1407 2043 29 LI:007788.1:2001JAN12 71440289V1 1493 2094 29 LI:007788.1:2001JAN12 71441919V1 1477 1997 29 LI:007788.1:2001JAN12 71435052V1 1496 2057 29 LI:007788.1:2001JAN12 71435995V1 1497 2015 29 LI:007788.1:2001JAN12 6630554U1 1507 2016 29 LI:007788.1:2001JAN12 71433818V1 1573 1890 29 LI:007788.1:2001JAN12 71449687V1 1822 1980 29 LI:007788.1:2001JAN12 71433309V1 1941 2085 29 LI:007788.1:2001JAN12 71440820V1 1 542 29 LI:007788.1:2001JAN12 71440319V1 887 1496 29 LI:007788.1:2001JAN12 71433851V1 872 1489 29 LI:007788.1:2001JAN12 71439124V1 928 1571 29 LI:007788.1:2001JAN12 71435518V1 915 1379 29 LI:007788.1:2001JAN12 71435541V1 932 1067 29 LI:007788.1:2001JAN12 71442095V1 929 1450 29 LI:007788.1:2001JAN12 71434718V1 992 1509 29 LI:007788.1:2001JAN12 71436909V1 1002 1618 29 LI:007788.1:2001JAN12 71436829V1 972 1306 29 LI:007788.1:2001JAN12 71435725V1 1094 1710 29 LI:007788.1:2001JAN12 71433312V1 1124 1652 29 LI:007788.1:2001JAN12 71437003V1 1136 1583 29 LI:007788.1:2001JAN12 71436059V1 1145 1891 30 LI:336872.1:2001JAN12 70986562V1 381 825 30 LI:336872.1:2001JAN12 70984072V1 399 737 30 LI:336872.1:2001JAN12 70985543V1 399 827 30 LI:336872.1:2001JAN12 71295516V1 399 823 30 LI:336872.1:2001JAN12 71295044V1 399 766 30 LI:336872.1:2001JAN12 70986344V1 399 652 30 LI:336872.1:2001JAN12 71295036V1 290 825 30 LI:336872.1:2001JAN12 3384358F8 322 825 30 LI:336872.1:2001JAN12 70985880V1 322 582 30 LI:336872.1:2001JAN12 71295290V1 322 572 30 LI:336872.1:2001JAN12 70986588V1 322 519 30 LI:336872.1:2001JAN12 70985351V1 322 551 30 LI:336872.1:2001JAN12 3384358H1 329 501 30 LI:336872.1:2001JAN12 71123582V1 329 433 30 LI:336872.1:2001JAN12 6535837F8 18 699 30 LI:336872.1:2001JAN12 3365081H1 1 161 30 LI:336872.1:2001JAN12 6535437H1 18 470 30 LI:336872.1:2001JAN12 71296536V1 570 1200 30 LI:336872.1:2001JAN12 71295432V1 606 825 30 LI:336872.1:2001JAN12 70983429V1 648 1210 30 LI:336872.1:2001JAN12 2261815H1 656 825 30 LI:336872.1:2001JAN12 71294916V1 672 1295 30 LI:336872.1:2001JAN12 70985853V1 679 1328 30 LI:336872.1:2001JAN12 3717638F6 765 1254 30 LI:336872.1:2001JAN12 3717638H1 765 825 30 LI:336872.1:2001JAN12 71269157V1 1060 1281 30 LI:336872.1:2001JAN12 70983024V1 512 1142 30 LI:336872.1:2001JAN12 71294736V1 512 825 30 LI:336872.1:2001JAN12 70986361V1 548 1192 30 LI:336872.1:2001JAN12 70986118V1 547 825 30 LI:336872.1:2001JAN12 70984218V1 1067 1300 30 LI:336872.1:2001JAN12 71295238V1 1069 1229 30 LI:336872.1:2001JAN12 71295235V1 1070 1711 30 LI:336872.1:2001JAN12 70985136V1 1073 1353 30 LI:336872.1:2001JAN12 g1980540 1450 1632 30 LI:336872.1:2001JAN12 g760823 1465 1597 30 LI:336872.1:2001JAN12 71295531V1 1076 1456 30 LI:336872.1:2001JAN12 3717638T6 1083 1574 30 LI:336872.1:2001JAN12 70984050V1 1224 1741 30 LI:336872.1:2001JAN12 70986990V1 1375 1588 30 LI:336872.1:2001JAN12 70983054V1 1076 1561 30 LI:336872.1:2001JAN12 6535837T8 1074 1504 30 LI:336872.1:2001JAN12 70985260V1 1076 1458 31 LI:1143291.1:2001JAN12 71568568V1 765 1287 31 LI:1143291.1:2001JAN12 71569363V1 770 1002 31 LI:1143291.1:2001JAN12 71571480V1 771 1002 31 LI:1143291.1:2001JAN12 71572931V1 778 1390 31 LI:1143291.1:2001JAN12 71228064V1 818 1333 31 LI:1143291.1:2001JAN12 71570836V1 828 1492 31 LI:1143291.1:2001JAN12 g1727418 844 1086 31 LI:1143291.1:2001JAN12 71227387V1 847 1377 31 LI:1143291.1:2001JAN12 70864247V1 848 1452 31 LI:1143291.1:2001JAN12 71573061V1 894 1518 31 LI:1143291.1:2001JAN12 2639294H1 895 1186 31 LI:1143291.1:2001JAN12 4957555H1 897 1195 31 LI:1143291.1:2001JAN12 70861696V1 903 1557 31 LI:1143291.1:2001JAN12 71569143V1 936 1629 31 LI:1143291.1:2001JAN12 71573232V1 924 1536 31 LI:1143291.1:2001JAN12 71556832V1 623 1034 31 LI:1143291.1:2001JAN12 7256767H1 632 1166 31 LI:1143291.1:2001JAN12 71573169V1 693 1501 31 LI:1143291.1:2001JAN12 6107631H1 672 996 31 LI:1143291.1:2001JAN12 71571503VV 682 1443 31 LI:1143291.1:2001JAN12 70864234V1 1148 1748 31 LI:1143291.1:2001JAN12 4825453H1 1156 1438 31 LI:1143291.1:2001JAN12 6577495H1 1184 1744 31 LI:1143291.1:2001JAN12 3559219H1 1118 1423 31 LI:1143291.1:2001JAN12 g1959565 529 978 31 LI:1143291.1:2001JAN12 7693774J2 528 1062 31 LI:1143291.1:2001JAN12 3181072H1 541 854 31 LI:1143291.1:2001JAN12 g1646925 52 386 31 LI:1143291.1:2001JAN12 2919186H1 34 312 31 LI:1143291.1:2001JAN12 6302587H1 1071 1420 31 LI:1143291.1:2001JAN12 71567814V1 1077 1215 31 LI:1143291.1:2001JAN12 g6986485 1076 1602 31 LI:1143291.1:2001JAN12 6177745H1 14 289 31 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1856026F6 1258 1734 31 LI:1143291.1:2001JAN12 1856026H1 1258 1505 31 LI:1143291.1:2001JAN12 71567623V1 1266 1737 31 LI:1143291.1:2001JAN12 g4874929 1411 1838 31 LI:1143291.1:2001JAN12 5023967H1 1249 1546 31 LI:1143291.1:2001JAN12 2972319H1 1249 1553 31 LI:1143291.1:2001JAN12 2375430T6 1262 1788 31 LI:1143291.1:2001JAN12 4402168H1 588 855 31 LI:1143291.1:2001JAN12 3537279H1 609 899 31 LI:1143291.1:2001JAN12 1615137H1 623 853 31 LI:1143291.1:2001JAN12 71572628V1 558 1334 31 LI:1143291.1:2001JAN12 71558534V1 586 1085 31 LI:1143291.1:2001JAN12 2886349H1 545 846 31 LI:1143291.1:2001JAN12 71569663V1 546 648 31 LI:1143291.1:2001JAN12 2375430F6 6 350 31 LI:1143291.1:2001JAN12 3541264H1 4 181 31 LI:1143291.1:2001JAN12 3541804H1 4 112 31 LI:1143291.1:2001JAN12 8114012H1 8 658 31 LI:1143291.1:2001JAN12 984132H1 686 1004 31 LI:1143291.1:2001JAN12 g4333939 1425 1841 31 LI:1143291.1:2001JAN12 g2751759 1431 1672 31 LI:1143291.1:2001JAN12 g8365378 1435 1844 31 LI:1143291.1:2001JAN12 g4069554 1437 1836 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LI:383639.1:2001JAN12 70684244V1 674 1321 36 LI:383639.1:2001JAN12 70682159V1 698 1342 36 LI:383639.1:2001JAN12 7202070H1 699 1153 36 LI:383639.1:2001JAN12 70682801V1 740 1264 36 LI:383639.1:2001JAN12 70685242V1 753 1169 36 LI:383639.1:2001JAN12 6740467H1 2124 2628 36 LI:383639.1:2001JAN12 6740467F6 2151 2549 36 LI:383639.1:2001JAN12 7645332H1 2246 2916 36 LI:383639.1:2001JAN12 6558258T6 2271 2342 36 LI:383639.1:2001JAN12 860487H1 2815 2891 37 LI:814346.1:2001JAN12 7668267H1 186 760 37 LI:814346.1:2001JAN12 7370451H1 192 819 37 LI:814346.1:2001JAN12 2836649F6 2310 2750 37 LI:814346.1:2001JAN12 g960192 2354 2569 37 LI:814346.1:2001JAN12 g711142 2410 2773 37 LI:814346.1:2001JAN12 71671661V1 1378 1476 37 LI:814346.1:2001JAN12 7610517H1 1485 2001 37 LI:814346.1:2001JAN12 71522964V1 778 1400 37 LI:814346.1:2001JAN12 7661510H1 165 763 37 LI:814346.1:2001JAN12 g6660058 1558 1995 37 LI:814346.1:2001JAN12 g6833878 1560 2003 37 LI:814346.1:2001JANI2 g8366667 1577 1995 37 LI:814346.1:2001JAN12 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LI:1144466.1:2001JAN12 6201236H1 652 1294 46 LI:1144466.1:2001JAN12 70953487V1 706 1363 46 LI:1144466.1:2001JAN12 70947711V1 754 1435 46 LI:1144466.1:2001JAN12 70947562V1 783 1456 46 LI:1144466.1:2001JAN12 70947510V1 790 1454 46 LI:1144466.1:2001JAN12 526973H1 860 1088 46 LI:1144466.1:2001JAN12 70936936V1 880 1506 46 LI:1144466.1:2001JAN12 70936152V1 907 1523 46 LI:1144466.1:2001JAN12 70954726V1 923 1395 46 LI:1144466.1:2001JAN12 71285983V1 930 1504 46 LI:1144466.1:2001JAN12 70950123V1 550 1164 46 LI:1144466.1:2001JAN12 g3752555 1919 2165 46 LI:1144466.1:2001JAN12 g3740213 1919 2165 46 LI:1144466.1:2001JAN12 3028285H1 1911 2170 46 LI:1144466.1:2001JAN12 g7319375 1919 2151 46 LI:1144466.1:2001JAN12 70935832V1 329 803 46 LI:1144466.1:2001JAN12 3629314F6 329 772 46 LI:1144466.1:2001JAN12 70936512V1 329 764 46 LI:1144466.1:2001JAN12 70949896V1 1398 1610 46 LI:1144466.1:2001JAN12 70950737V1 1405 1610 46 LI:1144466.1:2001JAN12 71286465V1 1423 1625 46 LI:1144466.1:2001JAN12 3028285F6 1911 2170 46 LI:1144466.1:2001JAN12 70938336V1 329 893 46 LI:1144466.1:2001JAN12 70936170V1 329 832 46 LI:1144466.1:2001JAN12 70938889V1 329 837 46 LI:1144466.1:2001JAN12 g1012093 1073 1392 46 LI:1144466.1:2001JAN12 3629314T6 1097 1484 46 LI:1144466.1:2001JAN12 70935940V1 1153 1521 46 LI:1144466.1:2001JAN12 2827437H2 2090 2148 46 LI:1144466.1:2001JAN12 6891021H1 1362 1625 46 LI:1144466.1:2001JAN12 70950703V1 1382 2023 46 LI:1144466.1:2001JAN12 6417428H1 2046 2148 46 LI:1144466.1:2001JAN12 70947377V1 550 1187 46 LI:1144466.1:2001JAN12 1369364H1 1158 1426 46 LI:1144466.1:2001JAN12 70947433V1 1209 1608 46 LI:1144466.1:2001JAN12 g787427 2025 2154 46 LI:1144466.1:2001JAN12 70949609V1 1327 1610 46 LI:1144466.1:2001JAN12 6763404J1 1020 1474 46 LI:1144466.1:2001JAN12 3881641T8 1926 2046 46 LI:1144466.1:2001JAN12 g5756510 1926 2135 46 LI:1144466.1:2001JAN12 3166278H1 1926 1976 46 LI:1144466.1:2001JAN12 g793623 2016 2157 46 LI:1144466.1:2001JAN12 70948226V1 1395 1624 46 LI:1144466.1:2001JAN12 70955217V1 1919 2120 46 LI:1144466.1:2001JAN12 g4597925 1926 2138 46 LI:1144466.1:2001JAN12 70937337V1 329 676 46 LI:1144466.1:2001JAN12 3629314H1 330 554 46 LI:1144466.1:2001JAN12 5725468H1 1919 2141 46 LI:1144466.1:2001JAN12 6128137F8 1 63 46 LI:1144466.1:2001JAN12 7609962H1 1 587 46 LI:1144466.1:2001JAN12 7606322J1 15 538 46 LI:1144466.1:2001JAN12 7408213H1 22 596 46 LI:1144466.1:2001JAN12 7287103H1 278 703 46 LI:1144466.1:2001JAN12 70938941V1 329 959 46 LI:1144466.1:2001JAN12 70936832V1 329 778 46 LI:1144466.1:2001JAN12 70936776V1 329 891 46 LI:1144466.1:2001JAN12 70937195V1 329 921 46 LI:1144466.1:2001JAN12 70936226V1 329 917 46 LI:1144466.1:2001JAN12 70948348V1 1244 1610 46 LI:1144466.1:2001JAN12 70950190V1 1253 1610 46 LI:1144466.1:2001JAN12 70948028V1 1264 1610 46 LI:1144466.1:2001JAN12 6110340H1 373 651 46 LI:1144466.1:2001JAN12 70938761V1 485 1218 46 LI:1144466.1:2001JAN12 70949010V1 616 1175 46 LI:1144466.1:2001JAN12 70938744V1 604 1150 46 LI:1144466.1:2001JAN12 70948930V1 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LI:758086.1:2001JAN12 292419H1 194 469 48 LI:758086.1:2001JAN12 292419R6 196 486 48 LI:758086.1:2001JAN12 2135293H1 763 1036 48 LI:758086.1:2001JAN12 3960046F8 333 926 48 LI:758086.1:2001JAN12 3960046H2 333 473 48 LI:758086.1:2001JAN12 g4114677 609 1055 48 LI:758086.1:2001JAN12 2705604T6 744 1011 48 LI:758086.1:2001JAN12 1871586H1 744 869 48 LI:758086.1:2001JAN12 1998855H1 744 926 48 LI:758086.1:2001JAN12 g3429159 744 1052 48 LI:758086.1:2001JAN12 g3674688 744 1053 48 LI:758086.1:2001JAN12 70806797V1 763 1181 48 LI:758086.1:2001JAN12 70810992V1 763 1208 48 LI:758086.1:2001JAN12 2135293F6 763 1223 48 LI:758086.1:2001JAN12 6864812H1 1 502 49 LI:765245.5:2001JAN12 5158962H1 439 729 49 LI:765245.5:2001JAN12 7987122H1 470 914 49 LI:765245.5:2001JAN12 8179752H1 509 1058 49 LI:765245.5:2001JAN12 7695539H1 516 588 49 LI:765245.5:2001JAN12 7695539J1 522 588 49 LI:765245.5:2001JAN12 7705549H1 534 1195 49 LI:765245.5:2001JAN12 5340204H1 1651 1805 49 LI:765245.5:2001JAN12 1815594H1 2092 2248 49 LI:765245.5:2001JAN12 4373124H1 2092 2209 49 LI:765245.5:2001JAN12 1217584H1 2092 2194 49 LI:765245.5:2001JAN12 4378621H1 1644 1826 49 LI:765245.5:2001JAN12 4434560H1 1646 1805 49 LI:765245.5:2001JAN12 g2539282 2092 2293 49 LI:765245.5:2001JAN12 6344377H1 2092 2229 49 LI:765245.5:2001JAN12 834630H1 1763 1826 49 LI:765245.5:2001JAN12 5172864T8 1771 2222 49 LI:765245.5:2001JAN12 5274313F9 1788 2293 49 LI:765245.5:2001JAN12 g6837363 1824 2299 49 LI:765245.5:2001JAN12 7452794H1 2092 2293 49 LI:765245.5:2001JAN12 55105765H1 2092 2254 49 LI:765245.5:2001JAN12 55105765J1 2092 2254 49 LI:765245.5:2001JAN12 1221711H1 2090 2247 49 LI:765245.5:2001JAN12 633496H1 2090 2189 49 LI:765245.5:2001JAN12 g2466878 2092 2298 49 LI:765245.5:2001JAN12 7990106H2 2092 2276 49 LI:765245.5:2001JAN12 g2881979 2092 2292 49 LI:765245.5:2001JAN12 6195105H1 2092 2276 49 LI:765245.5:2001JAN12 1921654H1 2092 2267 49 LI:765245.5:2001JAN12 574306H1 2092 2250 49 LI:765245.5:2001JAN12 2624265H1 2092 2159 49 LI:765245.5:2001JAN12 2510561H1 2092 2215 49 LI:765245.5:2001JAN12 6292645H1 1122 1359 49 LI:765245.5:2001JAN12 1668002H1 1747 1826 49 LI:765245.5:2001JAN12 1670091H1 1747 1805 49 LI:765245.5:2001JAN12 4144443H1 1748 1826 49 LI:765245.5:2001JAN12 5585830H1 1747 1819 49 LI:765245.5:2001JAN12 2266319H1 1749 1826 49 LI:765245.5:2001JAN12 4143570H1 1748 1826 49 LI:765245.5:2001JAN12 961991H1 1711 1826 49 LI:765245.5:2001JAN12 3292837H1 1720 1820 49 LI:765245.5:2001JAN12 341699H1 1722 1826 49 LI:765245.5:2001JAN12 1596869H1 1724 1821 49 LI:765245.5:2001JAN12 147603H1 1724 1805 49 LI:765245.5:2001JAN12 582805H1 1736 1805 49 LI:765245.5:2001JAN12 7969039H1 1742 2292 49 LI:765245.5:2001JAN12 5597415H1 1746 1805 49 LI:765245.5:2001JAN12 4120492H1 1747 1826 49 LI:765245.5:2001JAN12 2081409H1 1747 1826 49 LI:765245.5:2001JAN12 7270879H1 1142 1782 49 LI:765245.5:2001JAN12 7966934H1 1142 1522 49 LI:765245.5:2001JAN12 6374269H1 2092 2222 49 LI:765245.5:2001JAN12 2058225H1 2092 2221 49 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7703528J1 45 697 49 LI:765245.5:2001JAN12 7711494H2 59 616 49 LI:765245.5:2001JAN12 7403504H1 77 729 49 LI:765245.5:2001JAN12 7606736J1 86 591 49 LI:765245.5:2001JAN12 70279400V1 88 556 49 LI:765245.5:2001JAN12 8040796H1 90 783 49 LI:765245.5:2001JAN12 8039196J1 170 923 49 LI:765245.5:2001JAN12 7469804H1 194 737 49 LI:765245.5:2001JAN12 7702707J2 246 895 49 LI:765245.5:2001JAN12 7721162H2 268 933 49 LI:765245.5:2001JAN12 8113950H1 294 986 49 LI:765245.5:2001JAN12 7761684J1 313 933 49 LI:765245.5:2001JAN12 7712422H1 334 948 49 LI:765245.5:2001JAN12 967345H1 1451 1744 49 LI:765245.5:2001JAN12 70456979V1 872 1522 49 LI:765245.5:2001JAN12 55037478J1 930 1537 49 LI:765245.5:2001JAN12 55037632J1 948 1537 49 LI:765245.5:2001JAN12 70287234V1 923 1090 49 LI:765245.5:2001JAN12 7022025H1 948 1287 49 LI:765245.5:2001JAN12 6163469H1 987 1209 49 LI:765245.5:2001JAN12 70454085V1 997 1310 49 LI:765245.5:2001JAN12 70280465V1 991 1528 49 LI:765245.5:2001JAN12 70279487V1 1033 1686 49 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7054670H1 1512 2096 53 LI:239245.3:2001JAN12 1298202F1 1512 1942 53 LI:239245.3:2001JAN12 6310557H1 1767 2439 53 LI:239245.3:2001JAN12 3600715H1 1765 2057 53 LI:239245.3:2001JAN12 2592814H1 1773 2023 53 LI:239245.3:2001JAN12 385678H1 1778 2076 53 LI:239245.3:2001JAN12 4852963H1 1787 2080 53 LI:239245.3:2001JAN12 213146H1 1802 2039 53 LI:239245.3:2001JAN12 207370H1 1802 2028 53 LI:239245.3:2001JAN12 7924721H1 1811 2428 53 LI:239245.3:2001JAN12 g1378507 1829 2118 53 LI:239245.3:2001JAN12 027545H1 1761 1940 53 LI:239245.3:2001JAN12 6310542H1 1767 2382 53 LI:239245.3:2001JAN12 2521749H1 1153 1402 53 LI:239245.3:2001JAN12 g1970688 1169 1477 53 LI:239245.3:2001JAN12 71075977V1 1652 1829 53 LI:239245.3:2001JAN12 71078829V1 1641 1830 53 LI:239245.3:2001JAN12 70874334V1 1661 2081 53 LI:239245.3:2001JAN12 3808662H1 1254 1468 53 LI:239245.3:2001JAN12 7596425H1 1280 1747 53 LI:239245.3:2001JAN12 7596517H1 1287 1487 53 LI:239245.3:2001JAN12 70874514V1 1292 1977 53 LI:239245.3:2001JAN12 7737983J1 1298 1966 53 LI:239245.3:2001JAN12 5641551H1 1219 1460 53 LI:239245.3:2001JAN12 3372035H1 1225 1488 53 LI:239245.3:2001JAN12 2208403F6 1239 1713 53 LI:239245.3:2001JAN12 2208403H1 1239 1468 53 LI:239245.3:2001JAN12 1232232F1 1243 1882 53 LI:239245.3:2001JAN12 1232232H1 1243 1468 53 LI:239245.3:2001JAN12 2097186H1 1254 1350 53 LI:239245.3:2001JAN12 1616965H1 1984 2082 53 LI:239245.3:2001JAN12 4274892H1 1990 2266 53 LI:239245.3:2001JAN12 3217425H1 1998 2285 53 LI:239245.3:2001JAN12 3794510H1 1999 2310 53 LI:239245.3:2001JAN12 71231645V1 2012 2538 53 LI:239245.3:2001JAN12 2917810H1 2018 2191 53 LI:239245.3:2001JAN12 1662812T6 2023 2532 53 LI:239245.3:2001JAN12 g3959977 2025 2208 53 LI:239245.3:2001JAN12 2939339H1 2050 2297 53 LI:239245.3:2001JAN12 71076381V1 2054 2242 53 LI:239245.3:2001JAN12 7618579J1 346 532 53 LI:239245.3:2001JAN12 6585411H1 428 532 53 LI:239245.3:2001JAN12 7735630J1 452 1057 53 LI:239245.3:2001JAN12 4884036H1 471 540 53 LI:239245.3:2001JAN12 5721616H1 1086 1451 53 LI:239245.3:2001JAN12 3009701H1 1086 1290 53 LI:239245.3:2001JAN12 8181792H1 1147 1774 53 LI:239245.3:2001JAN12 7092994H1 88 397 53 LI:239245.3:2001JAN12 71232340V1 1645 2115 53 LI:239245.3:2001JAN12 g1685867 2134 2574 53 LI:239245.3:2001JAN12 g6838404 2149 2568 53 LI:239245.3:2001JAN12 g3883938 2151 2563 53 LI:239245.3:2001JAN12 1617213H1 2156 2373 53 LI:239245.3:2001JAN12 1617284H1 2156 2362 53 LI:239245.3:2001JAN12 g1378402 2158 2565 53 LI:239245.3:2001JAN12 g2907599 2160 2570 53 LI:239245.3:2001JAN12 g1368095 2162 2569 53 LI:239245.3:2001JAN12 7655349H1 955 1249 53 LI:239245.3:2001JAN12 2584851H1 957 1223 53 LI:239245.3:2001JAN12 3290971H1 969 1235 53 LI:239245.3:2001JAN12 1702825H1 972 1172 53 LI:239245.3:2001JAN12 1966577R6 976 1304 53 LI:239245.3:2001JAN12 1966577H1 976 1230 53 LI:239245.3:2001JAN12 2840445H1 1044 1291 53 LI:239245.3:2001JAN12 3371148H1 1071 1340 53 LI:239245.3:2001JAN12 7341833H1 1076 1582 53 LI:239245.3:2001JAN12 g1639712 1079 1419 53 LI:239245.3:2001JAN12 70874892V1 1086 1675 53 LI:239245.3:2001JAN12 1256326F1 1510 1876 53 LI:239245.3:2001JAN12 2846001H1 1631 1931 53 LI:239245.3:2001JAN12 g2011313 1634 2052 53 LI:239245.3:2001JAN12 2846005H1 1631 1933 53 LI:239245.3:2001JAN12 70874202V1 1500 2079 53 LI:239245.3:2001JAN12 g4988929 1504 2008 53 LI:239245.3:2001JAN12 g4080167 1504 1944 53 LI:239245.3:2001JAN12 1954746H1 1505 1758 53 LI:239245.3:2001JAN12 5732588H1 1504 1749 53 LI:239245.3:2001JAN12 4657133H2 1506 1759 53 LI:239245.3:2001JAN12 g3741631 2178 2574 53 LI:239245.3:2001JAN12 7367941H1 2178 2569 53 LI:239245.3:2001JAN12 7334888H1 2182 2572 53 LI:239245.3:2001JAN12 g4997973 2190 2572 53 LI:239245.3:2001JAN12 g3649391 2191 2583 53 LI:239245.3:2001JAN12 7653736H1 863 1030 53 LI:239245.3:2001JAN12 g677683 863 1010 53 LI:239245.3:2001JAN12 3746982H1 863 968 53 LI:239245.3:2001JAN12 3600609H1 863 963 53 LI:239245.3:2001JAN12 923998H1 863 956 53 LI:239245.3:2001JAN12 5066463H1 863 956 53 LI:239245.3:2001JAN12 2820190F6 866 1322 53 LI:239245.3:2001JAN12 2820190H1 866 1084 53 LI:239245.3:2001JAN12 2527015H1 866 1044 53 LI:239245.3:2001JAN12 1662845H1 866 1026 53 LI:239245.3:2001JAN12 1602695H1 866 970 53 LI:239245.3:2001JAN12 908279H1 884 1018 53 LI:239245.3:2001JAN12 g654291 894 1139 53 LI:239245.3:2001JAN12 3190503H1 921 1229 53 LI:239245.3:2001JAN12 3190494H1 921 1159 53 LI:239245.3:2001JAN12 3338674H1 922 1171 53 LI:239245.3:2001JAN12 4916345H1 945 1244 53 LI:239245.3:2001JAN12 1255777H1 950 1194 53 LI:239245.3:2001JAN12 1442744H1 340 532 53 LI:239245.3:2001JAN12 g3277690 2125 2575 53 LI:239245.3:2001JAN12 5648193H1 1975 2413 53 LI:239245.3:2001JAN12 1616909H1 1984 2229 53 LI:239245.3:2001JAN12 210406H1 1958 2142 53 LI:239245.3:2001JAN12 1966577T6 1962 2538 53 LI:239245.3:2001JAN12 5050857H1 1963 2218 53 LI:239245.3:2001JAN12 5873551H1 1913 2211 53 LI:239245.3:2001JAN12 2820190T6 1949 2525 53 LI:239245.3:2001JAN12 978588H1 1951 2252 53 LI:239245.3:2001JAN12 978588R1 1953 2308 53 LI:239245.3:2001JAN12 4202459H1 1889 2166 53 LI:239245.3:2001JAN12 5701154H1 1903 2184 53 LI:239245.3:2001JAN12 7653736J1 235 431 53 LI:239245.3:2001JAN12 1621168H1 206 437 53 LI:239245.3:2001JAN12 7731661H1 155 532 53 LI:239245.3:2001JAN12 4140667H1 182 473 53 LI:239245.3:2001JAN12 7726218H1 191 447 53 LI:239245.3:2001JAN12 7726218J1 192 447 53 LI:239245.3:2001JAN12 7255960H2 144 532 53 LI:239245.3:2001JAN12 g3539348 1 374 53 LI:239245.3:2001JAN12 g3931954 1 369 53 LI:239245.3:2001JAN12 776737H1 68 120 53 LI:239245.3:2001JAN12 1985067H1 76 345 53 LI:239245.3:2001JAN12 70876515V1 1550 2105 53 LI:239245.3:2001JAN12 70874022V1 1571 2180 53 LI:239245.3:2001JAN12 3864706H1 1563 1941 53 LI:239245.3:2001JAN12 70875501V1 1580 1915 53 LI:239245.3:2001JAN12 2102912H1 1590 1864 53 LI:239245.3:2001JAN12 71076168V1 1593 1860 53 LI:239245.3:2001JAN12 71078401V1 1600 2023 53 LI:239245.3:2001JAN12 1300869H1 1601 1870 53 LI:239245.3:2001JAN12 g1685978 1606 1939 53 LI:239245.3:2001JAN12 g2026868 1611 1979 53 LI:239245.3:2001JAN12 6162750H1 1623 2183 53 LI:239245.3:2001JAN12 2597777H1 1618 1922 53 LI:239245.3:2001JAN12 g1373526 1623 2083 53 LI:239245.3:2001JAN12 7182776H1 1625 2192 53 LI:239245.3:2001JAN12 7182777H1 1625 2208 53 LI:239245.3:2001JAN12 7182380H1 1625 2096 53 LI:239245.3:2001JAN12 7182715H1 1625 2164 53 LI:239245.3:2001JAN12 g2279137 2081 2570 53 LI:239245.3:2001JAN12 g2360853 2082 2567 53 LI:239245.3:2001JAN12 878611T1 2084 2526 53 LI:239245.3:2001JAN12 878611R1 2084 2471 53 LI:239245.3:2001JAN12 878611H1 2084 2326 53 LI:239245.3:2001JAN12 g4833713 2092 2569 53 LI:239245.3:2001JAN12 212294H1 2097 2321 53 LI:239245.3:2001JAN12 1696062H1 2078 2301 53 LI:239245.3:2001JAN12 702577H1 1414 1657 53 LI:239245.3:2001JAN12 5732556H1 1467 1726 53 LI:239245.3:2001JAN12 70874813V1 1486 2161 53 LI:239245.3:2001JAN12 70873366V1 1494 2015 53 LI:239245.3:2001JAN12 7746913H1 1378 2004 53 LI:239245.3:2001JAN12 70874721V1 1390 1736 53 LI:239245.3:2001JAN12 70874010V1 1394 1941 53 LI:239245.3:2001JAN12 71231919V1 1404 2088 53 LI:239245.3:2001JAN12 7618579H1 1398 2040 53 LI:239245.3:2001JAN12 4137232H1 1409 1718 53 LI:239245.3:2001JAN12 7736457J1 143 532 53 LI:239245.3:2001JAN12 g2670184 2495 2565 53 LI:239245.3:2001JAN12 2956393H1 2249 2532 53 LI:239245.3:2001JAN12 2955719H1 2249 2531 53 LI:239245.3:2001JAN12 g3932853 2252 2572 53 LI:239245.3:2001JAN12 g3202786 2255 2569 53 LI:239245.3:2001JAN12 g3679306 2256 2563 53 LI:239245.3:2001JAN12 g1994399 2269 2569 53 LI:239245.3:2001JAN12 g1390701 2268 2557 53 LI:239245.3:2001JAN12 2503776H1 2335 2569 53 LI:239245.3:2001JAN12 5326624H1 2311 2562 53 LI:239245.3:2001JAN12 g654218 2327 2575 53 LI:239245.3:2001JAN12 2504103H1 2335 2538 53 LI:239245.3:2001JAN12 g2674844 2404 2583 53 LI:239245.3:2001JAN12 g2563163 2381 2568 53 LI:239245.3:2001JAN12 2519285T6 2395 2633 53 LI:239245.3:2001JAN12 3703849H1 2397 2569 53 LI:239245.3:2001JAN12 1910802T6 2409 2533 53 LI:239245.3:2001JAN12 2883983H1 2433 2569 53 LI:239245.3:2001JAN12 2756734H1 2457 2569 53 LI:239245.3:2001JAN12 g3049728 2487 2563 54 LI:142384.5:2001JAN12 7603466H1 2612 3069 54 LI:142384.5:2001JAN12 g7155580 2612 3039 54 LI:142384.5:2001JAN12 g6641619 2660 3055 54 LI:142384.5:2001JAN12 g7701867 2668 3055 54 LI:142384.5:2001JAN12 7168104H1 2673 3030 54 LI:142384.5:2001JAN12 7692414J1 2702 3007 54 LI:142384.5:2001JAN12 g8008089 2734 3055 54 LI:142384.5:2001JAN12 7957058J1 2516 2933 54 LI:142384.5:2001JAN12 8036889J1 571 1163 54 LI:142384.5:2001JAN12 7400862H1 623 1127 54 LI:142384.5:2001JAN12 7380279H1 675 1246 54 LI:142384.5:2001JAN12 7582606H1 693 1129 54 LI:142384.5:2001JAN12 7720989H1 704 1315 54 LI:142384.5:2001JAN12 8324749J1 765 1190 54 LI:142384.5:2001JAN12 7725609H1 767 1239 54 LI:142384.5:2001JAN12 8002540H1 775 1401 54 LI:142384.5:2001JAN12 7440540H1 560 1148 54 LI:142384.5:2001JAN12 6991082HI 53 274 54 LI:142384.5:2001JAN12 g4195018 56 224 54 LI:142384.5:2001JAN12 g5444909 62 196 54 LI:142384.5:2001JAN12 g4736683 62 531 54 LI:142384.5:2001JAN12 g5765521 62 542 54 LI:142384.5:2001JAN12 g5110384 62 537 54 LI:142384.5:2001JAN12 g5744052 80 524 54 LI:142384.5:2001JAN12 7181281H1 85 634 54 LI:142384.5:2001JAN12 7586630H1 314 807 54 LI:142384.5:2001JAN12 7734637H1 331 842 54 LI:142384.5:2001JAN12 7633218H1 363 621 54 LI:142384.5:2001JAN12 7702987J1 361 573 54 LI:142384.5:2001JAN12 7633218J1 391 620 54 LI:142384.5:2001JAN12 3801178H1 366 564 54 LI:142384.5:2001JAN12 6606927H1 422 806 54 LI:142384.5:2001JAN12 5725556H1 465 939 54 LI:142384.5:2001JAN12 7721053J1 536 1154 54 LI:142384.5:2001JAN12 8002558H1 775 1449 54 LI:142384.5:2001JAN12 7726134J1 782 1004 54 LI:142384.5:2001JAN12 7726134H1 782 1004 54 LI:142384.5:2001JAN12 8081712U1 847 1484 54 LI:142384.5:2001JAN12 8268318H1 847 1301 54 LI:142384.5:2001JAN12 6459774H1 854 1149 54 LI:142384.5:2001JAN12 7717159J1 955 1589 54 LI:142384.5:2001JAN12 7717159H1 1039 1620 54 LI:142384.5:2001JAN12 7621301J1 1069 1705 54 LI:142384.5:2001JAN12 8024879J1 1075 1728 54 LI:142384.5:2001JAN12 7994967H1 1122 1796 54 LI:142384.5:2001JAN12 7693912J2 1137 1670 54 LI:142384.5:2001JAN12 7725609J1 1159 1826 54 LI:142384.5:2001JAN12 7940154H1 1211 1768 54 LI:142384.5:2001JAN12 7698739H1 1359 1994 54 LI:142384.5:2001JAN12 7329095H1 1552 2101 54 LI:142384.5:2001JAN12 7723473J2 1540 1994 54 LI:142384.5:2001JAN12 7328977H1 1552 1931 54 LI:142384.5:2001JAN12 7329035H1 1552 2203 54 LI:142384.5:2001JAN12 7329094H1 1552 2126 54 LI:142384.5:2001JAN12 55004912J1 1586 2270 54 LI:142384.5:2001JAN12 7691638H2 1609 2228 54 LI:142384.5:2001JAN12 7957058H1 1612 2239 54 LI:142384.5:2001JAN12 g6642420 1780 2135 54 LI:142384.5:2001JAN12 7692414H1 2099 2402 54 LI:142384.5:2001JAN12 8174401H1 2240 2847 54 LI:142384.5:2001JAN12 g6663726 2304 2734 54 LI:142384.5:2001JAN12 7732738H2 1 606 54 LI:142384.5:2001JAN12 8015486J2 47 135 55 LI:2068768.1:2001JAN12 8265489J1 1 509 56 LI:2118074.1:2001JAN12 716460H1 467 546 56 LI:2118074.1:2001JAN12 718453R6 467 533 56 LI:2118074.1:2001JAN12 3918663H1 246 550 56 LI:2118074.1:2001JAN12 3916704T6 430 520 56 LI:2118074.1:2001JAN12 718453H1 467 546 56 LI:2118074.1:2001JAN12 5181606H1 230 429 56 LI:2118074.1:2001JAN12 3918663F6 245 538 56 LI:2118074.1:2001JAN12 7267407H1 28 538 56 LI:2118074.1:2001JAN12 3918663T6 192 525 56 LI:2118074.1:2001JAN12 7996451H1 1 316 56 LI:2118074.1:2001JAN12 6909385J1 1 326 56 LI:2118074.1:2001JAN12 60203273D1 1 392 57 LI:1189068.4:2001JAN12 g645158 1270 1403 57 LI:1189068.4:2001JAN12 g5630439 1517 1966 57 LI:1189068.4:2001JAN12 5059372H1 1405 1519 57 LI:1189068.4:2001JAN12 g6711918 1503 1966 57 LI:1189068.4:2001JAN12 6360191F8 1276 1853 57 LI:1189068.4:2001JAN12 g566699 1124 1403 57 LI:1189068.4:2001JAN12 833564T1 737 1357 57 LI:1189068.4:2001JAN12 1941404H1 1352 1403 57 LI:1189068.4:2001JAN12 5974157H1 568 1153 57 LI:1189068.4:2001JAN12 082766H1 738 918 57 LI:1189068.4:2001JAN12 g6662399 1535 1966 57 LI:1189068.4:2001JAN12 g6836688 1535 1960 57 LI:1189068.4:2001JAN12 5290635T9 516 1112 57 LI:1189068.4:2001JAN12 g810895 445 785 57 LI:1189068.4:2001JAN12 5295053H1 323 586 57 LI:1189068.4:2001JAN12 6155906F8 325 768 57 LI:1189068.4:2001JAN12 5515480F8 345 524 57 LI:1189068.4:2001JAN12 3868687H1 367 628 57 LI:1189068.4:2001JAN12 2211930F6 441 787 57 LI:1189068.4:2001JAN12 2211930H1 441 704 57 LI:1189068.4:2001JAN12 g1859174 150 646 57 LI:1189068.4:2001JAN12 1213686H1 158 395 57 LI:1189068.4:2001JAN12 5515480H1 303 539 57 LI:1189068.4:2001JAN12 6155906H1 324 659 57 LI:1189068.4:2001JAN12 2656627F6 1245 1826 57 LI:1189068.4:2001JAN12 2656627H1 1245 1491 57 LI:1189068.4:2001JAN12 2656627T6 1522 1913 57 LI:1189068.4:2001JAN12 g518870 1092 1403 57 LI:1189068.4:2001JAN12 6519409F8 959 1404 57 LI:1189068.4:2001JAN12 g2269520 1659 1957 57 LI:1189068.4:2001JAN12 4777370F6 8 596 57 LI:1189068.4:2001JAN12 6519509H1 959 1403 57 LI:1189068.4:2001JAN12 6519409H1 959 1403 57 LI:1189068.4:2001JAN12 6360191H2 1226 1519 57 LI:1189068.4:2001JAN12 833564H1 737 1005 57 LI:1189068.4:2001JAN12 2657059F6 935 1525 57 LI:1189068.4:2001JAN12 833564R6 737 1222 57 LI:1189068.4:2001JAN12 2657059T6 1523 1917 57 LI:1189068.4:2001JAN12 g670756 1126 1403 57 LI:1189068.4:2001JAN12 g4196245 1146 1522 57 LI:1189068.4:2001JAN12 g2806335 834 1228 57 LI:1189068.4:2001JAN12 g810793 876 1224 57 LI:1189068.4:2001JAN12 3792243H1 888 1206 57 LI:1189068.4:2001JAN12 3144266H1 895 1239 57 LI:1189068.4:2001JAN12 2657059H1 935 1209 57 LI:1189068.4:2001JAN12 8213631H1 788 1244 57 LI:1189068.4:2001JAN12 833564T6 803 1363 57 LI:1189068.4:2001JAN12 g2657163 809 1224 57 LI:1189068.4:2001JAN12 2211930T6 809 1358 57 LI:1189068.4:2001JAN12 725454078 832 1195 57 LI:1189068.4:2001JAN12 8188401H1 1 496 57 LI:1189068.4:2001JAN12 5095219F6 1 465 58 LI:2118704.1:2001JAN12 2524694F6 666 1021 58 LI:2118704.1:2001JAN12 2518322H1 666 913 58 LI:2118704.1:2001JAN12 2524694H1 666 824 58 LI:2118704.1:2001JAN12 1624078H1 967 1021 58 LI:2118704.1:2001JAN12 5166183F6 388 695 58 LI:2118704.1:2001JAN12 5166183H1 393 535 58 LI:2118704.1:2001JAN12 7628180H1 389 596 58 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LI:054831.1:2001JAN12 70941133V1 254 907 66 LI:054831.1:2001JAN12 70944159V1 257 913 66 LI:054831.1:2001JAN12 71282425V1 323 959 66 LI:054831.1:2001JAN12 70941662V1 435 1058 66 LI:054831.1:2001JAN12 70943535V1 464 1025 66 LI:054831.1:2001JAN12 70944862V1 549 1172 66 LI:054831.1:2001JAN12 70943444V1 609 1282 66 LI:054831.1:2001JAN12 71282544V1 624 1161 66 LI:054831.1:2001JAN12 71282357V1 689 1326 66 LI:054831.1:2001JAN12 71281879V1 755 1311 66 LI:054831.1:2001JAN12 71031651V1 940 1154 66 LI:054831.1:2001JAN12 70944680V1 983 1300 66 LI:054831.1:2001JAN12 70943802V1 1057 1728 66 LI:054831.1:2001JAN12 70941544V1 1170 1773 66 LI:054831.1:2001JAN12 70941208V1 1207 1811 66 LI:054831.1:2001JAN12 70944835V1 1239 1790 66 LI:054831.1:2001JAN12 1577746T6 1643 1744 66 LI:054831.1:2001JAN12 g7703153 1643 1788 66 LI:054831.1:2001JAN12 70941278V1 1670 1951 66 LI:054831.1:2001JAN12 70941694V1 720 1245 66 LI:054831.1:2001JAN12 70942457V1 322 929 66 LI:054831.1:2001JAN12 70944789V1 8 561 66 LI:054831.1:2001JAN12 70944150V1 783 1300 66 LI:054831.1:2001JAN12 70942614V1 679 1072 66 LI:054831.1:2001JAN12 70941169V1 949 1300 66 LI:054831.1:2001JAN12 70942531V1 1033 1300 66 LI:054831.1:2001JAN12 70943671V1 949 1300 66 LI:054831.1:2001JAN12 70944285V1 1148 1756 66 LI:054831.1:2001JAN12 70942701V1 8 564 67 LI:1175083.1:2001JAN12 70229576V1 221 721 67 LI:1175083.1:2001JAN12 70230292V1 1 434 67 LI:1175083.1:2001JAN12 70234276V1 1 197 67 LI:1175083.1:2001JAN12 70229269V1 588 803 67 LI:1175083.1:2001JAN12 70229037V1 339 792 67 LI:1175083.1:2001JAN12 70230681V1 1 432 67 LI:1175083.1:2001JAN12 g4682831 379 843 67 LI:1175083.1:2001JAN12 70228423V1 412 864 67 LI:1175083.1:2001JAN12 g4684685 433 843 67 LI:1175083.1:2001JAN12 g1202200 447 846 67 LI:1175083.1:2001JAN12 g6568818 455 843 67 LI:1175083.1:2001JAN12 70232638V1 559 1065 67 LI:1175083.1:2001JAN12 2393170H1 51 291 67 LI:1175083.1:2001JAN12 70230756V1 359 833 67 LI:1175083.1:2001JAN12 g2717002 365 731 67 LI:1175083.1:2001JAN12 70232336V1 54 572 67 LI:1175083.1:2001JAN12 3932513H1 71 328 67 LI:1175083.1:2001JAN12 3696540H1 73 353 67 LI:1175083.1:2001JAN12 70232432V1 133 616 67 LI:1175083.1:2001JAN12 3085961H1 138 421 67 LI:1175083.1:2001JAN12 2190988H1 143 360 67 LI:1175083.1:2001JAN12 70232918V1 180 693 67 LI:1175083.1:2001JAN12 g2322443 276 559 67 LI:1175083.1:2001JAN12 70230724V1 359 837 67 LI:1175083.1:2001JAN12 g1240377 372 708 67 LI:1175083.1:2001JAN12 70233141V1 1 440 67 LI:1175083.1:2001JAN12 70228483V1 1 463 67 LI:1175083.1:2001JAN12 3274714F6 1 459 67 LI:1175083.1:2001JAN12 5863352H1 28 288 67 LI:1175083.1:2001JAN12 70228662V1 1 444 67 LI:1175083.1:2001JAN12 70224321V1 308 593 68 LI:2122897.2:2001JAN12 6597429H1 1027 1379 68 LI:2122897.2:2001JAN12 4062815T6 1027 1365 68 LI:2122897.2:2001JAN12 71745662V1 999 1377 68 LI:2122897.2:2001JAN12 2867016F6 1027 1361 68 LI:2122897.2:2001JAN12 3468525H1 1051 1305 68 LI:2122897.2:2001JAN12 4438637T8 1067 1287 68 LI:2122897.2:2001JAN12 5153965T9 962 1292 68 LI:2122897.2:2001JAN12 70926842V1 1133 1320 68 LI:2122897.2:2001JAN12 6205652F8 1141 1330 68 LI:2122897.2:2001JAN12 6840505F6 1004 1389 68 LI:2122897.2:2001JAN12 6597257H1 1027 1249 68 LI:2122897.2:2001JAN12 g6075478 972 1388 68 LI:2122897.2:2001JAN12 70925189V1 1237 1549 68 LI:2122897.2:2001JAN12 833806H1 1181 1442 68 LI:2122897.2:2001JAN12 g6075479 1065 1388 68 LI:2122897.2:2001JAN12 g6075480 1098 1388 68 LI:2122897.2:2001JAN12 g2162876 316 563 68 LI:2122897.2:2001JAN12 g1312222 1 559 68 LI:2122897.2:2001JAN12 70601491V1 1027 1120 68 LI:2122897.2:2001JAN12 70600306V1 650 1086 68 LI:2122897.2:2001JAN12 71744729V1 394 761 68 LI:2122897.2:2001JAN12 71747330V1 325 761 68 LI:2122897.2:2001JAN12 g314597 1112 1387 68 LI:2122897.2:2001JAN12 71746180V1 657 761 68 LI:2122897.2:2001JAN12 7123678H1 508 761 68 LI:2122897.2:2001JAN12 2060566T6 1027 1345 68 LI:2122897.2:2001JAN12 6335075F8 1093 1389 68 LI:2122897.2:2001JAN12 6335075F6 1082 1389 68 LI:2122897.2:2001JAN12 g1349341 990 1389 68 LI:2122897.2:2001JAN12 g2158912 1048 1389 68 LI:2122897.2:2001JAN12 1338987H1 1217 1389 68 LI:2122897.2:2001JAN12 6205652H1 1146 1389 68 LI:2122897.2:2001JAN12 6597357H1 1027 1388 68 LI:2122897.2:2001JAN12 6335075H1 1079 1389 68 LI:2122897.2:2001JAN12 4240910H1 623 761 68 LI:2122897.2:2001JAN12 71743319V1 399 761 68 LI:2122897.2:2001JAN12 7061305H1 531 761 68 LI:2122897.2:2001JAN12 71746935V1 305 761 68 LI:2122897.2:2001JAN12 2060566R6 508 761 68 LI:2122897.2:2001JAN12 4920522H1 653 761 68 LI:2122897.2;2001JAN12 70601467V1 508 761 68 LI:2122897.2:2001JAN12 4438637F8 508 766 68 LI:2122897.2:2001JAN12 4122257H1 674 761 68 LI:2122897.2:2001JAN12 g4269040 1035 1390 68 LI:2122897.2:2001JAN12 g3424416 1287 1389 68 LI:2122897.2:2001JAN12 8282552T1 902 1153 68 LI:2122897.2:2001JAN12 70602026V1 532 761 68 LI:2122897.2:2001JAN12 3690665F6 494 654 68 LI:2122897.2:2001JAN12 6583638H1 508 652 68 LI:2122897.2:2001JAN12 1653640H1 1105 1321 68 LI:2122897.2:2001JAN12 71741923V1 365 761 68 LI:2122897.2:2001JAN12 1551840H1 500 707 68 LI:2122897.2:2001JAN12 71738610V1 570 701 68 LI:2122897.2:2001JAN12 4438637H1 508 693 68 LI:2122897.2:2001JAN12 5351563H1 508 677 68 LI:2122897.2:2001JAN12 2060566H1 508 672 68 LI:2122897.2:2001JAN12 70599945V1 508 761 68 LI:2122897.2:2001JAN12 g2540873 1027 1391 68 LI:2122897.2:2001JAN12 g1422963 1173 1361 68 LI:2122897.2:2001JAN12 1422495H1 1027 1109 68 LI:2122897.2:2001JANI2 7061305F8 541 761 68 LI:2122897.2:2001JAN12 6597257F6 1027 1389 68 LI:2122897.2:2001JAN12 6597257F8 1027 1309 68 LI:2122897.2:2001JAN12 70601390V1 508 763 68 LI:2122897.2:2001JAN12 71746492V1 204 783 68 LI:2122897.2:2001JAN12 71743705V1 251 783 68 LI:2122897.2:2001JAN12 659903H1 1046 1323 68 LI:2122897.2:2001JAN12 g3050614 1263 1320 68 LI:2122897.2:2001JAN12 70602338V1 679 1112 68 LI:2122897.2:2001JAN12 71742394V1 210 927 68 LI:2122897.2:2001JAN12 71744775V1 201 821 68 LI:2122897.2:2001JAN12 3690665H1 494 795 68 LI:2122897.2:2001JAN12 7001467R8 202 794 68 LI:2122897.2:2001JAN12 7621750H1 237 772 68 LI:2122897.2:2001JAN12 71746378V1 282 786 68 LI:2122897.2:2001JAN12 6597429F8 1027 1402 68 LI:2122897.2:2001JAN12 71744345V1 723 1389 68 LI:2122897.2:2001JAN12 6840505H1 1006 1380 68 LI:2122897.2:2001JAN12 g2335604 958 1363 68 LI:2122897.2:2001JAN12 g892146 1046 1403 68 LI:2122897.2:2001JAN12 1841836H1 1170 1375 68 LI:2122897.2:2001JAN12 g5858210 1027 1390 68 LI:2122897.2:2001JAN12 70601310V1 499 761 68 LI:2122897.2:2001JAN12 2867016H1 1027 1166 68 LI:2122897.2:2001JAN12 2825806T6 1027 1346 68 LI:2122897.2:2001JAN12 70601290V1 1027 1252 68 LI:2122897.2:2001JAN12 1338987T6 1217 1281 68 LI:2122897.2:2001JAN12 2867016T6 1027 1275 68 LI:2122897.2:2001JAN12 6597429T8 1027 1285 68 LI:2122897.2:2001JAN12 6335075T8 1079 1285 68 LI:2122897.2:2001JAN12 3501989T6 1027 1275 68 LI:2122897.2:2001JAN12 g316924 1027 1246 68 LI:2122897.2:2001JAN12 7001467H1 937 1258 68 LI:2122897.2:2001JAN12 7001467F8 596 1258 68 LI:2122897.2:2001JAN12 2357307H1 1000 1240 68 LI:2122897.2:2001JAN12 4893845T8 1027 1216 68 LI:2122897.2:2001JAN12 70597232V1 707 1228 68 LI:2122897.2:2001JAN12 5970773T7 718 1204 68 LI:2122897.2:2001JAN12 70599974V1 508 761 68 LI:2122897.2:2001JAN12 70597746V1 508 761 68 LI:2122897.2:2001JAN12 g890921 984 1370 68 LI:2122897.2:2001JAN12 1997878T6 1133 1349 68 LI:2122897.2:2001JAN12 1919262H1 1077 1349 68 LI:2122897.2:2001JAN12 3690665T6 1027 1358 68 LI:2122897.2:2001JAN12 1225775T6 1027 1346 68 LI:2122897.2:2001JAN12 g3047646 1041 1351 68 LI:2122897.2:2001JAN12 70598341V1 508 761 68 LI:2122897.2:2001JAN12 g4649260 1027 1204 68 LI:2122897.2:2001JAN12 g5528625 983 1204 68 LI:2122897.2:2001JAN12 70598245V1 508 761 68 LI:2122897.2:2001JAN12 7354283H1 1027 1371 69 LI:2053195.3:2001JAN12 g5054453 29 286 69 LI:2053195.3:2001JAN12 g3147156 29 307 69 LI:2053195.3:2001JAN12 1308962H1 1 163 69 LI:2053195.3:2001JAN12 4742155H1 5 171 70 LI:439397.6:2001JAN12 7725467J1 444 1004 70 LI:439397.6:2001JAN12 417346H1 528 696 70 LI:439397.6:2001JAN12 5526237H2 751 1019 70 LI:439397.6:2001JAN12 71022920V1 777 1362 70 LI:439397.6:2001JAN12 70350975D1 804 1210 70 LI:439397.6:2001JAN12 7645980J1 1 608 70 LI:439397.6:2001JAN12 7725467H1 361 1004 71 LI:816379.6:2001JAN12 71862354V1 964 1396 71 LI:816379.6:2001JAN12 71862484V1 965 1396 71 LI:816379.6:2001JAN12 5755024H1 965 1396 71 LI:816379.6:2001JAN12 70514498D1 973 1396 71 LI:816379.6:2001JAN12 837155R1 999 1374 71 LI:816379.6:2001JAN12 70723496V1 1011 1396 71 LI:816379.6:2001JAN12 733063R1 1023 1396 71 LI;816379.6:2001JAN12 057744H1 1202 1392 71 LI:816379.6:2001JAN12 70510238D1 1215 1396 71 LI:816379.6:2001JAN12 70511221V1 1251 1375 71 LI:816379.6:2001JAN12 g4523810 1251 1396 71 LI:816379.6:2001JAN12 5353076H1 1251 1396 71 LI:816379.6:2001JAN12 621158H1 1252 1396 71 LI:816379.6:2001JAN12 621001H1 1252 1396 71 LI:816379.6:2001JAN12 2069960H1 1268 1396 71 LI:816379.6:2001JAN12 611497H1 1312 1396 71 LI:816379.6:2001JAN12 2318093H1 1548 1808 71 LI:816379.6:2001JAN12 2365110H1 1562 1788 71 LI:816379.6:2001JAN12 6541505H1 1563 2122 71 LI:816379.6:2001JAN12 2367584H1 1571 1799 71 LI:816379.6:2001JAN12 5262880H1 1617 1786 71 LI:816379.6:2001JAN12 2364628F6 1728 2154 71 LI:816379.6:2001JAN12 2364628H1 1728 1958 71 LI:816379.6:2001JAN12 2364628T6 1721 2204 71 LI:816379.6:2001JAN12 3562875H1 1762 2058 71 LI:816379.6:2001JAN12 640040H1 1154 1419 71 LI:816379.6:2001JAN12 5394221H1 1150 1405 71 LI:816379.6:2001JAN12 2869942H1 1155 1410 71 LI:816379.6:2001JAN12 2634306H1 1162 1412 71 LI:816379.6:2001JAN12 488003H1 1163 1417 71 LI:816379.6:2001JAN12 g2322646 1172 1608 71 LI:816379.6:2001JAN12 70923704V1 1184 1608 71 LI:816379.6:2001JAN12 2841649H1 1185 1422 71 LI:816379.6:2001JAN12 3034616H1 1188 1396 71 LI:816379.6:2001JAN12 g4175581 1188 1612 71 LI:816379.6:2001JAN12 4596909F6 1189 1375 71 LI:816379.6:2001JAN12 g2874255 1044 1393 71 LI:816379.6:2001JAN12 386476H1 1053 1330 71 LI:816379.6:2001JAN12 6514626H1 1074 1396 71 LI:816379.6:2001JAN12 70433255D1 1088 1396 71 LI:816379.6:2001JAN12 71275888V1 1120 1397 71 LI:816379.6:2001JAN12 71862635V1 950 1396 71 LI:816379.6:2001JAN12 70516131D1 958 1396 71 LI:816379.6:2001JAN12 71862788V1 961 1359 71 LI:816379.6:2001JAN12 2858353H1 1768 2033 71 LI:816379.6:2001JAN12 2961864H1 1772 2047 71 LI:816379.6:2001JAN12 5341535H1 1826 1934 71 LI:816379.6:2001JAN12 g1046751 729 1025 71 LI:816379.6:2001JAN12 71276608V1 771 1165 71 LI:816379.6:2001JAN12 71276635V1 777 1102 71 LI:816379.6:2001JAN12 70924007V1 789 1396 71 LI:816379.6:2001JAN12 71275891V1 794 1259 71 LI:816379.6:2001JAN12 70924234V1 794 1368 71 LI:816379.6:2001JAN12 71276231V1 802 1297 71 LI:816379.6:2001JAN12 5825651H1 817 1394 71 LI:816379.6:2001JAN12 70925679V1 828 1361 71 LI:816379.6:2001JAN12 70924744V1 840 1396 71 LI:816379.6:2001JAN12 70925722V1 843 1359 71 LI:816379.6:2001JAN12 70923524V1 852 1290 71 LI:816379.6:2001JAN12 70924039V1 866 1396 71 LI:816379.6:2001JAN12 7729811J1 879 1375 71 LI:816379.6:2001JAN12 71863033V1 875 1396 71 LI:816379.6:2001JAN12 71862558V1 886 1396 71 LI:816379.6:2001JAN12 71862587V1 922 1396 71 LI:816379.6:2001JAN12 70513587D1 930 1396 71 LI:816379.6:2001JAN12 70516118D1 936 1394 71 LI:816379.6:2001JAN12 8052754J1 1 624 71 LI:816379.6:2001JAN12 7764417J1 118 654 71 LI:816379.6:2001JAN12 7401916H1 190 685 71 LI:816379.6:2001JAN12 70923844V1 346 799 71 LI:816379.6:2001JAN12 70924180V1 346 933 71 LI:816379.6:2001JAN12 70924465V1 346 862 71 LI:816379.6:2001JAN12 70924539V1 346 895 71 LI:816379.6:2001JAN12 71276579V1 346 940 71 LI:816379.6:2001JAN12 70923858V1 346 896 71 LI:816379.6:2001JAN12 1260150F6 346 654 71 LI:816379.6:2001JAN12 1260150H1 346 590 71 LI:816379.6:2001JAN12 70923076V1 491 1036 71 LI:816379.6:2001JAN12 g712423 588 836 71 LI:816379.6:2001JAN12 g703559 588 849 71 LI:816379.6:2001JAN12 71276111V1 595 1199 71 LI:816379.6:2001JAN12 70924950V1 667 1097 71 LI:816379.6:2001JAN12 70925379V1 666 1226 71 LI:816379.6:2001JAN12 7964383H1 690 1267 71 LI:816379.6:2001JAN12 356585R6 724 1104 71 LI:816379.6:2001JAN12 2024316H1 1122 1406 71 LI:816379.6:2001JAN12 g3416935 1144 1396 71 LI:816379.6:2001JAN12 4157360H1 1147 1384 71 LI:816379.6:2001JAN12 4597309H1 1189 1435 71 LI:816379.6:2001JAN12 g1046650 1190 1396 71 LI:816379.6:2001JAN12 1493337H1 1192 1421 72 LI:2123452.4:2001JAN12 1456029T6 6 472 72 LI:2123452.4:2001JAN12 g5546101 191 470 72 LI:2123452.4:2001JAN12 1448389T6 58 469 72 LI:2123452.4:2001JAN12 g1067509 339 447 72 LI:2123452.4:2001JAN12 2928882H1 157 427 72 LI:2123452.4:2001JAN12 1456029F6 6 288 72 LI:2123452.4:2001JAN12 3448555H1 1 194 72 LI:2123452.4:2001JAN12 1456029H1 6 112 73 LI:474559.8:2001JAN12 71120072V1 1 647 74 LI:1089871.1:2001JAN12 70762020V1 1 125 74 LI:1089871.1:2001JAN12 70759980V1 1 704 74 LI:1089871.1:2001JAN12 70757962V1 1 481 74 LI:1089871.1:2001JAN12 2959305F6 1 471 74 LI:1089871.1:2001JAN12 70762245V1 1 554 74 LI:1089871.1:2001JAN12 g1972285 4 165 74 LI:1089871.1:2001JAN12 3887422H1 30 300 74 LI:1089871.1:2001JAN12 70761421V1 121 461 74 LI:1089871.1:2001JAN12 70758433V1 311 843 74 LI:1089871.1:2001JAN12 70757906V1 320 724 74 LI:1089871.1:2001JAN12 70763177V1 371 840 74 LI:1089871.1:2001JAN12 70762620V1 490 872 74 LI:1089871.1:2001JAN12 70761079V1 531 851 74 LI:1089871.1:2001JAN12 70762764V1 531 851 74 LI:1089871.1:2001JAN12 70759582V1 1236 1481 74 LI:1089871.1:2001JAN12 70759021V1 1285 1928 74 LI:1089871.1:2001JAN12 70758815V1 1294 1468 74 LI:1089871.1:2001JAN12 70757721V1 1302 1481 74 LI:1089871.1:2001JAN12 70767224V1 1310 1481 74 LI:1089871.1:2001JAN12 70761857V1 1314 1481 74 LI:1089871.1:2001JAN12 70764826V1 1381 1912 74 LI:1089871.1:2001JAN12 70758307V1 1409 1976 74 LI:1089871.1:2001JAN12 70760140V1 1774 2154 74 LI:1089871.1:2001JAN12 70761329V1 1779 2007 74 LI:1089871.1:2001JAN12 2959305T6 1821 2277 74 LI:1089871.1:2001JAN12 70760716V1 1843 2265 74 LI:1089871.1:2001JAN12 70762468V1 537 851 74 LI:1089871.1:2001JAN12 70758821V1 542 843 74 LI:1089871.1:2001JAN12 70761878V1 551 843 74 LI:1089871.1:2001JAN12 70762741V1 616 851 74 LI:1089871.1:2001JAN12 70757636V1 681 1265 74 LI:1089871.1:2001JAN12 70758209V1 685 851 74 LI:1089871.1:2001JAN12 70761553V1 685 851 74 LI:1089871.1:2001JAN12 70759811V1 685 1251 74 LI:1089871.1:2001JAN12 70761311V1 717 1320 74 LI:1089871.1:2001JAN12 70760042V1 759 1286 74 LI:1089871.1:2001JAN12 70760336V1 781 1320 74 LI:1089871.1:2001JAN12 70760101V1 1132 1481 74 LI:1089871.1:2001JAN12 70760117V1 1158 1484 74 LI:1089871.1:2001JAN12 70760813V1 1158 1315 74 LI:1089871.1:2001JAN12 70757952V1 1158 1374 74 LI:1089871.1:2001JAN12 70759158V1 1158 1394 74 LI:1089871.1:2001JAN12 70760818V1 1158 1394 74 LI:1089871.1:2001JAN12 70757680V1 1158 1467 74 LI:1089871.1:2001JAN12 7Q761293V1 1158 1458 74 LI:1089871.1:2001JAN12 70759646V1 1158 1609 74 LI:1089871.1:2001JAN12 70761118V1 1158 1458 74 LI:1089871.1:2001JAN12 70762739V1 1158 1481 74 LI:1089871.1:2001JAN12 70761840V1 1161 1477 74 LI:1089871.1:2001JAN12 70762279V1 1164 1481 74 LI:1089871.1:2001JAN12 70762802V1 1195 1481 75 LI:289608.1:2001JAN12 4786611H1 1 252 75 LI:289608.1:2001JAN12 5388881F8 111 661 75 LI:289608.1:2001JAN12 5388881H1 111 191 75 LI:289608.1:2001JAN12 5388881T8 113 630 75 LI:289608.1:2001JAN12 4786611F6 1 452

[0325] TABLE 4 SEQ ID NO: Template ID Tissue Distribution 1 LI:418914.1:2001JAN12 Sense Organs - 56%, Respiratory System - 24% 2 LI:246108.7:2001JAN12 Nervous System - 54%, Male Genitalia - 23%, Digestive System - 23% 3 LI:204262.2:2001JAN12 Unclassified/Mixed - 16%, Urinary Tract - 13%, Sense Organs - 12% 4 LI:331661.1:2001JAN12 Nervous System - 43%, Endocrine System - 29%, Hemic and Immune System - 21% 5 LI:335074.1:2001JAN12 Exocrine Glands - 86% 6 LI:154608.1:2001JAN12 Urinary Tract - 31%, Nervous System - 31%, Male Genitalia - 23% 7 LI:462889.1:2001JAN12 Embryonic Structures - 75%, Musculoskeletal System - 12% 8 LI:236680.2:2001JAN12 Unclassified/Mixed - 11%, CardiovascularSystem - 11% 9 LI:228186.1:2001JAN12 Sense Organs - 14%, Unclassified/Mixed - 11% 10 LI:721233.1:2001JAN12 Nervous System - 100% 11 LI:291759.2:2001JAN12 Digestive System - 17%, Urinary Tract - 13%, Connective Tissue - 12% 12 LI:292613.17:2001JAN12 Urinary Tract - 29%, Nervous System - 29%, Digestive System - 21%, Male Genitalia - 21% 13 LI:412959.15:2001JAN12 Embryonic Structures - 73%, Urinary Tract - 13% 14 LI:482512.3:2001JAN12 Sense Organs - 32%, Endocrine System - 10% 15 LI:413231.6:2001JAN12 Digestive System - 38%, Respiratory System - 23%, Nervous System - 23% 16 LI:203383.1:2001JAN12 Musculoskeletal System - 36%, Germ Cells - 25%, Connective Tissue - 18% 17 LI:133186.4:2001JAN12 Urinary Tract - 50%, Male Genitalia - 38%, Nervous System - 13% 18 LI:238576.2:2001JAN12 Urinary Tract - 12%, Respiratory System - 12% 19 LI:903914.3:2001JAN12 Unclassified/Mixed - 13%, Skin - 11%, Nervous System - 10% 20 LI:150817.1:2001JAN12 Nervous System - 100% 21 LI:219627.1:2001JAN12 Unclassified/Mixed - 62%, Urinary Tract - 15%, Male Genitalia - 12% 22 LI:197812.4:2001JAN12 Urinary Tract - 100% 23 LI:101525.1:2001JAN12 Cardiovascular System - 91% 24 LI:891123.1:2001JAN12 Musculoskeletal System - 73%, Male Genitalia - 27% 25 LI:813500.1:2001JAN12 Male Genitalia - 46%, Digestive System - 21%, Female Genitalia - 13%, Nervous System - 13% 26 LI:1037251.1:2001JAN12 Sense Organs - 42%, Hemic and Immune System - 13%, Endocrine System - 11% 27 LI:2032187.1:2001JAN12 Hemic and Immune System - 54%, Connective Tissue - 42% 28 LI:347572.1:2001JAN12 CardiovascularSystem - 32%, Digestive System - 28%, Cardiovascular System - 12% 29 LI:007788.1:2001JAN12 Hemic and Immune System - 67%, Nervous System - 33% 30 LI:336872.1:2001JAN12 Embryonic Structures - 40%, Female Genitalia - 27%, Male Genitalia - 17% 31 LI:1143291.1:2001JAN12 Skin - 19%, Urinary Tract - 14%, Stomatognathic System - 12% 32 LI:093477.1:2001JAN12 Unclassified/Mixed - 93% 33 LI:222105.1:2001JAN12 CardiovascularSystem - 12% 34 LI:816737.2:2001JAN12 Female Genitalia - 29%, Hemic and Immune System - 15%, Urinary Tract - 13% 35 LI:475524.1:2001JAN12 Germ Cells - 47%, Liver - 17% 36 LI:383639.1:2001JAN12 Hemic and Immune System - 75%, Respiratory System - 10% 37 LI:814346.1:2001JAN12 Urinary Tract - 31%, Cardiovascular System - 12%, Hemic and Immune System - 11% 38 LI:898195.6:2001JAN12 Respiratory System - 18%, Embryonic Structures - 14%, Liver - 13% 39 LI:210497.2:2001JAN12 Hemic and Immune System - 100% 40 LI:110297.4:2001JAN12 Endocrine System - 20%, Unclassified/Mixed - 12% 41 LI:2051312.1:2001JAN12 Nervous System - 39%, Respiratory System - 18%, Cardiovascular System - 15%, Female Genitalia - 15% 42 LI:350272.2:2001JAN12 Exocrine Glands - 19%, Cardiovascular System - 12%, Musculoskeletal System - 11% 43 LI:1085472.4:2001JAN12 Urinary Tract - 28%, Stomatognathic System - 20%, Female Genitalia - 14% 44 LI:1190272.1:2001JAN12 Skin - 50%, Nervous System - 11% 45 LI:1086797.1:2001JAN12 Embryonic Structures - 27%, Stomatognathic System - 19%, Digestive System - 16% 46 LI:1144466.1:2001JAN12 Embryonic Structures - 25%, Connective Tissue - 18%, Nervous System - 15% 47 LI:1147914.1:2001JAN12 Connective Tissue - 30%, Musculoskeletal System - 27%, Female Genitalia - 17% 48 LI:758086.1:2001JAN12 Nervous System - 27%, Cardiovascular System - 24%, Female Genitalia - 14%, Hemic and Immune System - 14%, Exocrine Glands - 14% 49 LI:765245.5:2001JAN12 Pancreas - 18%, Exocrine Glands - 15%, Connective Tissue - 14% 50 LI:335608.2:2001JAN12 Stomatognathic System - 48%, Digestive System - 15% 51 LI:405795.1:2001JAN12 Embryonic Structures - 58%, Female Genitalia - 19% 52 LI:014872.1:2001JAN12 Connective Tissue - 80% 53 LI:239245.3:2001JAN12 Skin - 13%, Sense Organs - 13%, Respiratory System - 13% 54 LI:142384.5:2001JAN12 Stomatognathic System - 21%, Skin - 18%, Musculoskeletal System - 16% 55 LI:2068768.1:2001JAN12 Unclassified/Mixed - 100% 56 LI:2118074.1:2001JAN12 Endocrine System - 52%, Female Genitalia - 37% 57 LI:1189068.4:2001JAN12 Connective Tissue - 29%, Sense Organs - 26% 58 LI:2118704.1:2001JAN12 Sense Organs - 60%, Nervous System - 13% 59 LI:031700.2:2001JAN12 Female Genitalia - 64%, Urinary Tract - 27% 60 LI:2120122.1:2001JAN12 Unclassified/Mixed - 34%, Sense Organs - 23%, Germ Cells - 11% 61 LI:816174.1:2001JAN12 Digestive System - 22%, Male Genitalia - 22%, Exocrine Glands - 22% 62 LI:1189569.11:2001JAN12 Sense Organs - 92% 63 LI:413584.1:2001JAN12 Unclassified/Mixed - 54%, Embryonic Structures - 11% 64 LI:791042.1:2001JAN12 Digestive System - 25%, Urinary Tract - 22%, Embryonic Structures - 20% 65 LI:1167140.1:2001JAN12 Embryonic Structures - 23%, Exocrine Glands - 19%, Nervous System - 12%, Respiratory System - 12% 66 LI:054831.1:2001JAN12 Digestive System - 60%, Hemic and Immune System - 40% 67 LI:1175083.1:2001JAN12 Germ Cells - 67%, Male Genitalia - 10% 68 LI:2122897.2:2001JAN12 CardiovascularSystem - 28%, Exocrine Glands - 18%, Cardiovascular System - 14% 69 LI:2053195.3:2001JAN12 Digestive System - 38%, Respiratory System - 38%, Hemic and Immune System - 25% 70 LI:439397.6:2001JAN12 Endocrine System - 33%, Exocrine Glands - 28%, Urinary Tract - 22% 71 LI:816379.6:2001JAN12 Hemic and Immune System - 29%, Urinary Tract - 17%, Endocrine System - 16% 72 LI:2123452.4:2001JAN12 Sense Organs - 71%, Embryonic Structures - 16% 74 LI:1089871.1:2001JAN12 Endocrine System - 55%, Female Genitalia - 27%, Hemic and Immune System - 18% 75 LI:289608.1:2001JAN12 Nervous System - 100%

[0326] TABLE 5 SEQ ID NO: Frame Length Start Stop GI Number Probability Score Annotation 76 1 177 460 990 g16551610 1.00E−11 (AK056259) unnamed protein product 76 1 177 460 990 g9837385 4.00E−07 retinitis pigmentosa GTPase regulator-like protein 76 1 177 460 990 g16553150 1.00E−06 (AK057442) unnamed protein product 81 2 70 383 592 g12698182 2.00E−15 hypothetical protein 81 2 70 383 592 g7021164 8.00E−14 unnamed protein product 81 2 70 383 592 g16876883 1.00E−10 (BC016722) Unknown (protein for IMAGE: 4075924) 82 2 239 2 718 g10437745 1.00E−120 unnamed protein product 82 2 239 2 718 g8926320 1.00E−115 corneal wound healing related protein 82 2 239 2 718 g12861811 1.00E−111 putative 83 2 114 362 703 g16751522 2.00E−35 (AB064543) dioxin inducible factor 3 83 2 114 362 703 g12002226 2.00E−32 C3HC4-type zinc finger protein 83 2 114 362 703 g10437296 2.00E−32 unnamed protein product 85 1 151 43 495 g15128221 1.00E−57 contains ESTs AU100786(C50379), C26898(C50379), ˜similar to Arabidopsis thaliana chromosome 1, F28N24.7˜unknown protein 85 1 151 43 495 g9502415 6.00E−46 Unknown protein 85 1 151 43 495 g15529270 6.00E−46 At1g29250/F28N24_8 86 2 104 569 880 g7770147 6.00E−16 PRO1847 86 2 104 569 880 g10437752 2.00E−14 unnamed protein product 86 2 104 569 880 g6650810 3.00E−14 PRO1902 89 1 85 1486 1740 g12006213 5.00E−32 DC46 92 1 125 196 570 g13938315 8.00E−42 Unknown (protein for MGC: 15634) 94 1 114 472 813 g12859423 2.00E−23 putative 94 1 114 472 813 g15919915 5.00E−23 putative 94 1 114 472 813 g1841551 5.00E−21 G16 95 2 110 1592 1921 g10438620 2.00E−24 unnamed protein product 95 2 110 1592 1921 g10437485 2.00E−23 unnamed protein product 95 2 110 1592 1921 g7020625 5.00E−23 unnamed protein product 96 2 100 1241 1540 g12698192 4.00E−19 hypothetical protein 96 2 100 1241 1540 g6690223 5.00E−13 PRO0470 96 2 100 1241 1540 g1389766 6.00E−11 unknown 99 2 60 1295 1474 g16303798 2.00E−09 (AF416714) unknown 99 2 60 1295 1474 g11493419 2.00E−09 PRO1367 99 2 60 1295 1474 g6690223 2.00E−08 PRO0470 103 2 135 71 475 g14250579 5.00E−07 hypothetical protein PP1628 103 2 135 71 475 g10441903 5.00E−07 unknown 108 2 197 125 715 g434779 1.00E−20 KIAA0112 108 2 197 125 715 g15278392 1.00E−20 homolog of yeast ribosome biogenesis regulatory protein RRS1 108 2 197 125 715 g12804751 1.00E−20 Similar to regulator for ribosome resistance homolog (S. cerevisiae) 110 2 257 113 883 g14017947 1.00E−27 KIAA1865 protein 110 2 257 113 883 g10636484 1.00E−27 polyglutamine-containing protein 113 1 129 1 387 g2589160 2.00E−60 DCRA 113 1 129 1 387 g2588993 3.00E−55 Dcra 113 1 129 1 387 g13277666 3.00E−55 Down syndrome critical region gene a 116 3 59 240 416 g14598201 4.00E−24 human CLASP-5 116 3 59 240 416 g16550121 3.00E−15 (AK055401) unnamed protein product 116 3 59 240 416 g14597912 3.00E−15 human CLASP-3 118 1 172 1105 1620 g4678717 4.00E−60 hypothetical protein 118 1 172 1105 1620 g3947678 4.00E−60 dJ206D15.3 118 1 172 1105 1620 g12853820 3.00E−17 putative 119 3 214 3 644 g12845866 5.00E−10 putative 121 2 204 116 727 g6841564 9.00E−16 HSPC172 121 2 204 116 727 g6650543 9.00E−16 unknown 121 2 204 116 727 g5531839 9.00E−16 PTD009 122 1 284 1375 2226 g14388466 3.00E−96 hypothetical protein 122 1 284 1375 2226 g14133251 3.00E−96 KIAA1479 protein 122 1 284 1375 2226 g10434456 3.00E−96 unnamed protein product 124 3 81 549 791 g5726235 2.00E−13 unknown protein U5/2 125 2 129 425 811 g14189960 2.00E−28 PRO0764 125 2 129 425 811 g11493463 2.00E−22 PRO2852 125 2 129 425 811 g9280152 6.00E−22 unnamed portein product 126 3 142 3 428 g1526432 3.00E−09 neutral calponin 126 3 142 3 428 g4432964 4.00E−09 h2-calponin 126 3 142 3 428 g51144 5.00E−09 h2-calponin 131 3 206 3 620 g16198439 1.00E−17 hypothetical protein FLJ13855 131 3 206 3 620 g15929470 1.00E−17 hypothetical protein FLJ13855 131 3 206 3 620 g10436290 1.00E−17 unnamed protein product 133 3 171 24 536 g14424725 8.00E−70 hypothetical protein FLJ13055 133 3 171 24 536 g10434892 8.00E−70 unnamed protein product 133 3 171 24 536 g12852801 9.00E−29 putative 135 1 186 460 1017 g13397124 7.00E−17 unnamed protein product 136 3 95 3 287 g5410527 3.00E−15 paracellin-1 138 1 73 55 273 g16549456 1.00E−07 (AK054840) unnamed protein product 138 1 73 55 273 g9437519 5.00E−07 MOST-1 138 1 73 55 273 g6690229 1.00E−06 PRO0483 140 1 103 148 456 g4809026 9.00E−37 suppressor of G2 allele of skp1 homolog 140 1 103 148 456 g15216168 9.00E−37 putative 40-6-3 protein 140 1 103 148 456 g12654187 9.00E−37 suppressor of G2 allele of SKP1, S. cerevisiae, homolog of 144 2 247 29 769 g14026730 8.00E−14 homoserine kinase 144 2 247 29 769 g7298468 5.00E−10 CG15164 gene product 144 2 247 29 769 g15075719 7.00E−09 PUTATIVE AMINOTRANSFERASE PROTEIN 145 2 79 1040 1276 g1911548 2.00E−27 cytochrome c-like polypeptide 147 2 208 155 778 g5106956 4.00E−97 FH1/FH2 domain-containing protein FHOS 147 2 208 155 778 g12697935 4.00E−61 KIAA1695 protein 147 2 208 155 778 g10438624 4.00E−61 unnamed protein product 149 3 73 246 464 g14189976 6.00E−27 PRO2972 149 3 73 246 464 g3415134 1.00E−14 Phyb1 149 3 73 246 464 g12857019 1.00E−14 putative 151 3 158 3 476 g7243081 6.00E−90 KIAA1350 protein 152 3 84 315 566 g288145 1.00E−05 put. ORF 152 3 84 315 566 g6690248 6.00E−05 PRO0657

[0327] TABLE 6 Program Description Reference Parameter Threshold ABI A program that removes vector sequences and masks Applied Biosystems, FACTURA ambiguous bases in nucleic acid sequences. Foster City, CA. ABI/ A Fast Data Finder useful in Applied Biosystems, Mismatch <50% PARACEL comparing and annotating amino Foster City, CA; FDF acid or nucleic acid sequences. Paracel Inc., Pasadena, CA. ABI A program that assembles nucleic acid sequences. Applied Biosystems, AutoAssembler Foster City, CA. BLAST A Basic Local Alignment Search Tool useful in Altschul, S.F. et al. (1990) ESTs: Probability sequence similarity search for amino acid and nucleic J. Mol. Biol. 215: 403-410; value = 1.0E−8 acid sequences. BLAST includes five functions: Altschul, S.F. et al. (1997) or less; blastp, blastn, blastx, tblastn, and tblastx. Nucleic Acids Res. 25: 3389-3402. Full Length sequences: Probability value = 1.0E−10 or less FASTA A Pearson and Lipman algorithm that searches for Pearson, W. R. and ESTs: fasta E similarity between a query sequence and a group of D. J. Lipman (1988) Proc. Natl. value = 1.06E−6; sequences of the same type. FASTA comprises as Acad Sci. USA 85: 2444-2448; Assembled ESTs: fasta least five functions: fasta, tfasta, fastx, tfastx, and Pearson, W. R. (1990) Methods Enzymol. 183: 63-98; Identity = 95% or ssearch. and Smith, T. F. and M. S. Waterman (1981) greater and Adv. Appl. Math. 2: 482-489. Matchlength = 200 bases or greater; fastx E value = 1.0E−8 or less; Full Length sequences: fastx score = 100 or greater BLIMPS A BLocks IMProved Searcher that matches a Henikoff, S. and J. G. Henikoff (1991) Probability value = sequence against those in BLOCKS, PRINTS, Nucleic Acids Res. 19: 6565-6572; Henikoff, 1.0E−3 or less DOMO, PRODOM, and PFAM databases to search J. G. and S. Henikoff (1996) Methods for gene families, sequence homology, and structural Enzymol. 266: 88-105; and Attwood, T. K. et fingerprint regions. al. (1997) J. Chem. Inf. Comput. Sci. 37: 417-424. HMMER An algorithm for searching a query sequence against Krogh, A. et al. (1994) J. Mol. Biol. PFAM hits: hidden Markov model (HMM)-based databases of 235: 1501-1531; Sonnhammer, E. L. L. et al. Probability value = protein family consensus sequences, such as PFAM, (1988) Nucleic Acids Res. 26: 320-322; 1.0E−3 or less; INCY, SMART and TIGRFAM. Durbin, R. et al. (1998) Our World View, in Signal peptide hits: a Nutshell, Cambridge Univ. Press, pp. 1-350. Score = 0 or greater ProfileScan An algorithm that searches for structural and Gribskov, M. et al. (1988) CABIOS 4: 61-66; Normalized quality sequence motifs in protein sequences that match Gribskov, M. et al. (1989) Methods score ≧ GCG sequence patterns defined in Prosite. Enzymol. 183: 146-159; Bairoch, A. et al. specified “HIGH” (1997) Nucleic Acids Res. 25: 217-221. value for that particular Prosite motif. Generally, score = 1.4-2.1. Phred A base-calling algorithm that examines automated Ewing, B. et al. (1998) Genome Res. 8: 175-185; sequencer traces with high sensitivity and probability. Ewing, B. and P. Green (1998) Genome Res. 8: 186-194. Phrap A Phils Revised Assembly Program including Smith, T. F. and M. S. Waterman (1981) Adv. Score = 120 or greater; SWAT and CrossMatch, programs based on efficient Appl. Math. 2: 482-489; Smith, T. F. and Match length = implementation of the Smith-Waterman algorithm, M. S. Waterman (1981) J. Mol. Biol. 147: 195-197; 56 or greater useful in searching sequence homology and and Green, P., University of assembling DNA sequences. Washington, Seattle, WA. Consed A graphical tool for viewing and editing Phrap Gordon, D. et al. (1998) Genome Res. 8: 195-202. assemblies. SPScan A weight matrix analysis program that scans protein Nielson, H. et al. (1997) Protein Engineering Score = 3.5 or greater sequences for the presence of secretory signal  10: 1-6; Claverie, J. M. and S. Audic (1997) peptides. CABIOS 12: 431-439. TMAP A program that uses weight matrices to delineate Persson, B. and P. Argos (1994) J. Mol. Biol. transmembrane segments on protein sequences and 237: 182-192; Persson, B. and P. Argos determine orientation. (1996) Protein Sci. 5: 363-371. TMHMMER A program that uses a hidden Markov model (HMM) Sonnhammer, E.L. et al. (1998) Proc. Sixth to delineate transmembrane segments on protein Intl. Conf. On Intelligent Systems for Mol. sequences and determine orientation. Biol., Glasgow et al., eds., The Am. Assoc. for Artificial Intelligence (AAAI) Press, Menlo Park, CA, and MIT Press, Cambridge, MA, pp. 175-182. Motifs A program that searches amino acid sequences for Bairoch, A. et al. (1997) Nucleic Acids Res. patterns that matched those defined in Prosite.  25: 217-221; Wisconsin Package Program Manual, version 9, page M51-59, Genetics Computer Group, Madison, WI.

[0328]

1 152 1 1525 DNA Homo sapiens misc_feature Incyte ID No LI418914.12001JAN12 1 atgagactcc atctcaaaac aaaagtaata acaaccacca taaaataata attaaaaata 60 agagccaagt cttgttttcc ggagaaattc cttacagaaa aaataagtaa tttgttccca 120 aattttcttg gttttataca cttataaatg agacaagagg actttcattc atcttttcag 180 ggcagtttga aagtcccctt aaaatattta tgccttgagg atttcgagaa attaaagtgt 240 ccagactatt cctagagcat aatatgtgtg atctcagaac ctaggatttt attctgcatt 300 ccatgagaat taaccggtat agaagaggaa tcgaggtaaa ctgtgaactg tgcttataat 360 ttctgatttg tccagctaag ctaaatgtta tttctttttt tccattgact ttgtacaagt 420 tgataagtta aatgttacat atgtaagttc ttatttctta gatgatcttt taaaattcca 480 ttgcttttct ttaattttag aaagagcgaa aaggaaagga tgagagaata ccaacgagaa 540 ctagaagaaa gagaagaaaa attaaaaaag aggccactgc tatttgaaag agttgctcag 600 aaaaatgcaa gaatggcagc agaaaagcat tattctaata ccctaaaagc actaggaata 660 tctgatgagt ttgtttcaaa gaaaggccaa agtggaaaag tacttgagta cttcaacaat 720 caagagacga aaagtgtcac tgaagacaaa gaaagcttta atgaagaaga aaaaatagaa 780 gaaagagaga atggggaaga aaattatttt attgatacca acagccagga ttcttacaag 840 gaaaaagatg aagccaatga ggaaagtgaa gaagagaaat ctgttgaaga atcacacttg 900 aatcatcaag gtctcctctc tatgcccttg ctgttgtttg cagcgtcagg gtgtcagcag 960 ccgcatttgt gtttagaaca tctgtgggga cgcttctgat atgtgcaggg ctgttgatca 1020 aagtcatctg tagcctgaaa agcctgaatc cagctgattg gtcatttgat cagttagagt 1080 aaggctttgc ctattcagtt ttaaaaatca ttgtgtatta tctgtttgca actatgattt 1140 tgtattttta aaaagtgaga accacagctg tcacaaactg attagttata aaaatataca 1200 ttatttcatt aattttactg gaaaaaaatg gcttagtatt gaaaggagag agaagtattg 1260 gtctttggtg gtttactttt tacaaaattt tggaaagtgt gaatcaataa ctatttttaa 1320 ttatactatt tgcccattct ttttctctgc agtgcacttt cacagaataa atcctctaac 1380 ttgttttgct gctctgcaga gaaaaagaat gggcaaatag tataattaaa aatagttatt 1440 gattcacact ttttctctgc agtgcatttc acagaataaa tcctctaact tgttttgctg 1500 ctctgagcca tgtttaaaag tatag 1525 2 748 DNA Homo sapiens misc_feature Incyte ID No LI246108.72001JAN12 2 ctactactac tactagattc gcggcccgtc gacggagata gaagtttcta aggaaaaata 60 tatctgcttc tatactattg gtgtgatgaa tgaggtatgt taaggatgag gtttaaagac 120 aattactttt aaaaatatta tgcatggtag atattgaact tatgacctat tctaataaat 180 tagagattgg atttcaatct gaatttggtt gtttttggca tgtccgtgta gaaaaacaat 240 tagcagaagt gtagcaaatt aattttctat gaatagttat aaatggttaa tatttctacc 300 agtttttaga gcgttttctt gaaaaatgca tggggataaa ttttttctct tgatatactt 360 tttctctcat agtctacatt tgttatgtat ttgtaaaaac tgttaggtta ctatacatta 420 aactagtagt atagaattac ttttcctggt tgtgtatgaa ctatattagt tttatcaagc 480 atttttttaa atacttcaaa agattttttt caagataatt ttttagtgag aacagtacag 540 acgactcact ttctattttt atgttgaaat gtgttttctt ttactgtgac tttgaaacat 600 acttaaccta aatatattct taaacttaag atttggattc atctatctgt gggatatcta 660 cctcctgcat attaatgagt aatgtgttgg tgataaatag aaaaaaaaaa tcactagatg 720 atttcagtag acattactat tgtcaaaa 748 3 1123 DNA Homo sapiens misc_feature Incyte ID No LI204262.22001JAN12 3 agaaaaatga ttagaaattg agaactattt tacgtgtttc taagttgttg gctacatcaa 60 agagatcatc tgtattctgc atatgggctg gctttggtga agctgatgac tggacttcta 120 agaaccgttt tcccaaatgg gttcccatat tcatgcaccc aaagcaatgg tccccaagca 180 ctgatgaaaa ctaatatgca tttcccaaag acccacacta tgtatcagga gcctgcacca 240 tgccatttga atgaccctca gcaatgtgcc tccctgccct caaattccca gttgataaca 300 gtgtttgatt aaatttccac tcaagccaaa catggttact aagaagagaa aaacctgatg 360 tttgcataat attttttttc ccctcgagat tccatctcaa aaaaaaaagg tgggtaaagg 420 gccatgagcc caaaccacta ggttgttcac cttttcatct gaaaatgctt tactctgact 480 atgtgctatt gggttttatt tccagaaaat atagttctcc ttttttctgc atgaaggata 540 catcgtggtg ccacatgctt taagcaattt aaacaagaga gataagagga aaatgcaacc 600 accacatctg acttgcccaa tgtagacttt cctctattag attgaagtac acaacctaat 660 atgatatatt attttgtagt atctcagact ttgtaaataa ataccattat ttttatatgg 720 aaattttata gaagagctat ttctgtatac gtaattactc ctgattttct gaaattgctt 780 ctggtagata acagacaagt cctaagcagt gttccactaa gggtggttcc aggcctgcct 840 gccgtggagt tgactggggg aattttacag ttttgcgatc ctaggatgcg tcccagacgc 900 tcagtcagaa gtgctggagg tggggcctgg gaagctgtat ttgtaatgaa ctctggtgtt 960 ttttgtccat taaagtgtat ctttgtccat cctataagat taaaggaaag aaaaagcatc 1020 tcaaatgagt gtaagttgtt cttgagaaaa aaatgtatca gacttttatg atttgaatga 1080 aatgtattat agaaaaaaat aaacacttta aaataaaaaa aaa 1123 4 1769 DNA Homo sapiens misc_feature Incyte ID No LI331661.12001JAN12 4 ggggtgcaga gacagggaga tgagagatga ttggggaagg agcgaggggg acggacaggc 60 acagagaaac agcgcgagga ggagagatcg agagagacgg ggcagaggtg gagagagatg 120 agagaccagc tgagaggctg cccgagagct tggggtgggg gaggggaaat ggatgaaaag 180 gcggaaaaag gactcgggag cggggaagag gtaaatggag atgtgggttg ggggcaagaa 240 tgggatgcag aggaaggaga ggaggatgaa ggagccagga tgcggggcag tggggagggg 300 gttgctatct gggcactggg tgaggggaga gcttgttccc ccaaggacgc ctgccaccag 360 gtgtccttgc cacaccttgt tccccaagga cacccaccaa acctgtgccc tggtgcgggg 420 gatagaactg acctttcaga ggctggaggc ccggggcaca ggcagccaag gccgcatcct 480 tttgggaaga actggagtga aggaagccac ttcagaggac gtagtgggtc cagctgactt 540 aggagtgggt cagcgccggg tggagaggag ggaggctagt tccctggtgg ggtagcctgg 600 caacattccc attccaccgc acctggccag ctgccatctt ggcagagcca gggggagatg 660 caccagggag tttggagtca ggaaggcaga gttgtgtggg ctgaagtctg cgggaacccc 720 agggtgacac aggcaagggg tagaagtcag agtggggacc aaaccataga ctggggccct 780 gggttctgca gaggtgtgga tggggcaggt ggcaggtgct ccagtggggg ccccaggtga 840 ggccctgatg gccctcctgg ggcaataaag acatcatggg aagggggctt tgtggtttgc 900 ctctgctctc gtcgggcgat ctggctttag ccttcaggag gaggtaagca gaggagatca 960 gtgcctgttt ctgaccccag gagggccttg ttgggctcca acctagagcc ttccggcttc 1020 aggtcccaag agaagtcccc ccctaactgt gaccccccta actgtgatca ggggtctgcc 1080 attgcccgct tttctctgcc tgatctgggg actcaggaga ggccacggca gccacagcct 1140 aggggtggtt cagtccctgg cccacagtct ggtcagttga gtccttctgg gaaccggggc 1200 tatgaaaact ttcgtctttg gggaccggta cccatgaagg aaaactttcc tgagggggtg 1260 aggaccaaag aatcaagatc cttttcaggc ctgatagcca agatgatgag aacttttaga 1320 taaggctgtg gggagagtcc ctggcctttt gagcatcctg cttgggcaca cggggaataa 1380 cctttctcca gcttccagtg tgaactgaga aagagaaagg gaaaccctgt ctttggagaa 1440 gctgggatct tcccagcacc agaaacttct gcaggcccct gcctggccca cggctaacct 1500 ttgggtggga ctggagtttc ctgaacaggg aacaagggag ccttccgcag agctctgatg 1560 ggcaggcctc cgagggcctg tgctgtgtgc tgttaggata gcttggtgtt gtctataccc 1620 cattagtaag ttttgtctga gtgtgtcctc gctgttcatt gtctaatttg gtaacattta 1680 ttttggtcct gaccccttct gctgctgctg ggtttaagct tcagtgcagg tggaatgaca 1740 ttcaaataaa gaaacacttt ctatcaccc 1769 5 663 DNA Homo sapiens misc_feature Incyte ID No LI335074.12001JAN12 5 acaaaatatg ttacaaaatc tgtgaggaaa aatacaagac tgataaaaat atatcaaaga 60 agagctaaat aaatgaagag atagtctgtt catgaggaaa actcagtatt atcatgatgt 120 cagtcctctg cttgatttac agattcaaca caatctcaat cacagtctca ggggctaagt 180 gtggtggttt atgcctataa tccagcactt tgggaggctg aggcaggagg atcgcttaag 240 cccaggagtt taagaccagc ctaggcaaca tagtgagacc ccatatctac aaaaaatttt 300 ttttgttagc taggcctggt ggcatgtgcc tatattccca gctatttggg aggctgaggt 360 gggaggactg cttgagccta ggagtctgag gtttcagtaa gttatgatca tgccactgta 420 ttccagcctg gctgacagag caagaccctg tctctaaaaa acgaaaaaaa ctcagcaggt 480 tattctgtgg atattagcaa actgattgta atgtttataa ggagaggtaa aagacccaga 540 atagtcaact caatattgaa agagaagagc aaggttggag gacccatagt acccaatttc 600 agtactttta ctataaagcc acagtaatca aggcagtgtg gtattggtca aaaaacagaa 660 aaa 663 6 758 DNA Homo sapiens misc_feature Incyte ID No LI154608.12001JAN12 6 agctaacttc agagtagtaa ttacacaata ggaatagtta gacattttat acttttttcc 60 cagaatattt tatgtataaa ttttggaaga aattaatcag atgttaaaat tggaaaccag 120 gcttaagatg gggcttagta ttatttaaaa ttagttgcta ggttatatag gcttattctc 180 attaagtttg aagatggtat ataaagttat atcacttctg ttttggcacc aaaaaaaggt 240 agacttatat atcacaaaat ttatacaata taaactgtat tatttaacca aaataatgta 300 acttaaaata agtcaaacat tttaaaatga aattgatatc ttattttgat ttacagttag 360 aatcttgagg tgttgcgtat gagaaatgaa tttattttac ttatttatag aaatgaggtc 420 ttgctcagtc aaccaggctg gagtgctgtg gcaccatctt agctcattgc aacctagaat 480 tcctggcctc anacaatcct cctgcctcga cctcccaagt agctgggatt acaggtgtga 540 gccaccatgc ctgactcaga aacttattta ttttctttca gttttcaaat tttaaacaat 600 gacttactta atattatgaa tagataccag tcatctcatt taataatttg tcttaataaa 660 tgtgatgggt ttgaatatta agaagatgaa ccattagcca ggaattctaa ttttatgttg 720 ctaagagatt ttaaaacttt accaatcttt taattaat 758 7 719 DNA Homo sapiens misc_feature Incyte ID No LI462889.12001JAN12 7 ggcggcggcc gaggcggcgt cgttatttcc gtggtccgga cagtgcgtgg cggcgcgggt 60 gaccacggga gaagtaggca taatggttat gaaagcttct gtagatgatg acgattcagg 120 atgggagctc agtatgccag aaaaaatgga gaaaagcaat acaaactggg tggacattac 180 ccaagatttt gaagaagctt gtcgagaatt aaagttggga gaactacttc atgataagct 240 atttggtctt tttgaagcca tgtctgctat tgaaatgatg gatcccaaga tggatgctgg 300 catgattgga aaccaagtta atcgaaaagt tctcaatttt gaacaagcta tcaaggatgg 360 cactattaaa attaaagatc tcaccttgcc tgaactgata gggattatgg atacatgttt 420 ttgctgtttg ataacgtggt tagaaggcca ttcactggca cagacagtat ttacgtgcct 480 ttacattcat aatccagact ttatagaaga tcctgctatg aaggcttttg ctctgggaat 540 cttgaaaatc tgtgacattg caagggaaaa agtaaataaa gctgctgttt ttgaagagga 600 agattttcag tcaatgactt atggatttaa aatggctaac agtgtgacag atcttcgagt 660 tacaggcatg ctaaaagatg tgggggatga catgcaaaga agagtaaaga gtactcgaa 719 8 2333 DNA Homo sapiens misc_feature Incyte ID No LI236680.22001JAN12 8 agcttttgaa gtggagatat gatagttctt gccgactgat acttttcggg cgcatgcatt 60 ttatgaaata ataggtatgt atctgcctca ttcttttagg ctatgtgttt ctctagattt 120 caacataatg tcccaatgaa ggtctatctg tatctatgca atccctaaat ttgtatttac 180 cttatgtggc gtatgatttt aaatgtgtgt atggaggctt atatttggat ccttgtagat 240 cggagagtgt tccatcatct agctactctg tttatatgcc acacagaaac taattatcac 300 atccatgtta ttaatcataa gattagttgt tgccactgtc tcccctctgc tgcctccaat 360 ataatcctcc gagcatacaa tatccttatt gggtgaactt gactgcagca aagacacagg 420 ggctactgtg ctgcacttta tgaaggcttg cggtgctgtc cacatgaacg acacatacat 480 gtttgcctgt gaaacagact tcattgcaca ttcctttttg ggtcgtgctg agccagagtt 540 cgcaggaggg tatgagcgaa gagaaaggca tgcaaagaca atagatatag ctcaagaaga 600 agttctgacc tgcttgggaa ttcatcttta tgaaagactg catcgaatct ggcagaagct 660 acgggcagaa gagcagacat ggcaagatgc ttttctatct tggtgttgat gctttacgca 720 agagttttga gatgaccgtg gaaaaagtac agggtattag cagattggaa caactttgtg 780 aggaattttc agaagaggaa cgagtaagag aactcaagca agaaaagaaa acgccaaaaa 840 cggaagaata gacgaaaaaa taagtgtgtg tgtgatattc catactccct tacaaaacag 900 cagatgacaa aggcacagta agccaagaga aggaaacaga cttcatagaa aatagcagct 960 gcaaagcctg gtggcagcac tgaagatggt aatacttgtg tagaagtaat tgttaccaca 1020 tgaaaataca tcatgtaccc ngtcctagca ggtggcaatc ttttggggtc ccctaaaata 1080 aagaaaggct tatctccaca ctgtaatggt agtgattgtg gatattcatg ctagcatgga 1140 agggagtgaa acaggttctc gggagggttc ggatgttgcc tgcactgaag gcatttgtaa 1200 tcatgatgaa cacggtgatg actcttgtgt tcatcactgt gaagacaaac gaggatgact 1260 ggtgatagct gtgtcccgga atgttgggca aattctgaag agaacgacac aaaaggaaaa 1320 aataaaaaga atgaaaaaga aaagcaagat tactgaaatg tgattgaaca tatcccagaa 1380 gcttgggaag ctgtattaca gatcccaggt aatcgaggag acctcaggga aataaccatg 1440 cacacagtgt ttcacccgtg acaaagacca aaggatacac atcctgaaag ctgttgcaag 1500 ctcctgaaaa ggggtgggca agccattgcc tttggtttga gccataggga aaaattgtac 1560 caccagtttt gccagaacct acagaaacgt tgtttggtcc cgattccgga aaatggtgcc 1620 aagagcttat gttgacctcc ttgatgagtc tgaatgtaac ttcagatgga gggaaatctt 1680 tatctcacaa gatggaaatt acagtcattt tatgggctta ataaaccagt cttttctaac 1740 aggcaataga gaacaatacc gacagcatct gaaggagaaa tttaataaat actgccggtt 1800 aaatgatcac aagggggccc atttgtagtg gctgggttga caacggctgg gaagcaaatt 1860 aaataaataa aaatagctct gtcttttcaa tgaaacactc acgatagact actggcgcct 1920 tctcctttcg aaaaactctt cattcatgtg acttatggtg aaattttatc ttaaatcaat 1980 gtggattctt tcttgtccta gggagacggg tggaggtatc ctcattagtt gcttgacttc 2040 aggcttgtgg tccttaagtt tgcgtggctg acgcgagagc ctgccatatg atgtaagcca 2100 tctcttttca ttaaatgttt ctccttcctg tggaggactt actaaaagca actttagtgg 2160 gcaaaaaagt aatgtgagta cttataattc tgtacagaaa tgacaatgag ctgaatatat 2220 ggttttacaa agtagacatc ccacttggca aaatgtttgg atgtaatgtt aaagcgcaat 2280 gtgcaaaatt taaaataaag aatatttatt aatacgcaca gtaaaaaaaa aaa 2333 9 5012 DNA Homo sapiens misc_feature Incyte ID No LI228186.12001JAN12 9 ttgtggtgta ttcaatttct cctctctcca cccctgcccc catctgtggc catctaagtt 60 agcaatacaa tttattttgg ccatttaaaa tttttctgcc tttgttttat ttcttcccaa 120 atatatttga aaatgaatga tctatatagc tgattttctg accacatata taattgcaat 180 ttttatttgc tcttcaaact attacaacat ttttgtcctt ataaggtttt ttgggcagat 240 aatgcgaggt ctgtggtgtt accttttata tactcctatt accttatgtt tgtgaagcat 300 tttacatttt acagagcact ttgattcatc tccctatttg ttcatttatt taactgttca 360 gttcactgaa atatttattg aacacctact ggcaaccaag tgactgtgct agtaacttgt 420 gatatacacg tagtgagagt ccaggcatgt aaccgatcat tataactaca ataacatccc 480 taaaccagac tttacaagta gataggatca acaatactct atcaattttc aactccaatt 540 ttctattcta cttaacatgg gaactagaaa ctgtttgcct gaagaatgtg tctgaaacat 600 aatatatcac tgcatgtctg tgctgtagac ctgttaattt tatctgtgga gaaaaaaagt 660 tactcaaaat tctccctgac ctaataatac tttctagttc actgcagtct tactgaccag 720 atgcaacagt tgaagtttga tttctcgacc caatatttct attgggtttt gaattattaa 780 tatcactgtt ttgaggtatt cagaaacacc agtgtatcaa aaaagcattt gcactttagg 840 tgtgtgtggt ggttatgtca tttattagac catcccagac ataagacaat cagggaaatc 900 agaaaactcc agcctcaaat gtgtctataa tttcctgttc tacccattgt catatcataa 960 caatggtatt acttcttaag gttttgatta agttgatcta gcctcaactt aaattgtaat 1020 acatctgcct aattattgtc tggaataact tttccaacca tcccaatgcc cactgctctc 1080 cacaatgatt attgtagaga agtaaaatgg taattattca agtaaagtca cataatttct 1140 ggagtcagtt tttcataaca agtttatgga atacatcatc attggcttct tcataatata 1200 tttattatga gtgaccagat tttgccctgg aggagcaaaa tgctcaaaac ttgttattat 1260 aggttaattt ccagctcact gttgacactg aaagattctg tgttacttta aacccaggga 1320 taaaaggctg gaaaaaaaaa aattaaatgt aagtcataaa ctagtactca gcttttccta 1380 gtttctaagg cttattaaca tttgcaaatt actccaataa atgtctttca taatggaata 1440 acataaaagc ttttgatttg ggcagatagt gatattttat ttattttcat tctggttgaa 1500 aaaaatctca gtggcttctc ttcattccac gagaaatttt tgatttttaa cagcagtctc 1560 tctttttctc agcattgcaa atatatatgt atatatacat tcatgaccaa agtatcgctt 1620 actgaccatg cagctgtaaa ccttctgtgc ctatcaaaca aatacatagc atgaaactaa 1680 ttttagaagt ttcatggggg aattttaggg gaaagtataa acctaagagt gagtgaatgg 1740 agatgattca tggaaaaaaa aataaaaatc taaatgtgct attaggcaga gttattaact 1800 tcttttagtt gttgtttgag atagagttct gctcttgtta cccaggctgg agtgcaatgg 1860 cgtgatctcg tctcactgca acctccgcct cccaggttca agcgattctc ctgcctcagc 1920 cgcccaagta gctgggatta caggcatatg ccactacagc cggctaattt tgtattttta 1980 gtagagacgg ggtttctcca tgctggtcag gctggtcccc agctcccgac ctcaggtgat 2040 ccgcccacct ccgcctccca aagtgctgga attacaggcc tgagccaccg tgcctggccg 2100 agttattaac ttcttaagag caatgtgcta ataaatattc attgatgacc agctcaaatt 2160 taggtcattc agacatccag acactgcggc acatattctg caagcaatgc tgagacccct 2220 gacatagaga aagcaaagga tatgcctatg attagtctaa aatgcagcca tcacccccca 2280 tacctcttct atggcattca tcctaacatc atggaggcct ttgtcctaca gaattatgtg 2340 acttgcacta gagaattagg tgaatgacca aaaagagact ttccatttat cttcctttga 2400 cttaaaaggc atgaaaataa ggcaaaaaaa tcaataaaat aattttcctg aggaaaggtt 2460 aagagatggc actttccttt ccgggcccag agctggattt ctctgaggtt ttgaccatct 2520 caggactcag acagactcca gtgctatttt ctggacattt gtggtgaagc ctcagcccac 2580 catgttcaag gtggtttgaa tgaaaacata ctcagattgt cacatttata gcacgggaat 2640 attacgcact cagaattagt cattcctggc agcatggcta cctctgtaga taacattagg 2700 caacatcaga gcttcacttg caaaagaaat gttaacaatc attttaggga aatcacgtga 2760 agtctcttta gaaatcagat catcttgtgt attggcgtaa ctccatgtct ctggggcccc 2820 tcatcggaga cagacgtggg gtaatgtctt ttcacttgat tggtcacaca acacaatctc 2880 gtcatcttgc ctgatttgta agcactttca tacagtgcct gggagagtac attacttctt 2940 caggggcaaa aaatggagag acgtcttttt tatatgccag ctgggatcat gggaacttcg 3000 aatgccagga atttactact gtttctggta attctgtgtg tagtcatttg aaactgttga 3060 acgtgtgaaa agagaacgaa attgggcacg tcttgcggcg ggggaggggg gagggggggg 3120 cggtggcttt ccagatttta tgccagttgc atcagcatgc agaatatttg taatgcattt 3180 caaagtggat ataatggcac ccctttgttc agaatcacaa agctcactgc ggcactgcta 3240 caagaggaca ctgaggaaaa tctggcccta tgaacctagt caaccccaag caaaaagaat 3300 gactatgtgt gtgagtgcag cacatggcca gttcgtttct cactgttttg gaaagccctg 3360 tgtgccaaac caaggacgtg tctttcaggg aaaggttaat tttccgaagt ttattaaaat 3420 agaacttgga aaaccaagca ttttgaattt attccagtcc tctgggcatc attcctattt 3480 cttctgccat gtcaaggaga aattccaagc cgtgcattct gtccatgcta agaataacca 3540 gcccatactt ctcggtgacc ttctgttgaa cgtacctgag cctgcaaatg taaaaatgat 3600 ggtatctgaa tttgcactaa tggtgtctga gagccaaaaa gagtgtgacc tctattggaa 3660 acctttgttc aaattcaata attcagagat gctacatact tctgcaagct tcctgattat 3720 gttcactgta atattaatga cctaagtttg aatgtatttc cttacagtcc attaatttga 3780 catccatctt ttacctgggg attattacaa ttgcaataag tcattaatgt tttcttcaca 3840 caggcttctt aaaccaagtt tctctgcagc tctttcggtt ctgcttacag tgtgtgggaa 3900 atctgatttt ttttccccta gtaatagttt gataagaaat ttagtgtatt gactgccctc 3960 agtgacacaa tttatcttta aaggtgtggg aagctggtgg ggaccaaatg ttacctgtgt 4020 ttttggctgt tgattgctat tttcagaagc aaaccatgtt tttcacttac agtaggaggt 4080 tccnaacaaa tttggggatt ttagaagggg gaggagggag ctattatgtg taagactgca 4140 tgtcatattt gactacatta ttaaaaacag gtaaatgagc attttgtttt taatttctta 4200 aataacctgt ctttcaacat acgttttgtt tcctttcttc cattagtgtt caaaaggttc 4260 tacccattgt ggaagaaatt ctgtgtgcag aattcagagg cacaaggctg atggcaagat 4320 agaaagttat tttggttctt aaacccaccc cgattgtgga aactgatact agctagaggg 4380 agctgtagaa aacaaagatt tcaggattgc acagtgtgtg ggcaatggga tggacgactt 4440 tttcccctat tcccacgcca cagtgcccaa gcgttcaagt ccccctggat cagacagatg 4500 ggattttagc tgctgcttta aatcctagtg ctggaataag tcaaggtact tcagttcagc 4560 tcttgcctct gtcactaatc ttgctttatg aactcctttg attttctgaa taagttccag 4620 aaggttctcc attattccgt ccttcttcca aactgggaaa tggctgtatc ctaattcctc 4680 aggatatttt tggatgtgtg ccctcaggta atttatgtgg aatgtgtaaa gacaagatgt 4740 ctcccaattc ctgaatattc cttccccttt tcccaatcct ccactcttgg actaccttta 4800 taacaacacc gagtacgcac agacctgaac ccatgcccaa gaagcacaca caatgactgg 4860 agctgtcggg aattcctgtc agtggcattc cctgagcact ggctctgtac aactcaatta 4920 taatttttta agaatcatac ctctgtatag atcttttgga ctgtactgat taaactttga 4980 tattgtggag taaattcaga agtgcaattt ta 5012 10 652 DNA Homo sapiens misc_feature Incyte ID No LI721233.12001JAN12 10 gtcaaccaac ctcgtcgatc cggttgcgac gcggtgtgct agaataacta ccgaccatgg 60 atggaggagg agatcaccga aggcttgaag aacctcaccg tcaccggaga cgcggcggct 120 tcgggcggag aagggcagag gaggggcggc ggcatcagca gcaaccgcat ccaggtgtcc 180 aacaccaaga agcccctctt cttctacgta aacctcgcca agaggtatat gcagcagcac 240 ggcgatgtgg agctatccgc tcttggaatg gccatagcga cagttgtgac cgtcgcagaa 300 attctgaaga ataatggatt tgctgttgaa aagaagatca ggacatctac tgttgacata 360 aacgacgaat cacgagggcg tccattccaa aaggccaaga ttgagataat cttgggaaag 420 agcgacagat tcgatgagtt gatggctgct gctgccgaag agaggggaga agttgaagaa 480 ggcgaagagc aggcttgaaa gaaaaaaaaa acagtaccga cgacaagcgg ctgttgttgt 540 ggtctgttag ttttgcttaa tttaatgcca tgcgcatgag agctggcatg cgttctcgct 600 catctacatc gccatggcaa tgtctggcaa actcatggat ttgatggatg ga 652 11 1270 DNA Homo sapiens misc_feature Incyte ID No LI291759.22001JAN12 11 gtaccttggt gatcatctcc agcctaaatt tcatcatccc ttctatggta ttcccaacaa 60 attatcatcc aacctatact taaaaacata tggtgagcca ctgcacccgg ccctgaaatt 120 tttttaaggt gaaaaatgtt ttgacaagtt ccctttttca gaataggttt ttgagcagaa 180 cttctttcag cttgttagac ccaactttgc ttttgtttag cttcacagca ttagctgaaa 240 gttgccaaac tggacattgt gcaataaagt agaattctat attgataagc aaactaattt 300 ccaaactaaa aatgtgatag ataaaagtgt gattaatcaa atgatatgat cagagtaaag 360 aattttgcca ttttgatcct tttactttgc ttttaagcca cctttatagt gttacccaac 420 ccatctttat ccttgtctgc aggggataat aatgaactaa tgtagtgttt taagataatt 480 taatggatac tatcccttcc caaactttgg ttagattttc ttgaaatccc cgaacatgtc 540 gtccttaatg acaaatcact gctattagac aattgaagtg ttcatttact ttgtaattcc 600 aataatcata gttatggaat tatgggaagg gtttggtttt tctgtcctaa taaatatggt 660 atattttttg agatggagtt ttgctcttgt tgctgaggct ggagtgaagt ggcatggtct 720 cggctcactg caacctccgt ctcttaggtt caagcaattc tcctgcctca gcctcccaaa 780 atgctgggat tacaggcttg agccactgct cccggctgat ttttgtatta gtggagacga 840 cagggtttca ccatgttggc cagggctggt ctcgaactcc tgaccacagg taatcagccc 900 gcctcggcct cccaaagtgc tgggattgca ggcgtgagcc acttagtatt ttgtaaccat 960 aagagaaagt atattttaac agcattacat tttcatgcca atttgacaag ttttggccaa 1020 ttttaataag aaactaagct ttatgtaatg taacaccgta atttatgaat ttgttcattg 1080 tcactgcctt tattcatgaa actgtcaaat agagtgtctt tcaagggttg caggatctta 1140 gagatagaaa gtaccttgag tgatcatctc cagcctaaat ttcatcatcc ccttctatgg 1200 tattcccaac aaattatcat ccaacctata cttaaaaaca tatggtggcc gggcatggtg 1260 gctcacgcct 1270 12 363 DNA Homo sapiens misc_feature Incyte ID No LI292613.172001JAN12 12 ctcaaggcca cagagctagt aagtggtgga accagatgtt gaacctgagt agtttgaata 60 acaaaaatca catttaattt attgttttgg ttgtttttta aggtaagaaa tctcaccgct 120 ttgttaccag ttcaggcagt aaaacatgta gaccgttagg agaaaaagag tcttacatag 180 agttttatga gcaattgtaa tgtaaaatat tgtcccatac ttttaagttt ttctgattaa 240 acttacatat ttttccccta acccacagga atatcgaaaa cagaaaaaaa agtgaaattg 300 gaagacaaaa gctcaacagc atttggtaag agaaaagaaa aagatnagga aagaagagag 360 aag 363 13 563 DNA Homo sapiens misc_feature Incyte ID No LI412959.152001JAN12 13 tccgtctcca aaaaataaaa taaaattgct tctacaacaa ccacatacgt tagaggtaat 60 tctctatgtg ataaagtata ataaaaactt tttaaaatgt gctgcatttg gcctgttata 120 tgccacagag tttgaatttc taatattctt tctatggttt agttgtggtt gaggatagtg 180 cagataacta ctctgtgagg tacaacactg tcttaatagc tcttggagtt ttaaaggaaa 240 accaaattta cttttggttt ccagataata taagcaagga aaactgtgtt ttcagaagct 300 cactggattg gcatagtttg tggtgttttc tatcccagtt ctttggcttt tactaaaaat 360 ggacgcctgg caaccaagta agttcttcct tttccttctt ttttcttttc ttttcttttc 420 tttttttttt tttttttagg ttaataaact ctctttcttc tttagctgtc tatgatatat 480 ttgaatcaaa atgtggtagt ttggtatttc agatagctaa cttttaactt ttttgctctc 540 tacattatag atctagaaag gca 563 14 2419 DNA Homo sapiens misc_feature Incyte ID No LI482512.32001JAN12 14 aagactccat ttcaaaaaaa aaaaaaaaaa tccactcata taaaagggtg agctcagctc 60 actgggttcc atttctcagt ggctttctcc atcctcattt gcaaacctca gagggataag 120 gcagttgaac ctgatgagca agatttataa cagcaaggga aacatttaat gcttagaatt 180 ctgagatcca gcacaagctc agtctgctgg gtagctcagc tcgctgccca ggaataggtt 240 atgacctatg ttctgccttt aggctggctg gggagatgcc cattctcaca gtttccagaa 300 agcaggcaag ggcaaaggtc aagacctgtg gtatttgggg tctttttggg tctgaaggat 360 ccctggaacc actgattttg gtttattccc tccagggtct aaagagaaca aacaggtgct 420 aggctcttac caaaacagat ggtagagaga gttgctggct atttaaaaag ctctttcatc 480 ttttaattca cctcttcttt tcacctcttt aaccactcct caggaacaga acacttctag 540 gactgggggt cttttagctc cataagcaag tgagcagatg ggacaagtta gtcttttctc 600 cctcgataca aaaggggatg ccccagtggt ttccctttgc ttcccaaccc taaaatttca 660 agtttaattt aaaatacgcc aatttacgct agaagtgacc aaattgggag ataattatca 720 agtcatgagg gaaagacaca agatttccgg tcattaaaga atgttaaagg gcgctataag 780 taggaaactt tctataacct aaatgatgtt ataagaatta tttttgagca ggagcaggaa 840 aggatgtaaa ttagtgatca cttcatactt ctaaatcaga aataggaaga ttaaaaccac 900 agaacagttt gtggatttct aattgctgta gctaaggtat cttactctgt ccactcttgt 960 tccaagtatc taactcttct gggaaaccaa ataggcttta gaaagagatt atcctatatt 1020 cctatcagta taatactaaa atgtaacttt ttaatcatct ggtttttaaa agataaacag 1080 tttagcccat ctctcccaga gaggcaaaca tagggaatat gacttcagga gcctcctaag 1140 ggctttattc attcaggccc ttcacacccg gtttccccct ccaacccaca ggccttttgc 1200 ttccaggtgg gcagggatta ctacgtttgg cctcttcagg caggcatcta ctctagggca 1260 tattgatcat tttagacact gggagaagag aacctcaaac tagggaggaa aagacagagc 1320 ctccacttag ttttgggagg ggatggcaga cagttcaagg agcatgagcg tccttaaggc 1380 atgttggcga tagggtcaga tgcaccaccc ataggagagg tttgtcaaca caaagacatg 1440 ggaaggttca gaggtttgtc aaccaaaaag accatggaag gttaggtttg tcaacacaac 1500 agacatggaa gatttagagg tttgtcaaca caaagacaca ggaagaatgg gctggcgaaa 1560 aatttagatg ttttcccatt tgggcacatt ttacttagct ggagaactag gtttaaaaca 1620 gcctgggtag gaaaattaga agcaagctgg atgcagtggc tcatgcctgt aatcccaaca 1680 cttttgggag gtccaggcag gaggatcact tgggcccagg aggtcaagcc tgcagcgagc 1740 tgagatcaca ccactgcact ccagcctggg gtgatagaac aagaccctgt ctcaaaaaaa 1800 aaaaaaaaac aacaaaaact taaaattggg ggagttgtcc ccccatgggt ttcctcactc 1860 caaaatgggg gcggatcttt cctattccta ttcttggcca ccttttgggt tgttggggtt 1920 caccagcctg tttagccaag tagctttggg cataggctgc ccaatctgag caaacaccag 1980 tgaggctcta ttgagcccaa gacccaagtc cttcaaagca cctgaaccac tgtggccttc 2040 tcagcctaca gccagtgtgg tctcttacat ggccacaaac gggacacaca gtgacaaaaa 2100 ggctcggaat gttacaatgg taaaaatgag tgatctccaa atccactgac agatataaaa 2160 ataggcttta gagaggaaaa gctgcctctg gtcaagtatg atcatggcag catggaattt 2220 ccaactcact tttttacaac tctcaacttc tatgtttaat catttgttac tatcacatta 2280 tttaacaaac ctagccagag gcattttttt aaatcaggcc ccaatatcag tattcttttt 2340 gtgtgtgccg aattttgtta tcacattttc tatgaagttg aaaaataaag ttaattttga 2400 ccaaaaaaaa aaaaaaagg 2419 15 996 DNA Homo sapiens misc_feature Incyte ID No LI413231.62001JAN12 15 gtcaatgaaa taccattgtc attttgtagt ttagaagggc ctgataggct gggatcaaag 60 aggtgggtag cctgtgaagt tagaggtaat gggggaaata gtagagctaa agggtaagaa 120 gttgaggtta aagaatggat tttggaattt gaagatttcg aggtgcagct gctccaggtt 180 cagttaatac tttctagatg ttgtacaaga cccatgatat tcctgttggt agaggacggt 240 ggagagtata taacgtggcc aaataataga gcttcttgaa aagtatttta gcccctccac 300 ttcatttaat ttcactcatt aaatgagacc cagatgaaat gaaaggccta gaatttaagt 360 acttgcatga gatcaaagaa ctatttagca tttgaaccaa gattaggcca cagttaaagt 420 tttgtaactg gaaggcaggg aatttttagt tgaacactga aactttgctt catacattcc 480 tgtctaagat gttatacatt gttcaatttg aaaacacttc tgtttcaaca gcctcaaaga 540 gttgctgaga gctaaattaa ttgaatgtcg gctggaagga tcagttgaag gcactctgta 600 aaggtaatca gtttcatttg gaagataaac taatcccatt tttctgatca ggattggttt 660 gggggcttgc ttatttttaa ggtatacttg agtattcaag catgatttta aacaatatat 720 ggaatctaat ctggtaatgg tttcctcttg gtggcatatg tagacctaat tcccacaatt 780 tattagaaat tttctgtttc tgttaagcgt gagcacttaa gattttctct ggcatcagaa 840 tatggaatct catgtctttc agcaacttta ttgtttctta tgttttaact taaatggaac 900 actttagggt tggcagactt atagaaatta tctctttcct gtctttaaca gtgaatattt 960 gaaaaattca tctatgaaag ctcttagaat gcactt 996 16 1242 DNA Homo sapiens misc_feature Incyte ID No LI203383.12001JAN12 16 acaaaacctt ctcagatatt ttgttgaacg tgggaccttt gttttttttt gttgttttgt 60 tttgttttgt ttttgttgta gttgttgttg ttgtttacca gcaggggacc cctgttttgt 120 ctatgtcaag aacaaagacc aggcaaaaga aatgtcaagc cgcatttaca aatgcaaaaa 180 tggacttgtt tttgatatgc ttttcccaac aataagggac atgagtcatt ggggcatgtt 240 acagagagtt tcagtaaaat tcagaaaaaa ataataaata tgaacagcca cagcatgccc 300 agaagccttt ttatggagcc aggcatggtt gacctgcttt ccatgtctca aaacattagt 360 ccctacaaga accctatgag gtttatcttc ttttcaccca ttttgagaga agaaaagttc 420 agctcagaga gctgcaggaa cattggggac atctccaagt cacagccaat aggtggcagt 480 catcagtgtg tcttggaagg gacaaacatt gagcttctga acagctactc cagaaactat 540 ggtgctgtgg tgaagtcctg gttaggagcc taggaaaatg gtgaaggaaa agatggtccc 600 agcctgcaaa gctgaagtca ggaacccacc aggatctccc ttctccctag cctggtggtc 660 cacatcatgc agatttactc tagattcagc ttagactcat ttttatacta ctcgggggac 720 aaggagggaa ctacagtcag taacagcagc atgagcctca ggtgctttgg ggattgaaat 780 tcagaccagg aaattccaat acatcagtgc atgtggagga catgagtatt taaggagaag 840 gttctaggct tccgaagtaa aattggatgt ggaggttggg gattgattca aacattaata 900 ctttcaagcg tttctatggt atttgtcagc tgtggagcaa cagcacacat ctgtattaat 960 agcctgtgtt aagagattac tgtgaatcct gaaaaacatc ctcattgtag agatgagaaa 1020 acacaggctt ttgcacatcc aatgtctcct taaagcatgt ggttcagaat tgagaacgtg 1080 cagagtgaga gtggtatgaa ttttcctgta agctacctga agttctgttt gctgtcatgt 1140 ggaagaaaag agccttggag aagttttatt tttttctgtt tggaaagaat acacagagca 1200 agatgattta caataaacct tttgacctaa cgcaaaaaaa aa 1242 17 577 DNA Homo sapiens misc_feature Incyte ID No LI133186.42001JAN12 17 ctggaaggca atttcttggg catttaccca tgccagaagg ctaacctggg gggagggggg 60 cgcttgtgct ggtgaggcac ttggatacat actgatgctg cctttcctaa ctgcatgtat 120 tttttccttt ttggaaaggt ggtagagact cagaagcttt ccttgttttc ttcaggcctg 180 ctcccagttt tcttaacagt ttcttttgtt gctttctctc tcccttgttg ctttccatgg 240 cagtaatcct cctagagtcc aagcagtctg ttgtatggag cagggtgtgt gggttttctg 300 ggcccatcat tatggctgct tcagagtcag aagaaagcca tagggcagta ggggagctcc 360 tattgcctag cccctctccc tttgtggctc ccactctagc tgcctatttt tgctcatcag 420 ctggtgagtc agtatgggcc agcagttctc cctccctaag cccttgctac tttatgggtt 480 agctttgcac ggttggtggc ttgaggggtg ggggcaactc accactgcca ggtaactccc 540 tgaagggtgg gagtggatta tcttctaggc tcttacc 577 18 1349 DNA Homo sapiens misc_feature Incyte ID No LI238576.22001JAN12 18 cagccaatag ccattgtgcg aaggcaggac tgcactaacc ttttcccgcc cctacccttt 60 gggccaatcc tttcttttga attctttgtg actggcaggc attcagacca atagtgatta 120 ggaaaccttg aagcctgccc aacgatcgtg ggcaggtagg tggtttctgg tttgttgggg 180 cgtgtgtatg tgtatttagg gggactgaag ggtacgtggg gccgaaacaa aaccggccat 240 ggcatgcagc ggaggaggag gacgggggcc ccgaaaggcc aaaattcgcg agcggggcgg 300 ggcagggcgc gacccttcga atgtagatat atgttttgga gactggtcgg ggaagctgtg 360 gctcagtgtg tgtgggccac ctgtactgtt ggccatgttc ttcatcagtg gctgggagac 420 cacggccaga acggcaagag tgtccaagta tgtaaaagct ggtatcatgc atgagagaag 480 ggtgtcccgc tttatgggcg agggagccag aagccccagg atctcatatt aaaaactcca 540 ccccgccccc aaggggccag aggacccnag ctacctggag agcaggaggg gggattccag 600 ccatttggtg ataccggggg cttccacttg ctcatttggt gttggtgctt ttcccttttg 660 gctttttcat caccgtcttt caatgcccat ggagcctttc cgcccggggt acaaggtgtg 720 gatctgggac aggggtcacc cagcctccag ctgggcagga ttccctcttt cctgtttctc 780 gccatcgttc ttcttgtttt tggctgctca gtaatttgag ctatgtctgc ttcctgtgcc 840 acctcccagc cagagaagaa ttcagtattt gaagggtccc tggctgacac cttccggtac 900 tcctgggacc cccttgaacc cctctaattt ctgttgggct aaaggccaag ccctgtgaca 960 tttgtccacg gaaggccctg gcgggaggaa ggagtgaagt ctgtgcacta tgatgggaga 1020 cgccttctgg ctcagaggct cacttcagtt aacgttgttt aaattcttct tgcccctggg 1080 ggaaggagga tggattgaga cgaatgtctt tcttcctctc ttaagtgctt tgctttcccg 1140 tgatttcttg aatttgatct ttcaaaggtg ggcaaaggnt ccctctgagc tcttccccca 1200 cctccccatc ttatctgaat ttaaatttaa ttgtttcact ccccagagtt taatatggag 1260 ttctgactct taaggggttc cgccccctca ctacctcctt taatacaaaa ttcaataaac 1320 acaggtgaaa tattaaaaaa aaaaaaagg 1349 19 7431 DNA Homo sapiens misc_feature Incyte ID No LI903914.32001JAN12 19 ggggtggaaa agaaacctca aataagaaaa ataattacaa taagaaatgg attttctttt 60 ttcccacaac agttatacat tataaagaac agactgtcgt agaaaactgt ctttgcttcc 120 aaatcagcag aggaccattg tatgtattgt caggtcttta tataagagtg aaacctttat 180 ttatgcttct tgtgagtaga gaataaattt taaaactaat tagatgaaat taagaacaga 240 gtattggaac atctctgtgt tttccggaat gtttactcag gtccatgaat gctgtgatgc 300 tgggaactta gggaagattc accaaaattt gagagtgata aaaatggcct aaagtgggaa 360 atggtgagca ctcttattat tagtgagatt ggtcaatcag cccatttgaa atgggtaaaa 420 aatactttca gtaaaataat tacatattat atataaaata tttcttttat tgagggcagc 480 tactgagtga taaaagcata gtagaaatca ctttggttaa aagtaactca aatttttctc 540 ttaagtaatc taccaacttc ctgatgtttt tctttaatat tttggaactg ttcaagacag 600 aatggagcct acatatatgg tgttccacta gtatgttgaa aatgtcatat catggagaat 660 ggagacacct tccaggtgtc tgttaaaccc atcttctctg tgtacttctg gcatcttttt 720 taggtaggat catttggcag gaggtagagt acctgtactt ttggcaccat tgaaaccagc 780 tctggcccac ttgtttgaat agctatcaga ctcagcgtct ctatatgctt tatatacagt 840 tgagagaacc agtgtttaat gctcttgaaa ttgtatcttc catgcttcag accagatgca 900 tttaacaaaa tggatatatt ccagctgtag ttgcccagtg tttacttaac acatctacat 960 ttttttcttg tctattttgg tccccttgat aggaaaagct ataattttag gcaggactat 1020 acgtcgattt gtagccatgc ttccttcctt tcccttgctc atccatgtta gctggcagtt 1080 tttcttttga aaagttaaaa ccgggatatg tgcaatagaa atatatatat atgtatatgt 1140 aaatactagt ggacgagtgt aactggtagt atttgaacaa gaaaatcacc aaatgtcttc 1200 cattttgaga tgtgtatagt tttgtaaagc attagtgctt ggtagcatat tgtagtgcca 1260 tgttaggggt tagtgcatga gtctagtgat tttaaacttc aggatgaatt attgataata 1320 acaaatagtg taaaaagagt ggaaaatcta aaccttttct tttttccata atgtctaaat 1380 ctgttatatt cttcctgggg aaaagagatt aaggcccaaa agactcattt atgaatagaa 1440 atgtggggtc aaaatctgag atactatatt tgaggacatt tcagctttcc ataaggtatc 1500 tggaaaccag ctgtctttgt gtcttatgaa acctcaagtc aaaatgagac cgcatttaat 1560 tattctgctt tgctcttttt ttggggtggg ggggagatag agtttcactc tgtcacccag 1620 gctggagtgc agtggcacaa tctttgctca ctgtaacctc tgcctcttgg gttcaagtga 1680 ttctcgtgcc ccagcctccc gagtagctgg gactacaggc acgtgccacc acgcccagct 1740 aatttttata tttttagtag agacggggtt ttgctgtgtt ggccaggctg gtctcaaact 1800 cctgacctca agtaatccac ctggcctgct cttttcatgt cttaacatgg catgtctttt 1860 agtttcatta ttttcctact ccttgtatgt tcaagaaatt acattttggc atgtcttatg 1920 gagatgctgt taattgcttc agcagagtgc ttttctaatc tgccagacca tttacaggtc 1980 ctgtttgcca gcatgctgtg tgcaaacact ccagtaattt ggagtattca attatttgtt 2040 agggctcttc ctatttccca aatgctgctg agattgtcta ttgatgggga tttttcagat 2100 cttcttgcat gagaactggg aaatgtacct gggtggctac ctacctaggt tgctaccgta 2160 gtgaagtaga ctttcccctt gggtataagt aagcctcaag acagctttca ctgtattatc 2220 tactattact tgtggcaaat aaaaccacgt caatttatgt tcgtgaaaga ataacgatag 2280 ctttctgtag agcaaggaat tccctacctc taaaagctgt ccttgagtaa ctcagaagct 2340 gggcagtttt ctgaggtgat ttttaaattt cagtattagg ggagagtccc agcactttgc 2400 tgacacagat tctacataac taatcgtatg atagccaaat gcaaaactat tataatgtgg 2460 tgtatcttgc gcatacacag gttaggaaca agtagactct ggcagcagat ctccagagac 2520 ccaagtttag gttctcatag tggtatttga agtagttata ctcctggctt aaagtagttt 2580 agtgcctggg agaatccatt actgaaaagc atttaactta aaaaaaaaaa aaaaaaaaaa 2640 aactgaaact gaaaaggtag tgaatacaga attagcacaa ttattttggg aagggatatt 2700 ttcctggttg aaaaaaaaag ccattaaaat atgagatagt aatttccagg agggtagaat 2760 ttagtagcaa taagttgtgg tggcttgtgt ttggtatttt ggctttagca cggggtggtc 2820 caatagaata aggtgatact acggggaggt tgggggggct ctgcaaccaa gagttgcaca 2880 agggccaggt gcggtggctt acacctgtgg tcccagcact ttgggaggcc agggtgggcg 2940 gatcacgagg tcaggagatc aggaccatcc tggccaacat ggtgaaatgc cgtctctact 3000 aaaaatacaa aacttagctg ggcatggtgg cgcatgcctg tggtcccagc tgctcgggag 3060 gctgaggcag tagaatcgct tggacctgag aggcggaggt tgcagtgagc tgagatcaca 3120 ccactgtact ccagcctggt gacagtaaga ctccacctca aacaaacaaa aaatgcacaa 3180 aaggaaaaaa tgttctggat aaagagcata tgaaaggtac tttcttttag caacagtatg 3240 aatgtatatg aatttatgct ttatgtgaga aataatcttt gtttgtaagt taaaggttaa 3300 agaccctggc ttgaaaaact gaaatgcaga cgggtgacga tgctggtgtg ataatgtaaa 3360 cctgttatca gtgcttaacc tggaaacaaa agtactacag ccccactgaa gccgctctat 3420 gggttttttg cttacgatgt tttagcaagc aagggcattt attttgtaga atggtatact 3480 ttctgctttg tctcctcatc tttctccact ggtttcctgg gtacattttt tttaaagggg 3540 aaagagaagt ttgtgagttt aatgtcttta aaaaaactcc caagaacatg gataagccgg 3600 atttctctca tgcttatgat tagggagtta ggatttaaag atgcaaagca gaaggactga 3660 aaggaatagc cagtgacata tgtttcagtc gggtgaggtg tgaaaccttg tctaatatag 3720 atgtgtccta tggcctgtga ctgcttattc tttatacaat ggaagaactc agcaaactag 3780 tttctttctt gatctgagga accacacagc tcacatcaga atataatagc tggaactagg 3840 gtgacttcac tccctttcac ctgatgtcta tcttggcctt ttagcacctt gactatccct 3900 gaaaagactg ggtctttgtt ttcccaggga aaaaacgaag tgatgtagat ctaagaaata 3960 gtgcctcttt aatatttaat tcttacatga caactaacac acagggaaaa ggcttatgtt 4020 aagttgatta tagctcctct taaaatgtcc tatgctgtca gttggtctta gagacatggg 4080 aataaccaag caatattcag acatctgcac tatctgggga cagcggttac atagtacaat 4140 gatgttccgg ccagtccagt tactgggcaa caatttaaag attacccgtt aaccagccta 4200 tgttaactag gcatctagaa tgctaagaat atatctacga gtttttcata tgtcttgaaa 4260 gtatacagtt aattagcttt tcaaagttac tggtggtcta catgtttact cttcttgtat 4320 ctgtgatatg caaaaagatg aagagctctt ggccccctcc aggagtttac attctcatgg 4380 tgctgttggt tcaagtcaga ttgctttaga tttattaatg aacattgctg ggctattaat 4440 tatatcctat ttgngatagg atcccttggt gaacagtttt aaaaaaggct agaagggctg 4500 tgctaaattt cagggtattg atagcttgag tttacattgt attagccctg ctcgttatca 4560 tttttgttcc ccagggagct atgcaggtaa tgctcattag catgaatcag aaaagaaacc 4620 attctgccta agagcatctt aaccatcccc ctaaaccacc tatgctctcc tgttataagt 4680 tgtcagtaaa tcacgaagaa aattaacagc tccttaagac tctacatccc tcaattctct 4740 ttcttttccc agagttttgt acattcattc tctatctcag atggaccagg atgttgcatt 4800 ataagccttt taaaactgat ctatgtggtc gctctactgt gaacactttt tgtgggattg 4860 agctcctatt ccccgttttt tagaaccagc catttgtata tatagatttt gggagcttca 4920 taccgtggca tgttctaagg caatttatta acccaacttg ttgagttgaa acttgcatgg 4980 atccttgtta atgtcccgta attcctctga atcaagggaa tttattttgc atgcttatta 5040 aacgtcaaac tgggtcggag ttgaaagtgc aagcaataag tgacaggacc ttaactctgg 5100 tttttagagt acgaacattc taatgcagga gctcaaaatg tccagtgttg tggttactag 5160 cttattttat atatgcattt gttaataatg aagcaataga gactaagacc aatagcttga 5220 atatattcag agttagtggt gcatgtggtg agatcaagga atttgttctt tactgccatt 5280 gacaaatggg ctagtatgat agatatagca gggggcaacc acatagacag ttcaaaactg 5340 gtcagggact tagggcgtag cagtggccca ccctgctaac cacttggcct ggttgccatt 5400 agttccccaa gcatgtttga aaacaaaaga cacaaactaa gcatggctga ataaaactag 5460 ctgcttatgg ctgtaatata tcagaaaggg tgcagagttt cagaaagagt atggaaagta 5520 gggaatgcca gtatggagtt atttgtaaat aactagatat ggcatcatgg ggtttgttta 5580 tgatatgctt tatgtagaac aaagtttgag gtcttttaaa actgggattt gagttgaaaa 5640 gagtcaggat gcacatattt ccactatttc aggattttct agattgacta gggcacatgt 5700 agtggatgat actggtacca actaccaaat gaccaactat aaagtacccc tgcaataagg 5760 ggagacttcc tttttgtaga atagtcctga aaaatactga cagatctgtg gttagtttgt 5820 tattttattg cataaaaaac agtttaaaca caattttata gcccaaagtt ttatccttga 5880 tgggtttggc ccagactggc aatttcttgg actaaaggct tttaatggcc agggttaaac 5940 agggagaaac tttttgccac tagaagaaaa tccttggcta tctatttttt gccaatagaa 6000 ggaaaatcct tggctattta tttttatttg atgaataaac acaatttatt gcagtagctt 6060 aaaaaaattt tttttttaaa cagtctcact ctgtcgccca ggctgagatc acaccactgt 6120 actccagcct ggtgacagta agactccacc tcaaacaaac aaaaaatgca caaaaggaaa 6180 aaatgttctg gataaagagc atatgaaagg tactttcttt tagaacagta tgaatgtata 6240 tgaatttatc tttatgtgag aaataatctt ttttgtaagt taaaggttaa agaccctgct 6300 tgtttcctaa atcagagggt tagagctgta gtagcttaaa attttccttg agaaaattcc 6360 tgactttaaa aataaccctt atataagtac aagtgattgt gacaaatgac gtaaaaaatg 6420 gcattcatga tgtctgaaac aagcctaaat agaattcaag attagactaa aatgattttc 6480 caccaaagcc acattccaag gttttaccat tcctatgatt gaaaaaaaat tttttgaaaa 6540 ctttttattt ccattctttc ctgtaggatt ttcgctacaa ataactttgg gaactgaata 6600 aagtggcaac tggtaacctt tccagtggtt cagaatttga attagacttc ttgtgactgt 6660 gatagtacgg tttccattga aatatatgaa gtgagatgtc atatcctgaa tatagtttgt 6720 cttcccccaa ttacttgata gcatgtctgg tcagccagta aagattaaga acagagttcc 6780 cctaaaattc cccccgatta atcccactaa aggcacatta aaaatacctt aatttttggg 6840 gaaacccaga catcacagat ttccncccat gaagtcctaa atcttcttta aagtcagaat 6900 aggtatctta gttatctgac agtattcagg tttcttctct cccttggtga tatgtcattc 6960 catcagtgaa aaaatatttt ctccccaggg ataagaaagg tattctggta atacattatc 7020 atcaatcctt aaacagtaac agtcttgggc accttattca caaaaccgac cccatttcct 7080 taataaccca gaaagattat ccttagactg tcccttcacg attatacttt accctacctg 7140 cccttgtaag aataagagtt gcctcactgt gtttacttgc tgtcctccat attctccatt 7200 gcaccattgc tgtataacgt taagagtttc attgaatatt attttaagta ttacaaaagg 7260 gcagcttgct tcttaactct atgcatcttc ggggttcttc gaagcaaatt taacttctct 7320 tgatgtaaca ccacaggaca ctgttcacca ccagtcggca agctctgcac ctgtgtatat 7380 actatatcct agcaataaag cagcatgggc tgagaatgca ctgaaaaaaa a 7431 20 4415 DNA Homo sapiens misc_feature Incyte ID No LI150817.12001JAN12 20 actgtggttc caactttctt gctgggtctc agcaatatta ttctcagctt ccaggggact 60 cccacatgtg ttagctgatg gtctccttca tcttcaatac tagtaatgat ggattgaatc 120 tttctcatgc cttgtgcctc ctgccttctt ttctgccatt cctttttctg gctcatctgt 180 cttcctcttc cacttgtaaa ggcccatgat tagactgggt ccatccaatc taagtactcc 240 aggataattt tcctaactta aggtttataa ctctaattgt gtttgtaaag ttccttttgc 300 catgcaatgt aacatgttta tagattctgg gaattaagac atggacatct ttggggaatc 360 acgaatctgc cagctacacc tggaatgact gatcttcata acaaagattg gtgttcatcc 420 aaaattcgta gactagcagc cctgttgacc aatactgagt gggtggtctt tctaaaatac 480 caatctgatc gtgcctcttt tttgctttaa aatccatcag agaaaattcc ccattgcccc 540 taaagacaaa atcccagggc aaagccttac catgttttca ggaaagttct ttataatcaa 600 gcatctctgc taatctctaa ctcacatctc accattctgc ctctgtctct gcctcctggc 660 tcctgccaca ctggatgatt ttctgaccat cctatggaat ctctgtacct gtttaaatgt 720 tcagccaagg gctatttctt ccacctgggg gcactccttc cccaaattac ttacccacct 780 accctataac gggcaactaa tatccaactt catactttca ggtttcaatt taatattctt 840 agttccttag tagaaagcct gctataatcc tacaagttag agttagaaat cattccccat 900 atgttgtcat agcagccacg tggccacaca cacatcattt atcatactgc tttgtaattt 960 ttttttgcct gtctttgatt ccccgtaagc tctaagctgt aagaaggcag ggattggtgt 1020 ctatatttgc ggtttaatct atagcactca actcatacct gggcataata tgttaccact 1080 cacaccaaat agtttagttc atgtaaataa attacgttca tctatgtaga cgttttatac 1140 acaagagtgc ccataaactt tggtttccaa ctgctctatt anatagagac aataattata 1200 accaatagtc aagcaccaaa ttttgtcatt cagggaccat ttcatttgaa ctctctatct 1260 gtatgaagta ggaattatta ttgagccaat gttatggaga aaattgaaac tcaaaaagga 1320 taggccaggt gtggtggctt acacctgtag tctcagcact ttgggaggtg gaggcgggca 1380 gatcataagg tcaagagatc gagaccatcc tggccaacat ggtaaaaccc cgtctctact 1440 aaaaatacaa aaaaaaatta gctgggcatg gtggcacgtg cctgtaatcc cggctacttg 1500 ggaggctgag gcaggagagt cgcttgaatt cgggaggcag aggttgcaat gagctgggat 1560 catgctattg tactctagcc tggcaacaga gcaagactcc gtctcaaaaa aaaagaaaaa 1620 aaacacacac acacacaaac acaaaacaaa aaagggataa atacgctgca agagcacatt 1680 ggcactcagg tggcaaagct aagatccaag gctagtgtgt ctgaattcca agcccaatag 1740 ccatggtacc tttctgaacc aaaaagagta ccttacagtt tataaaacat tatgccacag 1800 gtcctcataa cctcactcta agattaaaat ggtgatctct tttttggaca tgagagaaag 1860 ggactcatct caaggttagt gagattgggc caaagatcac cacagctaat aaatgtggca 1920 aacttcacga cctaaaagtc cagatatttt acattacatt cctcttgttc taactatacc 1980 atctaccaac tgggaagagg ctagaacttg gagagtggaa gaaactacct tggtaaggta 2040 ttctccaaat ctttgtgtca tcatctcata cctccctgca cacacacagc ccataaagaa 2100 cttagaccca tgaaaaatct atttagaaaa aaaaaggaac tcctctattc atgaatcact 2160 tatatattta tgcaggtggc aaaaagagag agaaaatgtt atgtggattt tattctccaa 2220 aaagatgtat aggtggtgaa taatggcagt tagttagctt gagaacaaat gttgattatc 2280 atagttatcc aaaatacata catggtatag aatccaacct tgagataaga aatctgtcac 2340 tatagtgtat gggtcaggac tctgttggcc tcctttgtta cgccagcgtt ccaaacaggg 2400 gcctcgtggt agttctttcc ctcttggtat tcatatcctt gtatattccc cttcccatat 2460 ggaatcaaga ttgaccttag taaacaacag aatactacaa gatgtgatgg gtatgtcatt 2520 ttcaacgtgt taacgtcata aaagacattt acatcttacc agcttggtct ccgtggatcg 2580 cttaacttag gtgaaagcca gtccgccata tcgtgagagc acaagccagg ctgggggaga 2640 ggttgctgtg tgaagaactg aaacccccta ccaaggagtc agtacaggct tatcaccacg 2700 tggcttaagc tacncttgga agccagatct tctagcgccc cagtcaagcc ctttaagtga 2760 gctgtagctc ccagcaaaca tcgtgaatga acattatgag gaaatcccaa agtcaaaacc 2820 cccccagcca agcagcttcg aatccctgac ccacagaaac tgagagatga ataaatgtat 2880 atttttagtc ttaacccacc taatttatta cactagagat agataaccat acaggccaac 2940 ggagtgacaa ctcctatttg gacttacctt taaccaaact gggacctctt taacctatgt 3000 aagtaaggaa agtctcagga gacatggtcc ttagggagag tggaactaga tacttccgaa 3060 gggtccaggc tcctttttct ttctctatca tctctgcttc tctctgcaca taagttgcat 3120 tctctttagt cttcttccac ctgacagaaa acatggccac caacgccaat caggcattac 3180 ctgctgactg ttctcgccat cgccaagttt ctaaacagca tggaaagtac tccagttggc 3240 ctataaaatg gatcacttgc tcatcctaga ccaatcagtg gaggcctagc tggtggaatc 3300 agtaaaaata tctatttaca tccaaaccgc attattaggg tggaaggaaa agaacatttc 3360 ttagaaacca catggggtgg gcagtttcct tggaagagaa acaagcagtc cactgctcac 3420 tgtatgttca cataggagaa tgaagacaca tacgtatgca tgcacaaggg gtttctctaa 3480 tgctaatcct ggggtgacag taaacatcat tttcatgaat cattttgtca cctggcccta 3540 aggaaaaggc tctctctagc caggaaaaca catcagccag atttccaatg agaagtaaat 3600 cttatctttc aaagagaaag gaaaaaaaat agcctaaagc agccccaaag tagaaaatac 3660 ctctgagatt tctttcctga gaacctaggg tctagatgat gagagaggaa taacaataat 3720 aatgataata gatgccatct atcatgcaca tgtcaggtac attaagctac tggatatcat 3780 tttgactcat atcacacaac tgataaatgc cagagcctag atgactcctg agtctgtctg 3840 ctgccaaagt ctaaacactt aatcactatg caaaatacca gagaaggaat tacagaagcc 3900 caagcctcaa ccaagaccat ggttagctcc taagctaaag aaaagcagag caagctgtcc 3960 tcagctcaga agctattttc tgtaaatttc atgtcaacca agatctctat ttcagcattc 4020 ccctgagagc cgggtggaag aactgaactc cagctcactc ctgctgctct tgtctatgaa 4080 acagagcaag acccaaagca aaagttttca gaattttgtt ataacaaaat ctctattttt 4140 cattgtcttc agaaataagt tttgcaaatc aattccagct ttgggtggtt ctcagaggca 4200 gttacattaa aagaaagccc atgtgactca ttcctgctga gagtgggcca ctttgctctc 4260 ttggaaaaag ggaatttaag tgttcatcaa ggcaggcatt acatcatcac tgacaagtca 4320 ggccaacctt cagatgagga ccatgtctgt tgtttgttaa gtgtgtcttg gggaagttaa 4380 tacttcatgt caaggtttct ttatctgaaa aaaaa 4415 21 2158 DNA Homo sapiens misc_feature Incyte ID No LI219627.12001JAN12 21 ctttttaacc aatattagta atagtaatct caaatctcat catcatcaaa atcttattta 60 tgaaatatag gagttagttc atatacagcc ttagcctttt ccacattata aaatatattc 120 catatatatg tgtgatcttc atttaatatt caagtaaatg ttgtaagata ttgttatttt 180 tattctaaca tttcacaggt atagaatctg aaactcagag gtcaactgat gtgtcaaaga 240 tacctccaca aatcagtacc ttgattaaaa ctaaaattgg agtcatcttc atatcttcat 300 ctttctccct cttcattagg accgattgta gtctgtttcc ctctcactca cttgcaatct 360 ttattgcttt agtgttgcat ttgattttta tctttgtttt tgttttaaat actgtcatta 420 aagtcataga aaaatctaaa gtaaaactgg ttgaataaaa attttaaaat cgactctaat 480 gtaataaacc agacaaaaat gatactttac atgttatatc ttccctttaa actacaaata 540 ttcattgagt gtataccctg tattaggctg ttggaataaa acagggaaga agacagaaga 600 aactgcaccg ccatcttaga tcttgcagcc aaattcctct gaacttttct ctaaagacgt 660 gctctggaaa aatgttgatc attttcctac atcatggagg tcttttcatg accacctttg 720 tctagacaat gtcctgtttt taggtgcacg tttgagggct ggagtctctg acccacagtg 780 ctgcagcctg cacgtggttt gtcctgactt ctttgctact tcacttttcg taaggctctg 840 agagtgcagg cccttgtggg tggacactgc agggtgagag gaagaagtaa actacttttt 900 tccgtttctg atgggggtgt gggtcagcag ctataagcaa cagggaccat ggggggcctc 960 agacttcagc acctgagagg cagtttcagt cgtattgggg agatgcaggc atctgggttg 1020 ctgcacatca ccagggcagg gttctctcag cagccctgga gtgcagagtt cccatcagct 1080 cagcagtgag gggcacatgg ggctccagtg gtgaggactc ttggtccttg gatgacaaca 1140 ctcccctgcc cacttctcca gccttccctg taaccctttg ccacctctaa ccaatcttct 1200 gtgttacatc tcttcggttt gcaatatgta gtgttcgtat atgactggac agtatctact 1260 ggagttaata tctatcagag taattatatc acaattgcaa tcttctccta agagtgaata 1320 gtgacattaa aaatttcaac attataaatt atgcagaaat aaaactaatt atacaaaaaa 1380 tacactctga atgtcagttt ttccctgaga caatctacca tttgatatac ggtgattcac 1440 acttcttaat atacaacatt gaattacttt tccaaaagcc tcttcaaatt ttgctgcaga 1500 attaaacttc acttgcacca gctctgaatt atgtgtgctt ttccttcttg gtcaatttca 1560 taggtgtatc attatttgtc ttttttaatt aatatgttta tataactttt catgtttatc 1620 catgtaacta ctgcttctat tgaaatgttt tcttcataaa tataaatgtg tttttggtat 1680 gaaaataata actggccaga tgcggtggct cacacctgta atcccagcac tttgagaggc 1740 cgaggtgggt ggatcacctg gggtcaggag ttcgggacca gcctggccag catggtgaaa 1800 ccccatctct actaaaacta caaaattagc tggtgtggta gcacgtgcct gtaatccaag 1860 ctacttggga ggctgagaca ggagactcag tcaaacctag gaggcagaag ttgcagtgag 1920 ccaagatcac gctattgcac tccagcctgg gcaaaaagga gtaaaactct gtctcaaaaa 1980 gaaaagaaaa aaaatagtaa ctctttgtga atagtatcaa ctaaaatatt tttatttcag 2040 tttcattctg atattttgtg tcatcagaat tttttaaagt atttggttta atatattaac 2100 tttaatactt tccgttaact ggtttgtgtg gcttacaaag gtctttaatg gccatttg 2158 22 321 DNA Homo sapiens misc_feature Incyte ID No LI197812.42001JAN12 22 cccattaaaa gagccagtaa atcctgtgga aaatggcctt cagtgatctt acatcgagga 60 ctgtgcatct ttatgataat tggatcaaag atgctgaact tgaaagtcac gtacaggact 120 taaggtgtgt gctgaaaata ttaaattacg ggaaaaaatt atttatttta aaattatttt 180 attctgcttc ctgagccagc ccagcatgct tttcctggct tgttttcttt ctactgctac 240 cagaggaaga acagagaaat gatgtcattt gatttttccc cctcctgagt caatgaaaga 300 ataaaataaa atatatctct c 321 23 2311 DNA Homo sapiens misc_feature Incyte ID No LI101525.12001JAN12 23 caaaaatcag tttagagcct cctcatatga cacctggaat gaatgtagta aaaaaaaaat 60 gaaattacag aaaaacaaaa tgttctgcaa ggagattttt ttcccaggct taaaagttat 120 agaataaatt acaaaggaaa ttatgagcag atttggctaa ataaaaactt aaaatttgaa 180 aggagtgcaa acagacttgg aaaatataaa catgagaaat gattaatgtc caagttagat 240 taaaacatca cccaaattat tttaaaaagt aagaaaacta agctgtttaa tatgatgagg 300 aaacaaaaaa cagctagtaa taattttaag gaaattgttt aaacttaaca gtaatttcat 360 taaactaaaa atttaaataa tagtatgcca ttttattact aaggagaaat ttgatttgct 420 aattaaggaa tggtcaaagg acgcttaaaa tttgttggtg acagtatatt ataactatta 480 gcaatttagc agttttttaa aaatgtctaa atttttctta aagccttgag cccagaattt 540 tgaggccagc ctgggcaacg tggcaagacc tcatctctaa acaatacaaa acaatccata 600 aaaagaagag tagttctagt ttcaagaact actgctattt ttagtccttg tgagttctct 660 gtcccattca ttatctcttg tgattccttc ttttggtaga agtaacaggc atagttaata 720 ttttggtgta gaaatgactt taaattatca gcgtcttgga gtgtaaaaat cattttacat 780 tataagatgc aattttttaa atttaattgc cctatgagta cttttctcat gaaaaatttt 840 agatatggat tatgttcatg ttaatataat atataaaatt gtgatataga gaaaatgaaa 900 gaattgaact ttcatttagc tattttctct gtaactctaa atataaatct gatgatataa 960 ccaaaagaat gttaactcat aaattatcat tttaggatat aatttattta aagtagtcta 1020 agttattttc atttatcaga gcagttttac tttgagttat gaggattcga gattgagtaa 1080 atcactattc ttgtgatagg ttccttccct tggatatttg aatgcttccc acataataaa 1140 gcacatggaa aggtttatat ctacccttaa gggaacctag ggagaaagag atggatgtgt 1200 gagagatgta cataaataat agtgtatggt gaaggatacc aggagtacaa tgtagtctca 1260 tgagatataa cttctaaata agggtatagg agaccaagca tggtagctca tgcctgtaat 1320 tccagtacct tgggaggcca aggcagcgga ttgcttgagc ctaggagttc aaaaccagct 1380 tgggcaacat ggtgaaacct catttctaca aaaaatacaa aaacttagcc aggtgtggtg 1440 gcacgtgcct gtggtcccag ccacttggga ggctgaggta ggaggatagc ttgagcttgg 1500 gaggtggagg ttgcagtgag ttgagatcgc gccactgcac tccatagcct gggcaacaga 1560 gcaagactct gtctcaaaaa ataaataaat aagggtgcat ggaaatcagg ggaggctgca 1620 atgatggaag tagtatttga attgatctgg gaatggtagg gttacaggag gagttgtgag 1680 aggcagccca ggtagaggcc atggcttgcc atcaaagcaa acaggaatgt gttattgtta 1740 tttagaaaat tgaaagcagt gtagattgaa gtgactctaa tgggtgaaag gtataatcta 1800 atttaaacat ttaatgaaga aatgctgtgc cagataatgt taaaggtatt ggtgagtaaa 1860 gccaaaaaga agagattagg aaatttcctg gatggcagct gaaaacattt ttgtctttgt 1920 ttttggagct tatggagcta atgaagccct ttgagcagta atgtgctctt acctcctata 1980 ggaagtagca atattaattg aataattatt gtgttttagg aaatgttcta agggctttgt 2040 ctgcattaat ttttaaaaat cctcagacac ctctgtgagc gttctcatct caatgtaaga 2100 aaaccaaggc ccagaaaacc aagtcaagta acttgcccaa gatcacaaaa tggaattagg 2160 atatgaactc agcagttggc tccagagctc atactctcaa ccaggaaaat aaatctaata 2220 gcattgcaaa gaattaattg gaaaatggag actggagaca gaaaccagtt atgtgactgc 2280 tggcataatt caaggaaaag aaaataatgt a 2311 24 978 DNA Homo sapiens misc_feature Incyte ID No LI891123.12001JAN12 24 gggctggtta cagcagctct accccttcag gatgcaatca tgggagcgca gatgggacca 60 gcagaaagat gccgaggcgt aagggctgag cggcatgacc ctgctgccga gcctgattcc 120 ctccggtgca ggctgagagt ggctggagcg gctgccgcgc gaccatccgg ccctggagca 180 ccttcgtgga ccagcagcgc ttgctcacgg cccacgcaac ctgggagacc tgtgccagcg 240 cctcttactg caacgtggag tcactaccag agcaactatg tagttcgatg ttgcctgggc 300 ctcatgcctg tactgtgctg gtgaacgtac ccctatgtta tgctgagtgg ctcctggact 360 gtctattatc gcgccgacct ggttaccata tcatcattat gctgcgtcat ccttggagtc 420 caagcttgtg ctctattggc cgagaggatg atgctccaga cgcatcagta tgctctggac 480 atggaggcat ctccttcccc ttcttctggg tctggctggt gcgcggctcg gcctgtcttc 540 tagggtgcta gtgagccacc ctgtggtggt catcggactc ccacgatgca cttctcacca 600 gattgaggct gtggacggcg gagtgatgct tggagatgtg aaccctgtgt gattgttgtc 660 ttcattggac ctgcctggcc tccctgggcc aagcatgcgc ccaccgccgt gcccatgcct 720 tgtcctgcaa ctggctctgc ttgctctggg cccacatgtc tgccagtccc catcacaatg 780 ccctggggat ggtgatcccc gcctttgaaa ataaatgctg ttatgcggtg tcattcatgt 840 gaaaaaaaac aaaaaaatgg gcggactccg accagactta agtgagactc gttcagaacg 900 cccgtgaaat aaaatctccc gggacctggt taacctgaca ggcgatagat ccttgccaag 960 taaaacaggc gcccttcc 978 25 2075 DNA Homo sapiens misc_feature Incyte ID No LI813500.12001JAN12 25 gaaatctgta ctctcctgtt ttgctgagaa ggagactgag gatcacataa atagtaagga 60 acttgcagga gtcacccaac tcttaagctg caaagttggc gtttgagccc ccgagtctga 120 ctccagactc gagtccctaa actctgtgct acagaatttt ttgctgtcat ctgctggagg 180 atatccattc tttaatctat ggcaatactc ataaattctc tcaggaaagc cactggaatt 240 atggctttag ttatttgttt ttaaaaaagt ctattccctg attatggtaa ttgatctttc 300 ctttgagggc aagtgccagg atagaactta atcaatatta aagtcatatt tcattctaat 360 ttctgtagta tctcctatca cattagatct taggaaatac ccaagtggat aagtaaatga 420 tacacttgcc ccagatgact gaccttcatt ttctgttgtc aattatttct cctcttaacc 480 ctcaacaatt tcttttctct ccctgattgt ctctcctaat ctcctttatt tttgtcttct 540 tgagacattc actgatcttt ttcctttctt ctttttcctc atccgtctga attgcattga 600 tcagtaaaga ccctcaaatc ctcatggttt tcacacattt ctagtacaag tcattccttg 660 gccccactgg gttttagtgg acttctgggg tgtccaccta catgctaatg ttgtggacgc 720 aggtagttgt cctaagtggg atccggatag acatatgtgg gaaattgtag gagttgcagg 780 aggggtctga caaatgggac ttttgttggc attaagatgg ttcaagtcta tgcctggaag 840 ctgagtttac ccttaaatgt gcatctcaag tctcggcaga ggaagtgtgt tgaaactggg 900 cagcacgtgc aagggtggtt agtccagtgg gccgttacaa cctagcactt gtccaggcag 960 cttccttggg naacagaaga atgtttatag aattaatgtg cctgtgtgtt acacacatat 1020 aaactgacct atgttttcaa aagttacatg gtgagtgctg gttgaaaaga cttgaggaaa 1080 attttctcag atagctttaa aatgaggcat gtgctgtcat tggtagagcc ttcgtttagt 1140 atgcaactga tacttgaaat atgactttct ctgttagtgg ctttaacagg ttccagtaat 1200 ggttgtgtga tactcttcat tttattaggg ttcaacagtt catcaaaggg aagagaaatg 1260 taggggctcc tatttgaaaa atttatgtgt gtttatttac acataaatat gtacatttgg 1320 gtcaggtgca gtggctcaca tttgtaatcc caacactttg ggagcccaag gtgggcagat 1380 catttgaggt caggcatttg aggccagcct ggtcaacatg gtgaaacctg tctcgactaa 1440 acatacaaaa aatttagcca ggcatggtgg cacacacttg taatcccagc tatttgggag 1500 gccgagatag gaggatcgct tgaactgtgg aggcgggggt tgcagtgagc tgagatcatg 1560 ccactgcact ccagcttggg caacaataaa taaccataaa taaaatttaa caaatatagt 1620 atgtacattt gcatatccta ttcccattga atattatcta aacttgcctc atatttctta 1680 actcagaagt tacatgcatc ctccttaaca agtgggtgag ctagataaat ctcaggggat 1740 taaaaaagat tcaattactt atcttttggg gtgaattgat gaataagaaa ctgtaatagc 1800 aaccctctgg acctactagg catctgtaat tggtaggctt ttccgacatt ttttccttca 1860 cagacttaag caacccgaag cacaaggtgg gattaaatta aatgactaaa ataagaagag 1920 aaaccagaat atcatatccc gggttccaga tcccatgaat tgtcacagta gtgtggttac 1980 agtggttttt accagttaca agttagcatt gccttgactt ataacgcaaa caaacagtag 2040 attctacttt aggcttaagc aaaaaaaaaa aaggg 2075 26 1959 DNA Homo sapiens misc_feature Incyte ID No LI1037251.12001JAN12 26 ggtaacatgt taggagttaa tgttgcaaag agtagtttac atcttcactt tctgaagaca 60 cttgaattta ggaccgatgt atctgtgaca agcatgccag aagtggcagg ggccatcagg 120 gctaaccact tcacacctac catcgtccca tggggatcca agacctgaga taaagcaaca 180 tggagttcat tgtcctgttg cttacttact gcaatgtctt tggccctcct tttcaactgg 240 ttcctctgtt gggcccaaag gttgggagta ggagacagta tcccaggctg acagggcttg 300 ccctttacct tgggcacctt gttaattttt agcctgtgcc cttccccacc tttgccctcc 360 cagtggttgg tatgtgggaa gcacatctca agttcctgtg acttcatgtc tctaaaccaa 420 aggatgaagc gtctggtctc tgctatgatg tgtggtatcc gatggccctt tccctggact 480 agtctggagc cgtgcctcca cattgtaccg gacactgtga ttcctggact cccttctcct 540 ttcctttctt tccttcacgg tcacagcagt cccttgtaac tgtatccacg catccacagg 600 aacctcagtg tttttcctct gctggtttgg ggcacaagga atgccttagg gtatcggggt 660 aaggctgtta ttacctagag ctttagcatc ccaggccagg gggctgccat cttcttcaca 720 gacatccctg aaaggaagct cctttggggc agggaggtga ggacttcatc tcaacatcgg 780 ctggtggatt ggtaggggag ctttttcttt tcatttcctt tttggttggt ttatgttttt 840 gatgttgctt tttggtaaca tgttaggagt taatgttgca aagagtagtt tacatcttca 900 ctttctgaag acacttgaat ttaggaccga tgtatctgtg acaagcatgc cagaagtggc 960 aggggccatc agggctaacc acttcacacc taccatcgtc ccatggggat ccaagacctg 1020 agataaagca acagcctgcc cagatccctc tgttcatcct atcccttcca aggttggtcc 1080 atgccaacat aacctctggg catcagacat cagcaggtct gtgtgcctcc agccctggtt 1140 aacgggcagg tttctcttta gccctcttcc tgcacttggc gagcaaaggc actaccagta 1200 gagaagggcc atccagccgt gccccagcct ggacccctgg ggctcagata agaggtgctg 1260 agcccctgtg tcaaagttgt taaatgtttt tgttttgttc cattgtagct cttttttttt 1320 ttttttcccc tttctccgtg ggtgatgtga tttatacaaa aaaaagttaa gctgctttaa 1380 aaggccctgg aaggggaatg tcgagagagg aggagacaag gacatgatgc cctatgttac 1440 ggaggtgtag acggtgttgg ttttttggcc aaaaagccgt gggttagagt gactctgaat 1500 ttatcttggc acccctccgt gaatgtggac ccccacgagt acccttccgt gtgtggaagg 1560 gctcccgtgg attttcccta acacccaccc tctccccctt cagccaatgt tgatggcaga 1620 gagagataag aacttgggag cccatgttct cactggagag gaaaacttgt acatctggct 1680 ttcgcggaga caggttccac gttacgctct gtagtacatt atctttacta tgtgctagga 1740 tatcatgatt taaaaggaca aaaaaatgtt aaataacttg aatgagcttg tattataaca 1800 ttaatattat tgagagtatc tgctttccag ggctgaagcg attcagttca ttattctagt 1860 cctgctttag tcctttgtaa ctttgtggta attatgcttt tctttttaat acaaaaaaat 1920 gtataaaaat aaacacgttg aacaaggcaa aagaagaag 1959 27 1442 DNA Homo sapiens misc_feature Incyte ID No LI2032187.12001JAN12 27 ctatgattgg agggcttagg tctggaggat tcaagagtgg aagaggaatt taaggggtcc 60 cctagtctag tctctgcccc tggatagtgt ccagccttgt atatttctag aggtggatcc 120 caggagtggc tctgatggcc acattagcag gacttacgtt gtaactgatc atgtcagcct 180 tcagaagagt atccccgcca cttgcgtggc ctcctcagat ggggatttat ctggatctct 240 gtggttccct tctcagccgg aacaaggtcc cagtatccca gtcatttctt caatgctgat 300 aggggtatgt tggaatccga agccacttcc ccgccttcaa gccccagatg ggcatgctct 360 ccgggtaaca tttgctatgg agaagagaca ttgtgtctct cgccgtccct ttacctggct 420 ccatgccctg cacccatggt cctgtgccca cgcctcgtcc cccacagttg tgccgtgact 480 gctaggggca catccagtct accatacgtg gctgcagcag ctggactgga gggcagagcc 540 gtgtaggtgc agagggccct gggcatcccg aggtcgcagc cactctaccc tggggcctca 600 tggggctaga cgagcagctt ccgatacgga cctctgccca tgagtctcat gcatgtcgca 660 cttcttgttt cctgaaagga gagaaagggg ggggtcacag caacatgccc gtggcctttc 720 tgctctgttc gcccaacccc agctgaggcc tgctgcacag gtcaatgcca ttcagttatc 780 gttaattgta catgtcactg ttgttccttg aaggtagtag tcaaggatca ggaggggcaa 840 gatagtcttc tgctgggcct gtcgtggggc tcggagcaga aggtgtagca agcaatgcac 900 tgtgttcggg gagcccccat cagcctcctt gtgccaaact gggcccccat gccacagtct 960 ggctttccct ccatctgccc caggacacag agcaagaagg acatcagttg ccacagtcat 1020 gtgatccccg tgccatcgtg ccttaggaac agccttcccc caccagcagc catggcatgg 1080 ctggggcatt taaccaagcc acctactgcc aggaattgga gcctgcagtt ccctcctgtg 1140 tcaagtagct tactgcagca gctggtactg agggcagagt ctgtgggtgc cagagaccct 1200 gcatgtaggt cacaggttga ggcccagcca ctctcactgg ggcctggctg ggtaggcaag 1260 tagctctggg gcacacctca agtgaccaaa tgctattaat ttccatcctt tagcaggctg 1320 ggccctaggc aggaagctgg cttctgggag aggagtgaga acgtgcaggg cctgccatag 1380 cttgcgtgct tgaggaggtg gcatccgtgc ttgctccttg aggagggtgg catctgtgtc 1440 tc 1442 28 3666 DNA Homo sapiens misc_feature Incyte ID No LI347572.12001JAN12 28 gtcattcagt ggatgtgatc tgtggctcac aggggacgat gtcaagctcc ttcctggctc 60 cttctcagcc ttgttgcctg taactggctg ctcagtccac cattgaggaa caggccaaga 120 catttttgga caagtttaac cacgaagccg aagacctgtt ctatcaaagt tcacgttgct 180 tccttggaat tataacacca atattactga agagaatgtc caacaacatg caataagttg 240 ctggcgagac aaatgtgtct agcccttttt acaaggaaca gtccacactt gcccaagatg 300 tatccactac aagcaaactt cacgacatct ccacatgtca acgcttcagc tgtgcacggc 360 ttcttcaagc cataaaactg tgagtcttca ggttggtcat cacgaagcac agagagcaaa 420 ccggttgaac acaatttcta atatacaaat ggagccacca atcctaacag taactggaaa 480 acgtcgtaac ccagataatc cacaagaaat gcttattact tgaaccaggt ttgaatgaaa 540 taatggcaaa cagtgttaga ctacaatgag aggctctgtg ctctgggaaa gctggacgat 600 ctgaggctcg gcaagcagct gaggccattg atatgaagag tatgtggtct tgaaacactg 660 agatggcaag agcaaatcat tatgaggact tattggggat tacttggaga ggagactatg 720 aacgtaaatg ggggtagata ggctatgaca tacatgccgc tggccagtta gcattgaacg 780 atgtggaaca tatcttttga agagattaaa cacattatat gatacatctc ctatgcctaa 840 tgtgagggca aagcttgatg aatgcctatc cttcctatat cagtccaatt ggatgcctcc 900 ctgctcattt gcttggtgat atgtgcgggt agattttggg acaaatctgt actcttctga 960 cagttcccct ttgggacaga aaccaaagca tagatgttac tgtatgcaat ggctggatcc 1020 aggcctggga tgcacaagag tatatatttg acggaggcac gagaagttct tctgtatctg 1080 cttggtcatt ccttagtatg actcaaggag ttctgggaaa attccattgc taacggatcc 1140 caggaaactg ttcagaatag cagtctgcca ttcccacatg cttgggacct gtgggaaggg 1200 cgaacttcag agatccttat gtcgcacaca aggtgacaca tggacgactg tcctgacagc 1260 gtcatcatga gagtggggca tatccaagta tgatatggca tatgctagca caaccttttt 1320 ctgctaagga aactggagct taatgaagga gttccatgaa gctgttgggg aacactcatg 1380 tcaactttct gctagccaca cctaagcatt ttacacaatc cactgtgctc ttctgtcacc 1440 cgagttttca acgaacgaca atgaacacag aaactaaact tcctgctcaa acacagcact 1500 cacgattgtt ggggactctg ccatttactt acactgttag agaacgtgga ggtggatggt 1560 ctttaaaggg gacaattccc caagagacca gttggatgaa aacagtggtc gggagatgaa 1620 gcgcagagat agttcggggc tggtggaacc ctgtgcccca tgatgcaaac atatctgtga 1680 ccccgcatct ctgttccatg tttctacatg attactcatt gcattcgata ttaacacaag 1740 ggaccctgtt accaaattcc acgtgtcaac gaagcacttt tgtcaacgca gctagaacat 1800 gaaggccctc tgccacaaat tgtgacattc tcaaattcta cagaacgtcg tggacagaac 1860 actgttcaat actgctgagg cttggaaaag tcagaaccct tggaccctag gcatgggcac 1920 acactgtcgt aggagcaaag gaacatgaag tgtaaggcca cctgctcaac ttactttgag 1980 cccttattta cctggctgaa agacccagaa cacagaattc ttttgtggga ctggagtacc 2040 gactggagtc catatgcaga gcaanagcat cacaagtgag gataagccta aaatcagctc 2100 ttggcagata aagcatatga atggaacgac caatgaaatg tacctgttcc gatcatctgg 2160 ttggatattg ttaattgagg cagtactttt taacaagtaa aaaatcagat gattcttttt 2220 ggggaggagg atgtgcgagt ggctaatttg taaaccaaga atctcccttt aatttctttg 2280 tcactgcacc taaaaatagt gtctggatat cattcctaga aactgaaggt tgaaaaggcc 2340 atcaggaagt cccggagacc gtatccatga tgctcttccg tctggatgag ccaccgccta 2400 gagtttctgg gggatatcac gcccacacct tggagcctcc taagaccaca gccgccctgt 2460 gttccacata tggctgaatt gtgttattgg aattgtgaat gggagagtga taagtggttg 2520 gcactatgtc aatcctgagt cttgcacctg gggatcacga gagtcggaga gaatgaaata 2580 atattatgcc agagagtgga ggagaaattc cttaatgcct gccactcgag taattagcac 2640 aaaggaggag aaaataaatc cacggagttc ccacaacacc tgatgagatg gtcaagagcc 2700 tccttttaga aaaaaatcta atgtttttcc tcttgaaggt gatttttgtt ggtatgtaaa 2760 tgttaatttc atggtataga aaatataaga tgataaagat atcattaaat gtcaaaacta 2820 tgactctgtt cagaaaaaaa attgtccaaa gacaacaagt gccaaggaga gagcatcttc 2880 attgacattg ctttcaagta tttatttctg tctctggatt tgacttctgt tctgtttctt 2940 aataaggatt ttgtattaga gtatattagg gaaagtgtgt atttggtctc acaggctgtt 3000 cagggataat ctacaatgta aatgtctgtc tgaatttctt gaagttgaaa atcaaggata 3060 tatcattgga gcatagtgtt ggatcttgta tggaatatgg atggatcact tgtaaggatc 3120 agtgcctggg aactggtgta gcttgcaagg attgacgaat ggcatgcact tagctcactt 3180 gtcactggca tccattggtc aaggactgac atgctttcct tcacagtgaa ctcagttcca 3240 acgtactatg gtgaatttgc cacaccgtga atgtttggaa tcgatcatgc ctttcttcca 3300 ggttgacacg gttctataag agagagagaa ttccacgggg aacccggtag aggacacctt 3360 gctttgttca acttccaagg gtgctgtgag tcaaacatcg tccctgagca acacacaaac 3420 tatgagccac aggggccctc cgctgaaact cccaccgagc caatgcgctg agtagaaaac 3480 tcagtttcta actgttctct atactgtggt aggtgaaatg gaaaattccc agctgtaatg 3540 ttcacccctg ctgaaagtgg gtaaccccgt cttcttaaat ctctttgtta tttgctcacc 3600 agtgtttgag ccagtgctga gcaccaagcc agacactcca ataaatggct agatttacac 3660 cactcc 3666 29 2094 DNA Homo sapiens misc_feature Incyte ID No LI007788.12001JAN12 29 gtaggcggag agaagggaaa aaaggatgtg ggaccctcat gggaccctat gcaccccttc 60 ttgggtaggt gaagagaagc tgcccttctt gtggctcgga gcttggggtt gaagagaaga 120 gggggaaagg aaatccgatt tccatccagt tgttcccccc agagctggtg gagcatatca 180 tctcattcct cccagtcaga gaccttgttg ccctcggcgc agactctgcc tgctacgttc 240 cacgaagtgt gcgatgggga aggcgtgtgg agacgcatct gtcgcagact cagtccgcgc 300 ctccaagatc agggttctgg agtccggccc tggaagagag ctgccagttc gtgaacgtgt 360 acaccttgcc ccaggaacct cccgttctcc gttgcctctg tcccgcctta gccttcctgc 420 tctctaaagt cccctgatga cccccacact cccaacagtg ccttccaggg cccctttctc 480 cggaaaacgg gtccagttca aacattctac ccttgcagta cttcctccaa gtctttcgga 540 atccacccac agcaccccgt taacgggctt ccctgcccaa ggtctccctc tgtacacaga 600 cacttcccgc tttttcccta gagcgcatcc ctcactcccc aaacctgaag tttctacctc 660 ctctaaccca aggcttctag aactacactg ttgatattct gtggcaaaat aattccttga 720 tgtggaggag ctgtcctact gcatggtagg gatagtttaa gcagcaaacc tggacctacc 780 acccaccaga tggccagcag catccccact taattgtgac aaacaatgcc cttgaaggac 840 aaaatcaccc ctagcctgag aaacatgcca gtaaaccctc ttacccctcc agggatcccc 900 cagcgctgta cttcttacac tcactgggag attacacaga gaagggggac ccagaaaacc 960 agatccacac agctaggggt gagggaggat gaccggcctt catcaatcat tccttttcac 1020 atcctgatat cgtgtcgtct tcatctttat ctttctttat tctttgaatt tattttattg 1080 ttttattatt tagtttattg gacccgtggg ttgcaccgaa gggaagaact tcgggctcct 1140 caaaagagaa gtgtgtgttt tccagttctc ccgaggcatc atagttgtga agtcgcatcc 1200 cttgaggtgg gttatgaaga acctccgtgg gaatcgtgga tagcttttac actcccaggt 1260 gggggcgcct atatcccata gagaaaattg gggtcgccca acagctgctt gagctagagg 1320 ggcctcctta gacccccaca gaccaggggg gagagtgtat tttggagggt gcattacccc 1380 agggggtgta ttcgcgatac tcgtgtggga cctcttcacg cttttatgac ccctgtggaa 1440 ccagcagact cccgcttgct cctctcactt gccgtgccaa ggttaggcct ccgtggaggg 1500 acgggccaac ccagaagggg ttggcgctga tagggattgg aaaggctctg aacgttatta 1560 taggactctc agatttattg atcccagtag gggcagggga accccccagg gagaggttat 1620 gccaaaagag gatcagctgg ggggctcggc ttcgcgaggg aggctcgagc gaggagagta 1680 tcgcttgagc ccaggagctc taaaccaagc ctgggcaaca atagtgagat cccatctcta 1740 actctctttt ttgaacgaga ctcagctgtg ggactgccac ggttgagtgg cttggagaac 1800 tctgggaact cagagttcct ctggaaggga aatggaatcc ctatccccgt ttcatatctt 1860 gttacgctag atcctattct gtgctcttgg ctacacaaca cccttggcca tggtggatga 1920 aatttggccg aatcttcaat gcacacggag aattatcaga ttacgggcat gctagggaca 1980 caggggacta aaatggaccg aggaaggatc acttgaaacc cacggtgaag gcggaggttt 2040 cagctgaacc gagattgcac tgctgcactc cagcctttcg actctgtttt caag 2094 30 1741 DNA Homo sapiens misc_feature Incyte ID No LI336872.12001JAN12 30 aaaatagtca tccttaactg gtttggacca tctttcatta gtaaaatcaa aagcatatgt 60 gcacagtaaa attcctagac tgcagacgca ggctcacctc ccacagccaa ccccttagcc 120 ccttgaactg ctcgcatgag gacctcagac acacttctct aaacacccct tttcatatga 180 aaatactgga ggcagagtgt ccttccattt gtgggtttct atttttattt ttgagacagg 240 atctcagtct gtcacccagc ctgtgatcgc accactccac tccagcctgg gcaacagagt 300 gagacttagt ctcaaaaaaa agggaaggtt gaatttttac ttcatattca cccccaatta 360 acttcagttt ggattaaaga gctaaaacta gaagcaaagt ttttcttcta aaacattgga 420 agacaatatt gcatttttta taatcaaagg gtctttctga aagtgacaca caagtccccc 480 atctgtaagg gaaaagtttg agatttgagt atgcaaattg gtattttcca taagacaaaa 540 gaaagcataa aggaaagcaa tgagctgtat aaaatattca caaaatatct atccgaagat 600 gtatatcaga tatattgaga gaccctaaca agatcagtaa gacagaaaga aactcactta 660 aaaaaagtca gtgcgctttt ctacattttt tcccaaaata aaaggattgg gcaaagcaca 720 taagcagacc attcatcaaa gaagtaaaga tgactgatta ataagaaaaa gatggtaaca 780 tcactaataa tcagtaaggc caggcacagt tcatgcctga ctttgggatc ccttgaaccc 840 aggagttcga gaccatcctg ggcaaaatgg cgaaacccca tctctacaaa aaatacaaaa 900 attagctggg cgtgatggca cgtgcctgtg gtcccagccg cttggggggc tgaggtgaga 960 ggatcacttg agcccaggag ttcaaggctg cagtgagccg tgtttgcgcc actgccctct 1020 agcctgagtg acaaagtgag acactattaa aaaaaaaatc agtaaaatgt aaatccttgc 1080 attcctgatg ttgatacgca tggcttcttt tttaaaaacg ttcagtctta ctagaggttc 1140 tcaaataatt ttttcgagag cgcacagctc ccgggttcat tcatattcca cattttggtg 1200 ttcaaattca atgaagtctg ctttttggtc ttcctttgtt ctgctaattg ttggggtcac 1260 actttaactt aatcgctttt tgtcggtatc tcggtggaaa gctccacgag agtaattgaa 1320 ttctgagaaa ccctctttgt gcaataaata aaaagacacc tctccatagg ccatgagtaa 1380 tatgttccct cttcatagac acctggcaca tatatctggg ggcccacacg gatatgttaa 1440 taataggctc ataaatattg caactttctt ctttgccctc tgtgtaagaa taaagagttt 1500 ctggaatatt ttcttggaga aatctctctt tggggaatta attatagaca tataggtgtg 1560 ttaacattcc caggcgcaat attctagaga tcgtccctgg tatcccctct taatacatgg 1620 aaatttagag tccaaatccc acatatgggc cagaaaacaa taacactttg ggataggaat 1680 tcaggttatt ttacaatcaa ttaagagtta ttttataaac ccgggaaaaa aaaaaaaaag 1740 g 1741 31 1943 DNA Homo sapiens misc_feature Incyte ID No LI1143291.12001JAN12 31 ggcatcccgg tcatctgcac gtggttatgc tgccggagtt tgggccgcca ctggtaggaa 60 aagtaacttc agctgcagcc cccaaatgcg agtgagccga gccggtagcc atggagggcc 120 atgagcgtgg aggagctgct cgcaaaggtc agaagcagga cgaggcgaga gaagtagaca 180 acgcatcacg gtgcacaagg aggctggaag ctgcagtttg acctggggca acctgcttgg 240 cgttcggacc gggaaccccc cggaccggga ctctcggtgc gccggaccca acgccggagg 300 ccgagcctac atggccctgg gcgcgggaca atcacgcaat ctgctcatca accagctgtg 360 gcagtctgcc caacgggagc gcgtggaaag aggcgataag tggcgcggct gccggagccc 420 accacacgcc tgccgcgaga gaagcctctc gccccgaccg cggccactta cacgctggca 480 gcagttcgcg gcgcctcaag ggcatcctgt cccaagaaga agaccaacct ggtgtgggga 540 cgaggtgagt ggcctagtgg cggcggcgct gggggctacc agcgcgtccc gggacgacac 600 caaagaatgg ctgattgagg tgcccggcaa ttgccgaccc cttggaggac cagttcgcca 660 agcggattca ggccaagaag gaaagggtgg ccaagaacga gctgaaccgg ctgcgtaacc 720 tgggcccgcg cgccacaaga tgcagctgcc cagccgcggg ccgggcttgc accctaaccg 780 gacaccagag taaaggagga gctggggccg cgccatgcaa agtggctcat aggtctccaa 840 ccgcctctgt ggggcgcttt cagggagcgc ctccccaagg gagataggtg ccctcggggc 900 tccggcaaga aaaggatagt ttctaacccc ttttcggggg actttgctag ccgtagtcta 960 tagaaccacg ttggagctgc cttcgtgtca tggaacagca agtaagcctc agctggattg 1020 tgtactaggg ccaccaatta acgcagatgc agggaggatg gaccaggtga ggacgttgcc 1080 gccaagtagg taggaaatat gagccacgaa aggggcaaga gaaaggggag gcctggcagt 1140 gcgcctgggt ggcaaggagg acagggggcc gcccctagtc caaggcaggg gaaggaagtg 1200 aaagggggcg cttgtgtgag ggcaccgatt gaattctggg cccgcctggc tatgggtggc 1260 aaggagaaca agggaggaca gcgcccaggg aggaaagaag gagggaagta atcagtttct 1320 aaactgtccg gacccggtct gttaaaccaa ggtcctataa ctacctacat tgttagcttc 1380 taggcaatta ttacggggac tcagaaggac ctggccgctg cccttcattg agtttaaagg 1440 gacaggattg cccttccgtc caggacacgt atgtaagtgt tggactgcac aaaattaatg 1500 tttttcccca caacccgaga ctttggagat taagaactta tttgaggatt tcaagaatta 1560 ggggaaataa atttggtgga aacccgggaa atgagttcta ttcttaaaca gccttttttt 1620 ttcttcctta ctgttcggat atcacaggcg aggtacgagt tggccatatt ttcagagact 1680 tagatttgcg ttatatgtct ctgccttatt tttacaacaa gtttgtgtat cagagcggga 1740 gtgcggggga gggaaagaaa acaaacagtt tcagaattga aattaggcca agtgactgtg 1800 tttaaagatt aagtaataaa gatgtcttat ctagtgtgac ttttaacttt ctgtactact 1860 gggtagaaat tgtacttgaa gccggttacc tggatacctg gttacagtat tatttttgtt 1920 tactttctga aaaacactaa gca 1943 32 1529 DNA Homo sapiens misc_feature Incyte ID No LI093477.12001JAN12 32 tggcaggagc aggtggacag atcctagcca tagatctaat tgctgatgaa gaaagaggct 60 gctggcctta gtgcctttct gatactctag caagaagcgg ggggcaaaaa gagctaaaat 120 tgccacctga tttgcagatc tcagaagcaa atgaaaagga gcttcaccat ctcgagggat 180 gagaaagaat gctgcttcct tttctttctt tctgctctct tttctcttgg gaaggagaat 240 gaactcatgc tgggctcctt cttcaggatt ctcagtgggt ctgagctgtg ggaagctagc 300 attctgttat ctcaggggca cgtggagctc tttccaccaa gacctcctga ttggcatgga 360 taaagcccca gaggctgctt tcaaatgagg ccagagtaat ggagtataat ggagcaaacc 420 tcctggtgga agagttcagt cctactgcag tgataaatca ggaagccttt atgaggggcc 480 agtaatggga cagtggggag tgagttgcca aacctggctc cacatgactt cgaggctctt 540 tgtgggtcct gtttttagcg ccaatggggg attcaggctc aatcttttct gggtgtcctg 600 ggaatattcc tgaagggttt aatttggata gttttagagt tgcatctgtt ataaagattt 660 aataatgagt ttttatggca cttggagcct ggttttgtta gatgttactt tagaaataat 720 aacagcactt tattgctgtt attattgagt gcttactata tactaggtgc attattcatc 780 ataatcatta acaatgaatt ttttttttga gatggagtct ctctctgttg cccgggctga 840 gtgcagtgcc gtgatcttga ctcactgcaa cctccacctc ttgggttcaa gcaattctcc 900 tgcctcagcc tcctgagtag ctaggactac aggtgcacac caccacgcct ggctaagttt 960 tgtattttta gtagagatgg ggggatttca ccatgttggc cagactggtc ttgaactcct 1020 gacctcaagt gatccacctg cctcggcttc ccaaagtgct gggattatag gagtgagcca 1080 ccccacccag ccaacaacga atattaatgc agtacttatg atgttcctat aactcataag 1140 cacacttacc tcaccaggtc ttagaagaac actccctctg gtagccatca cgtaacgcgt 1200 gaggtcattt gaggccctga gctgagatta cttgttctaa aatggccctg ctgataagct 1260 atcatggtac gaagtcagcg gttttgggca tgtctttcca ccagcttctg gaagatacag 1320 cacacaggcc gttcccctct cccccatttt aaagtggcag gagaaggtgc caatgaagaa 1380 aataaacagg gctgttcctg gctctgtgtg gatcagaggg tgataactgg ttcaggatcc 1440 tagcttatca tgtgctgcac atgatattca cagagcattc ggctccggag gctttgcact 1500 gtttgtaatg cattgtcaaa acttggtgt 1529 33 2944 DNA Homo sapiens misc_feature Incyte ID No LI222105.12001JAN12 33 tcaaccacgt tgatggttcc agcaagcctg cggtgctggc ggccccgtct ggcctggagc 60 gctacggcct aagcgctgcc ccccccgccg ccccgccgcc gctgcggtgt gaacagcgca 120 gccgcttcga gtacccgcca ccgccggtga gcctgggaag cagcagccac accgcgcgac 180 tgcccaacgg cctggggggc ccaaacggct tccccaaacc aacaccagag gagggacccc 240 cagagctgaa ccgtcagagc cccaattctt cttcagcggc ggcgtcggtg agcgtctcgg 300 cgtggaacgt cacggtggtg ctggttacgg ggctgcccaa cccggggggg tggcggaggc 360 ccggcagctc accgtgcccc ccaacctgct atccgcagat cgctgcttaa cggcccggcc 420 agcgctgcgg tactcccccc acgctcccag ccctgggcag cgctgtgggc cgcccgaatg 480 ccgtgctccc tccagggggc tcctgagggg cccctgcttg tctctgggga gtaccccggg 540 tgtatcggcc acgtcgtcct ccgcgtcgtc ttcgacctct tcgtcggtgg tcagatggtg 600 ggcgtgggtg ctgggtggta agaggcccgg ctcggtgtcg agcacagacc aggagcgcga 660 gttgaaggag aagcagcgca acgccgaggc cctggccgag ctgagcgaag agcctgcgca 720 accgcgcccg aggagtgggc cagcaagccc aagatggtcc gcgacacgct gctcacgctg 780 gcaggctgca cgccctacga ggttcgcttc aagaaggacc actcgctgct gggccgcgtt 840 ttcgccttcg acgccgtctc caagcccggc atggactacg aattgaagct gttcattgag 900 taccccacgg gctcgggcaa cgtgtactcc agtgcatctg gtgtggccaa gcagatgtat 960 caggactgca tgaaggactt cggccggggc ctatcctcgg gtttcaagta cctggagtac 1020 gataagaagc acggctccgg ggactggcgc ctgcttggag acctgctccc cgaagccgtg 1080 cgcttcttca aggagggcgt gcccggcgcc gacatgctgc cccagcccta cctggacgcc 1140 agctgtccca tgctgcccaa ctgctctggt gagtctgagc cgcgccccca gcgcaccccc 1200 ggggaccggg gccttgccgc ccgccgcgcc gtcgggccgg ggcgcagccg ccagcctgcg 1260 caagagaaag gcctctccgg agcccccggg actcagccga gggcgcagct gaaagctggc 1320 gcgaggaaca gcagaggcag cagctggatg gcgaaccaga gcgagggcgc ctgaagcgtc 1380 accatggtcc cgccgggggc ttcgcggcgc caggggcacg cggcgggggg tccgcactcc 1440 agccagcccc acacctcgtg ggaccccatt ccaaccagga ccaccccacc tgagtcagcc 1500 ccccagaacg ggtccgtccc ctatggccgc tcatcatgtc ggtggaagat tacctctggg 1560 cacagcgcac tcgcccaggg atggcagtcc ggtgcactct accactgcgt cggcgcggcg 1620 aaacagcagc agcccagtct cgccggcctc cgtgccgggg cagcgccgct tggcatcacg 1680 taacggggac ctgaatttac aggtggcgca ccccagccgc ctagcgccca cccgggcatg 1740 ggaccaagtg cacccccaaa acattccgga ttcccccatg ggcaacagcg gacccctctg 1800 ctgcaccatt tgccacgaac gttgggagga tacgcatttc gtttcagtgc ccttccgtcc 1860 cccagccaca aattttgctt cccttgctcc tagagagagt atcaaaggcc aagggggcca 1920 ccggccgang tgtattgccc cagcggagag aaatgccccc tagtcgggtc gaatgtacct 1980 tgggccttca tgcagggcga aatcgcgact atcttagctg gggatgttaa agtgaaaaag 2040 gagagagacc cttgaaccac tgggcagcca cctcctttgc cctagaccag ctcctctcca 2100 atcctgaggg cccctccccc aacccaactc gaccctccct cccctcaccc ccaaggtgta 2160 gaattgtgaa tataacgaaa ctgcaaaaag ttagtcctta tgtatagaca ttatttgcgt 2220 cgtatgtttc tatattttga aacaaaggta tgtaacttct tcatttgaag gataagctgg 2280 tttgtgttaa gcagtatagt attgggtggg gtcatttgca tcatatcgtt agcatttatt 2340 tggtggcaga atggtttgcc ctaggtacag caattcaatc agcccccttt tagccaacga 2400 actggctgct cggtgtgtac tttttgtaaa tgttatgcac tctctgaaag gaaaaacaca 2460 cacaaaagaa aaagactttt tttttttttt tttttttgcc aaggccagtg ttgctgccta 2520 aaaaaaaaaa aaaaaaaaaa aaaaaantgc tataaaatgg tgaaagcttc gcttgctaga 2580 gctgcgccaa gtgttgaaag tcttcacttt attttgttct gttttgtttt gtttttctgt 2640 tttgtttgca aaatggtaag ggggtgtcgg gggggatggg gtgtattttg ttgcaagttt 2700 gtgaggggaa aatgttttgg tttgtttcta ctgacctgga atgtgttgga tctacacgtg 2760 ttgtctttgt ttctgcttta ttgatgcacg gatgcttttg aacagtagag cgaaatgcta 2820 gacatggagg aatctgctct gtttgtcctt ctatacattt ctgtagttaa cagaacactg 2880 taatgtgcct tggagcttag tcaacttgta ataaattcaa ttgatattaa aaaaaaaaaa 2940 aagg 2944 34 4024 DNA Homo sapiens misc_feature Incyte ID No LI816737.22001JAN12 34 gggggctgcc aatggaggag gaagatggcg gcggggcgcg aggtgaggtg ttgacagtgg 60 aaaggggttc gggctcgggg ggcgggggga cgcggaggcg atggcccgcg ccggccgcag 120 gggcggataa aaaagccgtc gcgctgcggg agtgggcggg agggagaggg ggtgtccgag 180 ggccacaaga gtatgtacgg ggctgtacag agcatggtgt ggcgggtgct tgcaaccgcg 240 cttgttctgt ctgcaccagc aagctctacc tcctggctcc gcgttcggtt ctggcacttg 300 gaactggatc tggctggcgc tgcctggcgc agccgtctct gccgcaggtc ctagctgccg 360 ctcgggattc acgctccgga atgcccccgg cagtcggcag gaaccgccgt ctaccaccgg 420 tcacccgcgc tgggggggtc tgtgcctgcc ctgcagccca ccatgcggaa tgcgctgggc 480 gcgcggacgg gtcgttcctt ggaagaaagt cctgcctgtg catatgggcc ctggtgaatc 540 accgaggtgg agcaggaacc ccagcttctc aggacatgcg agagcctcgt ggtgtggtgt 600 ataggccgtg ggcaattctc taccattagc gtctacgacc accaaaggta ttttcaaaag 660 aaactaattc cagattgatg gattgaaatt ttaaaacaaa cagcaagaac tttctgggcc 720 tagattgttc aaaatactca ccagaatttg caaatagtaa tgacaaagat gatcaagttt 780 taaattgcca tttggcagtg aaggtgctgt ctccggaaga tggaaaaagc agatattgtg 840 agagctgctc aggactttgg ccagtgagta gcccagaagc aaaggagacc cacagatttg 900 gatgtagata cgttagccag ttgtacttag ttcaaatggt tgtcctgatc ctgatttaag 960 ttatttgaag ttcggtccct gtggacagca catttagcct tttttccgct ggcacagtca 1020 gattgactga gatggtctct ttgccttccc acctaaacat cagttatgag gactttttct 1080 ctgcccttcg tcaatatgca gccctgtgaa cagcgtctgg gaaagtagtg gtcattggtt 1140 gcataatctt gatttgaggc ttgtggagga aaggaaccaa gtgactctga tgtttacaaa 1200 gcacctatga aaccctgtac acacctatga aaccctgtac acacctagtt cataatcttc 1260 ataatttatc aacaaacaca aaaaagtgtc ttacttgaga gtgagtgtgt gcgtgtgtgc 1320 gtgcacacat gtgcacgttt gtatgtgtgg aaataaactt ataaatgggg acgtattgga 1380 gaaggaaata catagaccta caactttgga gcaaatagca gtgatgtttt aggaactgaa 1440 atgtcacact taataaagtc ttcagcccag ctacttccct gttttcgtcg gggagaaggg 1500 ggcctgatta gaactgttac atggttagtc gttctcgcgc ggcgagccgg cgcaataatt 1560 tttggttcaa agtcacttct tagatgacac aaactttaat gttttaaaga ataatatatt 1620 gacttacctg aactgaagtc attactgagg ttgaaaggga gcccccagag gaaagtgagt 1680 tactgtgttc gctcaccatg ttaaaagact tgctcagcct tcaagacgca gagaggaata 1740 cctatacttc agatatccgc ccattttcat ctctcttcat tatagtcaaa cagtgtgact 1800 tgagaagtgt tgctctggat gtctgtattc tggcttatga agattatttc gacacaaaga 1860 actcttacta cattgaaatg ccgactttta acaaatttac atattggatt aggcagtcaa 1920 aagacccaac caagcataaa aggtcagtaa gttgtaatct taaaagtaaa ggtggaaaac 1980 tcattataaa tggaagaaaa gttttgatgt tccttttgtg tttgatgggc agtatgccat 2040 attatatcca aagttggtgt aaaaaatagt tccatcaact attttcattt aaaataaaca 2100 tttgagggaa gttaccaagg cagctttttt cctcaaaagt aacctgttcc tctttggaac 2160 agcacatttt aggggcatgg gttaatacct gagattttta ctcagtaaat cctgatggtt 2220 actgtgtgta aaatatcctt taaggtagga ttgaaggccc tctgtggggc aatattatgt 2280 tacccaaagc ctatataaat tacattttac atgttctctt ggtatggaca gagagcagcc 2340 actgggttct gttatttttt aaaatgaatc accagaattc ttgacaggtg tttagtattt 2400 cttccctcac tgctgattct tggatagaaa ccattcttta tatttgatag gctgttttca 2460 gaaaactctt atcaacaagt gtacaatagt tatctaaaac tgtacattta gaatggagca 2520 gtttaatact agatctcaga agttttgaaa aatagcaaag aagactggat ttggaaagca 2580 ttggtctaca attggttgtt aaattctgaa gctatgaaga ataaatgttt caactttgga 2640 ttatgaaacc ccatttatga tttttttaat taaccctttg aaattaaaaa tgattaaact 2700 aaattttggt ccagtgacat tactttgcac tgcataatcc attatacgtt gtacgacttt 2760 ttttttttgg ttgaaattaa ttactgaaag tttggggtga agctacagca tatctaacca 2820 gagaatttct gatttggttc cctaatactg tgattattat tatattgagg catttgtagt 2880 gtgcagattg aagcacgtga attttatgcc ttttgtaaac atgataggta ataaatgtct 2940 ttataaacat tctggagtat gttatagctt taatgaatga aatttaatgg acctgattaa 3000 aatgaaggga tttaatcgtt gttaaagtta agttagtcca ataaattacc ttactggaat 3060 atagtccaag tcactaaagg tttaatattt gcattgtttg tgcttttatt ttctccttcc 3120 attcataatt atatacttga aagtacatct gtagcctatg acttgagtct cttgaacttc 3180 taggaagagg caaactacaa actactagga ttctgatttc agatataggc attccagaat 3240 cttctcttat acgagttcac ctgctagtat aatctccaca acttgaatgg ccttggtatg 3300 tatctgtaat tgctgccaaa atcatcacaa gctgtacgtc atcaaggctc cctgttgcac 3360 tcccaagaag aactgttcat tttaacacaa acagtgtatg tcttatattc tgtattagga 3420 aaatattgtc tttaaataag tatcttgtaa gacacattcc cacaatggaa aaattaccgg 3480 aattaaacct gtattaatag gatggctagc ttgggagcta tagcctagaa tttggtagga 3540 tgttgatatt ccattcccag ttctcacttg tgtctttgtt tcttatataa ctataataat 3600 tggttatctg ttatataagt ttaataaggt ggttttaata tgtaatagct aaattctggt 3660 atattgtgac tatacgctta tagaatgcct gtctttgtag taggtatagg tgattataaa 3720 tatttatatc taacagtgcc agaatacact ggtgcatatc tacaagttta atctttggaa 3780 tgtttgttac taggattagc tccctcctcc ttctggtgtg atggtaccaa tgaatagagt 3840 ccaatccaaa tccttgtgca tgctcatgta tggactttga caacatgtaa cgtaatgtgt 3900 aaagcaagtt tttatgatta aggaatcaaa tttattgaat tttattattg aaagttgaaa 3960 cgttaacatg tataaacaaa aaaacaataa aataataaac tattttcatt gactataaaa 4020 aaaa 4024 35 1675 DNA Homo sapiens misc_feature Incyte ID No LI475524.12001JAN12 35 ggcgggccca gcgaccccag cctccagcgc ccccctctga caagcctggg attcgcacgc 60 ccgctgccgt cagggacagg gtctctgccc ctcctccggg gcggtggtcc agtgacgtca 120 ccgcttcttt aagacccccg cctccgcccc tgtcccgaca ctcggcctag gaatttcccg 180 ttatctcctt cgcagtggca gctccttcaa cctcgccatg gcctctgcct ggaatgcaga 240 tccttgggaa ggttcggtcc tgacactgct gggcttgggt gaatggccct ggtctcctgt 300 gccctgccca tgtggaaagg tgactgcttt catctgtgca acagcatcgt ggtggcccag 360 gtgtgtttgg gagggccttg tggatgtcct cgcgtggtgc agagcaccgg ccagaagcaa 420 gtgcaaggtt gtactgactc acttgctggc gctgccacag gacctgcgag gctgcacgtg 480 ccctctgagt gcatcgccct cctctgtggc cctgttcagg cttgcttggt ctaaccatgc 540 tgggggccaa tgttgtacca cctgtgttgg atggacgact ggattccaaa ggccctgcct 600 ggtgctcaac ctctgggatt tgtcttttgt catctcaggg ggtccttgac gctaagtccc 660 cgtgtggctt ggacgggcgc catgccggtc ttccggggac cttctattaa ccccctggtg 720 ggctgagcgc ccaaaaacgc gggagctggt gggcctccca tcaacaatgg gctgggcggc 780 ctcaggccat tttgttgctg ggtgtggggg ttgctgtgct gcactttgcc cctcaggggg 840 ggtcacacag ggcccctagc catttacatg gccctgttag tcaacatctg cccgtgcaat 900 ctctcggggg ccactctgag ttaccactac gcaagaatta cgtctgacgt ggaggttgga 960 atgggggctc acgctggcgg ctaagagcca tccagaagtg gcatggtgcc caacagcttt 1020 ggtgatgggt tcgtaccttt ttgtttctgc ctgcctgcta tttgttcttt atgagctgag 1080 cgatatttaa gacattcatt attgaaaact gatgaccaaa ggtgttgacg tcagactctc 1140 cacttaggct ctgcttgttt ctccaccctt ggattgattg gagccaaaga gggggatgct 1200 ttgagatttt gggatcttgg aacatgcccc atttaagaag ccagtcaagc tatggaaact 1260 aattgacgga ggctgcttgc tgtgctgggc tttgcaacaa ggacaggact gtccccaaag 1320 agtttcctgc tgctgactag ggggtctggg cttcctctag aatgtacaac tggacagctg 1380 gccccgcaat cctaactcaa ggtactactg gagctcctct cttcaccccg tgggaaaaac 1440 aaatggatct ggttaacaaa gggactgccc acctccggaa cttctgacct ctgtttcctc 1500 catcctgata aggacgtcca ccccccagtg tccaggtccc acgctatgta gaccccctgc 1560 gccctacctc caacacttgc acccgttctc gccctcgtct cactccgtct cacgccccat 1620 tttactactc acatttttat caacataaag catgttttag aaagtgcaaa aaaaa 1675 36 2916 DNA Homo sapiens misc_feature Incyte ID No LI383639.12001JAN12 36 gcggctgctg cggagaaatt ggagatgggg accgccctgg acatcaagat taaaagagcg 60 aataaagttt atcacgccgg ggaagtgctc tctggcgtgg tggtcatatc gagtaaggat 120 tcagtccaac accaggaagt gtctttgacc atggaaggaa ctgtaaacct ccagctcagt 180 gccaaaagtg tgggtgtgtt tgaagctttt tataattctg ttaagcctat ccagattatc 240 aacagcacca tagaaatggt gaagccgggg aaatttccca gcggcaaaac agaaatccct 300 tttgaatttc ctctgcactt gaagggtaac aaagttctgt atgagacgta tcatggcgtg 360 tttgtcaaca ttcaggtgag agcttcctag tcctacgcga ctgacttcac aagttttctt 420 ctgacaaacg gtgtggtctt tctctcaacg ttaggtagac gggcccaaga atttaatact 480 gtgtttattg gctgagacct cgcatgtata ttcgacgtta atttctcatt tccctgataa 540 atgcatttga tgtatggccg ttatttctga tgggagcctc caaggcactc gtgctgtaac 600 ttcggtttcc ctctgtttct ctctgggctc ttttcacggc cacctgcacc attgtaaagg 660 gatgctttta tatgtctggt aacacgatat ggcccgtaac ttctttctgg gcacgtagca 720 cttaagcttg tctcgtttta taagcttcca cagtatctcc tttgtttaac accccacaag 780 gctacgtact gttgacaata ggcatggtgt tcgtttacat gaaccaaccc ttgtcccaat 840 gaaggggaaa gtggattaat gacttccctg gttctaacct ctgctggtta agggaccgtc 900 tcttgacagt ctcgctgttg ttgtctcagg agcacgtgga gtccaccgcg gggtgagata 960 gcctttcctt tatgcagcag aaagaaagat acttttgtga tagcagcctc gcagcacttc 1020 ccttgcttgg atgagacaca actcttcagt cttataatgc aagtagggat gaaagtcagc 1080 gaattttttt ggctttatta acgtttgggt cacataattt ggccttatgt agatacatta 1140 tcctgctgaa aataatagaa cctgtaaaat aaaagccccc caaacccctg tgagtgttta 1200 aagattcatc tgtatgggag ttttatgaat tgcctaagag aatctgtcca gaggaaacac 1260 atgtagtatg atgtacatct tctgtgaagc aaaagaagtg tttctagatc ctttattgtt 1320 agcaccaaag gctttggaca gccccaaggt aagccagcca gtgatgatct gagtagtacc 1380 tggattcaga ggaagctgcg tacgtagcca tgcagatacc aattgctggt atgtgggtgg 1440 ggagtcttct gatcagcttt ctaggttggg actgtttcca ccctgaaaga aactgaatga 1500 aaaatgcctt tttggcaata ctgaagatat cttgaacatt gattttggaa attattttta 1560 ttatctaccc agaatcagta tcgacttgct ttatccacac ggcagttctt taatatggtt 1620 gatttaaaaa tacaagaata tgttcattag aaactggaat aagatcacgt tttcagtgat 1680 catatttgtt aactcctgcg ttcatcaaga cttaccaaaa gaagatgaat ttgtttaaag 1740 tccaaattgg gaaccccatc cttttccaca tgtttgccaa gacagatgtt cagatataca 1800 tagaaaacgt gtgtgctggc caggcacagt ggctcacgct tgtcatccct gcactttggg 1860 aggccatggc aggaggattg cttgaaccca ggagttcaag accagcctgg gcaacaacgc 1920 aagatctcat ctctacaaaa gaaaacaaaa caaaaagctt gtgtgcttct gttgctgcag 1980 agctgtgtgt acattggagg ctacttaaaa tatagtagga gagttttaac taggtggtcg 2040 gtctccctta gtaaagggaa attaattggc cccgtaccct cgtccttttc atcatccaga 2100 tgtttaccaa tttgagggtt aacgctcagg gttactacaa tttggaattc agtacctccc 2160 caacttatct caccgatttt ctaacaatgg aagagatttc ttagcttaac ctctgaattc 2220 ccaaggactt tatcacactt attgtcattc agcacttaat agtattttgc catctttgtt 2280 cacctaaaaa tttagatttt tgatctaaat cattttaaag ttagtttcag agtcttgata 2340 ctttcatctc aaaatacctc attgcgcatc tccaaaaact aaggacgttt gtctctataa 2400 ttacagttaa catttgcaca cctatcagaa tttgtaaaaa ttctcaagta ttgattaatt 2460 cttgattcat atcaaaattt gtcgtctttt gagaaaataa atttaagaga aactaagatt 2520 atgttttttt aaatcctgtg cgatcatnnc catccannnt ccattcatnn ntcattcatg 2580 cgcattattt ggcaggtctt tttcttacag ttttatagta gagcaagtgc cgcccagaga 2640 cggcagtgac ttcctgtggt cacacaggcc agcctcagcc tgcgggtcca gaccagcact 2700 cctcggcccg cactgtttac cgcacttact ctaaaggtta acataggcac atttctttgg 2760 atagaaactt ttgttgctaa accctaatat catctttctt aaattatgtg ccaagaaatt 2820 tttcattcat aaattgaatt gtgttgtaac aatctaaaac ggtaaaaatc ataaatcaga 2880 ataaaggatt taaaagatag acgtgctggg tgcagc 2916 37 2773 DNA Homo sapiens misc_feature Incyte ID No LI814346.12001JAN12 37 gggggggctg tcgttggctg gagcagcggc tgcgcgggtc gcggtgctgt gaggtctgcg 60 ggcgctggca aatccggccc aggatgtaga gctggcagtg cctgacggcg cgtctgacgc 120 ggagttgggt ggggtagaga gtagaggggc ggtagtcggg gagtggtggg agaaggagga 180 ggcaggcgaa tcagcgttat aatactaggc gcagaatgca ggacccgaag cctaaacttc 240 caggagggtg agcgaagagc tgtgctttca tgggcctctt cgtctatgaa gcaaagtgtg 300 tagaaggttg ccaataaagg actcgacaag tgaaatatct tcatacatta catgtggttg 360 gaactaaaaa gttcgggatt gaactgggtt ccggagagca gagtactcaa ataacgatgg 420 acaccaattt gcagaataca gcgagaactt caaaaagcca atcaggacgc agtatggcag 480 acgcgggaag atgaagaagg ggctgccccc aggaacagaa gacatctggt cttgcaacag 540 acaaactgtt gaagtgaaaa cgaaagaaga acaaacagaa aacacctgga aatggacgat 600 ggtggcagta ccagtgagac cccctcagcc tcctcggaag gaaaagggcc cgcggtagat 660 cctactgttg aacaatgagg aaaccattca tggaacagag ttaaagttta aagtaacaga 720 ttccctgaag agctaaaacc cgtggcttgt ttgatgactg ggacttaatt taccaggcaa 780 aaacagctct ttttatcttc ctgccaagga agaattggtt ggaattccca ttcctttgag 840 gattatgcag aattacaaga aatcctcgtg gaaacactga taataaggag tatgcggtta 900 atgaagttgt ggcagggata aaaggaatac ttccacagta atgttgggta ccctagcgta 960 cgtcgtataa atttgtagta gacctacagt atgcttgatt attcttgcag tatcatcccg 1020 tatgctaccc tatgtcccag gtgtatggag cgcctactat ctcctgagta ttatttgtac 1080 gtatattggt agccacagtt ggcttataca cctctggatg agtaagagcc cttgctttta 1140 ttactcaagt tatcttcacg atttcgctaa tagtagcctg gcataagaat tctgcaactt 1200 tgttcagtgc cagcgagtta tgtaagtggg ctcctccctc gaggtaccac tcgcggaagg 1260 ctgtgtgaga gggcaccttc tcacactcac acttaatgtt gtggagttct ccgctataac 1320 aaccactttt tgtgtttctt atgtctattc ttcttgtaca cacaacgaat gtggctttga 1380 gagaatgtta agtgtaataa cccattgatg tttgtttttt gttttgattc ttaaacagag 1440 aaaaaataaa atgggggtaa tagctccttt tttcctatct tacctttttt ttcacttcaa 1500 agttcctgcc agtgtattca acaatggaca acagagggat atgctgtacg cgtgttatta 1560 ttagcctagt tgacaaagct gcttttagaa tgctggtggt tctattcctt tgaccactac 1620 gcacttgtta ataatacatg ttaatgctat atgacataaa tgctctgatt cctagtgcca 1680 aaggttcaat tcagtgtata taactgaaca cacgtcatcc atttgtgcta tttgtttttt 1740 tgattatggt gcgttaaagt aaagagccca tcctttgcaa gtcatgccat gtttgttaca 1800 ttaggcattt gtatcttggc tcaaacttgt tgaagacatg gtggcttgtt tcatggtttt 1860 atgtatttgt gtctaatgca cgttttaaca tgtatagacg caatgcattg tgtagctagt 1920 gttttctgga aaagtccaat cttttaggga attgtttttc cagatcttca atagagattt 1980 tttttttaaa ttccaaaaaa aaaaaaaagt aaagtttttg ctatgactcc ccagctaaaa 2040 actacatttc tccatctctc tagtagctga gtaagaccat atgactaagt accagtggaa 2100 tatgagcaag atgatacatg caactttcac ctcacttgtt taaaataaaa ttatttatct 2160 ggactctgtg gactctctct ttccccttcc ccactgactg gaagataagt gtgacaatgt 2220 cctagcttga ccgtgcagat taagacaaga ccctaagagg tggcagagca acataaagga 2280 aggagcccgt gaaagaccca gcagcctgaa tgtgtgacct gttgttatat gataaataaa 2340 cttctttctt actggagcca ctatattggt ctcttgttaa cattagttta gcctttatca 2400 taacaaatag accaacaaaa ctagttcctt ggttttattt cccctaagcc tttcctgatt 2460 tgtgtttcac ccctaataaa acattgtgat tttcccttct tagtaggttt tcctaaactg 2520 tatacaaact acattctgtg tgtaaagtat gggaaagtat ttttttaatt ccatctcaaa 2580 tctagcttac cttattgcac ttacgtattt aactgtgcca tttgtaatag ctataaaaag 2640 ccctgtgttc agatagaagt ttcatgaatt cacttaatag caatgcatta agtgcaaaat 2700 taataacagt gctataatgc tacctaaaat aataagaaaa gggataagac attgtccttg 2760 tgcttaagaa act 2773 38 4405 DNA Homo sapiens misc_feature Incyte ID No LI898195.62001JAN12 38 gggaggagga ggcagagagg agtggagggc ggagtagacg gaggaggctg ctgcagagaa 60 gaaagtgtca gagccggtaa gtgagccagt caccttagag caggggacag cggacagcgc 120 cccagggctc gcttcgcaga tatgtggtcc caagttgctg agctgcccca tggggtcagg 180 tcggtcgcct gtcagtcggc gccgagaaga gactgttggg gcgctggggc cgggcctcgc 240 ggagcgccag agtgcgctct cgctggctga cagcctatct cgggagccag aggaggcccc 300 gggctttgtc ctgcctggtg gtgctggggt ttcgcatcct ggacagcttc cccagacagt 360 gtttggaatt cagggcaagg aagaaagtac gtgcgccccc atttaaccct cgggacctgg 420 cgaaatcctg ctacgtgggt agtgaacatg gtatcgggga ctgaaggaaa tgctggtaaa 480 gagtgttagt ctggagccat actttccctg ccctgttcaa gctccctgga ctgtccggaa 540 gcggagttgt ttgtaaaggc aaatgcagac gcctcctcct cctgtcactt tcgggacaag 600 ttaacaatct tcagattcgt tattaaagcc tcgtgtaccc tatgtgcttc tatcaggttc 660 ggctttagag tgtggtgaaa gggtactttt catggtgcat ggaatggaaa gccaatgcgc 720 aaggtgtacc aacattcgac caggagagac tggaatggta tgtaacaagc cgctgcaccc 780 ttggagaccc caacaaactg ccagaagggg ttccccaacc tgcccgcatg ccctatatct 840 cagacatagc actcttcgac aaaccttggg aagtgattaa ccttcttgag aaagcatccg 900 ggagctatgt gatgtggtgc tagttgtggg cgccaagaag atatatgccc atcgagtcat 960 tttgtcagca ctgtagatcc ctacttccga gctatgttta caggagaatt tggcagagag 1020 ccgtcagaca cgaagatagt gatccgagga cattgaacga gagggcgtat ggaatttact 1080 gattgacttt gcgtataccc tccccagata acaagtagaa cgagggcaaa tgttcaagac 1140 tcttctgcca gctgcttgcc tcctccagct ggcgagaaat acaggaagcc tgcttggaaa 1200 ttcttaaaag agacaaatta gatcctttct aactgcctgg gcattcgggc tttgtgctga 1260 cacaacattc atgtcgtgaa gttgctaagg aatagcagac aagttcaccc aacataactt 1320 tcaagaggta atggagagtg aagagttcat gttgcttccc agccaatcaa gctctattga 1380 tataatatcc agtggatgag ctataacgtt cgcagttgaa gaacatagtg ttcaatagca 1440 gtgactggac ctgggtcaca aatacagtta tttcagggaa agacgtcctc aagttacacc 1500 caggtgtctg cagccatgtt cgtttcgcct ttgctttagt cccatagttc ctgggtacgg 1560 cacatgtagg tctttgatct cgcactacaa tcacaaagta gatgaagcaa tgacagagaa 1620 tcttggtatg atgaggccta taagaagcta cgctacctaa ctatgccaga caaagtaacg 1680 accaactaat cgtcaaggta cccaaggagc gagactcacg gaaacgctat ctcgatgata 1740 ggaggaatgt atcttctttg acagttggtg gattggtgca cgtggagatg cccatttccc 1800 agtgttgaac gactatgatc cacagaccaa atgaatggag aatggtggct tcaaattgag 1860 caaaaggacg acgcggagtt tggggtcagt gttcttgatg atctgttata ggtgcagtag 1920 gaggcccatg atggatcctc attatctcaa tagtgtttga aagggtatga ccccaaaaca 1980 aaccggtggg agcagtgcat gtggggccnc ccctnaatcc aaagcacctg caggacaaag 2040 tgttggtgta ccagtacctt gaaggctttc tttatgtctg tgggtggcca ggatggtgtg 2100 tcttgtcgct caacagttgg atgagaggta tagagtcgca gtaaggagta gagcaaatgg 2160 acatgcgggt agctctacta ctgagtcacc agaaagacta ggtgtcgact gtgcgctgtg 2220 ttaggaaggg ttctttatat gctgtccggt ggctctcgag cgcggacatc tcgcatctca 2280 acacagtgga acgtctacaa tcctcaggaa aaacagatgg cacacttata gcccctatgg 2340 ggacccgggg ggaaacacct aaggctgtgc aggtatatca ggacatgatc ttatgctgtt 2400 aggaggtaga gatgacacta cagaagctga gcagtgctga gagatacaac cccagatgcc 2460 aaaccagtgg tctccagctg gtggccatga cattcacgcc gtaagtggag ttggcctggc 2520 agatggtcaa tggacagctc atggcagtag gaggtaattg atggcacaac atatcttgaa 2580 gaccatagaa gtttttgagt cctgatgcca atacatggag gttatatggc gggatggaat 2640 taccgtcggc ttagggggtg gcgtaggagc ttattaaaat gacacattgt gaatccccca 2700 tatttggtga acacagtagt tagtacagtc tttgtattta ttccctcttg tttctggggt 2760 agctttgacc cttggagctt tgtaccagct tgagtaaaac attagaacat attttagtta 2820 tttgccggtg cctcaaccat atggaaatac aatcctaatg aaagtacttc acctgcaaga 2880 cgccaccttt gcacaagaat tttcaactct gtggcagata ggatatgtta tttttggttt 2940 ttaatgttat catggcgttt ttgttgtttt cgttttgaac ttatccttcc tcccactcaa 3000 ttaaagataa gaagaaaaaa ttccacagca gcaaatactt actttgtttg taagggtatt 3060 catttaggtt tgaaaataca tatttaataa gggcagaagg gcatatatat gcatttggca 3120 tattatttct agacactcta tcacacatga ttccactaac aaggattacc aggaattaaa 3180 ggtcaggtat gcaaaatgta ttagctaccc attattctcg tctctaacca ccagaagact 3240 tgaaaatctt aaaaaaaaaa accaaaaaaa caagaaaagg caacatctca ttttaaatta 3300 gtacaattca aaagggatac taaattcaat taaaaaccag gactcagaca ctacagtttt 3360 catcagtgta attttatgtc ttgtttcttt ctatatgaac ttgtttattt agtctttttt 3420 tcataatatt ctcatagagt ttctggctag aatctagaag ctctgctcag tggcctctta 3480 taaaaacaat attataagtc tcnatcatgc tgtcttgagg aatccaagag aatcacatgc 3540 agctctgcaa cagtttttgg ctcaaaaatg ttactgacta aagcaactgt ccttcctgtt 3600 tccttattgc taccaaggac cagcagggag aaatgttcct tctcgccagc agtgaattct 3660 gttatgcaat ttattcttga tgctcaggcc tggttaagtc tgaggtctta ccgtttaata 3720 acagcctcca agggaatgaa ttattcagtt aatgtaatag cacacattaa agagtgtaaa 3780 atcaattgag gcattttatt aatatctttg gcttcttttt atacattacc atatgtatca 3840 ttatcggttc attctataaa ggtcaatgtg tactagcttc atctcgaaag ttgcactgta 3900 tctggtaaaa agatagaaaa ttgtttaagg aaaaaataat ttcaaatggt taaagttttt 3960 tttcctcaat tgtaattcaa tagacaaatt gtttgtctaa tatattttgc aagtaaaaat 4020 cttttgaata agactaactg catgttaaat aggaataacc tccttgctcc ctttccccaa 4080 ctacaaaaat gtttagacaa actttgtgtt taacatttaa agatcatttg cacctttttc 4140 aaggaaaaaa agtattgagt aaacaattgt ttacatatat catttatgct tttttctagc 4200 atgtataact tttttaaata aaggtagtat ttaccattaa aaaaatttta gctaatgctt 4260 tttatccttg tacttttgtt atttaatttg gaatttctgt ttctatataa tttattttat 4320 ctgtatgtaa agttacaagt gctttcaact tggaggaata aaaggattgc cagctggaaa 4380 aagtaagaga gaaaaaaaga gaaaa 4405 39 417 DNA Homo sapiens misc_feature Incyte ID No LI210497.22001JAN12 39 gttgtcacag aaattgcatt tgtatttata atttgtgctt tctccaaaga aagttctatg 60 gaagataggt aaatttctgc ctactctgac atgattacaa atgctggttt tttcgatgac 120 acaatcagat ttttaaatat atcattactt gatttccctg taaggcaagt tagaagagag 180 gtaaactagt atatccaagt tatggctgag tctacaggag aagcaaaagt tggacttaac 240 caccaagctt ctataaggag gatgctgtgg aaatacgtcc agtaccagaa tgtcccaagg 300 aacacctggg caacagaata ttggtcaagt tgctgacctt gaagttcgag attgaaattg 360 agcccctgtt tgccagcatt gccctctacg atgttaaaga caggaaaaag atctcag 417 40 2476 DNA Homo sapiens misc_feature Incyte ID No LI110297.42001JAN12 40 tgagttatgt gaaaatatcc ctcagtacaa aacatttgtg gtttcacaga tgactctctt 60 gttttgccgt aatgctacca agtttatgga aactagtcaa ctgaaggatt tttctgttgt 120 gttatgtgta aatgtctgaa cagtaaaatc atctgtgtat tcctgtaaca ttcacgaagt 180 atgaggaagt gggtttctcc ttgtttgatg tgagtggttt tgcttgttgc atgggttccc 240 tgtgctttgt aacttgcatg aacacaacca ggtttctcaa caatgatttg tctgctgact 300 cttttcagag atagtggagg aaaaaaaatg tattaaaacc ccaaattatc ctaggtttcc 360 aagtaggaaa aataaagata catatgactt ttattattat tcgatgataa ttagctttat 420 ataatgtggc atccttcata aaaattcact atgttgtgag gcaaacagat ttctcactat 480 catccagtgt accctgctca ccttctcact cctagcaccg ttcttctggt ctgtgttgaa 540 aagggtatca ttcatgtggt ttcagtttag aagagtccct cagagctttg cctcaagcaa 600 tttcaaattg tagtgatacc ttaaatcatg tattcaggat gccttcttta gcatttagaa 660 ccccgactag acttatactt tgactaaagt cagaggcaga cccatttagg gaacagattt 720 tgttctttgc ttttatgata catttgtaac tcacagctgt tagcatgacc tcacatcact 780 gcgtaggaac ccggaattca cattctcctg gtcaggtcac gaaaaagaac acaggcttga 840 ctattgtcca tgaagttact ttccccttga ctaaaggttt ccccttaggg tacacattgc 900 taattttaaa cctttttggc ctttcctaac cccctttttg gttacctttt ccaaaatcaa 960 gacactttta agaaacaaag atagttttct gaacatttct gtgtccgtgc ctggttcctc 1020 cctggttggg attcgcagat gtaatatcga gtaattcatc aactggtctc aattttcctg 1080 gaacagcatt tcactggtaa tccctcattg tcaccgttat ccccctgctt caaagatgtg 1140 ccagttccac ttgggtaatt aacgttggga aaatgcaggt ttatgaatga ctgtggactt 1200 ttagaggatc aaatcaataa attggatttt ttattttttg cagggcagct gccctcactg 1260 ttttaaataa agaatcttac ataagaatgt tgacaacatt catcagtaag ccattggcag 1320 aaaatttgat ctgcatgtcc tagaccaatc gattacaagg tgtctgtggg tctgtggttt 1380 agggcggccc agtcccattc attccttttc cgccttgggc actcatgaga gagatgccaa 1440 gttcagtgtg gatttttctt ggtgctctat gggagaaagt ggagtcttgt gtgcttactg 1500 gaagagtccc aaaaaccaga gaccattttc atttactggc ctcattaaat attctccaac 1560 attcaagata ggccgggttc accgggtaat tggggaaact taagtgttgg aggaggcagg 1620 ggctgaaggt gtcaaaacct cctcagtagg ataacccctt tctccccttt ggaccatctt 1680 gccatctttc atgagtgttt ccccatggtg tttttgcatc cagagttgac aacaactcca 1740 atttctgcct tggaatttac tcagtttctt ataaattaaa aatgtgcatt ttatataaag 1800 atgcatttta tataaaaatg cacaccttta atctctatat ggcagcatat acatatatat 1860 atataaaatg cacactttta atctctatat ggcagcattt ttgaggcttt atatctgccc 1920 gtgtaccctc aactgcctcc tttttgcaga gaacgatccc cacagggaac tggtctggga 1980 acactgtctg gacattaatt ggatgcttaa aatccaatat acccaccaca tatcaaaggt 2040 tgggattttc agagtccttc ttgatttctg agctgaaacc ttaacaaata gggaatttgg 2100 cagggaagac acctgggttt ttaattcaga accctattta tatactgtta aaatttgagg 2160 tactatagtt tatataaaag tcggatgtta agatattata tttcagtact aggagcttct 2220 ttgcagtcat taacatgaca aattaagtaa taaatataca aagtgattgt ccataaatta 2280 tcattgaatt ttttgtttat ttggtagtgt tctgtattta tctgcacttt gtgtatatat 2340 acacacatac atatgccaac catgtaaata acctcatgtt tattcctaat ctaaattgcc 2400 acaatatttt taatgtatgg ttacactgtg ttttaaatta ctttaaaaat aaactttgta 2460 agcagaaaaa aaaaaa 2476 41 1627 DNA Homo sapiens misc_feature Incyte ID No LI2051312.12001JAN12 41 gggaaaagga accaacatca ataactattt ggggaacagg gggaaggtgg gagagttttt 60 aggaatgttt acctatggaa atgtcttgcc attgcagatc tctctttcat ggtgtattca 120 agtgcatgtt cattttgaac attctatttt gtgtttctct gtgttaaatt agcttacctt 180 acagcattaa atctccatat cgccattcct cctcttagag cgggcataaa catataccct 240 tatcttttaa aatatcttac agcattattt cccttcacaa acagaaaagt gagatgaaaa 300 agtagagatg actgattcaa agaaaagtga tagaataccg aagatgactt gtgaaaagga 360 cctggagtgg gttaattaat gaagaatgaa aaaagtgatg gccagcataa tagagagtgg 420 cttgtgagaa ggaagagaat attaactcaa gacttaaaag agcaatgaga cagtaatgga 480 gcacacctaa acggcattct gatcgctgac aaatttcctt tgcaggtatg aggtctctac 540 catagataga aatgacatca tcttctgtac ctaggtattc aacctttgga tccctatatc 600 agactctcag atacgtgtta aacgttggta tcctagggaa tcctttatgt agaaagacca 660 gaaagacttg gaggaggaag aggatgagga aagtaaggag atatattatg gtagaaaatt 720 gtacacacgc taacaagctt ctacagtaat caagaatccg gtgaatgata acaacgggac 780 gcgaaaactt aagttcaagg accagttagt tgatttggaa gttcctccac tagaagacac 840 tactacttct aaacaattat tttgaaaacg aaaggaatat gtttgggaaa ctgtcacaat 900 tatgtatttc caatgatttt ggacaagaag atgtgctcct ggtcacttac taatggaagc 960 tgtgaagaaa acaaggatag gacaatactg gtagagagag atggaaaatt tgaacttctg 1020 aatttacaag acattgccag tcaggggatt ttgcctccca ttaataatgc aaatagtaca 1080 gaaaatgacc ctcagcagtt gttaccctag atcttcctaa ctctctctgt gcagtggcac 1140 gcaagtaaag aagattctac agcaaagagt tcatgctgtc actcactcat caagcaggag 1200 agccgctggc ttatatcgct cagccaccac tcaaccgcaa gacttgtcca agctctgctg 1260 tcaactcaga gtcgaagtaa agggaatggg aaatctaatc acaggacaca gtctgcacat 1320 atctcaccag tgacttcaac atactgtctt tcccctcgac agaaagaact acaaaaacaa 1380 ctagaagaaa agagagaaaa actgaaaaga gaggaagagc gacgaaaaat agaagaagag 1440 aaagaaaaaa agagagagaa tgacatagta tttaaagcgt ggttgcaaaa gaaaagagag 1500 caggtcttag aaatgaggag aattccgcga gcaaaggaaa ttgaagacat gaacagtaga 1560 caggaaaacn gagatccaca acaagctttt cgattatggc ttaaaaaaaa gcacgaagag 1620 cagatga 1627 42 1559 DNA Homo sapiens misc_feature Incyte ID No LI350272.22001JAN12 42 aggccccggc gccgcccgga actgcagcgg gtggcagtag agaagagcat cacagaagtt 60 gctcaggagc tgacagagct ggtggaacat cttgtagaca ttgtcagaag cctgcagaat 120 cagaggcccc tatcagaatc tggaccagac aacgaactga gcatcctggg caaggagaac 180 tcctggaagc cccgtcttcc tcctcatgcc cattgcctga ccagagccac cctgcacttc 240 aggagagctt ctcggtttgc ttcagtgggc catccatcca acctgttaac ttgaagagcc 300 tttcctgcag cctggaggtg tccaaggatt cccgtacagt gactgtgtct caccgcccga 360 caaccctatc ggctggagct gtgaaaaggt tttctaccaa gccaggtctt atgttcccca 420 ggccctgtct tctggaaaag cattactggg aagtggacac taggaattgc agccactggg 480 ctagttgggg tggcttcctg ggagatgagc cgcgaccagg tcctgggaag gactatggac 540 tccttgttgt gtggaatgga aggggactag ccagctctct gcatggcaca tggtcaagga 600 aactgtcctt ggctcagaca gacctggggt ggtgggcatc tggctgaacc ttgaggaggg 660 aaagcttgcc ttctatttca gtggacaatc aggagaagct tctgtatgag tgtaccatct 720 ctgcctcctt ctcctttgta ccctgcctta ctggctgtta tggcttacat cctggaaatt 780 acctgataat aaagcaagta aaggtgtaag gtttcctaag ggattacaac acagtggttt 840 cctggtctct ctccctgtcc atcaatcagg gtagtaactt gacttttaag aataccactt 900 tttagaaaaa ttacgataga gatgggatct cactaggttg cccaggctgg tgtcgaattc 960 ctggtctcaa gcagtcctcc cacctcagcc tcccaaggtg ctgggattac aggtgtgagc 1020 caccacacct ggccaagaat accacttttg aagttaatcc ttttgtgtga tacaggatga 1080 acttgggatg tttgaaccct ggacattcca aataaagaat aggcccctgc ctggctcctg 1140 ggagataacc tctaagccat tagaatatct tgcctgataa gagtgttttt gtttacctgt 1200 ggggccttgg ggcccatgca gtaattccag cttgaccctt gccaaggtca agcctgagga 1260 gacctaagtt agccattgtg ggccaatgaa gcatagccaa tagtggtcaa tcccttagtt 1320 aaagccctgg acaaccttag gctatgggtg agctactctg gttggtaata tctctgtgca 1380 cacatccatt gtagccacac atcattgctg ggagaattaa gcattatcct gaagactctg 1440 ccacggagag gataattgga agttctcttg gagccttacc ttatgtgcct tttttcattg 1500 ctgattttaa tctgtatcct ttcactgtaa taaactgtaa ctatgagtgc aacaaaaaa 1559 43 3597 DNA Homo sapiens misc_feature Incyte ID No LI1085472.42001JAN12 43 cgcacctgca cccggcggag ccggaggagg gcgacagcaa cgtggcgcgg actacgccgc 60 ctcccgggcg cccccctgcg cccagctccg aggaggagga cggagaggca gtggcacact 120 gatgggcgag ctgagcgcag agctgcgaag ggggaactgt ttgcagttag cagccgctgc 180 tccctttctc cctctcttcc tccctctttt gccactgtct gggccccatc tgggattcct 240 ggggcccttt ggaaaagagt tggtgaaatg cgcagccggc tgtggacggg ggaggaggaa 300 tggggacaga gggagcaggt aggaaacact tgtagttggg ggtggggggc gtctccctct 360 ggccccctgt ctgtcttcct ctccgcggtg gagcaaacat gtggacgttg cctggcagct 420 taaaccttgg tagatctggg tttataatcg gccattctta agcacgtagg ggttaggggg 480 aaagttcgga gtacccattc ctgccgttgc ttcctatcct gggcttggca agaatcctgg 540 tagaaaggcc agagtgggtt tgtggagtcg ccactgcggg accagcacga aagctgcctt 600 gtctgctttg gcggagctga gctgtgtatg ggatccagga ggctggggtg atattatttt 660 atgggattcc tggagcgcag ggctggtgaa tccatgacaa ggtccgggag cagcagacca 720 aaaccacagc agcctcctat taagtgtaac aaatagttaa gcaaactcgg gctacaaaca 780 aagactttgc tacctccctc ctcctacaac cccgcaagta attagccttc taggagctag 840 gctctatagc tgagtgctcc tgctacactc ctgctccacc cgccccttcc taggttacaa 900 gtaaatcatt gtcaagggcc agccagggga aggtttcaat taaggttctg ttctgctgcc 960 tttgtttctc ccctgctgtt gtaggcactt acagctgcgt tgttatgaaa ggagggaata 1020 gccctttgtg tctttgatct aattaaacct gcttggctgt gtttatccgc agggcaggtc 1080 acagataggg ttggctgtgc cactccatta aagtatctat tgtggaagca gccaaaaagg 1140 gctgctgtgg caggaattgg ttaatttctc cttccacttc ccttcctgaa tcagtgaagg 1200 gagccctttt aaaacaaggc tttggtggta atcctgtgat ttttttttct cccccatacc 1260 ctcactgggc ccatccctgc tcaccctcac ttttgttctg ctggtgggta aaatcttagg 1320 ctgaacacat atttcaatgg tcaagatact tattttgcta taccacactt gatgcaattg 1380 aattcaaggt gcaaagtctt gtactgaagc agtctccttg tggcttggga gaaacacctc 1440 cttcagaggc cctttgttaa ctaacgaggg gcgacgttga tcatagatgc cacctggtta 1500 agcaccgaaa tctgactttg gtgacaggtc ctaaaggcac agcttggctg attgtgagat 1560 ctgtcacgcg gcaggctgag cagatactac ttggttttgc ttggtatgag atactactgt 1620 ttgcttagta tgagattttt tccagcctgt ctcttaaact cctgtgacat cttcaatgat 1680 atgtgccctc agttgcagca taggcttctc tgctggccta ttgccattgc tgtctcaaaa 1740 gttgagtgaa ttttgaggcg tctttttttt ttttcctctc tgtgggagtc gttgtaaact 1800 actgtgtcca agctcatttg gtgatatgat tctgaacagt tggaatagaa ctcatagtta 1860 agtggtacag ccatggctat cgtcaggcct gttgcctgga gatctctaag ttaaggcaac 1920 aagacttaca agaatttctc taatacactt gttttccaca ctatggacgt tgaggccata 1980 gtctttaaaa gcttggacct ttgtagcacc tcaacatgaa agggcattag ctatgtttcc 2040 tgtttttaca gtgatcacca aacagatctt gccactttga ttgttaaaaa tgaaccacat 2100 tctagccctg gtctgggact ttggagggag atgaatttct tgtgggcaat gtcacatcta 2160 gtgtccatat tgtatactct cacagctttg tgtttattct ctttgctcat ggaatagcag 2220 aacaagatta aacatgggtt aaagaacttt taggagaacc tgctgtatct aacccagttg 2280 gattttcttt catgcttaac acagtagtga aaatagaacg taggccgggc acagtggctc 2340 atgcctgtaa ttcccagcac tttgggaggc tgaggcaggt agatcacctg aagttaggag 2400 tttcgagacc agcctggcca acatggcgaa accctgtctc taccacaaat acagacaaat 2460 tagctgggcg tggtggcagg cgcctgtaat gcctgctact tgggagcctg aggcagaaga 2520 attgcttgaa gctgggaagc agaggttgca gtgagccgag atcgcaccac tgcactccag 2580 cctgggcagc tagagcacag tagtaataac caccggtgta gacaagtcag gagggaagaa 2640 tagaatggca ctgtccagct ctgggctagc cagatcaact ccccccaccc gtcttcttcc 2700 ttctgtccca gaatggaaaa tgatgtatgg tcagtacacg ctgaagtata gcagcgactg 2760 tgttaagaga gagcagtgac tctctcttct agagaagagg ttttcaatga acagggcttg 2820 gaaatggaac tagaaatagg aaatagatct tttcagatgc tgctttccca tgtaatacaa 2880 gcgtttctac aagggtacca cgaggtgtga aatattgtga cacttataga acatgtgatt 2940 ctttattcgg gaattttctt agggttatta cacttaaagc aacaaaccaa ctagtaacag 3000 ctccaggaac aggggaatga atcaactctt ggttctttcc tgaaagacgg cagtgttgtg 3060 gattaagtga gtttttaatt gccctggcag tggcttcatt tgacacttta gaaaaaataa 3120 acatatttaa tacattttgg tttctcctta ggaataacga ctgtagaacg tgtttagtac 3180 tgtgacatta cggatgctct ttgaagggaa agaaatatcg attctaatgt tccttccaga 3240 agttctgggc agggataagc aggacatcga ctggaacgta tgctaaactg aaagcagaca 3300 aatttctatt ttcttacctg agcaaatatt ttgtttgaaa ctgcttatgt atgtcaaagg 3360 agcccacaac ttcagctaca caactttttg tatttgaaag aactcatact ttttgtagct 3420 tttatttcac atttaattta aagtgacttt tagcactaaa atgcctagaa gattttactc 3480 cagacctata aggaaatgtt tagtttttat gacaaatgac aagtcgatgg ttaaacttct 3540 catgtctttg gtgctttggc ctatagcact ggacaaacca gaacaatgga aacatat 3597 44 1090 DNA Homo sapiens misc_feature Incyte ID No LI1190272.12001JAN12 44 ggccggcggc aagtgctgtg atgcggttcc ggggaggggc cgtcgggtag aggctgaata 60 ccagtttccg agcggcaagg caagcgatgg cgatttttaa gtgtgtatgt ggtgaacaaa 120 agctggcggc ttgatttacc acgttggaca gctacgcgcc atcgggctga ggctgagaaa 180 actttcacgt tatacccgtt ggatctgctg ctcaagctac acgatgagcg tgtggttggt 240 tgctttcggc cagcgggacg gcatccgagt gggtcatgca gtgctggcca tcaatggcat 300 ggacgttgaa tggcaggtac acggccgacg ggaaagaggt gctggagtat ttgggttaac 360 cctggctaat tacccggtgt ccattcgatt tggccggccc cgcctcactt ctaatcagaa 420 gcttattgct gggcctccat gttccactcg ctctttgcca tcgagatccc aagactgtct 480 cctgaaacag gggaagctca ggcaattgag atgctggagt gcagacagca tgtcaaattg 540 cacttgctac cagatcactg acagggatca agtttgtggt tctagcagac tccctagggc 600 aagcctggaa ctaggattct cttctccgaa acgactttat gatgacttgt actcagacat 660 tttgccgctc atagaatgcg cagttcttat tcgcgttaga aagtgcctac tcaggtgtga 720 gctcttttga cccagaaccc tgaagctagc tctggacggt ggcagagaag gcatggaact 780 tttggactat gggtcatagg ctgaaccatg ttaatggacc ccccaaattc tgaagagttc 840 atgcaacaag aatactgcgt gttagacacg tccaagtgga aatcccagca gccttgatta 900 gtgcacttga aagtgggaga atgctgaccc tgatgacttt gtactgattc ctgagcctta 960 acacttgtgc tctttccttt ctgtatatgc catggtctta cttttccaac tctgtacaga 1020 tttatttatg gaggagctag gtccataaaa tgttgtaatt aaaaatccct ttgatcttgg 1080 aaaaaaaaaa 1090 45 3608 DNA Homo sapiens misc_feature Incyte ID No LI1086797.12001JAN12 45 caaaaatttt cggcatgtat ttcatctaga tcatgtcctt attggatcct ctaaattagc 60 agtggtttgg cataatagtg ttttagtgtt tatctatttc tacattagaa atacatcttg 120 gtgttttgtt tttttcccga gcctgctagg gcgagggggg tgaatggtta gatgagttta 180 aaaataatgc agcccttgtt tagtcacctg tagaatatga gaacatttta acagcacctc 240 tcttatcttg cagatatatt gccaacgatg ctacatgcag cagacagctg gtgagcttgc 300 atacacacac acacaaatat acatgcacat acatacacag aatgcagtac tagttaagta 360 tttccttcct atctttaata aggtaagaga atatttagac cattaaaaaa aaaatacaaa 420 taagaaatag aagagagaaa tggagccaag gggactaagg agagaaccag aaccatctaa 480 cacaggaaaa tttatatgca ttaaagcacg atccttttta tttcttataa gtctaaatgt 540 ggccttcgca aatgctaatt ctacttctat ctatcataac aggaatagca atgtttagaa 600 aaccctttgt cctagcctga aatgttaacc taaccaatgc agagaagtag aagatgaatc 660 tacaataatt attatttccc aagctatgta cttgccatgg tttgttacca agaatattcc 720 ttatgatttc ccaggtcctc agtaattgct aaagcaaacc cacacttgca ctgcactcaa 780 accatatggc ttcaaaatgt atcccacaaa ataggtgcag tgctgagaat gaggaagaca 840 aaaaggtcat ctcattacag ttggataaag atcaccacgc tttatatgtg gcgttctcta 900 gctgcattat ccgcatcccc ctcagtcgct gtgagcgtta tggatcatgt aaaaagtctt 960 gtattgcatc tcgtgacccg tattgtggct ggttaagcca gggatcctgt ggtagagtga 1020 ccccagggat gcttgctgaa ggatatgaac aagacacaga attcggcaac acagctcatc 1080 taggggactg tccatgaaat tgtgcctact tcaactacat cagattacaa aactatttgg 1140 cggtccaaca tctggtgtac gatgggaaag tccacttctg gagagtccaa ccagatggtc 1200 cacatgcaat gtcctcatca cctgtgtctt tgctgctttt gttttggggg cattcattgc 1260 aggtgtgtgc agtatactgc tatcgagaca tgtttgttcg gataatacag aaagatccat 1320 aaagatgcat agaccagcca ggacagagca cagactccag tggaagtttt gccaaactga 1380 tatggtctct ttgacagccc tgtcaaggaa tacctaacag taatattgat tctcctaaac 1440 tgtatagtaa ctctgctaac cagtcggaaa gagctaccac ccaatggaga tactaaatcc 1500 atggtatatg gaccatcgag ggcaacctcc agagttggct gctcttctct actctctgag 1560 tctacacccg tgcttcacca gaagaccctg caggccatga agagccactc agaaaaggcc 1620 cactggccat gggagcttca aggaatagaa acccctcagt tttttccgtc tagtccgcca 1680 cctcattccc cattaagtca tgggcatatc cccagtgcca ttgttcttcc aaatgctacc 1740 catgactaca acacgtcttt ctcaaactcc aatgctcaca aagctgaaaa gaagcttcaa 1800 aacattgatc accctctcac aaagtcatcc agtaagagag atcaccggcg ttctgttgat 1860 tccagaaata ccctcaatga tctcctgaag catctgaatg acccaaatag taaccccaaa 1920 gccatcatgg gagacatcca gatggtcaca ccagaactta atgcttggat cccatgggat 1980 cgatgtctga ggtcccacgc tataagtgct cctaaccggg aggcatcgct atactcccct 2040 ccttcaactc tccccagaaa tagcccaacc aagcgagtgg atgtccccac cactcctgga 2100 gtcccaatga cttttctggt aagacaaaga gtttatcgac gcaggatgtc ctacccagag 2160 gcactctata tctgctatgc cgtaaaactt aaactcgcca aatggtgtgg ttgtgattca 2220 gaccgcctag tatgaaccgt ggaggaaata tgcccacccc cactggggcg aaggtggact 2280 atattcaggg aacaccagtg agtgttcatc tgcagccttc cctctccagt acagtagcta 2340 gctacaccag taatggcact cttcctagga cggttatcta aagtaggacg ccgtccttaa 2400 atacctgacg tgcctaccat aagccttcct ttgttcctct atacccctat ctgtcagacc 2460 tactgaacct aatacactat actaggcctc aagtgtgcta ttcccatgtg gctttatcct 2520 gtccgtgttg ttgagaggat gatgttgtaa gggtacctta aaacaagaga ctcgctatgt 2580 attttaagag aaccaagtgg ccaaagaaac tctttcctaa ctttggcaac atcagaactt 2640 ggccacatgt agctactgca gcaaggcttc tgtgtacttg cctgaaaaca aaggaaggtg 2700 ctggtcattc catttctttt gtttgaagct aaagagatgt gtagctcaca ggggctacct 2760 taccagtata aagagctgat aacagtactc agaagaatct gtgaacaaat acttgaaaat 2820 gggttcaatg tagactgcca ttatgtgtgg tcttcccatt aaatgtgaac gagttttaat 2880 atgtatgcat tcaccttgcc tccttgcaca aatgtcacaa ccaagatggt aatatctcaa 2940 agacatgaac ttgtagatta ccaagccagt ttgctaaaca attcaatctt tgacccaagc 3000 tgtagcattt ttttttcatg tgtggcatct ttttcatgcc accaacaaac ttgttgtgtg 3060 tgtgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttct gtacccacta ggatttgttt 3120 aagggtagcg cccattgcat ctttttgtgc tatggagttg tttacattaa cgcatgaccg 3180 aagcgagaga caatactatt tcccacagga gctccattgg gttcagcttt gaaagaggaa 3240 tagaatgcga ggctcctttg accatcaaaa tgatgaactt tacttatgtg gtacccaatg 3300 ccagaatgta agagttgcaa gtgattttgt gctgctattc attaaaactt gtattccagt 3360 cttgccagct taaggagatc aagatattaa gaggtatcct tgatttattt tccagtattc 3420 agtagtaaaa ttttcctgtc cactgtgaat caaagcctga gtcactctat ttaaccttgg 3480 gacacactaa tcaaggttat attttgattg tgttcctttc ccccccccca atagtaaaat 3540 ttctccctcc tttaaactcc tcctaacccc cccaagggta aggaaacaaa aaacaaacaa 3600 acaaacaa 3608 46 2170 DNA Homo sapiens misc_feature Incyte ID No LI1144466.12001JAN12 46 agtgggatgg ccttatacct cccagccgtg aatgccagac tatcaagcat tgcccggagg 60 aagcaaactc ttcgtataaa aaaagcaggc catctgctta acccttggct ccaccataag 120 gcactgggac tcgggatttc tctatctgat agaggtattt tctgtggccc tgggagctgt 180 ctgtctttcc cctaccccca aggatgccag gaagacgtcc accattagcc atgtggcaac 240 ctttacttct atgcctcaca agtgcctttc agagagcccc aattctgctt tcccacaaaa 300 taaacctaat gccatcaggc aaaacatttc tgtgtctgta tctgccctgg tatattgcgt 360 cattcctggg ggtcaacatc ctggcctact ctaggggtag gtgacggaga gctgtttcag 420 tatttccagc cagaccagcc atgcagccca ccttgagcag gtttgtccgg tggaagaagt 480 gagaatagtc ccccggttct ctcacaggag aaactcccct ggtctctcta tcagcaacag 540 aaaaccaagc cagatggact ttgcaaacta atcaattttg ggattttact gtcttctgac 600 caaccacagt gactgagatg gggctgggac caagaagccc cagtgggagt gaaacagccg 660 agggaaccag agtctggctg agcttgtggg ccagatattt acacactggt gtcacagcnc 720 gacacctgca aaacccaggg gcaagggcag tacccgggga aaactggctg gagttgctag 780 cggtttgggg aagttgcaca ccctttcata gataccctcc ccctttaacc cctccagtgc 840 agattctgag aaaactccaa gggcttctct ggcctaacct tagtataatc ccctgtttcc 900 ctactacata catataactt gtgccattcc cccaggtaat tgacccaaag tccctggcct 960 ctagctgtgc ccattggtgc aatcgatcag aatcccttgt ctctcaatag tattttgact 1020 tctctaagaa tactctgtat ttcggaagct gaaacctcac ttgggatcca cttgttggga 1080 acccaagtac ggagccctta catagcccgg aaaggagttt caggagcaat gcccactttc 1140 ccttcccatc ccctccctct gggtactggg ctcttcccca tagtccatat ttacccctat 1200 ttatctccca ttaatttctg tcttcctctc tcaccttttc cacatgtctc tagcatcctc 1260 ccaggattta aaatcatctt tacccaactt atctgtgaag gtaatggcaa aagaacatct 1320 ccaaattaag tactcctttt cttcaaagga gtttccatgg gatgtacagc tagtataaaa 1380 taaaaatatg ggaagatgtc caattcttaa aaacccataa gggccaaatt aagcaccaaa 1440 ctaagctgcc ccagacccgg gtgagtggaa cccagtttta tgaataaaaa tgcttgtctc 1500 agcactatat gtggatatca aaaattgtga acaacttgaa cacctatcag gaggagaata 1560 ctgttaatca attatggcac attcaggaga taagtgttgt tacagtcatc aaaaattgta 1620 tatgagggcc agcacggtgg ctcacacctg taatcccagc actttgggag gccaaggcag 1680 gcggatcacc tgaggtcagg agttcgagac cagactggct aacatggtaa aaccctgttt 1740 ctactaaaaa tacaaaaaag taaccgggtg tggtggcacg tgcctgtaat cccagctact 1800 cgggaggctg aggcaggaga atcgcttgaa cccgggaggc agaggttgtg gtgagctgag 1860 attgcactat tgcactccag cttgggcaac aagagcgaaa ctctgtctca aaaaaaaatt 1920 gtatttctga agaattgtta agaacattgg aaattcttga gatataatat tgattgggaa 1980 aaagatgaaa ctatatggta tgatctcaat atgtcctgat gaataaaaac ataatacaga 2040 ggacattatt ctgagataaa atacatcaaa atctttccat tttatttgta tacttttaca 2100 atttttgatt ttttaaaatg tattctgata cacaaaataa taaaaatgaa aaataaaaaa 2160 tttggccggg 2170 47 1394 DNA Homo sapiens misc_feature Incyte ID No LI1147914.12001JAN12 47 gagggccagg agactattac acagactaaa ggtgggggtg agtgggttgg aatggccgtg 60 attggatgct agaaggatcc ggcactgaca agaaaagggg agggacatta gtgggaaact 120 ggtaaaatct gaataaagtc tttagttaat agtaatgtac tgatgttaaa ttcctggttt 180 cgataactac accattatac cattacaaaa aacatggctg ggcaaccccc tttgggtccc 240 gtccctttgt atgggagctc tgttttcact ctattaaatc ttgcaactgc actcttctgg 300 tctgtgtttg ttacggtttg agctgagctt tcgctcgccg tccaccactg ctgtttgccg 360 ccatcggaga cctgccgctg acttccatcc ctccggatct ggcagggtgt tcatgtgctc 420 ctgatccaga gaggcaccca ttgccattcc tgattgggct aaaggcttgc cattgttcct 480 gcangactaa gtgcccgggt tcatcctaat cgagctgaac actagtcgct gggttccacg 540 attctcttcc gtgacccacg acttctaata gagctataac actcaccgca cggcccaaga 600 ttccattcct tcgaatccgt gaggccaaga accccaggtc agagaacacg aggcttgcca 660 ccatcttgga agtggcctgc cgccattttg gaagcgacct gccgccattt tggaagcagc 720 ccaccatcat cttgggagct ctgggagcaa ggacccccgg taaacacttt gggcgaccag 780 cgaagggacc tccaaggtga attgatactg taaaactaca aatggttcat caaatggagc 840 ccctagatgc agtccatgac gtaagatcca ccgtagaccc gccggaccgg tctcccagcc 900 catgctctgg tgttaatgac atcgaaggca cccctcccaa ggaaatctca gctgcacaac 960 ccctcctatg ccccaattca gcaggaagca gttagagcag tcatcggcca acctccccga 1020 tagcacttgg gttttcctgt tgagagtggg gactgagagg aactagctgg atttcctagg 1080 ccgactaaga atccctaagc ctaggctggg aaggtaacta catccatctt taaacatggg 1140 gcttgcaact tagcatcaca cccaaccaat acagagagct cactaaaatg ctaattaggc 1200 aaaaaacagg aggtaaagaa atagccaatc atctattgcc tgagagcaca gcaggaggga 1260 caatgatctg gatataaacc caggcatttg agctggcaat ggctaccctc tttgggtccc 1320 ctccctttgt atgggagctc tgttttcact ctatttcact ctattaaatc ttgcaaccgc 1380 actcttctgg tccg 1394 48 1392 DNA Homo sapiens misc_feature Incyte ID No LI758086.12001JAN12 48 cttggatatc tgctcatttg gcccgatgag aagagaaaaa cagaaaacaa aagctctgag 60 tgggtagagc gtggggggag cttgaagctg ttattaaagg aaggtatgat taactcctaa 120 ctcacagccg cttcagctca tctccatggc tcagccacca ggccagcctt tgctgtcacc 180 taacagataa ttattgtctt ttctacaata tgattaagtg gaaggagaat cagaacactg 240 tagaactgga tctgatattt cttgttagca tatatatata tatttaatct atgtgcttgt 300 ccttgaaaac agcacttcct gtacccagca atcacagagc tgctcttgga atttaacacc 360 ctggtggttc tcaaatgcca tctgaaaaac attattagtg ttacccatca tgacctctgg 420 gtagtggaag gtgaatggga gaaatctctc cccatttgaa gaaataggga accagtctca 480 ctttgttgcc caggctggag tgcagtggca caatcttgct cactgcaacc accacctccc 540 gggttcaagc gatcctccca cctcaacctc ccaggtagct gggtctgcag gcgtgcgcca 600 ccacacccgg ctaatttttg tgtttttagt acagaaagag tttcaccatg ttgaccaggc 660 tggtctcaaa ctcctaacct caagtgattg gcccacctgg gcctcccaaa gtgctgggat 720 tacaggtgtg agccactgca gcccagccta cgaagttgtt tttgcggtta agcagcaatt 780 tggaaacgaa gcatttctga ggagctcagt ttaagaaaca ctgtgatgtt gtgttttaaa 840 cctatgaact cccctccgta gctcatccct ctacttttcc atctaacccc agtactggca 900 ccttctctat gattagtaaa tttcttcagc tagaaatgtt acagtctgtt ttttaacaat 960 gaagtcagga cccagtggat tatagcattg ttacacttca tgctcatgtt atataaaatt 1020 gcataaaatg tattaaaatt tatgtctgct cttatctctg ccttgcaaag aatgaatttg 1080 tatagctttt aactaagcat gtaacggggg cagcaccaca tctggaattc aagctgactt 1140 tctcacgtac cgtaatcttt gtgcttggtc taataagtac aaccccatgt gtgtttatca 1200 tttttttatt gtatgcacaa tcttgagagt acattccttt ttagttctgt attgatttgt 1260 tctcttggtc gtctgttcag aaatacattc aatacctttg gggaagggca aagatgattt 1320 ctgcaaatgt tgcccttttt tattaaaaat agcttctgtg gtctttctta taaaagcaat 1380 acatgtttat tg 1392 49 2299 DNA Homo sapiens misc_feature Incyte ID No LI765245.52001JAN12 49 cccccgcccg cccgccagcc atgagctcca cgcagtttca acaaggcccc tcggtacggg 60 ctgtcggccg aggtcaagaa ccggcctcct gtccaaatat gacccccaga aggaggcaga 120 gctccgcacc tggatcgagg gaactcaacg ggctttccaa gcggccccga attccagaag 180 ggcctgaagg atgggactat cttatgcaca ctcagggaca agctacaacc cgggtccgtc 240 cccaagatca accgctccat gcagaactgg caccagctag aataaccctg tccaacttca 300 tcaaggccat ggtcagctac ggcatgaacc ctgtggacct gttcgaggcc aacagacctg 360 ttatgagagt gggaaccatg acgcagtttc aggtgtctct ttctcgccct ggcggggaag 420 gccaagacta aggggcttca gagcaggggt ggacattggc gtcaagtact caggagaaag 480 caggagccgg aatttcgacg atgccaacca tgaaggctgg ccagtgcgtc catcgggctg 540 ctagatgggc accaatctaa tgcgccggcc cagttcaggc atgactgcct acggcacgag 600 gaaggcatct ctatgacccc atagaaccat atcctgcccc cccatgggac cacctcgacc 660 tatcagcctc caagatgggg cacgaacaaa gtgcgcccag ccaaggtggg caatgacggg 720 ctccccggga cccggcggca cattctatga taccaagctg ggaaccgaca caagtgtgac 780 cacgtcctcc aaagtcccct gcagatgggc tacaacgcaa gggcgccaaa ccagaggcgg 840 ccaaggtcct tcggcctggg gcccggcaag ataatatgag ccccaaagta ctgccccgca 900 taaggcacca cgtggccgaa tggggcttcc ctcggggcac ccggcgcatc tgccccggac 960 cccggggggg acggtccctg agaatatccc cccttactac cacggaggaa ggccggctaa 1020 ctgaggcgtc cccagctaca gctctctccc cacatcgttc tgcccacttc tgggtttttg 1080 ggttttttct gtgttttcat cttttttggt tttttttctc ttaacccgtt cagtgctgcc 1140 agttcaacca ggggttctgt gagttgtcag cggtgggact cggcgcagca gagctttttc 1200 tcccctttgt gccttgactc cttcgcaagg cctgacgcca ctagggctag taggggagaa 1260 gggtggtcaa ggccattatt cccaattacg ttgtagggcg agggctccct gtgcgtggca 1320 catttcaggc tagtcgctgg ggaaagaaga gcacctggcg ctatgcgaac ggacaccggg 1380 tccccagacg gtatctctgg tatgcctcgc ctcttccccc tttgtgtcac gctgagcagt 1440 ttgggtggtt tctatagccc gcaagtttca ggaatgtatt cacacaaaga aaaatactat 1500 ttttcccccc caggggtggg tgcaagtgac agtggagaga gtgtctagga aatgagtccc 1560 ctgggacaag gggacnctgg gccgtgatgt taaatatgct ccggcttccc aagtgactgg 1620 atttgcgcta ggaccntttg cagatcaacc agacttncga gaccctcatg acctgccccg 1680 gggccaggtg gacgaacacg ctgagggcac gtacaagtga agtgaaattc tgagttngct 1740 ctggggcttt aagcctgacc ccctctccat gctccccgcc ccaactcact tctggccttt 1800 cagtagattt gttttttcag ttgtggttgt tgcccaggct ggagtgcagt ggcgccatct 1860 tggctcactg cacctccacc ttccgggctc aagcgattct ccagcctcag ccccctgagt 1920 agctaggact gcaggtgctc caccacgccc agctaatttt tgtattttta gtagagatgg 1980 ggtttcccca tgttggccag gctggtctcg aactcctggc ctcaggtgtg atccgcccgc 2040 ctccgcctcc ccaagcgctg agattacagg tgtgagccac cgtgcccagg ccctcagtag 2100 gttttaagga gtcacaccag ccctcctccc ttctgggcgc acgacctagc gtttatatct 2160 gctccatctt cccacggcca catgcccacg ccaagtactg cacagggacc ccccacccca 2220 ggggacctgc tccgtgagat aatgtgaaat acgactgtgg accaacacgc aagtaaaacc 2280 tctggtttgt acgaaaaaa 2299 50 1098 DNA Homo sapiens misc_feature Incyte ID No LI335608.22001JAN12 50 gtcaaagcct gcttataaac caacctcctt ccttccacta aaataattgt gcaaacgggt 60 tgtcctttcc aattcttttt ggatacctta ttattaataa gtttatattt ctccattatt 120 aaattattcc cactttcagc gtgttctaaa aaactttaat tattaattat agaagaatat 180 tttctattat tcaaatacat tattaaattt taattttagc aatgtggcaa aaagtttaga 240 aattctcatc ttaaagaatt ttctcagtaa agggcaagcc caaattacat ctaatgaaat 300 atggtcccat taataaggta agctattgga gaaaaaagat aaaatggtat agtggtggtg 360 tactaaacat gaagagatta caaagactta tggtggagta gaaaaaggcg aggttggcag 420 aaactgggac acaggacagg gagtaccttc aaaacattat atggccaggc acggtggctt 480 atgcctgtaa tcccagcact ttgggaggcc gaggtgggca gatcacttga ggtcaggagt 540 tcaaaaccag cctggccaac atggtgaaaa cctctctact aaaaatacaa aaaaaattag 600 ccatgcgtgg tggtgggtgc ctgtaatccc agctactcgg gaggctgagg caggagaata 660 gcttgagcca gggaggcaga ggctgcagtg agccaagatt gcgccactgc actccagcct 720 gggcgacaga gccagactcc gtctcaaaaa aaaaattatt atatattttt atgtgtatat 780 aaatatgcac gtagatgtat acatgtatag aaaaagcctg gaaaaatgca cctgaaactt 840 ttacagtgat cttctgggtt gggagtgaca aaagggcctt acccttgttt gtaatggttt 900 ccttttgtat aacagaatgt accatgtatt acttatgtaa aaaattttac cctcacactg 960 tatttactct tacaattggc gtacagtatt ttattgtata gatggtcatt atttattcag 1020 tctgttaata atggtcattt aagtttttct ccagttgaca actctaaata acattgagat 1080 aaatgtagat aaaaaaaa 1098 51 2238 DNA Homo sapiens misc_feature Incyte ID No LI405795.12001JAN12 51 gttattagaa tatacactgt catgtcatgc tatatgtaag ataattagca accatgaaca 60 ccattattac acagtttgtt ttgaaaatgt gttaatcctg cctccaacct aaattttgtc 120 aaggggcttc tatttctttt tttggggggc aggtaatatt tctcttggtt atgatatgac 180 ataatattta agaactacag attctgtttt tcttggcatt agtggtgatt gggaggaata 240 gaaaagaatt acaagcataa tattccagca cagttacgtg tgagatgtaa attaaaactg 300 ttctataaat ttgtaagttt caaacaagta taactgttaa gcaaacacag caggaaattg 360 taaactgttt cgtgcaagag ggtgttttag ggcatttttg ccaaggttag gtttcaggct 420 catagaccta ctatgtataa ttatcacaat attttcaagt aaagtttaca agattcttta 480 aatttgggaa gtccaaaatt aaagacttaa tttaattgtt atttttttga gacagggtct 540 tgctcctgtt gcccatgctg gagtgcagtg gtgtgatttc ggcttactgc aacccccgcc 600 tcccgggttc aagtgagatt cttgtgcttc atccacccaa gtagctggat tacaggcatg 660 caccaccata cctggctatt tttgtatttt tagtagagat ggggttagac catgttggcc 720 aggctggtct tgaactcctg gcctcaggtg gtacacccac ctcggcctcc caaagtgttg 780 gattacaggc atgagccacc atgcccagcc aatatattag aatttctata aatgctgttt 840 gaagtaacat ctttactttc taagagtcca aaaattagca aacaggtaca tgttcaaagg 900 taaatgctaa gaaattgggt aatccactct aacagagaac agagattgta tctattaatc 960 tatagaagga attgcgtaac tcattatttt gggaataatg cttgtcttta catggattat 1020 gtctatcaat ctgtagaagg aattgcataa ttcattattt taggaataat gcttgtcttt 1080 acatggggca agtaagaggt taattattag tgtggattct tcttaaaagg aaattagaaa 1140 ttatctacat gacaacatat cctccctacc agtgactaaa ggaggcagaa taggagtatc 1200 tatgcaagct tttaacactg acattgtccc aaagtaaaat tagcagataa aatcatatat 1260 gacagctgtt agtataattt ttgcttttgc tattgtttta taatttgaca actttttaaa 1320 actttagaat tcctaatgtc ttgtcttaaa agtttttcag gctgggcatg gtggctcaag 1380 cctgtaatct caacatgttt agacccagac aggaggattg cttgaggcca ggaatttgaa 1440 attgtcctgg gcaccgtagc gagactctgc tttctaccaa aataatttaa aaaaaaaaaa 1500 aattgccagg tatggtgatg tgcacctgta gtcctaacta ctctaagcct gaggcaagag 1560 aattgtttga tcccgggggt tcaaggttgc agtgagctgt gattgtgggc cactgcactc 1620 cagcctgggt gacagaacaa accctatctc aaagaaaaca aagaaaaaag gaaaaaagaa 1680 aacccccttt ccagtgttct attatagaca ttttcattga tcaataagtc actttttctc 1740 tagtgcaatg gattcttatt tttatgtgaa tcatcaacaa aatcaatgca accaacttag 1800 gctgttctgt ttaaataaat taagaaatga gggtgtgtga agttctaaaa ttgtacagaa 1860 ctatgcttat ataaaaagtt tatttctact cctgtggtat ttcagaaatt cttaagattc 1920 ctgaggatac tactttctct aagtatcaaa tgaccactag cctggaataa taaatagtaa 1980 gcaagacagt aaatactaca gataaacaac attttcccaa agttaatcca cattctaaat 2040 tgggaaaagt gagtaataca ttcaagaagc agatatatat attcttaaaa tacgatgctt 2100 tggcttactg ttttcttaaa gctttctgtg tctgggcttt cttttattgg tttagagtga 2160 attttatggg ttctatgagt actaaaaatt ctgtttatat atattgtttt aatgtaacac 2220 attatatagg tgttttcg 2238 52 1359 DNA Homo sapiens misc_feature Incyte ID No LI014872.12001JAN12 52 tatcctcaat atggctatca tttctaggat acaaccgaaa tttgctctgt gcatgtttta 60 cctaaaattt tagataaaaa tgtaaagaag tatatttgag aatgtaagaa tttcatagtg 120 actgaaccag aatctgcctt tagnttcttc tggctttaca tcctccttaa ttctatgcaa 180 ttctgggtat ggaagaaaac taatgcagaa attgatctga agtattggca aacagaagac 240 ctccaatttt cccaatattt ttcctaaggc tttcctgtgc ttctccccaa cactgattgg 300 ctagcattga tagcttattc actgtcggta tggacccttt aatattatgt gttttattta 360 aagacattag tccagggtga ccataggaaa tacttcaagg aggataaccc tgaagatcct 420 atagctgcta atactcaaaa tgaaacttaa aaaaaataat gatttttgcc atggatcaga 480 gccaattcaa ttctagcttg agaagtgaat tcaggtcata tctgaaagcc ttacctttgt 540 tagaaattag gtccaaagac ctaagtgata attcaagtta tgggctttgt gggagatggc 600 aaatccagcc taaggaaagg agttctggaa ttttacaatt tcacattaaa ttacacgtca 660 gtatgtggca ttgggggaat ggtagaaatt ctcagtgcta agaattgagt ggccccttta 720 accagctacc ttgaccccca aagccaagat ttgtaatgga aaaatattgt atgggcaggg 780 tgctgtggct tacgccacag cacttgggaa ggctgaggct ggcggatcac tcgaggtcag 840 gagtttgaga ccagcctggc caacatggcg aagccccatc tctactaaaa atacaaaaat 900 tagccgggat ggtgacacac acttgtagcc ccagctactc gggagactga ggcaggagaa 960 tcgcttgaat ccaggaggcg aaggttgcag ttgagccgag atcacaccac tgtactccag 1020 cctgggtgac agagcaagac tctgtctaga aaaaaagaaa aagaaaaata tcatatgact 1080 aatagtctgc ctcatatacc taatcttttc ccagtttaaa acatctttct ttaatatacc 1140 cgttttctca gttttaaagt ttctcagttc aaaattggca aagatttcag agttgaagcc 1200 cttgctttct ctactaccat tccttttcct ctactcctag cagatttctc ccaaatctgt 1260 tttcagtatt ggtagccaga gttccttttt ttcttccttt ttaagaagaa aatagaacca 1320 ggcatggttg catgtaccta taggcccagc tactctgta 1359 53 2633 DNA Homo sapiens misc_feature Incyte ID No LI239245.32001JAN12 53 gcttctcttt aaaattgacc caaggcatga gccactgcgc ctggccagca aatgcttttt 60 gtgcagaata cacttctttc aggcattgtc aggtgctgtt ttgtttaagc tctaactcac 120 ccctggaata cagtgcgaat gatgacaacc aggccaagca gggcttgatt catcatggtc 180 acatccagcc cccacccccg gccaactaac cacgtgcagg ctcctcttcc agactcacca 240 gggggcctcg aggcccccgg catctccctt ggccctgggt gtgggtttta ccaagactgt 300 gtctttcatg acatcatagc cctaaccatg tgagaagaag gagaaggccc ccctttcttc 360 attaaatctg aacaaaacag gaaagtgaga ataggctgat ttttaaagag ttaacggggc 420 aatgcagcat tgcattctgg agggaacgat cctggccaca gccgccaaac aaacattcac 480 taggcctctt ctgttttcat acccttgtaa gtgggttatg tggtgggtat ggtcagtttt 540 ttcttttttc ttttcttttc ttttttttga gacagagttt cgcttttgtt gcccgggctg 600 gaatgcaatg gcgcgattca gctcactgca atctccgcct cccgggttca agtgattctc 660 ctgccttagc ctcctgaaaa gctgggatta cagggccctg ccaccaagcc cagctaattg 720 tatttttagt agagacagga tttcaccatg ttggccaggc cagtctcaaa ctcctgacct 780 caggtgatcc acctgcctca gcctcccaga ctgttgggat tacaggcatg agccaccacg 840 cctggccagt ttcttcattt tacatatggt cacattggcg cctagaacag ttaggtcgct 900 cgtcacatag ggcagttaag tggagaacca ggtttcaaaa tccaggtaag aaaaccatca 960 tcattaactg agcaccagct gtgctaagcc tgccacgggc gtatccttgg cagcctcaca 1020 acagtgggga ggtcctgtat cctgaatgtc ctcattttac agatgaggac attgaggaga 1080 agagacttac ccagggctca cacagcagct cagcctgttc caggggcctg gtgcagtgcg 1140 tgttctttgc caccagcctg tcactccagt ggcagctcca gaaaacggag gctgttgctt 1200 ttatccctaa actgcatcca cagagaaagc cccaagaagg aggttggggc cagctcataa 1260 aaagcctgaa atgccaagcc aaggagtgga tgcctccagt cataatttag aacaaagtca 1320 agtataaatt tacagagaaa aaattctaag acagttggat gttgtcctgt atggtgagga 1380 agggacaggt ttttctgtgt agggaactgg aaccagaccc acaactgcac gctatgtgag 1440 ctgtcatgtg caaacctgat ccccaagcag cttttgaagg ttgtttgttg tgtctgtttg 1500 tttacctgtc ttgggcttct gttgcttttg gcaaagaggt acttcaaaca tagggagggc 1560 ctggatctga tgggggagca ggtcttctat gctgacctac gtactacaaa ggccaaagga 1620 aggcacaagg aagctgtcta cgggtgtatc tagaacaacg tagactcata gaggggctat 1680 tggctaccta ctatgcgtac cccctagaga tagtaccagg ccattacaat ttaatccggc 1740 tttctctagc ggtgggcgta gagaatagga gctacccgcc ttggcggggc agtgctaaca 1800 ggtggagcta gggggatttt cgctggggaa tgaatttgaa gggcttcttt gaaaagcccc 1860 caaatgttgt tcccaaaggc gtctttaact ctgggcataa gcattggaaa gccgctgttc 1920 atgacaggac atggcactgg gatggctggc agagagccct ggctgggagt tagggagccc 1980 tgggttggaa tccaggcccc acctctttta tgccacaggt ttggtcaagt tctctcccgc 2040 tcagggtaag ggctgtgaaa ctccctctta cagctaagaa catgcagctt agtgagggac 2100 aagacccttc tagagcttta acccctaatt ccccccccag ggagccccga ggccggcatt 2160 attcctcccc attacaggtg atgagcctca aattcagaga gcgttaagca acctgctcag 2220 ggtcaccgtc taacaacagg cagttagagt caaggtataa acccaggtct gtttttgtac 2280 ccagagtccc cagactaact gttggtagga atctttggta accagtcatg ttttcttcct 2340 tgttttggcc gctgggaagc tcaaaggtca aattcgagac cctttttttt ttccaattgt 2400 gctgagtctc ctactagact cgcttcattc tagctttctg gcttttaccc tttaccctaa 2460 tctttttatt tttatgctat tgtactttat ttttgtatgt tgctgagata tcatgttttg 2520 caacaagatg ggctatatct aaataaagac atgatcaaag gtttgattta aaagtctgga 2580 ctaaatgctg tggtccatat ctttatcaga acacatacat ttaataactt tta 2633 54 3055 DNA Homo sapiens misc_feature Incyte ID No LI142384.52001JAN12 54 cccggttctc ggtggtagcg ggagcgggcg ggagcagcgg ccgctctggc tcggcggacg 60 tgctgccgag tagtcccggt atagcgaagc agcgatggcg gagagtccga gctgaggagg 120 cggcaacggc gggcgccggg gcggcgggcc ccggggcgat gcagctgttg ctggtgttgt 180 tggcgttagc ggcagcggcg gcgggttcgg gccgcctttc ctgcctggat gtgtgggcgg 240 cggcggcgga gtgtgggcgg ggcctggggg cccggggagc ggcctggctc cgctgcccgg 300 gctcccgccc tcagccgttg cccacggggc cgcgctgcat tagccactgg agaccccacg 360 ctcagctccg actgggacgg acgagcgcac cgagccgcag tgtctactcc ggatcaagcg 420 ggatatcatg tccatttata aggagcctcc tccaggaatg ttcgtatgta cctgatactg 480 ttgacatgac taagattcat gcattgatca caggcccatt tgacactcct tatgaagggg 540 gtttcttcct gtacgtgttt cggtgtccgc ccgactatcc catcccaccc acctcgggtc 600 aaactgatga caacgggcaa taacacagtg aggtttaacc ccaacttcta ccgcaatggg 660 aaagtctgct tgagtattct aggtacatgg actggacctg cctggagccc agcccagagc 720 atctcctcag tgctcatctc tatccagtcc ctgatgactg agaaccccta tcacaatgag 780 cccggctttg aacaggagag acatccagga gacagcaaaa actataatga atgtatccgg 840 cacgagacca taagagttgc agtctgtgac atgatggaag gaaagtgtcc ctgtcctgaa 900 cccctacgag gggtgatgga gaagtccttt ctggagtatt acgacttcta cgaggtggcc 960 tgcaaagatc gcctgcacct tcaaggccaa actatgcagg acccttttgg agagaagcgg 1020 gggccacttt gactaccagt ccctcttgat gcgcctggga ctgatacgtc agaaagtgct 1080 ggagaggctc cataatgaga atgcagaaaa tggactctga tagcaggttc atctgggaca 1140 gagacaggac ctttcatggg gagcctgagg gtttagaccc tgctccgcat gctccccttc 1200 ccccactcaa agagtcccag cagaatccct tcccccccac cccaggaatg tgagaggcac 1260 tgtgtatctc ccgtccagac tcagaagtca tcctgcaaga tggcaagaac caaagcaatg 1320 ctccagatcc cagggtgtgg agagtagggg gcctagtacc caggtctgac ctccttggca 1380 actgggagca tctggggcct tcgttcatcc attcatcccg tatcaggggc ccaaggtacc 1440 ctttacaagg agcactctag agcgagggcc tttggcacaa aacaaaacaa ccaacacacc 1500 tctccacagg gtccagctcc ttagtggata cgtggaagat ggcacttgca attccaagag 1560 ggagtgtgcc caaatgattt ataggggata cctggaaggg agctatgggg tgggggctgt 1620 ctgtgacact taagcagtct gggtggttgt ctatattgta ctgtcttcag tcttgcaagc 1680 agtggcttcc caatgccctt ttcctcccat gccttcctat ccccacatta tattacccac 1740 atggccaagc ataattttgt ttttcctaat tatataagtc acttgtatct agacagacca 1800 aaggagaagg aacagtggtg gagtctaggc tgctagatca gtaagcttat acctagcacc 1860 tgagcacctt tctacccctc ccctctttac ctcaccactt attctagatg taagacagaa 1920 agtaaattgt gactgggact taaccaaggt acttggtaaa gcctgcatgg caccgtaaga 1980 agctgaacaa tactgtatgt ttaccgcaat cactgatttg aacaagttcc caacacagag 2040 cacgctgctc gtgtatatgg gattagagcc actacataga ctagtctctt accgattttc 2100 ataaatacta gtcctcactt caagcgcccg aggattgtgg ggagcaaggg tagccaactg 2160 gcagaggggg taggggctgg gactctggag gctcctcccc ttctatctct tccttctgcc 2220 tcccccgtgc ccccagctgc tcttgtcact gtctctgatg ggtatttgcc tggctatagt 2280 aagcttctct atctgtattt agctgcagtg atcctttagc tggttggctc agaaaaaaaa 2340 aaatgtgctt aaggtgcccg tgtatattcc ttgggcatca agggaatcca tccttcccct 2400 ttttgatatg ttctccccgt acttccagat ttattgttat ggctcccagt gggtattggc 2460 gattcttgtg atgcagggcc tcagtcagtg tccagccatg cataagggag aggatagtgt 2520 gtacctgccc tgccctctgc tatgaaggtc tctgccttgt ggatcatggg actccccttg 2580 gaggatctgt gcaaaggggg gctgggcaca aaggagaatg tcctatttgg gagggcagga 2640 atgcacaagg aactggacag tgtgattggt gggcttgggg aacggaagtt tatcttggat 2700 accctgtgaa gaggctgggt ctctgtcaca tgaagatcga aatagggtcc ctgcttccgt 2760 gttccctctt ccagtcctcg agctagctcc tgggcgttag aagaatgctc ttggtctgtg 2820 ggtccagtgt tgtctgtcag tccagtttaa gtgttcccac tttcatagtg agccatcctc 2880 tacttagggc ctgccatagc tgcagagcat gtctggcata cgcagcctga ccttttatgc 2940 cctatatctt gagttgagga aatatacgca caggagtcaa tagagatgtc tttatatctg 3000 actgtatata aatgaagttt ttttgttttt ttttgttttc ctttttggtg caata 3055 55 509 DNA Homo sapiens misc_feature Incyte ID No LI2068768.12001JAN12 55 actgttaata gcatgagaat agagaccagt ctgtgtgttc agtgttaaaa ttctcagtgc 60 ccagtagagt gcctggcata gtagatgctt aataaatact tatgggcccg gcatggtggc 120 tcacgccttt aatcctaaca ctttgggagg ccacaggtgg gcggatcacg aggtcaagag 180 atagagacca tccttgccca catggtgaaa ccccgtctct gctaaaaatg ccaaaattag 240 ctgggtgtgg tggtgcgtgc ttgtagtcct agctactcca ggacgctgag gccagttaga 300 atcgcttgaa cccgggaggc agaggttgcc agtgagccag agattgcgcc cattgcccca 360 gcctgggcag tggagtgaga ctccgtctcc aaaaaaaaaa aattaatata agtggcatgt 420 tgtatttata caatatccct gcataatgat aatcataatg atagtcatgc cttatatcca 480 gataatcttt atctgttcat aaagtgatt 509 56 538 DNA Homo sapiens misc_feature Incyte ID No LI2118074.12001JAN12 56 ggcccgaggc acaatggggg tgaccatccc tgccctgctg gctgccagga gcggctgctg 60 agtcttcagg cgtggatgca gcctgggagg aagccatagg gcgctatatc acaggcctgg 120 ccttcaccat ggcgggaggg agaccgcatc tgaagaggag tttctccatc atcccctgct 180 ttgtcttcgt ggcgggctcc ttctgctatg acagtaccta cgccaagccc tacccagggc 240 ctgaggctgc cagccgagtg cctcctgctc ttgtctacgc actggtcact gccgggccca 300 ccctcacgat cctgctggga gagctggcgc gtgccttttt ccctgcacca ccttcagccg 360 tcccagtcat cggggagagc accatcgtgt ctggggcctg ctgccgcttc agccccccag 420 tgcggaggct ggtccgcttc ctgggggtct actccttcgg cctcttcacc acgaccatct 480 tcgccaacgc ggggcaggtg gtgaccggca atcccacgcc acacttcctg tccgtgtg 538 57 1966 DNA Homo sapiens misc_feature Incyte ID No LI1189068.42001JAN12 57 gcggcctgag cgcccggccc gaccccggcc atggggtgct agctacgatg caggcgagta 60 acgaggactc ggaccaggac cgagaggcgc ggcaagctgg tgctggacgc taggcagccc 120 cccctaccaa agctctcaac tggagaccga gcccaatgta ccaaagccat gcctatccgc 180 tcgcactgat gagcagtgcc ctgctctact tccatccttg ccaagacagc gcagcaacat 240 cattgatgtg tctgctgcag actcacaggg catggagcag catgagtaca tggaccgtgc 300 caggcagtac atgcatccgc ttggcttgtg ctgagcagca gcctgaccca ttggaagaag 360 ctgcaccgtt gcgcgtcctc ttaccagtcc tagcacatca agtgctaggc cagtgagccc 420 atcccgttct ctgatatgca gcaggttcag actgatttca gatccacacc ttgttcacag 480 taagatattc aattcaattc agcaaacatt tgttgtgtgc ttgctgctct gtgcctgacc 540 agaagaaatg aagccaagat acaaataata gaaccctgtc atgagcacag aaagacctgc 600 tgagtttcta ttgattgtgg taaaccagcc tgcatccagt tccaagtaac agctgcccac 660 ttagtgaata cgtctctcat gtttcaacac tcagttctag tgtagcctct tctataaagc 720 ctttcttttg ccagatagaa attggttaat gtgttcctgt gttagggctg attgttttga 780 tgatccctat tcatggtctc ccctgtatcc atctcttttt gcctataaca ttgtagtccc 840 atctcactct gatgctggga ccagacatgt tgacttgttt ttagccaatg agatgtcgat 900 atacatgaag caaacaggaa gctttaaagg aggcctgccc tcttgctctt tgccagtgcc 960 catgagaaca tggctgatca gctggagggt ttatgtagat gtgtaggtga gtagacatgc 1020 gaaagagcct agagatacct agctgatagc ctatctctag actagcctct actagtctag 1080 ccttaccccc tagtctaaga tctaggagag tctacccaac ccactagatg tactgccgac 1140 tacatgtagt aagcccagcc aaagcagaag aaccctccag ctgactctaa gacttagaag 1200 caataataaa tgtttattat cttaagccac tgtgttttgg gatggtttat tacacggcaa 1260 tagctaactt ctgcatgccc ccactgtact tcaaacaaaa ttttattaca gcttgtttac 1320 tcatctgtga aatggagaca aaccctacct tgagaactat tgtacatctg gcatcaggtg 1380 ctcaataaca tggaagcagt tgtattctct gttaatttca ttataaccaa ctttgtttac 1440 tccctataag cttgaggaca gggacaagac tcagacttct ttctcccttc tcatcattac 1500 cctggcattg agcctggcca aaaaaaaaaa aaaatccata ttcactaaag gttttgatgg 1560 acaaattgaa aattggtttg gacaatggaa aaattgaaag aagaaattga aggatttaat 1620 ggagttcttc aaggttgtca cattagagag cttgactgct ggggagaact gacaagttgt 1680 tgattgctgc cgatgcttta ctcctgtggc tgtgtttttg ggagttcagt ctttcccttc 1740 tgcttttctg gcttttgacc aggaggtatt cagatgccag cactcttcta tctggtccag 1800 actgactaac ttgtatgcaa tgacagggtt taggggcata cctgccttgt ttcggaactg 1860 gaatttctca tttccaaatt gacagtatct ttaactgttt tgttttttaa ctgtaaaagc 1920 taatatgata gatgaataaa gtgaaatgac aagaagtaca tcaaat 1966 58 1021 DNA Homo sapiens misc_feature Incyte ID No LI2118704.12001JAN12 58 aagcaactct gctgttttca catactgatc ctgctatcca tgtcatgaac ccataatcac 60 tgagaactat tccagctgtt aggtattaaa gtggaaacac tctcttcctg gaccacaact 120 tcctcatttt ccagttctca ggtacactga cttggtcatt gacctcatta cattcacgaa 180 cgctttgaat cctctatttt gtactacgta cctttatctt ttatctttac ataattgcct 240 ctgtaacttt agagttcatg accacttcaa taactcttct gacagcacct tcaaaattac 300 cgcttctatt ttttacctgg tatgatgtca actcttgatt atttctgctg aacaacaact 360 ctgttccacg gggagtctta atgagaggtg acagcgtgca ggcagccctt gctcgctctc 420 cgtgcctcct taggcctcgg tgtccactct ggcagcgctt gaggagccct tcgccccggc 480 cgctgcactg tgggagcctg tctctggtct ggccaaggcc ggagccagct cccttggctg 540 gcagagaggt gtggagggag aggcgcaggt gggaaccagg gctgcgcatg gggctcgcag 600 gccagcatga gttccgggtg ggtgggtgca ggcttggtag gccccgcact cggagaggcc 660 agcccatgcc actggcccca ggcagtgagg gggcttagca cccagaccag cagctgcaga 720 gggtgcgcca ggtcccccag gagtgccagc ctgatggcac tgtgctcaaa ttcttgctgg 780 gcctcagctg cctccccaca gggcagggct cgggacctgc tgcccaccat gcctgagcct 840 cccctcccca ctgtgggctc ttgtgtggcc caagcctccc cgacgagcac cgccccctgc 900 tctgtggcgc ccggtcccat tgaccaacca agggctaagg ggtgcaggtg cacggtgtgg 960 gacttgcagg cagctctgcc tgtggccctg gtgtgggatc cactaggtga agccagctgg 1020 g 1021 59 2542 DNA Homo sapiens misc_feature Incyte ID No LI031700.22001JAN12 59 ccccacccga aacacactca gcccttgcac tgacctgcct tctgattgga ggctggttgc 60 ttcggataat gacctccagg accccactgt tggttacagc ctgtttgtat tattcttact 120 gcaactcaag acacctgcag cagggctgtg agaaaaatgt gaaagaccag tattttcaca 180 ttagccaggt accagaaaca cagaagactg agcacccgcc acgtgtaagt ggggccaggg 240 ctggtcatcg tgcccatgtt gccatcctga tgggctgctt gccacaatga gggatcttct 300 tgcaatacat cgcttgcttc tttgccttat ttctctgctg ggttcttgat atgtggccac 360 ctggactgac tgttggatgg tgaatgctga tgactctctg tgaggtgagc acaaaatggc 420 cgaggcctct ggtgggaatg cgtcacaaat gcttttgact gggattcgca cctgtgatga 480 gtacgacttc cagtacttgc ggagcatccc ttgaagctgg tgtgtaactc gagctgttga 540 tagattgact tgcagatatt ctagctgggt tgtggatata tttcacccgt gctccttggt 600 cattgactgc gtgaaattcc tccctgatga gccgtacatt aaatgtccgc atctgcttgt 660 gttgctggac gccacgttac tcaatagcag gtaccccagg aatcattggc tctgatgtgg 720 tatgctgttg atgtgatatg tggaacgttc tactttggtt ttgcacaata tatttcttgg 780 tatccaatta taaattgggg ttggtcctgg tggctcggaa tggctggggt ctctgggttg 840 ctttttggct ggagctgttc tcacctgctg cttatatctt tttaaagatg ttggacctga 900 gagaactagt ccttattcct tgaggaaagc ctattcagcc gcgggtgttt ccatggccaa 960 gtcatactca gcccctcgca cacgagacgg ccacaatgta tgctgtagac acacagggtc 1020 gtaaaactgc acgtttcagg gtcgtgtttg catatgattt aatcaatcag tatggttaca 1080 cttgataaaa taagtaagtc aatccaggaa ccagttattt agaattgcat attggaatta 1140 aattaatggc tagcttaatc aaaaggttgg attctcctat acttttgtac tttctagtac 1200 tgcttatatt ttcccgtcat tctctctgct aaccttccac cttatgcaca cacgtttccc 1260 taatatttta agaataagtc tgctaggact gtagaaatat ttgctttgtg gatttcgata 1320 tagctattag agagttagtg acatagtaaa tagttgaaaa gtgagaatga gtacttagga 1380 cagataagca atgttccaaa agaggtccag ggaccgctaa tgctttgaag agatgaagaa 1440 acgttacttt gtgctaccac tggactttgt ggttgcacat tgttgtactt gttaacaagt 1500 ggggtgaatt actttgataa tctttgagga agagttattc ttgttaaagt tcaaagctag 1560 tagtgtcaag tgcgctacgc cagttacatc tgagttatag ttaaagacag aagaaaggaa 1620 ataacaacgt tcgtatagca gccagctggc tgagagttga acagacgaag agctgccccg 1680 cccaccccca aatgtcaaga ggcaaagtgc taaaattgat actgggagcc tcgtggtgac 1740 tttctacctc tactaacaac ataaggggat ctccatatta tttcaccagc tattctagct 1800 ttgctggata tattggccaa atggattaga ctacagaatt agtttaaacc aagagaattt 1860 acgtcattta ttagattaaa ctatccaaat actatggtaa tatagctatg ttgaaaattc 1920 atcaatgtca agtgccccac acgagccatt gaaatcatca ggcactaaag caactatatt 1980 acgaccatat ggccaaaatt ctagatcaaa tatactttct gatactaaga taaactaaac 2040 gttcacgaat tttacttaaa caaatcaatg ttgcggctgg tgcacggtag ctcgcgtctg 2100 taatcccccc aaagcgctgg gattacaggt gtgagccaat gtgcccggcc tatctgctcc 2160 ttcttaaagt tcttacatta aacaattagg agaagaatac agttaaatag tgatttaaat 2220 agatantcac agactatcta gggaaaaaaa tgtaaaattt tttggagact acatatttta 2280 ttttattttt ttagatttgg gaaagacaaa tatttctctc attagacagt aaaacaactc 2340 tggaaagtaa tctgaagaga ttgtttgtga acacatgcat ctaacttagc acagagtagc 2400 agaactttga aatgaaggaa aagtaggatc cagttatttg ggtgttggtg ggcaagatct 2460 taacactaac gttgatacag cttcaggata tcagtaagca tacatttaca agtaaataac 2520 tgaaaatcca actcaagcag ac 2542 60 1759 DNA Homo sapiens misc_feature Incyte ID No LI2120122.12001JAN12 60 ttatatattt aaatcactaa actgactctt tgacttaaaa ggctcaaaaa aagtcatctc 60 aaaaatacaa cacactttat aaccttttat aagtatttgt gtagcttctt gaatttatat 120 ttttaaatca ttctcattta acttgtcagg gccttttcct gaaagccagg agagtgaaat 180 cttaacctgc atttaaagtc tcataaaact ttgtcagctt ataaccaatt ttattatttt 240 agattttctg gactctctct caagagttag taattctcat gaagtcacat tccttccatc 300 cccttgggga aaattttatt tcttaaaatt gcatgggaaa tgagagcttt tttaaaagaa 360 aaaaagtttt atattcacaa tgatatgtag tggctttgtg cctatttctt acttgtcaca 420 aggggtaaga tgtttgaaaa ttgctatctt cttatatata aaaatgtacc tttgaataat 480 ttccccagtt taactatttt tagaaatggg agcaaagttt tgcccattgg tacatggata 540 ttgtgggata agtggaaaga atatgacaca gaattttttt gtttagagtt ccagggtacc 600 cgtgctcact acagactgaa attctgtgca gtctaataaa tgaatcagag cctttccatc 660 ttgtctgggt agtccctaag gttccccttt taagaagggt ttcggttttt agaagtgcat 720 tataaattcg tccaacagtg cactttcagt gcctcctaac ctccctctac caagtatgaa 780 ctgcatgcat gggctaatgt atgattttgg ctgcatatcg cttcatgtgc attgttcact 840 atttggtgaa ctggtgtatt aaagtaaaat actgactggg aacatgaatt ccaaaaatgg 900 tgtatcatcc ttctagtatt gattcccact ttgagaaaaa ttggtgtcat tcagtgagtt 960 ttatatacaa ggatttttgc ccttatgaac atacatacat acatagctat acagatgata 1020 caccattctc gttgatttgc cctgctagat tgcattatta tgctgtagaa ttttagaggc 1080 ttagtagtct tttctctctg ctgtgcggtt tatcttctag aaactgatat agaggattac 1140 tgctatttgc gttaaaaatc caagatggta tacaaactaa atttggttga cggatcagac 1200 tagccaatat aaatccaaat gggccagagg gtagaacatt ccacccagaa tgtattacac 1260 attgtgaact aaatgttttc tgttgctgac attttgtagg cttctgaaat ttaatgggac 1320 ttttacaagg tttacctttt ttcctaaagt ttaattttta aactgactta aatgttcttt 1380 gaccctttgg ttatatttaa gaagttgact tccctaattt ccttgttatg tttattttta 1440 aatattcttt ctctttaaaa gttgggatac taataataaa tattcagcaa gtattgtttt 1500 gcatttaaat ataaaatctt gttatttgga ttttaatagt ttatattaaa tgcccttaag 1560 atttattaaa attttggatt aactgaactc tgcttttttg tcactggatt aataagcagg 1620 cttgtatctg acataatagc ttaataaggc agtgacaatt taaatttgtc atgagtataa 1680 attgaaaaat cataatttag aaatcggaga ttgaatattt catggcattt atatttagtg 1740 tttaaaataa tgattaatg 1759 61 1035 DNA Homo sapiens misc_feature Incyte ID No LI816174.12001JAN12 61 gccatcttaa cggaagttgt tactggtgga cggtatccaa gttactggtg gtaaatctgc 60 agcaacctca attctttcct cctcagaaga aagaatttga ctgaggggca taaggcagaa 120 ggagggaccg aggcaagttt cagagcaacg gtgaaagttt attacgcttt angctgggca 180 cagtggctca tgcctgtgat cccagcattt tgggaggctg aggcgggtgg attacttggg 240 gtcggtagtt cgagaccagc ctggccatca tnntgatgag acctcgtctc tactggggat 300 agaaaagtca gctgggcatg gtggtccatg cctctaatcc cagctactcg ggaggctgag 360 gcaggcgaat cagttgagcc tgggaggcgg aggttgcagt gagccaagaa agtttattaa 420 gctttagaac agtaaggaaa ggaaagaaaa gaaggaaagt ataacttgga agagggccaa 480 gcaggtgacc tgagaaacca ggtgcagggc ttgccctctt gacttggggt tttatatgct 540 ggcatacttc cgggatcttg tgttactttt ccccactcct gagatctttt tgagaagctg 600 atgatcagtc tcaggtgttt tctattgcgg gggtgggggg cgggcggggg agctgcctgt 660 ccctggcacc acctgtgacc aattattact ttacagaaac atttaacaac cgcctgacca 720 tcacctgatg gttgcccaac actcttggtg tgtgtcgggg gagccctctc ctgccttgct 780 cagacctgaa tgtacccatt gtaacaaacc ccttctttgt atactttgat atggtgacat 840 ttcttgtcac ttgcctcatt gtgaattttt atagatgtgg ctaagtcata tgcttccttc 900 tgaaaaatta tgtcaaatac tagcagtttc tcactgtttt ttgccctaga aacaacaaac 960 taaccttgaa gtgaaaggcc tttctgcgtt tatcttacct tttttgagca gcattaaaac 1020 tgttttactc agacc 1035 62 915 DNA Homo sapiens misc_feature Incyte ID No LI1189569.112001JAN12 62 ctgatatgtt ccagccacca tactaggtgc tttatgaatg tgatctggca tatcttcatc 60 cacacacttt taggaagctg ttagtgatgt tcattttgta ccatcacaag gaaacggaag 120 cttggagagg ctaggctctg cctgtggttc cccacagtca ggaactaacc agaaggcggg 180 agacttgaga ccttggcacc aggctgtcct acctccccag ccaggggatt cattacaatt 240 aaatgacagc tacttcccca cctccattat atacccaagc agtgctcaga ttaaatgggg 300 gactgggagg aaaaatagaa gccacttgat ctttgcgtgt gtgctgattt acagatcaaa 360 gaaggttaca ggaagttagg ctaacaccct tgttgcagca tttcccccaa atttcactaa 420 ccatgttcta tctgaatctt gaaatgtggt gagaggttcc ttccagttaa tcagaagata 480 ttgcctctaa gaccctgtat aaaaagtatt caaagccatt tatttctcaa cacagaggtt 540 cccatggatg agtgcaccca ttcaagttgg gttagttggc ttctgtttgg tgtttgctac 600 acccctgtgt tgtgccctgt ttcctcagaa aaggtatgta tttgttattc gtcagaatca 660 tcatgagtat taatcctaaa aaccaattga aggtgcaggt gccattattc catttcattg 720 gcagggaagt tgagactcaa aagatactga agccagggtc tcttaaaagg aagggatgga 780 ggcagaaatc aaacccacat ctgtctaatt tcagatgcac ccagctcttt tctaccccct 840 tccattaaat ttgaaaatgc tttattcttt tgtgagaatc agattaactc tgatgcaatg 900 tgctttatga aattt 915 63 1337 DNA Homo sapiens misc_feature Incyte ID No LI413584.12001JAN12 63 cggctcgagc ccttgggcgg tggtggaggt ggtaaccgtg atagtagcag ctccggcggc 60 agcaacagcg actacgaggg atggcggcgg ctgcagcagg aactgcaaca tcccagaggt 120 ttttccagag cttctcggat gccctaatcg acgaggaccc ccaggcggac gttagaggag 180 ctgactaagg ctttggaaca gaaaccagat gatgcacagt attattgtca aagagcttat 240 tgtcacattc ttcttgggaa ttactgtgtt gctgttgctg atgcaaagaa gtctctagaa 300 ctcaatccaa ataattccac tgctatgctg agaaaaggaa tatgtgaata ccatgaaaaa 360 aactatgctg ctgccctaga caggttttat tcactgctga ctccccagtg cctagaacag 420 tgcctgggat gcagtaggta tttaataagt atttgctgat taataggtta tgcagatgag 480 tgatgtgata ggtttttctt tctaggtgca gatgctaatt tcagtgactg gattaaaagg 540 tgtcaagaag ctcagaatgg ctcagaatct gaggtggtga tggaaccagc cctgtgaggg 600 cacaggcaaa cgaggggaag aaagcatcct ccatggaagc ggtacattgg actgatacct 660 ccagctgaag ggcctcctgc natgccatgt gaagctcagc tagggcagaa ctggtacaag 720 gagcctaccn atatgcagga gcattaactc gccgttcggg agactgagat ctatgtttcc 780 ccactccagc ttgcttcgtt tacaggtaga ggagctatgt aaaggaagta aggctgtcag 840 agaagaagaa ggatcggatt gatgccttcc tacgggaggt caaccagcgg gccgtcgagg 900 gtgccctcag tgctctgaga cagagctcac tgaccaggca tggctcccag ctgggggttc 960 gagttgccct cccaccaagt gccctatgcc cgtgacaggg ctgtttccga cttcctagcc 1020 cccaagccca ggattactgt atgtgaggca agctaccttt ctgggcaacc tagcatccga 1080 ccagatcngt caaatgtgga atgtaggcac tgaccaatgc ccaggagaaa ttcctacaga 1140 gacaagagac gggctcgaac cagacgctac ttccagcaag cggtgcccat ctaccgtggc 1200 ccacttcggc tcaccaccat gagcccagag accacccctc ttaggcagct gtttgcttct 1260 ccttacacaa atttggctgc caccatgaaa ccctcactgt tgctgccgcc gcgtggaaag 1320 gatgagcgcc tggtcac 1337 64 1463 DNA Homo sapiens misc_feature Incyte ID No LI791042.12001JAN12 64 ggctcgaagg ccggaggggc cttgggcggg tggcttctct gggtcccacg gttcctgccc 60 aggctcttcg aaccaggacc agtgcggaac agcaagccat tggagagtcc tgagcagaga 120 aaggactgac ctgcctcatg ttttaaatct ggctgccgta ttggaagtag attggaggaa 180 aaaaaagtgg aagccctggg acccaccatc atgaacaatc ggggagaaga caagaggcca 240 gcaaaggaat gaacacaggg acgcatgaga catttggtgc cgaagacctg ggtcagcggg 300 actcctttgg gagaccagtc ccccatcctc accctcactc tgtgaagaga tccacctacg 360 accttgggtc ctcagaccaa ccagcctaag gaacatctca cctattttaa atcgggaatg 420 tcaggcctct gaacccaagc taagccatca tatcccctgt gacctgcatt tatacatcca 480 gatggcctga agcaaatgaa gatccacaaa agaagnaaaa atagccttaa ctgatgacat 540 tccaccattg tcatctgccc taccctaact gagaagatat attctccccc gcccttaaga 600 aggtactttg tatgcctatc ccaaacctat aagaactaat gataatccca ccaccctttg 660 ctgactcctt ttttggactc agcctgcctg cacccaggtg aaatatacag ccttgttgct 720 cacacaaagc ctgttggtgg actctcttca cacggacccg cgcgacattt ggtgccgaag 780 acccgggaca ggaggactcc ttcgggagac cggtcccctg tcctcgccct cactccctag 840 ggagatccac ctacgacctc aggtcctcag accaaccagc ccaaggaaca tctcatgaat 900 ttcaaatcgg attcccaact atatgaagac accctagctg gacgatcagt tcttattaag 960 aacctgactc ctcaaactct acaacctcga tggaccggac cctacttagt catctatagt 1020 accccgactg ctgtccgcct gcaggatcct ccccactagg ctcaccgttc cagaataaag 1080 ctgtgtccat cggacagcca gcctaatccc tcctcttcct cctggaagtt gcaagtactc 1140 tcccctactt cccttaaact cagtcgtatt tcgaagaaca gtcataaccc ttatgagcct 1200 aatacatccc ttcattctat taggtctttc gtccttaccc tactttttgc aacagggctt 1260 tacgaagtca cccccaccac ttaggccgag ccccaagaaa ctagtcatcc ctactatctt 1320 ctgtctggtc atactcctat tctccattct caactactta taaatgccct actcttgttt 1380 acacggacgg tttacactgt ttcttcaagc catcacagct gatatctctt agtgctatcc 1440 ccaaactgcc actcttaact ccc 1463 65 1558 DNA Homo sapiens misc_feature Incyte ID No LI1167140.12001JAN12 65 cttaacacac ataagataat tcatactgga aagaaactcc acaaaccaga aagatgcaat 60 aatgcttttg acaacacctc aagcttttct aaccataaaa agaatcatat tggtgagaaa 120 tcctagaaat gtgaagaatg tgacaaagtc tttaaatggt tgtcatactt gacttttttc 180 tttttttgag atgaagtctc actcttgtcc cccaggctgg tgtgcaatgg catgatgtcg 240 gctcactgca aactccgcct cccaggttca agtgattctc ctgcctcagc ctcccaagta 300 gctgggatta caggcatgag ccaccactcc ctgccttact tgattacatt caatataatt 360 catactggaa agaaatccta caagtgagag caatgtggca aaacttaacc accttattgc 420 acagaaaagc atttatgttt gagaaaaatt atacaaatac agactgtgaa aaagacatta 480 atatctgctt acatcttaac accagagagt tcatacttaa taaaagcaag ataagggcaa 540 ttactgtcaa aaggtctttc agaaaaatat aaccctttaa agtgaagaag agaatttata 600 ttgaagatgg acattacaaa cataaagagg gttgtagtac ctttacttga atcaaatttt 660 attgtacaca ttttgtacta gaggaaaact ctgaagcagt tgctcaagct ttgttcaaca 720 ttagggcact tatattggaa aagtgtcttg cagatataat aaatgtggaa aaacactttt 780 tcaaaaacta catcagaaaa caccagagtt tatactgaag aatatttttg aagatgcact 840 aaaaatgaaa aaatatttaa tccaaattag ggctatgtaa atatcagaat ttataataga 900 aatatataag gaactgacac tgcagatata ctaagtcaag agttctgagt atagaaaata 960 atctaaaact aaagttgata gaaaaagtat ttgtatataa atttaagagg agtaaaagat 1020 tttttgcaga gtaataacta cattctaagt atactttatt tcttgaaaaa attacagact 1080 ttgaaagcaa atgatgtaat tcaacactca ttttctggtg tttcttcatt cttattcact 1140 tgtgaaagca tgtgataatt gttgcatcaa aggtatgaga gattcttttc cattaggtgg 1200 gcatttatga tcttttctat ggacaagtaa ggacattaga atgtaagatg catgatgaaa 1260 aagtggagag gttctttgtg gttaacttat actcttgagt gatatatgag gtaggtgtta 1320 agagtattgt tcttttgcat tatgagaaaa ctagtagtat attattagta tattattgta 1380 ctaattgtac ttttatataa taaaatgcag cacattttta aaattttaca ttatgtgtga 1440 agttaatggt ttcaacattt ttaacatgtt aatntcttgc cagtggcttt aaagtataga 1500 taaattaaat aataatattc ctgttgggta aatatttatt cttattttaa tcgaatta 1558 66 1811 DNA Homo sapiens misc_feature Incyte ID No LI054831.12001JAN12 66 ggtcgaggga cttggagcta gaatgactgt aggatacatt ttagttatgt actatcacta 60 tagttaaaag tagtaggtta tgtacccaaa aactgttttg cattgaaata actttggtat 120 catcaagtaa tgtaaggagc tatcaccatt tcaaatattc tactccactt tcccaataaa 180 tacatttatc ttcaccatta tctctatcat cattataacc agcaattact gcgcaattat 240 gccaggcact aagcatcatc tcagtaaatc ctcagaacaa tcttatgagt taggttctat 300 atcatgtcca tcttgcaggt gagaaatttg aatcttggaa tatttaaata tattgtataa 360 ggtcagaaga taataagaag tggcaactta gctgggtgca gcctcccaaa gtgctgggat 420 tacaggcatg agccaccggt ttccggccag agccatattc tttaatagct atctgaactg 480 gagccaggaa tcacatctca tgaaaaagga gaacattgag aaaatcatag cctaaatata 540 atatacagac ttcatacctc taattttagg aggctatcaa gcagtatcca aggcaaagtc 600 aagatggtca acatttttct caatatttag tgttgagccg attgcagtgt tcaggcaaat 660 ggacaactga gaactcagat aattccaaat cttcactggt caaaataatt ccagtttttt 720 ttaattaatt cattcactta gtcagtatac agatgatgtg cttttagcat ctaagatctt 780 taaatcagat gtaactaagc attccccatc tcccaaggct attctatgta tccttagaat 840 gattaactta aacgatagaa tatcctagta tgtcctcaaa tagattggtt gtgaaacata 900 cagcaagatg atcaaatcag tgacatttct gaatagaatc atgaactata aaccctttat 960 atgttggaag atatcaaccc aaacggggct tctaactctt gattgctgat ctgtagcctt 1020 tctttctgga gaaaaatctc ttgtagttga tgacggtgaa aagataagag gaatgtctgc 1080 tgctggcctg ggtcccccct gctggaggtg tctggcaatg tgttagcttg gactggtagt 1140 tcgagcttgc acactgggag gggctaatca aatagcagcc tcccacaagg ccagcaggtc 1200 tggcagctgg tgttcccagt attcctgtaa aacttccttg aaggactgac actcagttgc 1260 accctgttta ttgacaaagc tcaggctggt tttctgctgt tatattagtc cattctcatg 1320 ctgctaataa agacataccc aagacagagt aatttataaa ggaaagaggt ttgatggact 1380 caggttccgc gtggctaggg aggtttcaca atcatggcag aagatgaagg aggagcagag 1440 ggatgtctta catgagagtg tgtgtgcgga gaaactcccc tttataaaac catcagattt 1500 catgagactt atttactatc aggaaaaaga cccgctccca tgattgaatt acctctcact 1560 aggtttctcc catgacatat ggggattatg ggagctataa ttcaagatga gatttgggtg 1620 gggacacagc caaactgtat cagctgtttt ctagggcact cactcacagc ataacaatgt 1680 agcacctgcc tcacactgtc aactgctacc tgtggcctag gtgcatttca caggatggcc 1740 aggcattgcc ctgaaccacc tgggctacag agcaaggctg ctttaaacaa aataaaaaat 1800 aaaaaaaggg g 1811 67 1065 DNA Homo sapiens misc_feature Incyte ID No LI1175083.12001JAN12 67 gcgctgcggc ccctgctcta cctcctagcg ccggtgcgcg gccgaggccg cactacctgt 60 ctgcgggaaa gcgggatcca ccccaggacg tcgggtcgct gccgacataa tgtcaagtgg 120 aaactatcag cagtcagagg ctcttagcaa acccactttc agtgaggaac aagcctctgc 180 gttagtggag tcagtgtttg ggttgaaagt ttccaaggtc cggccacttc ctagctatga 240 tgaccaaaac tttcatgtct acgtttcaaa aaccaaagat ggcccaactg aatatgtcct 300 caaaataagc aacaccaagg ctagcaaaaa tccagacctg attgaagtgc agaatcacat 360 catcatgttt ctgaaagccg ctggatttcc aacagcctct gtgtgtcaca ctaaaggaga 420 caacacagct tctctcgtgt ctgtagatag tggctctgaa atcaaaagct acttggtgag 480 gctgctgact tacctcccag gaagacccat cgctgagctt cccgtcagcc cccagctatt 540 gtatgaaatt ggaaaactag ctgccaaatt ggataagaca ctgcagagat tccatcaccc 600 aaagttaagt agtcttcatc gggagaactt catctggaat ctgaaaaatg ttcctcttct 660 ggagaaatac ctgtatgccc tgggccagaa tcgaaaccga gagattgttg agcatgtcat 720 tcatctgttc aaggaggaag taatgaccaa attaagtcat tttcgagaat gacctagcac 780 cgtgccaggc ccctagaaga cccagtaaag atctgttgaa taaactgtaa gaatgaacac 840 accactacaa gtgccaggtc ctggtccttt caaacaacgt ggagaaaacc cagttccaga 900 tttaggaatc aataccatat gtctggcaaa gactctttgc tcttgcaagt gccttcttct 960 gttcaggctt ttagcgcccc tggactacaa cagaacttta ctttctggta ttcttagtct 1020 ccctaacctc tgcacttcat attatgtagg cagataaaaa ctctg 1065 68 1402 DNA Homo sapiens misc_feature Incyte ID No LI2122897.22001JAN12 68 gaatcgcctg atgacaatgc tcagaatgtg tctccatcat taagagatac atgactacct 60 accccatcaa tcttgcctat tccagaaaca aagtgaaatt aataatataa aattggtttg 120 atcaatttat gaattacatt gtcattgaaa gtaggagaac tagaccagga ggcactggtg 180 tgaccctgga gtagatggaa ctgtttgtgc atgtgtcttt cttaccttcc attctcataa 240 agaattagca cattccccac atacaccctg gccagactgt gtctttggga ctgcagcact 300 aaggtgtgtt tttgtttgtt aacttattcc cagtgcctgt gttgaccagg aggctttggg 360 aataaaggta cataaaggtc ttggagcctg gatgagcctg tggtcaagag atggcaggca 420 gtgtccttga atttggaatg tgactcacac tctgcctgta agggaaagaa agagagatca 480 gactggtacc ggggtctatg tagaaaggga agacagaaga gactgcattt tgaaaaagac 540 ctgcacttta aacaattgct ttgctgagat gttgttaatt tgtagctttg ccccagccac 600 tttgccccag ccactttgac ccaacctgga gctcacaaaa acatgtgttg tatgaaatca 660 aggtttaagg aatctagggc tgtgcaggac gtgccttgtt aacaaaatgt ttacaagtag 720 tatacttggt aaaagtcatc gccattctct agtctcaata aaccagggga acaatgcact 780 gtggaaagcc gcagggacct ctgcccttga aagcgggata tgtccaaggt tctccccatg 840 tcatagctga aatatggctc tggggatgag aaagactgac gtcccccagc ctgacacctt 900 aaagggtctg tgctgaggtg gattagtaaa agaggaaagc ctcttgcagt tgagatagag 960 gaaggccact gtctcctgtc tgnccctggg aactgaatgt ctcggtataa aacccgattg 1020 tacatttgtt caattctgag ataggagaaa aaccgcccta tggtgggagg tgagacatgt 1080 ttgcagcaat gctgctttgt tattctttac tccactgaga tgtttgggtg gagagaaaca 1140 taaatctggc ttacgtgcac atctagtcat agtactttcc cttgaactta attatgacat 1200 agattctttt gctcacatgt tttttgctga ccttctcctt attatcaccc tgctctcctg 1260 ctacattcct ttttgctgaa ataatgaaaa taataatcaa taaaaactga gggaactcag 1320 aggccggtgc cagtgcaggt ccttggtgtg ctgtgtgccg gtcccctggg cccactgttg 1380 tttctctaca aaaaaaaaac aa 1402 69 307 DNA Homo sapiens misc_feature Incyte ID No LI2053195.32001JAN12 69 accattcctg ccccacccta actgatcaat tgactttgtg acaatacacc ctccccgccc 60 ttgtgataat gtactttgtg atattccccc acccttgtga atgtactttg tacaatacac 120 cctccccacc cttgagaagg tactttgtaa tatgctcccc cacccttaag aaggtacttt 180 gtaatgttct ccccaccctt tgtactttgt aagatccacc ccctgcctgc aaaaaattgc 240 tcctaactcc actgcctatc ccaaacctat aagaactaat gataatccca ccaccctttg 300 ctgactg 307 70 1362 DNA Homo sapiens misc_feature Incyte ID No LI439397.62001JAN12 70 ccgtgagcgc cacaagagcc cggggacgca tgatgcaccg agacagagaa gttctcagct 60 tggcctgggc aagcccccag caacccctct gtcgcagtag acagtgagca ccgggccagg 120 accggggaga tgctgacagt acatgctagt atgaagagtc ccgctgacca gcaggcctga 180 ggacaccaca cacaatcgcc gcagcagagg catggtccag agcagcggct ttgagctgag 240 ctacctggag aaggtgtcag aggtgaagga cacggtgcgt cgacagtcac tgctacacca 300 tctctgctcc ctagtgctcc agacccggcc tgagtcctct gacctctatt cagaaatccc 360 tgccctgacc cgctgtgcca aggtggactt tgaacagctg actgagaacc tggggcagct 420 ggagcgccgg agccgggcag ccgaggagag cctgcggagc ttggccaagc atgagctggc 480 cccagccctg cgtgcccgcc tcacccactt cctggaccag tgtgcccgcc gtgttgccat 540 gctaaggata gtgcaccgcc gtgtctgcaa taggttccat gccttcctgc tctacctggg 600 ctacaccccg caggcggccc gtgaagtgcg catcatgcag ttctgccaca cgctgcggga 660 atttgcgctt gagtatcgga cttgccggga acgagtgcta cagcagcagc agaagcaggc 720 cacataccgt gagcgcaaca agacccaggc cggggagatg ctgacagtca tgctagtatg 780 aagagtctgc tgaccagcag gcctgaggac accacacaca atcgccgcag cagaggcatg 840 gtccagagca gctccccaat catgcccaca gtggggccct ccactgcatc cccagaagaa 900 cccccaggct ccagtttacc cagtgataca tcagatgaga tcatggacct tctggtgcag 960 tcagtgacca agagcagtcc tcgtgcctta gctgctaggg aacgcaagcg ttcccgcggc 1020 aaccgcaagt ctttgagaag gacgttgaag agtgggctcg gagatgacct ggtgcaggcc 1080 actggggact aagcaagggt cctggcctgg aggtgtgaag gtgctgtatc ccggaaatct 1140 atctggaccc tggactgcag tgcaggagat gacagagtga ggagggccca gagcagaatt 1200 ctggccccag aactctgtgc ccaggagcca tgccttgagc agtattagcc gtgtgtgtat 1260 gcatgtgagt gtgtgtgtat gtgtgtgtgt gcatgcatat gccttgtgca tgtgtgtgag 1320 ctccttgaac gcacggagca aaataaattt tcttcctaat cc 1362 71 2204 DNA Homo sapiens misc_feature Incyte ID No LI816379.62001JAN12 71 tggatttggg gtcaaagctt aatttccttg tatgagatga gaataataac cctatttcgt 60 aggttatcct atttcataag gattaaatct ttaaaataca tatgaagcag ataggatatt 120 tctggtagtt atattagata tgattacttc caaatttata ttgggatgga tatgttttta 180 tacatatatg aaatgtcaca tacataatgg tataaaaaca tatccatccc aatataaatt 240 tggaatcaga ctgtccagct gcctttctag ctttgggatt tggggtgcaa agcttatatt 300 tcccttgtat gagatgagaa taataaccct atttcgtagg ttatcctatt tcataaggat 360 taaatcttta aaatacatat gaagcagata ggatatttct ggtagttata ttagatatga 420 ttacttccaa atttatattg ggatggatat gtttttatac atatatgaaa tgtcacatac 480 ataatggtgt tttttcctgt ttaaaaatgt ttaattgtag aatacgtgaa aagcaaaagc 540 acaatgaaga aaatgtgaga gtatccataa tccctaactc agaaataacc actatatgac 600 tttgtagaaa cacatataga ggcatttaaa gacatcttat ttgatatcat actattggtt 660 gtttttaacc ttttaaaaaa ttactttgta atattgtcac tccaattcaa atatttttcc 720 ccaactactt tgtgataaaa gcagttaaat ttcccaaagt aaataaaaac tccttgccta 780 tataaaaaca tgtgaaagct gaaagatagt gaacatttgg cttaaaatat taacaacttt 840 attgctttct ccccctattc ctagttgctg ggcatattgg attttaccca tcataggcgc 900 tgttctctta ggtttcctgt accgctacta cacatcggaa agcaaatcct cctgaggagg 960 ccttgctgaa gttagaaagt gcatccactt tggggcgaaa actagagact tgcttggggg 1020 ctgcagaagt gccctctcct cgaatcctgc cagttgcatt cttccccctt ggagccaaga 1080 cgattggcca gacatcacct cagatctgag accagcgtct tccatctctc agagccttac 1140 tcccaaagta cctgctcact gttccgtgtt gaacaattgc cggtgtttcc tctcttcact 1200 ggtttccatg agtaccctta tatttcacaa ctttctgttc ataagttata gtgacattgc 1260 tctttggtaa aaatgcctgc tttccaatac tttgattgca tattagacat tcttaacagg 1320 gcggcagtct agtgttgaaa gttttatttt tccatttttc ttttaagtaa atttttttta 1380 aaaaattctg atttagggct aggtctggtg gctcaggcct gtaatcctgg cactttgggg 1440 aggccaaggt gggaagatcg cttgaggcca agagttcaag accagcctgg gcaacatagc 1500 gagaccccta tctgtattaa aaaaaaatct gagtttaatt cgtgtttatt tatcataagg 1560 ggtttaattc ctgaagtaaa ggtttgcacc tattaaactt aaaactgcca aatgattttt 1620 gttcttttat gtgcgtgata aaaatacaaa gaatggtgtg gccacctcct ccctttcaag 1680 ctagggcagc aggtagctct tcccagcccc tgagcccagc cccttcccaa gtggtgccag 1740 acaaaaaact acatggccct ttcatgtctt gggggtggaa agggagggat gaattggggt 1800 gatagaaccc tggtgaattc agagtaatct ttctttagaa aactggtgtt ttctaaagaa 1860 acaggatagg agtttagaga aggcaccaaa gctttcactt tggtttggca ccagtttcta 1920 accatctgtt ttttctaccc tagctatctt ttattggtaa aatataaatg tataattatg 1980 tttgtagagc tttaccaagg agtttccctc cttttttgtt tgttgattag caaatttttg 2040 attctccatt ttccaaaagt aagagactcc agcatggcct tctgtttgcc ccgcagtaaa 2100 gtaacttcca tataaaatgg tatttgaaag tgagagttca tgacaacaga ccgttttcca 2160 tttcatctgt attttatctc cgtgactcca acttgtgggt ttgt 2204 72 469 DNA Homo sapiens misc_feature Incyte ID No LI2123452.42001JAN12 72 gtccattctt taatactgtc tttccaaagt gtaagattcc ctaataggga gtcgctaaaa 60 tgtctatcta aatacagtct atcaagcaag aattctgtga ctgatttttt tggtaacagt 120 actttgattt gatacttgta tacaagttgg ttgaacatat tactctggtc agtttttaaa 180 ggctgactat ggttaatttg catattttag aagtacattt taggggtaat actagatcat 240 atagataaat attatcacca actaccatag ctaatattcc tttcctttct gcaggtcaat 300 ttttctgtgg aaataaatat tgtgataaaa aagaaggctt aaagagttgg gaagttaatt 360 ttggttatat tgagcatggt gagaagagaa atgcacttgt taaattaagg ttatgccaag 420 aatgttccat taaattaaat ttccatcggc aggagaaaag aatgatgtc 469 73 647 DNA Homo sapiens misc_feature Incyte ID No LI474559.82001JAN12 73 aaagacacaa tcaatacaga cgggcaagtg ctgagtcgaa cataacatca gtccctagca 60 attcaagaaa caccagtgac tgcgttttaa aattcagcag actcccttga atatggtact 120 taaaaaaaaa aaaaaaaagg gctcattcta cccgtggagc ctactgaaaa attattgttt 180 ctgaggggtt gagaaacaaa agggaagaga gctacgggca ttgaactacg tttggagagt 240 gacttgatgc aaagaacacc aacattttca tttacccatg ggaccaatta aacaggcgat 300 ttcaaacctc tttgcaacaa caaattttct ttattaacaa ttttcttcac ggttaaaatt 360 tttagcgcct taaaaggcct attaggcttc ctaattttta ctaaacagcg ggcaactctt 420 tggacaaggg actcggcgcc tcagaaaatt ttccaacgcg gttaccacaa cgagattttc 480 caacgcgtaa ggacgcgcct caaaaaccgg cttctttagg gggcgatttt ttggcaccct 540 gggctttggc tcggggaccc tacgaattta aggtcttctt tatttggcat tacgcggaac 600 acttgcgggg cccacgttta acttggcgcg ttaattactg gcgactt 647 74 2282 DNA Homo sapiens misc_feature Incyte ID No LI1089871.12001JAN12 74 gggatagagg aaacagctgt gatagcagca gtaaaagccg gaaccgaggt tggaaaccta 60 tgagagaaac attaaatgtt gatagtattt ttagtgaaag tgaaaaaaga cagcatagtc 120 caagacataa accaaatatc agtaataagc ctaaatctag caaggatccg agttttagta 180 attggccaaa agagaatcca aagcaaaaag gtttaatgac catatatgaa gatgaaatga 240 agcaggaaat aggaagcaga agttcccttg aatctaatgg aaaaggagca gagaaaaata 300 aaggccttgt agagggtaaa gtgcatggtg ataattggca gatgcaaagg actgagtctg 360 gatatgaaag cagtgatcac atcagtaatg gttctactaa tttggactca cctgttatcg 420 atggaaatgg tacagtaatg gatatcagtg gtgttaaaga aacagtgtgc ttcaggtaat 480 gtaaaagttg agtgaatcat ttttccatca ctcttctttt ttgttaattg catgaagtaa 540 tttttgaagt ttggggtcaa ttaaatagaa cagaaacagc atgagctgtt ttaaagagct 600 ttaaaaagtt tgtttctttt aaacacaagt atgtttctgt aaagaaacct aggatattgt 660 agtttatttg atattttaga tttccatttt gaatagttat ttcctgattc caaaaatagc 720 agctttttat ttttagaaaa tttggaaagt acagaagttt attatcattg ttgtgtcact 780 gtcaacaatt gattggtttt aaagcacaga cttcaattgg tatcatctaa gtcattaagg 840 tggttgttta attcttcttt ttttggtggg aggggaagga gtctcactct gttgcccagg 900 ctggagtgca gtggcgcaat tacgggtcac tgcaacctcc gcctcccagg ttcaagcgat 960 tctcctgcct taacttccca agtagctggg actacagaca cgcaccacca cgcctggcta 1020 atttttgtat ttttagagac ggggtttccc caggctactc ttgaactccc aacctcaggt 1080 gatccacctg ccttggcctc ccaaagtgct gggattacag gcctgagcca ctatgcccag 1140 gctgttgttt aattcttcaa tctatataat gtttataatc ccatctctaa catttgtaac 1200 tcagaactga agctagtttt tactgtcaca ctcattctca tggaagagat attttccctt 1260 tagcaaatat aaaaaaaatc agccaaataa ctttgtgttc gattaattct aaatacattt 1320 attatattac tgtttaatcc ttctaacaat gtgtttgttt gatattagct gatatttgac 1380 cacatttgtt attaaaaggt agatttgcaa aaatcaactg ctcatgtttt atgaaaatgc 1440 ttgtttcaat aaagacttaa ggaaagggcc aggtgtagtg tttacacacc tgtaatcaca 1500 gcaccttggg aggctgaggc aggaggattg cttgagccca ggagttcaat actagcctga 1560 gcaacatgga aagatctcat catctctagg aaacagtttt aaaatattag ccaggtattg 1620 tggcatatgc ctgtggtccc agctacttgg gaggctgagg tgggaggatt tttgagccca 1680 ggaggtcgag gctgcagtga accatgtttg taccactgca ctccatcctg ggcaaaagag 1740 caaaggtcct ggctcaaaaa aaaaaaaaag atttgacatg gaaagggtaa ttttataatt 1800 cttcttggaa tggagtagcc tagggtagta gaaagatcag gactttataa ccagatagac 1860 ttagatttta attattgggc aaattaattt gacttttaca gtctttatct tctgtaaaat 1920 gaagataaca actactttta agtattaaat aatgtacatt aagccctaga acagcacatg 1980 gcatataata aatgtttaac aaatgttgtt tttttttaga ctaaacaaag gcagtccata 2040 atacctgatg tgtttagtgt gtattttatt ttctagtgac cagattacga caagcaacct 2100 aaataaagaa cgtggggact gtacctccct tcagagccaa catcacttag aaggtaaaaa 2160 acttatttga atataatagt tgctgtaaaa aatgaattat agtaatttat ggtttgctat 2220 tatgtatctg agagaaaatc ctatatgact ataaaaatta tttttaaata accctaaaac 2280 tt 2282 75 661 DNA Homo sapiens misc_feature Incyte ID No LI289608.12001JAN12 75 tgcaatgtta cttataatag tggacacctt ttagccanan gaccaaactt agcatcccta 60 acaattgana agaaactgac gttgtgtgct tcctgatgtg atgtgatact ggtagtagtt 120 cctaaatact ggaagacata taaaagtcta aagaaaataa aaactgctca tcatccaacc 180 tgctagaaat aatcacctga ggtcaggagt ttgagatcag cttgggcaac atggtgaaac 240 ctcgtctcta ctaaaaatac aaaaattagc tgggtgtggt ggcacatgcc tgtaatccca 300 gctactcggg aggctgaggc acaagaattt tgaactcggg aggtggaggt tgcagtgagc 360 cgagatcaca tcactgcact ccagcctggg tgacagagac tctgtctcaa aaacaaacaa 420 aaactgggat gactgataca atatgtacgt atctatatct ctatataaat atatataagg 480 aatcatatgc acatatgcat gatacgtgta tatacatgat acatagatgt catacatggt 540 tatatagcaa tggatatcca tggtatgcat gatacctgaa gtatatactt ttacctatga 600 gtatatgagc agtttttcat gtcatgaaat gttttaaaat gtgtttaact gcataataat 660 t 661 76 177 PRT Homo sapiens misc_feature Incyte ID No LI418914.1.orf12001JAN12 76 Ser Phe Lys Ile Pro Leu Leu Phe Phe Asn Phe Arg Lys Ser Glu 1 5 10 15 Lys Glu Arg Met Arg Glu Tyr Gln Arg Glu Leu Glu Glu Arg Glu 20 25 30 Glu Lys Leu Lys Lys Arg Pro Leu Leu Phe Glu Arg Val Ala Gln 35 40 45 Lys Asn Ala Arg Met Ala Ala Glu Lys His Tyr Ser Asn Thr Leu 50 55 60 Lys Ala Leu Gly Ile Ser Asp Glu Phe Val Ser Lys Lys Gly Gln 65 70 75 Ser Gly Lys Val Leu Glu Tyr Phe Asn Asn Gln Glu Thr Lys Ser 80 85 90 Val Thr Glu Asp Lys Glu Ser Phe Asn Glu Glu Glu Lys Ile Glu 95 100 105 Glu Arg Glu Asn Gly Glu Glu Asn Tyr Phe Ile Asp Thr Asn Ser 110 115 120 Gln Asp Ser Tyr Lys Glu Lys Asp Glu Ala Asn Glu Glu Ser Glu 125 130 135 Glu Glu Lys Ser Val Glu Glu Ser His Leu Asn His Gln Gly Leu 140 145 150 Leu Ser Met Pro Leu Leu Leu Phe Ala Ala Ser Gly Cys Gln Gln 155 160 165 Pro His Leu Cys Leu Glu His Leu Trp Gly Arg Phe 170 175 77 45 PRT Homo sapiens misc_feature Incyte ID No LI246108.7.orf32001JAN12 77 Arg Gln Leu Leu Leu Lys Ile Leu Cys Met Val Asp Ile Glu Leu 1 5 10 15 Met Thr Tyr Ser Asn Lys Leu Glu Ile Gly Phe Gln Ser Glu Phe 20 25 30 Gly Cys Phe Trp His Val Arg Val Glu Lys Gln Leu Ala Glu Val 35 40 45 78 124 PRT Homo sapiens misc_feature Incyte ID No LI204262.2.orf12001JAN12 78 Ile Asn Thr Ile Ile Phe Ile Trp Lys Phe Tyr Arg Arg Ala Ile 1 5 10 15 Ser Val Tyr Val Ile Thr Pro Asp Phe Leu Lys Leu Leu Leu Val 20 25 30 Asp Asn Arg Gln Val Leu Ser Ser Val Pro Leu Arg Val Val Pro 35 40 45 Gly Leu Pro Ala Val Glu Leu Thr Gly Gly Ile Leu Gln Phe Cys 50 55 60 Asp Pro Arg Met Arg Pro Arg Arg Ser Val Arg Ser Ala Gly Gly 65 70 75 Gly Ala Trp Glu Ala Val Phe Val Met Asn Ser Gly Val Phe Cys 80 85 90 Pro Leu Lys Cys Ile Phe Val His Pro Ile Arg Leu Lys Glu Arg 95 100 105 Lys Ser Ile Ser Asn Glu Cys Lys Leu Phe Leu Arg Lys Lys Cys 110 115 120 Ile Arg Leu Leu 79 168 PRT Homo sapiens misc_feature Incyte ID No LI331661.1.orf12001JAN12 79 Leu Gly Lys Glu Arg Gly Gly Arg Thr Gly Thr Glu Lys Gln Arg 1 5 10 15 Glu Glu Glu Arg Ser Arg Glu Thr Gly Gln Arg Trp Arg Glu Met 20 25 30 Arg Asp Gln Leu Arg Gly Cys Pro Arg Ala Trp Gly Gly Gly Gly 35 40 45 Glu Met Asp Glu Lys Ala Glu Lys Gly Leu Gly Ser Gly Glu Glu 50 55 60 Val Asn Gly Asp Val Gly Trp Gly Gln Glu Trp Asp Ala Glu Glu 65 70 75 Gly Glu Glu Asp Glu Gly Ala Arg Met Arg Gly Ser Gly Glu Gly 80 85 90 Val Ala Ile Trp Ala Leu Gly Glu Gly Arg Ala Cys Ser Pro Lys 95 100 105 Asp Ala Cys His Gln Val Ser Leu Pro His Leu Val Pro Gln Gly 110 115 120 His Pro Pro Asn Leu Cys Pro Gly Ala Gly Asp Arg Thr Asp Leu 125 130 135 Ser Glu Ala Gly Gly Pro Gly His Arg Gln Pro Arg Pro His Pro 140 145 150 Phe Gly Lys Asn Trp Ser Glu Gly Ser His Phe Arg Gly Arg Ser 155 160 165 Gly Ser Ser 80 63 PRT Homo sapiens misc_feature Incyte ID No LI335074.1.orf12001JAN12 80 Gln Ser Lys Thr Leu Ser Leu Lys Asn Glu Lys Asn Ser Ala Gly 1 5 10 15 Tyr Ser Val Asp Ile Ser Lys Leu Ile Val Met Phe Ile Arg Arg 20 25 30 Gly Lys Arg Pro Arg Ile Val Asn Ser Ile Leu Lys Glu Lys Ser 35 40 45 Lys Val Gly Gly Pro Ile Val Pro Asn Phe Ser Thr Phe Thr Ile 50 55 60 Lys Pro Gln 81 70 PRT Homo sapiens misc_feature Incyte ID No LI154608.1.orf22001JAN12 81 Glu Met Asn Leu Phe Tyr Leu Phe Ile Glu Met Arg Ser Cys Ser 1 5 10 15 Val Asn Gln Ala Gly Val Leu Trp His His Leu Ser Ser Leu Gln 20 25 30 Pro Arg Ile Pro Gly Leu Xaa Gln Ser Ser Cys Leu Asp Leu Pro 35 40 45 Ser Ser Trp Asp Tyr Arg Cys Glu Pro Pro Cys Leu Thr Gln Lys 50 55 60 Leu Ile Tyr Phe Leu Ser Val Phe Lys Phe 65 70 82 239 PRT Homo sapiens misc_feature Incyte ID No LI462889.1.orf22001JAN12 82 Ala Ala Ala Glu Ala Ala Ser Leu Phe Pro Trp Ser Gly Gln Cys 1 5 10 15 Val Ala Ala Arg Val Thr Thr Gly Glu Val Gly Ile Met Val Met 20 25 30 Lys Ala Ser Val Asp Asp Asp Asp Ser Gly Trp Glu Leu Ser Met 35 40 45 Pro Glu Lys Met Glu Lys Ser Asn Thr Asn Trp Val Asp Ile Thr 50 55 60 Gln Asp Phe Glu Glu Ala Cys Arg Glu Leu Lys Leu Gly Glu Leu 65 70 75 Leu His Asp Lys Leu Phe Gly Leu Phe Glu Ala Met Ser Ala Ile 80 85 90 Glu Met Met Asp Pro Lys Met Asp Ala Gly Met Ile Gly Asn Gln 95 100 105 Val Asn Arg Lys Val Leu Asn Phe Glu Gln Ala Ile Lys Asp Gly 110 115 120 Thr Ile Lys Ile Lys Asp Leu Thr Leu Pro Glu Leu Ile Gly Ile 125 130 135 Met Asp Thr Cys Phe Cys Cys Leu Ile Thr Trp Leu Glu Gly His 140 145 150 Ser Leu Ala Gln Thr Val Phe Thr Cys Leu Tyr Ile His Asn Pro 155 160 165 Asp Phe Ile Glu Asp Pro Ala Met Lys Ala Phe Ala Leu Gly Ile 170 175 180 Leu Lys Ile Cys Asp Ile Ala Arg Glu Lys Val Asn Lys Ala Ala 185 190 195 Val Phe Glu Glu Glu Asp Phe Gln Ser Met Thr Tyr Gly Phe Lys 200 205 210 Met Ala Asn Ser Val Thr Asp Leu Arg Val Thr Gly Met Leu Lys 215 220 225 Asp Val Gly Asp Asp Met Gln Arg Arg Val Lys Ser Thr Arg 230 235 83 114 PRT Homo sapiens misc_feature Incyte ID No LI236680.2.orf22001JAN12 83 Ser Ser Glu His Thr Ile Ser Leu Leu Gly Glu Leu Asp Cys Ser 1 5 10 15 Lys Asp Thr Gly Ala Thr Val Leu His Phe Met Lys Ala Cys Gly 20 25 30 Ala Val His Met Asn Asp Thr Tyr Met Phe Ala Cys Glu Thr Asp 35 40 45 Phe Ile Ala His Ser Phe Leu Gly Arg Ala Glu Pro Glu Phe Ala 50 55 60 Gly Gly Tyr Glu Arg Arg Glu Arg His Ala Lys Thr Ile Asp Ile 65 70 75 Ala Gln Glu Glu Val Leu Thr Cys Leu Gly Ile His Leu Tyr Glu 80 85 90 Arg Leu His Arg Ile Trp Gln Lys Leu Arg Ala Glu Glu Gln Thr 95 100 105 Trp Gln Asp Ala Phe Leu Ser Trp Cys 110 84 233 PRT Homo sapiens misc_feature Incyte ID No LI228186.1.orf22001JAN12 84 Ser Phe Glu Thr Val Glu Arg Val Lys Arg Glu Arg Asn Trp Ala 1 5 10 15 Arg Leu Ala Ala Gly Glu Gly Gly Gly Gly Gly Gly Gly Phe Pro 20 25 30 Asp Phe Met Pro Val Ala Ser Ala Cys Arg Ile Phe Val Met His 35 40 45 Phe Lys Val Asp Ile Met Ala Pro Leu Cys Ser Glu Ser Gln Ser 50 55 60 Ser Leu Arg His Cys Tyr Lys Arg Thr Leu Arg Lys Ile Trp Pro 65 70 75 Tyr Glu Pro Ser Gln Pro Gln Ala Lys Arg Met Thr Met Cys Val 80 85 90 Ser Ala Ala His Gly Gln Phe Val Ser His Cys Phe Gly Lys Pro 95 100 105 Cys Val Pro Asn Gln Gly Arg Val Phe Gln Gly Lys Val Asn Phe 110 115 120 Pro Lys Phe Ile Lys Ile Glu Leu Gly Lys Pro Ser Ile Leu Asn 125 130 135 Leu Phe Gln Ser Ser Gly His His Ser Tyr Phe Phe Cys His Val 140 145 150 Lys Glu Lys Phe Gln Ala Val His Ser Val His Ala Lys Asn Asn 155 160 165 Gln Pro Ile Leu Leu Gly Asp Leu Leu Leu Asn Val Pro Glu Pro 170 175 180 Ala Asn Val Lys Met Met Val Ser Glu Phe Ala Leu Met Val Ser 185 190 195 Glu Ser Gln Lys Glu Cys Asp Leu Tyr Trp Lys Pro Leu Phe Lys 200 205 210 Phe Asn Asn Ser Glu Met Leu His Thr Ser Ala Ser Phe Leu Ile 215 220 225 Met Phe Thr Val Ile Leu Met Thr 230 85 151 PRT Homo sapiens misc_feature Incyte ID No LI721233.1.orf12001JAN12 85 Asn Asn Tyr Arg Pro Trp Met Glu Glu Glu Ile Thr Glu Gly Leu 1 5 10 15 Lys Asn Leu Thr Val Thr Gly Asp Ala Ala Ala Ser Gly Gly Glu 20 25 30 Gly Gln Arg Arg Gly Gly Gly Ile Ser Ser Asn Arg Ile Gln Val 35 40 45 Ser Asn Thr Lys Lys Pro Leu Phe Phe Tyr Val Asn Leu Ala Lys 50 55 60 Arg Tyr Met Gln Gln His Gly Asp Val Glu Leu Ser Ala Leu Gly 65 70 75 Met Ala Ile Ala Thr Val Val Thr Val Ala Glu Ile Leu Lys Asn 80 85 90 Asn Gly Phe Ala Val Glu Lys Lys Ile Arg Thr Ser Thr Val Asp 95 100 105 Ile Asn Asp Glu Ser Arg Gly Arg Pro Phe Gln Lys Ala Lys Ile 110 115 120 Glu Ile Ile Leu Gly Lys Ser Asp Arg Phe Asp Glu Leu Met Ala 125 130 135 Ala Ala Ala Glu Glu Arg Gly Glu Val Glu Glu Gly Glu Glu Gln 140 145 150 Ala 86 104 PRT Homo sapiens misc_feature Incyte ID No LI291759.2.orf22001JAN12 86 Thr Ile Glu Val Phe Ile Tyr Phe Val Ile Pro Ile Ile Ile Val 1 5 10 15 Met Glu Leu Trp Glu Gly Phe Gly Phe Ser Val Leu Ile Asn Met 20 25 30 Val Tyr Phe Leu Arg Trp Ser Phe Ala Leu Val Ala Glu Ala Gly 35 40 45 Val Lys Trp His Gly Leu Gly Ser Leu Gln Pro Pro Ser Leu Arg 50 55 60 Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro Lys Cys Trp Asp Tyr 65 70 75 Arg Leu Glu Pro Leu Leu Pro Ala Asp Phe Cys Ile Ser Gly Asp 80 85 90 Asp Arg Val Ser Pro Cys Trp Pro Gly Leu Val Ser Asn Ser 95 100 87 34 PRT Homo sapiens misc_feature Incyte ID No LI292613.17.orf12001JAN12 87 Pro Thr Gly Ile Ser Lys Thr Glu Lys Lys Val Lys Leu Glu Asp 1 5 10 15 Lys Ser Ser Thr Ala Phe Gly Lys Arg Lys Glu Lys Asp Xaa Glu 20 25 30 Arg Arg Glu Lys 88 70 PRT Homo sapiens misc_feature Incyte ID No LI412959.15.orf32001JAN12 88 Tyr Ser Phe Tyr Gly Leu Val Val Val Glu Asp Ser Ala Asp Asn 1 5 10 15 Tyr Ser Val Arg Tyr Asn Thr Val Leu Ile Ala Leu Gly Val Leu 20 25 30 Lys Glu Asn Gln Ile Tyr Phe Trp Phe Pro Asp Asn Ile Ser Lys 35 40 45 Glu Asn Cys Val Phe Arg Ser Ser Leu Asp Trp His Ser Leu Trp 50 55 60 Cys Phe Leu Ser Gln Phe Phe Gly Phe Tyr 65 70 89 85 PRT Homo sapiens misc_feature Incyte ID No LI482512.3.orf12001JAN12 89 Val Cys Gln His Asn Arg His Gly Arg Phe Arg Gly Leu Ser Thr 1 5 10 15 Gln Arg His Arg Lys Asn Gly Leu Ala Lys Asn Leu Asp Val Phe 20 25 30 Pro Phe Gly His Ile Leu Leu Ser Trp Arg Thr Arg Phe Lys Thr 35 40 45 Ala Trp Val Gly Lys Leu Glu Ala Ser Trp Met Gln Trp Leu Met 50 55 60 Pro Val Ile Pro Thr Leu Leu Gly Gly Pro Gly Arg Arg Ile Thr 65 70 75 Trp Ala Gln Glu Val Lys Pro Ala Ala Ser 80 85 90 85 PRT Homo sapiens misc_feature Incyte ID No LI482512.3.orf22001JAN12 90 Ala Leu Glu Arg Lys Ser Cys Leu Trp Ser Ser Met Ile Met Ala 1 5 10 15 Ala Trp Asn Phe Gln Leu Thr Phe Leu Gln Leu Ser Thr Ser Met 20 25 30 Phe Asn His Leu Leu Leu Ser His Tyr Leu Thr Asn Leu Ala Arg 35 40 45 Gly Ile Phe Leu Asn Gln Ala Pro Ile Ser Val Phe Phe Leu Cys 50 55 60 Val Pro Asn Phe Val Ile Thr Phe Ser Met Lys Leu Lys Asn Lys 65 70 75 Val Asn Phe Asp Gln Lys Lys Lys Lys Arg 80 85 91 53 PRT Homo sapiens misc_feature Incyte ID No LI413231.6.orf12001JAN12 91 Glu Val Glu Val Lys Glu Trp Ile Leu Glu Phe Glu Asp Phe Glu 1 5 10 15 Val Gln Leu Leu Gln Val Gln Leu Ile Leu Ser Arg Cys Cys Thr 20 25 30 Arg Pro Met Ile Phe Leu Leu Val Glu Asp Gly Gly Glu Tyr Ile 35 40 45 Thr Trp Pro Asn Asn Arg Ala Ser 50 92 125 PRT Homo sapiens misc_feature Incyte ID No LI203383.1.orf12001JAN12 92 Tyr Ala Phe Pro Asn Asn Lys Gly His Glu Ser Leu Gly His Val 1 5 10 15 Thr Glu Ser Phe Ser Lys Ile Gln Lys Lys Ile Ile Asn Met Asn 20 25 30 Ser His Ser Met Pro Arg Ser Leu Phe Met Glu Pro Gly Met Val 35 40 45 Asp Leu Leu Ser Met Ser Gln Asn Ile Ser Pro Tyr Lys Asn Pro 50 55 60 Met Arg Phe Ile Phe Phe Ser Pro Ile Leu Arg Glu Glu Lys Phe 65 70 75 Ser Ser Glu Ser Cys Arg Asn Ile Gly Asp Ile Ser Lys Ser Gln 80 85 90 Pro Ile Gly Gly Ser His Gln Cys Val Leu Glu Gly Thr Asn Ile 95 100 105 Glu Leu Leu Asn Ser Tyr Ser Arg Asn Tyr Gly Ala Val Val Lys 110 115 120 Ser Trp Leu Gly Ala 125 93 123 PRT Homo sapiens misc_feature Incyte ID No LI133186.4.orf32001JAN12 93 Leu His Val Phe Phe Pro Phe Trp Lys Gly Gly Arg Asp Ser Glu 1 5 10 15 Ala Phe Leu Val Phe Phe Arg Pro Ala Pro Ser Phe Leu Asn Ser 20 25 30 Phe Phe Cys Cys Phe Leu Ser Pro Leu Leu Leu Ser Met Ala Val 35 40 45 Ile Leu Leu Glu Ser Lys Gln Ser Val Val Trp Ser Arg Val Cys 50 55 60 Gly Phe Ser Gly Pro Ile Ile Met Ala Ala Ser Glu Ser Glu Glu 65 70 75 Ser His Arg Ala Val Gly Glu Leu Leu Leu Pro Ser Pro Ser Pro 80 85 90 Phe Val Ala Pro Thr Leu Ala Ala Tyr Phe Cys Ser Ser Ala Gly 95 100 105 Glu Ser Val Trp Ala Ser Ser Ser Pro Ser Leu Ser Pro Cys Tyr 110 115 120 Phe Met Gly 94 114 PRT Homo sapiens misc_feature Incyte ID No LI238576.2.orf12001JAN12 94 Glu Lys Gly Val Pro Leu Tyr Gly Arg Gly Ser Gln Lys Pro Gln 1 5 10 15 Asp Leu Ile Leu Lys Thr Pro Pro Arg Pro Gln Gly Ala Arg Gly 20 25 30 Pro Xaa Leu Pro Gly Glu Gln Glu Gly Gly Phe Gln Pro Phe Gly 35 40 45 Asp Thr Gly Gly Phe His Leu Leu Ile Trp Cys Trp Cys Phe Ser 50 55 60 Leu Leu Ala Phe Ser Ser Pro Ser Phe Asn Ala His Gly Ala Phe 65 70 75 Pro Pro Gly Val Gln Gly Val Asp Leu Gly Gln Gly Ser Pro Ser 80 85 90 Leu Gln Leu Gly Arg Ile Pro Ser Phe Leu Phe Leu Ala Ile Val 95 100 105 Leu Leu Val Phe Gly Cys Ser Val Ile 110 95 110 PRT Homo sapiens misc_feature Incyte ID No LI903914.3.orf22001JAN12 95 Ser Phe Thr Leu Ser Pro Arg Leu Glu Cys Ser Gly Thr Ile Phe 1 5 10 15 Ala His Cys Asn Leu Cys Leu Leu Gly Ser Ser Asp Ser Arg Ala 20 25 30 Pro Ala Ser Arg Val Ala Gly Thr Thr Gly Thr Cys His His Ala 35 40 45 Gln Leu Ile Phe Ile Phe Leu Val Glu Thr Gly Phe Cys Cys Val 50 55 60 Gly Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser Asn Pro Pro Gly 65 70 75 Leu Leu Phe Ser Cys Leu Asn Met Ala Cys Leu Leu Val Ser Leu 80 85 90 Phe Ser Tyr Ser Leu Tyr Val Gln Glu Ile Thr Phe Trp His Val 95 100 105 Leu Trp Arg Cys Cys 110 96 100 PRT Homo sapiens misc_feature Incyte ID No LI150817.1.orf22001JAN12 96 Thr Leu Tyr Leu Tyr Glu Val Gly Ile Ile Ile Glu Pro Met Leu 1 5 10 15 Trp Arg Lys Leu Lys Leu Lys Lys Asp Arg Pro Gly Val Val Ala 20 25 30 Tyr Thr Cys Ser Leu Ser Thr Leu Gly Gly Gly Gly Gly Gln Ile 35 40 45 Ile Arg Ser Arg Asp Arg Asp His Pro Gly Gln His Gly Lys Thr 50 55 60 Pro Ser Leu Leu Lys Ile Gln Lys Lys Ile Ser Trp Ala Trp Trp 65 70 75 His Val Pro Val Ile Pro Ala Thr Trp Glu Ala Glu Ala Gly Glu 80 85 90 Ser Leu Glu Phe Gly Arg Gln Arg Leu Gln 95 100 97 92 PRT Homo sapiens misc_feature Incyte ID No LI219627.1.orf32001JAN12 97 Trp Gly Cys Gly Ser Ala Ala Ile Ser Asn Arg Asp His Gly Gly 1 5 10 15 Pro Gln Thr Ser Ala Pro Glu Arg Gln Phe Gln Ser Tyr Trp Gly 20 25 30 Asp Ala Gly Ile Trp Val Ala Ala His His Gln Gly Arg Val Leu 35 40 45 Ser Ala Ala Leu Glu Cys Arg Val Pro Ile Ser Ser Ala Val Arg 50 55 60 Gly Thr Trp Gly Ser Ser Gly Glu Asp Ser Trp Ser Leu Asp Asp 65 70 75 Asn Thr Pro Leu Pro Thr Ser Pro Ala Phe Pro Val Thr Leu Cys 80 85 90 His Leu 98 57 PRT Homo sapiens misc_feature Incyte ID No LI197812.4.orf32001JAN12 98 Ile Leu Trp Lys Met Ala Phe Ser Asp Leu Thr Ser Arg Thr Val 1 5 10 15 His Leu Tyr Asp Asn Trp Ile Lys Asp Ala Glu Leu Glu Ser His 20 25 30 Val Gln Asp Leu Arg Cys Val Leu Lys Ile Leu Asn Tyr Gly Lys 35 40 45 Lys Leu Phe Ile Leu Lys Leu Phe Tyr Ser Ala Ser 50 55 99 60 PRT Homo sapiens misc_feature Incyte ID No LI101525.1.orf22001JAN12 99 Leu Met Pro Val Ile Pro Val Pro Trp Glu Ala Lys Ala Ala Asp 1 5 10 15 Cys Leu Ser Leu Gly Val Gln Asn Gln Leu Gly Gln His Gly Glu 20 25 30 Thr Ser Phe Leu Gln Lys Ile Gln Lys Leu Ser Gln Val Trp Trp 35 40 45 His Val Pro Val Val Pro Ala Thr Trp Glu Ala Glu Val Gly Gly 50 55 60 100 144 PRT Homo sapiens misc_feature Incyte ID No LI891123.1.orf32001JAN12 100 Phe Pro Pro Val Gln Ala Glu Ser Gly Trp Ser Gly Cys Arg Ala 1 5 10 15 Thr Ile Arg Pro Trp Ser Thr Phe Val Asp Gln Gln Arg Leu Leu 20 25 30 Thr Ala His Ala Thr Trp Glu Thr Cys Ala Ser Ala Ser Tyr Cys 35 40 45 Asn Val Glu Ser Leu Pro Glu Gln Leu Cys Ser Ser Met Leu Pro 50 55 60 Gly Pro His Ala Cys Thr Val Leu Val Asn Val Pro Leu Cys Tyr 65 70 75 Ala Glu Trp Leu Leu Asp Cys Leu Leu Ser Arg Arg Pro Gly Tyr 80 85 90 His Ile Ile Ile Met Leu Arg His Pro Trp Ser Pro Ser Leu Cys 95 100 105 Ser Ile Gly Arg Glu Asp Asp Ala Pro Asp Ala Ser Val Cys Ser 110 115 120 Gly His Gly Gly Ile Ser Phe Pro Phe Phe Trp Val Trp Leu Val 125 130 135 Arg Gly Ser Ala Cys Leu Leu Gly Cys 140 101 64 PRT Homo sapiens misc_feature Incyte ID No LI813500.1.orf12001JAN12 101 Thr Tyr Val Gly Asn Cys Arg Ser Cys Arg Arg Gly Leu Thr Asn 1 5 10 15 Gly Thr Phe Val Gly Ile Lys Met Val Gln Val Tyr Ala Trp Lys 20 25 30 Leu Ser Leu Pro Leu Asn Val His Leu Lys Ser Arg Gln Arg Lys 35 40 45 Cys Val Glu Thr Gly Gln His Val Gln Gly Trp Leu Val Gln Trp 50 55 60 Ala Val Thr Thr 102 95 PRT Homo sapiens misc_feature Incyte ID No LI1037251.1.orf12001JAN12 102 Gln Gly Leu Pro Phe Thr Leu Gly Thr Leu Leu Ile Phe Ser Leu 1 5 10 15 Cys Pro Ser Pro Pro Leu Pro Ser Gln Trp Leu Val Cys Gly Lys 20 25 30 His Ile Ser Ser Ser Cys Asp Phe Met Ser Leu Asn Gln Arg Met 35 40 45 Lys Arg Leu Val Ser Ala Met Met Cys Gly Ile Arg Trp Pro Phe 50 55 60 Pro Trp Thr Ser Leu Glu Pro Cys Leu His Ile Val Pro Asp Thr 65 70 75 Val Ile Pro Gly Leu Pro Ser Pro Phe Leu Ser Phe Leu His Gly 80 85 90 His Ser Ser Pro Leu 95 103 135 PRT Homo sapiens misc_feature Incyte ID No LI2032187.1.orf22001JAN12 103 Ser Leu Pro Leu Asp Ser Val Gln Pro Cys Ile Phe Leu Glu Val 1 5 10 15 Asp Pro Arg Ser Gly Ser Asp Gly His Ile Ser Arg Thr Tyr Val 20 25 30 Val Thr Asp His Val Ser Leu Gln Lys Ser Ile Pro Ala Thr Cys 35 40 45 Val Ala Ser Ser Asp Gly Asp Leu Ser Gly Ser Leu Trp Phe Pro 50 55 60 Ser Gln Pro Glu Gln Gly Pro Ser Ile Pro Val Ile Ser Ser Met 65 70 75 Leu Ile Gly Val Cys Trp Asn Pro Lys Pro Leu Pro Arg Leu Gln 80 85 90 Ala Pro Asp Gly His Ala Leu Arg Val Thr Phe Ala Met Glu Lys 95 100 105 Arg His Cys Val Ser Arg Arg Pro Phe Thr Trp Leu His Ala Leu 110 115 120 His Pro Trp Ser Cys Ala His Ala Ser Ser Pro Thr Val Val Pro 125 130 135 104 90 PRT Homo sapiens misc_feature Incyte ID No LI347572.1.orf32001JAN12 104 Arg Ser Ser Met Lys Leu Leu Gly Asn Thr His Val Asn Phe Leu 1 5 10 15 Leu Ala Thr Pro Lys His Phe Thr Gln Ser Thr Val Leu Phe Cys 20 25 30 His Pro Ser Phe Gln Arg Thr Thr Met Asn Thr Glu Thr Lys Leu 35 40 45 Pro Ala Gln Thr Gln His Ser Arg Leu Leu Gly Thr Leu Pro Phe 50 55 60 Thr Tyr Thr Val Arg Glu Arg Gly Gly Gly Trp Ser Leu Lys Gly 65 70 75 Thr Ile Pro Gln Glu Thr Ser Trp Met Lys Thr Val Val Gly Arg 80 85 90 105 153 PRT Homo sapiens misc_feature Incyte ID No LI007788.1.orf12001JAN12 105 Gln Thr Met Pro Leu Lys Asp Lys Ile Thr Pro Ser Leu Arg Asn 1 5 10 15 Met Pro Val Asn Pro Leu Thr Pro Pro Gly Ile Pro Gln Arg Cys 20 25 30 Thr Ser Tyr Thr His Trp Glu Ile Thr Gln Arg Arg Gly Thr Gln 35 40 45 Lys Thr Arg Ser Thr Gln Leu Gly Val Arg Glu Asp Asp Arg Pro 50 55 60 Ser Ser Ile Ile Pro Phe His Ile Leu Ile Ser Cys Arg Leu His 65 70 75 Leu Tyr Leu Ser Leu Phe Phe Glu Phe Ile Leu Leu Phe Tyr Tyr 80 85 90 Leu Val Tyr Trp Thr Arg Gly Leu His Arg Arg Glu Glu Leu Arg 95 100 105 Ala Pro Gln Lys Arg Ser Val Cys Phe Pro Val Leu Pro Arg His 110 115 120 His Ser Cys Glu Val Ala Ser Leu Glu Val Gly Tyr Glu Glu Pro 125 130 135 Pro Trp Glu Ser Trp Ile Ala Phe Thr Leu Pro Gly Gly Gly Ala 140 145 150 Tyr Ile Pro 106 73 PRT Homo sapiens misc_feature Incyte ID No LI336872.1.orf22001JAN12 106 Gly Pro Gln Thr His Phe Ser Lys His Pro Phe Ser Tyr Glu Asn 1 5 10 15 Thr Gly Gly Arg Val Ser Phe His Leu Trp Val Ser Ile Phe Ile 20 25 30 Phe Glu Thr Gly Ser Gln Ser Val Thr Gln Pro Val Ile Ala Pro 35 40 45 Leu His Ser Ser Leu Gly Asn Arg Val Arg Leu Ser Leu Lys Lys 50 55 60 Lys Gly Arg Leu Asn Phe Tyr Phe Ile Phe Thr Pro Asn 65 70 107 73 PRT Homo sapiens misc_feature Incyte ID No LI336872.1.orf32001JAN12 107 Asn Gln Lys His Met Cys Thr Val Lys Phe Leu Asp Cys Arg Arg 1 5 10 15 Arg Leu Thr Ser His Ser Gln Pro Leu Ser Pro Leu Asn Cys Ser 20 25 30 His Glu Asp Leu Arg His Thr Ser Leu Asn Thr Pro Phe His Met 35 40 45 Lys Ile Leu Glu Ala Glu Cys Pro Ser Ile Cys Gly Phe Leu Phe 50 55 60 Leu Phe Leu Arg Gln Asp Leu Ser Leu Ser Pro Ser Leu 65 70 108 197 PRT Homo sapiens misc_feature Incyte ID No LI1143291.1.orf22001JAN12 108 Ala Trp Arg Ser Cys Ser Gln Arg Ser Glu Ala Gly Arg Gly Glu 1 5 10 15 Arg Ser Arg Gln Arg Ile Thr Val His Lys Glu Ala Gly Ser Cys 20 25 30 Ser Leu Thr Trp Gly Asn Leu Leu Gly Val Arg Thr Gly Asn Pro 35 40 45 Pro Asp Arg Asp Ser Arg Cys Ala Gly Pro Asn Ala Gly Gly Arg 50 55 60 Ala Tyr Met Ala Leu Gly Ala Gly Gln Ser Arg Asn Leu Leu Ile 65 70 75 Asn Gln Leu Trp Gln Ser Ala Gln Arg Glu Arg Val Glu Arg Gly 80 85 90 Asp Lys Trp Arg Gly Cys Arg Ser Pro Pro His Ala Cys Arg Glu 95 100 105 Arg Ser Leu Ser Pro Arg Pro Arg Pro Leu Thr Arg Trp Gln Gln 110 115 120 Phe Ala Ala Pro Gln Gly His Pro Val Pro Arg Arg Arg Pro Thr 125 130 135 Trp Cys Gly Asp Glu Val Ser Gly Leu Val Ala Ala Ala Leu Gly 140 145 150 Ala Thr Ser Ala Ser Arg Asp Asp Thr Lys Glu Trp Leu Ile Glu 155 160 165 Val Pro Gly Asn Cys Arg Pro Leu Gly Gly Pro Val Arg Gln Ala 170 175 180 Asp Ser Gly Gln Glu Gly Lys Gly Gly Gln Glu Arg Ala Glu Pro 185 190 195 Ala Ala 109 81 PRT Homo sapiens misc_feature Incyte ID No LI093477.1.orf12001JAN12 109 Asn Cys His Leu Ile Cys Arg Ser Gln Lys Gln Met Lys Arg Ser 1 5 10 15 Phe Thr Ile Ser Arg Asp Glu Lys Glu Cys Cys Phe Leu Phe Phe 20 25 30 Leu Ser Ala Leu Phe Ser Leu Gly Lys Glu Asn Glu Leu Met Leu 35 40 45 Gly Ser Phe Phe Arg Ile Leu Ser Gly Ser Glu Leu Trp Glu Ala 50 55 60 Ser Ile Leu Leu Ser Gln Gly His Val Glu Leu Phe Pro Pro Arg 65 70 75 Pro Pro Asp Trp His Gly 80 110 257 PRT Homo sapiens misc_feature Incyte ID No LI222105.1.orf22001JAN12 110 Thr Ala Gln Pro Leu Arg Val Pro Ala Thr Ala Gly Glu Pro Gly 1 5 10 15 Lys Gln Gln Pro His Arg Ala Thr Ala Gln Arg Pro Gly Gly Pro 20 25 30 Lys Arg Leu Pro Gln Thr Asn Thr Arg Gly Gly Thr Pro Arg Ala 35 40 45 Glu Pro Ser Glu Pro Gln Phe Phe Phe Ser Gly Gly Val Gly Glu 50 55 60 Arg Leu Gly Val Glu Arg His Gly Gly Ala Gly Tyr Gly Ala Ala 65 70 75 Gln Pro Gly Gly Val Ala Glu Ala Arg Gln Leu Thr Val Pro Pro 80 85 90 Asn Leu Leu Ser Ala Asp Arg Cys Leu Thr Ala Arg Pro Ala Leu 95 100 105 Arg Tyr Ser Pro His Ala Pro Ser Pro Gly Gln Arg Cys Gly Pro 110 115 120 Pro Glu Cys Arg Ala Pro Ser Arg Gly Leu Leu Arg Gly Pro Cys 125 130 135 Leu Ser Leu Gly Ser Thr Pro Gly Val Ser Ala Thr Ser Ser Ser 140 145 150 Ala Ser Ser Ser Thr Ser Ser Ser Val Val Arg Trp Trp Ala Trp 155 160 165 Val Leu Gly Gly Lys Arg Pro Gly Ser Val Ser Ser Thr Asp Gln 170 175 180 Glu Arg Glu Leu Lys Glu Lys Gln Arg Asn Ala Glu Ala Leu Ala 185 190 195 Glu Leu Ser Glu Glu Pro Ala Gln Pro Arg Pro Arg Ser Gly Pro 200 205 210 Ala Ser Pro Arg Trp Ser Ala Thr Arg Cys Ser Arg Trp Gln Ala 215 220 225 Ala Arg Pro Thr Arg Phe Ala Ser Arg Arg Thr Thr Arg Cys Trp 230 235 240 Ala Ala Phe Ser Pro Ser Thr Pro Ser Pro Ser Pro Ala Trp Thr 245 250 255 Thr Asn 111 208 PRT Homo sapiens misc_feature Incyte ID No LI816737.2.orf32001JAN12 111 Gly Leu Pro Met Glu Glu Glu Asp Gly Gly Gly Ala Arg Gly Glu 1 5 10 15 Val Leu Thr Val Glu Arg Gly Ser Gly Ser Gly Gly Gly Gly Thr 20 25 30 Arg Arg Arg Trp Pro Ala Pro Ala Ala Gly Ala Asp Lys Lys Ala 35 40 45 Val Ala Leu Arg Glu Trp Ala Gly Gly Arg Gly Gly Val Arg Gly 50 55 60 Pro Gln Glu Tyr Val Arg Gly Cys Thr Glu His Gly Val Ala Gly 65 70 75 Ala Cys Asn Arg Ala Cys Ser Val Cys Thr Ser Lys Leu Tyr Leu 80 85 90 Leu Ala Pro Arg Ser Val Leu Ala Leu Gly Thr Gly Ser Gly Trp 95 100 105 Arg Cys Leu Ala Gln Pro Ser Leu Pro Gln Val Leu Ala Ala Ala 110 115 120 Arg Asp Ser Arg Ser Gly Met Pro Pro Ala Val Gly Arg Asn Arg 125 130 135 Arg Leu Pro Pro Val Thr Arg Ala Gly Gly Val Cys Ala Cys Pro 140 145 150 Ala Ala His His Ala Glu Cys Ala Gly Arg Ala Asp Gly Ser Phe 155 160 165 Leu Gly Arg Lys Ser Cys Leu Cys Ile Trp Ala Leu Val Asn His 170 175 180 Arg Gly Gly Ala Gly Thr Pro Ala Ser Gln Asp Met Arg Glu Pro 185 190 195 Arg Gly Val Val Tyr Arg Pro Trp Ala Ile Leu Tyr His 200 205 112 177 PRT Homo sapiens misc_feature Incyte ID No LI475524.1.orf22001JAN12 112 Arg His Arg Phe Phe Lys Thr Pro Ala Ser Ala Pro Val Pro Thr 1 5 10 15 Leu Gly Leu Gly Ile Ser Arg Tyr Leu Leu Arg Ser Gly Ser Ser 20 25 30 Phe Asn Leu Ala Met Ala Ser Ala Trp Asn Ala Asp Pro Trp Glu 35 40 45 Gly Ser Val Leu Thr Leu Leu Gly Leu Gly Glu Trp Pro Trp Ser 50 55 60 Pro Val Pro Cys Pro Cys Gly Lys Val Thr Ala Phe Ile Cys Ala 65 70 75 Thr Ala Ser Trp Trp Pro Arg Cys Val Trp Glu Gly Leu Val Asp 80 85 90 Val Leu Ala Trp Cys Arg Ala Pro Ala Arg Ser Lys Cys Lys Val 95 100 105 Val Leu Thr His Leu Leu Ala Leu Pro Gln Asp Leu Arg Gly Cys 110 115 120 Thr Cys Pro Leu Ser Ala Ser Pro Ser Ser Val Ala Leu Phe Arg 125 130 135 Leu Ala Trp Ser Asn His Ala Gly Gly Gln Cys Cys Thr Thr Cys 140 145 150 Val Gly Trp Thr Thr Gly Phe Gln Arg Pro Cys Leu Val Leu Asn 155 160 165 Leu Trp Asp Leu Ser Phe Val Ile Ser Gly Gly Pro 170 175 113 129 PRT Homo sapiens misc_feature Incyte ID No LI383639.1.orf12001JAN12 113 Ala Ala Ala Ala Glu Lys Leu Glu Met Gly Thr Ala Leu Asp Ile 1 5 10 15 Lys Ile Lys Arg Ala Asn Lys Val Tyr His Ala Gly Glu Val Leu 20 25 30 Ser Gly Val Val Val Ile Ser Ser Lys Asp Ser Val Gln His Gln 35 40 45 Glu Val Ser Leu Thr Met Glu Gly Thr Val Asn Leu Gln Leu Ser 50 55 60 Ala Lys Ser Val Gly Val Phe Glu Ala Phe Tyr Asn Ser Val Lys 65 70 75 Pro Ile Gln Ile Ile Asn Ser Thr Ile Glu Met Val Lys Pro Gly 80 85 90 Lys Phe Pro Ser Gly Lys Thr Glu Ile Pro Phe Glu Phe Pro Leu 95 100 105 His Leu Lys Gly Asn Lys Val Leu Tyr Glu Thr Tyr His Gly Val 110 115 120 Phe Val Asn Ile Gln Val Arg Ala Ser 125 114 91 PRT Homo sapiens misc_feature Incyte ID No LI814346.1.orf22001JAN12 114 Thr Gly Phe Arg Arg Ala Glu Tyr Ser Asn Asn Asp Gly His Gln 1 5 10 15 Phe Ala Glu Tyr Ser Glu Asn Phe Lys Lys Pro Ile Arg Thr Gln 20 25 30 Tyr Gly Arg Arg Gly Lys Met Lys Lys Gly Leu Pro Pro Gly Thr 35 40 45 Glu Asp Ile Trp Ser Cys Asn Arg Gln Thr Val Glu Val Lys Thr 50 55 60 Lys Glu Glu Gln Thr Glu Asn Thr Trp Lys Trp Thr Met Val Ala 65 70 75 Val Pro Val Arg Pro Pro Gln Pro Pro Arg Lys Glu Lys Gly Pro 80 85 90 Arg 115 122 PRT Homo sapiens misc_feature Incyte ID No LI898195.6.orf22001JAN12 115 Thr Glu Glu Ala Ala Ala Glu Lys Lys Val Ser Glu Pro Val Ser 1 5 10 15 Glu Pro Val Thr Leu Glu Gln Gly Thr Ala Asp Ser Ala Pro Gly 20 25 30 Leu Ala Ser Gln Ile Cys Gly Pro Lys Leu Leu Ser Cys Pro Met 35 40 45 Gly Ser Gly Arg Ser Pro Val Ser Arg Arg Arg Glu Glu Thr Val 50 55 60 Gly Ala Leu Gly Pro Gly Leu Ala Glu Arg Gln Ser Ala Leu Ser 65 70 75 Leu Ala Asp Ser Leu Ser Arg Glu Pro Glu Glu Ala Pro Gly Phe 80 85 90 Val Leu Pro Gly Gly Ala Gly Val Ser His Pro Gly Gln Leu Pro 95 100 105 Gln Thr Val Phe Gly Ile Gln Gly Lys Glu Glu Ser Thr Cys Ala 110 115 120 Pro Ile 116 59 PRT Homo sapiens misc_feature Incyte ID No LI210497.2.orf32001JAN12 116 Pro Pro Ser Phe Tyr Lys Glu Asp Ala Val Glu Ile Arg Pro Val 1 5 10 15 Pro Glu Cys Pro Lys Glu His Leu Gly Asn Arg Ile Leu Val Lys 20 25 30 Leu Leu Thr Leu Lys Phe Glu Ile Glu Ile Glu Pro Leu Phe Ala 35 40 45 Ser Ile Ala Leu Tyr Asp Val Lys Asp Arg Lys Lys Ile Ser 50 55 117 97 PRT Homo sapiens misc_feature Incyte ID No LI110297.4.orf22001JAN12 117 Ala Ile Gly Arg Lys Phe Asp Leu His Val Leu Asp Gln Ser Ile 1 5 10 15 Thr Arg Cys Leu Trp Val Cys Gly Leu Gly Arg Pro Ser Pro Ile 20 25 30 His Ser Phe Ser Ala Leu Gly Thr His Glu Arg Asp Ala Lys Phe 35 40 45 Ser Val Asp Phe Ser Trp Cys Ser Met Gly Glu Ser Gly Val Leu 50 55 60 Cys Ala Tyr Trp Lys Ser Pro Lys Asn Gln Arg Pro Phe Ser Phe 65 70 75 Thr Gly Leu Ile Lys Tyr Ser Pro Thr Phe Lys Ile Gly Arg Val 80 85 90 His Arg Val Ile Gly Glu Thr 95 118 172 PRT Homo sapiens misc_feature Incyte ID No LI2051312.1.orf12001JAN12 118 Ile Phe Leu Thr Leu Ser Val Gln Trp His Ala Ser Lys Glu Asp 1 5 10 15 Ser Thr Ala Lys Ser Ser Cys Cys His Ser Leu Ile Lys Gln Glu 20 25 30 Ser Arg Trp Leu Ile Ser Leu Ser His His Ser Thr Ala Arg Leu 35 40 45 Val Gln Ala Leu Leu Ser Thr Gln Ser Arg Ser Lys Gly Asn Gly 50 55 60 Lys Ser Asn His Arg Thr Gln Ser Ala His Ile Ser Pro Val Thr 65 70 75 Ser Thr Tyr Cys Leu Ser Pro Arg Gln Lys Glu Leu Gln Lys Gln 80 85 90 Leu Glu Glu Lys Arg Glu Lys Leu Lys Arg Glu Glu Glu Arg Arg 95 100 105 Lys Ile Glu Glu Glu Lys Glu Lys Lys Arg Glu Asn Asp Ile Val 110 115 120 Phe Lys Ala Trp Leu Gln Lys Lys Arg Glu Gln Val Leu Glu Met 125 130 135 Arg Arg Ile Pro Arg Ala Lys Glu Ile Glu Asp Met Asn Ser Arg 140 145 150 Gln Glu Asn Xaa Asp Pro Gln Gln Ala Phe Arg Leu Trp Leu Lys 155 160 165 Lys Lys His Glu Glu Gln Met 170 119 214 PRT Homo sapiens misc_feature Incyte ID No LI350272.2.orf32001JAN12 119 Ala Pro Ala Pro Pro Gly Thr Ala Ala Gly Gly Ser Arg Glu Glu 1 5 10 15 His His Arg Ser Cys Ser Gly Ala Asp Arg Ala Gly Gly Thr Ser 20 25 30 Cys Arg His Cys Gln Lys Pro Ala Glu Ser Glu Ala Pro Ile Arg 35 40 45 Ile Trp Thr Arg Gln Arg Thr Glu His Pro Gly Gln Gly Glu Leu 50 55 60 Leu Glu Ala Pro Ser Ser Ser Ser Cys Pro Leu Pro Asp Gln Ser 65 70 75 His Pro Ala Leu Gln Glu Ser Phe Ser Val Cys Phe Ser Gly Pro 80 85 90 Ser Ile Gln Pro Val Asn Leu Lys Ser Leu Ser Cys Ser Leu Glu 95 100 105 Val Ser Lys Asp Ser Arg Thr Val Thr Val Ser His Arg Pro Thr 110 115 120 Thr Leu Ser Ala Gly Ala Val Lys Arg Phe Ser Thr Lys Pro Gly 125 130 135 Leu Met Phe Pro Arg Pro Cys Leu Leu Glu Lys His Tyr Trp Glu 140 145 150 Val Asp Thr Arg Asn Cys Ser His Trp Ala Ser Trp Gly Gly Phe 155 160 165 Leu Gly Asp Glu Pro Arg Pro Gly Pro Gly Lys Asp Tyr Gly Leu 170 175 180 Leu Val Val Trp Asn Gly Arg Gly Leu Ala Ser Ser Leu His Gly 185 190 195 Thr Trp Ser Arg Lys Leu Ser Leu Ala Gln Thr Asp Leu Gly Trp 200 205 210 Trp Ala Ser Gly 120 140 PRT Homo sapiens misc_feature Incyte ID No LI1085472.4.orf12001JAN12 120 Arg Thr Cys Thr Arg Arg Ser Arg Arg Arg Ala Thr Ala Thr Trp 1 5 10 15 Arg Gly Leu Arg Arg Leu Pro Gly Ala Pro Leu Arg Pro Ala Pro 20 25 30 Arg Arg Arg Thr Glu Arg Gln Trp His Thr Asp Gly Arg Ala Glu 35 40 45 Arg Arg Ala Ala Lys Gly Glu Leu Phe Ala Val Ser Ser Arg Cys 50 55 60 Ser Leu Ser Pro Ser Leu Pro Pro Ser Phe Ala Thr Val Trp Ala 65 70 75 Pro Ser Gly Ile Pro Gly Ala Leu Trp Lys Arg Val Gly Glu Met 80 85 90 Arg Ser Arg Leu Trp Thr Gly Glu Glu Glu Trp Gly Gln Arg Glu 95 100 105 Gln Val Gly Asn Thr Cys Ser Trp Gly Trp Gly Ala Ser Pro Ser 110 115 120 Gly Pro Leu Ser Val Phe Leu Ser Ala Val Glu Gln Thr Cys Gly 125 130 135 Arg Cys Leu Ala Ala 140 121 204 PRT Homo sapiens misc_feature Incyte ID No LI1190272.1.orf22001JAN12 121 Thr Lys Ala Gly Gly Leu Ile Tyr His Val Gly Gln Leu Arg Ala 1 5 10 15 Ile Gly Leu Arg Leu Arg Lys Leu Ser Arg Tyr Thr Arg Trp Ile 20 25 30 Cys Cys Ser Ser Tyr Thr Met Ser Val Trp Leu Val Ala Phe Gly 35 40 45 Gln Arg Asp Gly Ile Arg Val Gly His Ala Val Leu Ala Ile Asn 50 55 60 Gly Met Asp Val Glu Trp Gln Val His Gly Arg Arg Glu Arg Gly 65 70 75 Ala Gly Val Phe Gly Leu Thr Leu Ala Asn Tyr Pro Val Ser Ile 80 85 90 Arg Phe Gly Arg Pro Arg Leu Thr Ser Asn Gln Lys Leu Ile Ala 95 100 105 Gly Pro Pro Cys Ser Thr Arg Ser Leu Pro Ser Arg Ser Gln Asp 110 115 120 Cys Leu Leu Lys Gln Gly Lys Leu Arg Gln Leu Arg Cys Trp Ser 125 130 135 Ala Asp Ser Met Ser Asn Cys Thr Cys Tyr Gln Ile Thr Asp Arg 140 145 150 Asp Gln Val Cys Gly Ser Ser Arg Leu Pro Arg Ala Ser Leu Glu 155 160 165 Leu Gly Phe Ser Ser Pro Lys Arg Leu Tyr Asp Asp Leu Tyr Ser 170 175 180 Asp Ile Leu Pro Leu Ile Glu Cys Ala Val Leu Ile Arg Val Arg 185 190 195 Lys Cys Leu Leu Arg Cys Glu Leu Phe 200 122 284 PRT Homo sapiens misc_feature Incyte ID No LI1086797.1.orf12001JAN12 122 Tyr Gly Leu Phe Asp Ser Pro Val Lys Glu Tyr Leu Thr Val Ile 1 5 10 15 Leu Ile Leu Leu Asn Cys Ile Val Thr Leu Leu Thr Ser Arg Lys 20 25 30 Glu Leu Pro Pro Asn Gly Asp Thr Lys Ser Met Val Tyr Gly Pro 35 40 45 Ser Arg Ala Thr Ser Arg Val Gly Cys Ser Ser Leu Leu Ser Glu 50 55 60 Ser Thr Pro Val Leu His Gln Lys Thr Leu Gln Ala Met Lys Ser 65 70 75 His Ser Glu Lys Ala His Trp Pro Trp Glu Leu Gln Gly Ile Glu 80 85 90 Thr Pro Gln Phe Phe Pro Ser Ser Pro Pro Pro His Ser Pro Leu 95 100 105 Ser His Gly His Ile Pro Ser Ala Ile Val Leu Pro Asn Ala Thr 110 115 120 His Asp Tyr Asn Thr Ser Phe Ser Asn Ser Asn Ala His Lys Ala 125 130 135 Glu Lys Lys Leu Gln Asn Ile Asp His Pro Leu Thr Lys Ser Ser 140 145 150 Ser Lys Arg Asp His Arg Arg Ser Val Asp Ser Arg Asn Thr Leu 155 160 165 Asn Asp Leu Leu Lys His Leu Asn Asp Pro Asn Ser Asn Pro Lys 170 175 180 Ala Ile Met Gly Asp Ile Gln Met Val Thr Pro Glu Leu Asn Ala 185 190 195 Trp Ile Pro Trp Asp Arg Cys Leu Arg Ser His Ala Ile Ser Ala 200 205 210 Pro Asn Arg Glu Ala Ser Leu Tyr Ser Pro Pro Ser Thr Leu Pro 215 220 225 Arg Asn Ser Pro Thr Lys Arg Val Asp Val Pro Thr Thr Pro Gly 230 235 240 Val Pro Met Thr Phe Leu Val Arg Gln Arg Val Tyr Arg Arg Arg 245 250 255 Met Ser Tyr Pro Glu Ala Leu Tyr Ile Cys Tyr Ala Val Lys Leu 260 265 270 Lys Leu Ala Lys Trp Cys Gly Cys Asp Ser Asp Arg Leu Val 275 280 123 129 PRT Homo sapiens misc_feature Incyte ID No LI1144466.1.orf12001JAN12 123 Leu Thr Gln Ser Pro Trp Pro Leu Ala Val Pro Ile Gly Ala Ile 1 5 10 15 Asp Gln Asn Pro Leu Ser Leu Asn Ser Ile Leu Thr Ser Leu Arg 20 25 30 Ile Leu Cys Ile Ser Glu Ala Glu Thr Ser Leu Gly Ile His Leu 35 40 45 Leu Gly Thr Gln Val Arg Ser Pro Tyr Ile Ala Arg Lys Gly Val 50 55 60 Ser Gly Ala Met Pro Thr Phe Pro Ser His Pro Leu Pro Leu Gly 65 70 75 Thr Gly Leu Phe Pro Ile Val His Ile Tyr Pro Tyr Leu Ser Pro 80 85 90 Ile Asn Phe Cys Leu Pro Leu Ser Pro Phe Pro His Val Ser Ser 95 100 105 Ile Leu Pro Gly Phe Lys Ile Ile Phe Thr Gln Leu Ile Cys Glu 110 115 120 Gly Asn Gly Lys Arg Thr Ser Pro Asn 125 124 81 PRT Homo sapiens misc_feature Incyte ID No LI1147914.1.orf32001JAN12 124 Pro Thr Thr Ser Asn Arg Ala Ile Thr Leu Thr Ala Arg Pro Lys 1 5 10 15 Ile Pro Phe Leu Arg Ile Arg Glu Ala Lys Asn Pro Arg Ser Glu 20 25 30 Asn Thr Arg Leu Ala Thr Ile Leu Glu Val Ala Cys Arg His Phe 35 40 45 Gly Ser Asp Leu Pro Pro Phe Trp Lys Gln Pro Thr Ile Ile Leu 50 55 60 Gly Ala Leu Gly Ala Arg Thr Pro Gly Lys His Phe Gly Arg Pro 65 70 75 Ala Lys Gly Pro Pro Arg 80 125 129 PRT Homo sapiens misc_feature Incyte ID No LI758086.1.orf22001JAN12 125 Trp Lys Val Asn Gly Arg Asn Leu Ser Pro Phe Glu Glu Ile Gly 1 5 10 15 Asn Gln Ser His Phe Val Ala Gln Ala Gly Val Gln Trp His Asn 20 25 30 Leu Ala His Cys Asn His His Leu Pro Gly Ser Ser Asp Pro Pro 35 40 45 Thr Ser Thr Ser Gln Val Ala Gly Ser Ala Gly Val Arg His His 50 55 60 Thr Arg Leu Ile Phe Val Phe Leu Val Gln Lys Glu Phe His His 65 70 75 Val Asp Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser Asp Trp Pro 80 85 90 Thr Trp Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His Cys 95 100 105 Ser Pro Ala Tyr Glu Val Val Phe Ala Val Lys Gln Gln Phe Gly 110 115 120 Asn Glu Ala Phe Leu Arg Ser Ser Val 125 126 142 PRT Homo sapiens misc_feature Incyte ID No LI765245.5.orf32001JAN12 126 Pro Ala Arg Pro Pro Ala Met Ser Ser Thr Gln Phe Gln Gln Gly 1 5 10 15 Pro Ser Val Arg Ala Val Gly Arg Gly Gln Glu Pro Ala Ser Cys 20 25 30 Pro Asn Met Thr Pro Arg Arg Arg Gln Ser Ser Ala Pro Gly Ser 35 40 45 Arg Glu Leu Asn Gly Leu Ser Lys Arg Pro Arg Ile Pro Glu Gly 50 55 60 Pro Glu Gly Trp Asp Tyr Leu Met His Thr Gln Gly Gln Ala Thr 65 70 75 Thr Arg Val Arg Pro Gln Asp Gln Pro Leu His Ala Glu Leu Ala 80 85 90 Pro Ala Arg Ile Thr Leu Ser Asn Phe Ile Lys Ala Met Val Ser 95 100 105 Tyr Gly Met Asn Pro Val Asp Leu Phe Glu Ala Asn Arg Pro Val 110 115 120 Met Arg Val Gly Thr Met Thr Gln Phe Gln Val Ser Leu Ser Arg 125 130 135 Pro Gly Gly Glu Gly Gln Asp 140 127 68 PRT Homo sapiens misc_feature Incyte ID No LI335608.2.orf32001JAN12 127 Met Tyr Thr Cys Ile Glu Lys Ala Trp Lys Asn Ala Pro Glu Thr 1 5 10 15 Phe Thr Val Ile Phe Trp Val Gly Ser Asp Lys Arg Ala Leu Pro 20 25 30 Leu Phe Val Met Val Ser Phe Cys Ile Thr Glu Cys Thr Met Tyr 35 40 45 Tyr Leu Cys Lys Lys Phe Tyr Pro His Thr Val Phe Thr Leu Thr 50 55 60 Ile Gly Val Gln Tyr Phe Ile Val 65 128 88 PRT Homo sapiens misc_feature Incyte ID No LI405795.1.orf32001JAN12 128 Ile Val Ser Lys Thr Val Asn Thr Thr Asp Lys Gln His Phe Pro 1 5 10 15 Lys Val Asn Pro His Ser Lys Leu Gly Lys Val Ser Asn Thr Phe 20 25 30 Lys Lys Gln Ile Tyr Ile Phe Leu Lys Tyr Asp Ala Leu Ala Tyr 35 40 45 Cys Phe Leu Lys Ala Phe Cys Val Trp Ala Phe Phe Tyr Trp Phe 50 55 60 Arg Val Asn Phe Met Gly Ser Met Ser Thr Lys Asn Ser Val Tyr 65 70 75 Ile Tyr Cys Phe Asn Val Thr His Tyr Ile Gly Val Phe 80 85 129 85 PRT Homo sapiens misc_feature Incyte ID No LI014872.1.orf32001JAN12 129 Asn Leu Lys Lys Ile Met Ile Phe Ala Met Asp Gln Ser Gln Phe 1 5 10 15 Asn Ser Ser Leu Arg Ser Glu Phe Arg Ser Tyr Leu Lys Ala Leu 20 25 30 Pro Leu Leu Glu Ile Arg Ser Lys Asp Leu Ser Asp Asn Ser Ser 35 40 45 Tyr Gly Leu Cys Gly Arg Trp Gln Ile Gln Pro Lys Glu Arg Ser 50 55 60 Ser Gly Ile Leu Gln Phe His Ile Lys Leu His Val Ser Met Trp 65 70 75 His Trp Gly Asn Gly Arg Asn Ser Gln Cys 80 85 130 112 PRT Homo sapiens misc_feature Incyte ID No LI239245.3.orf32001JAN12 130 Ala Pro Ala Val Leu Ser Leu Pro Arg Ala Tyr Pro Trp Gln Pro 1 5 10 15 His Asn Ser Gly Glu Val Leu Tyr Pro Glu Cys Pro His Phe Thr 20 25 30 Asp Glu Asp Ile Glu Glu Lys Arg Leu Thr Gln Gly Ser His Ser 35 40 45 Ser Ser Ala Cys Ser Arg Gly Leu Val Gln Cys Val Phe Phe Ala 50 55 60 Thr Ser Leu Ser Leu Gln Trp Gln Leu Gln Lys Thr Glu Ala Val 65 70 75 Ala Phe Ile Pro Lys Leu His Pro Gln Arg Lys Pro Gln Glu Gly 80 85 90 Gly Trp Gly Gln Leu Ile Lys Ser Leu Lys Cys Gln Ala Lys Glu 95 100 105 Trp Met Pro Pro Val Ile Ile 110 131 206 PRT Homo sapiens misc_feature Incyte ID No LI142384.5.orf32001JAN12 131 Arg Phe Ser Val Val Ala Gly Ala Gly Gly Ser Ser Gly Arg Ser 1 5 10 15 Gly Ser Ala Asp Val Leu Pro Ser Ser Pro Gly Ile Ala Lys Gln 20 25 30 Arg Trp Arg Arg Val Arg Ala Glu Glu Ala Ala Thr Ala Gly Ala 35 40 45 Gly Ala Ala Gly Pro Gly Ala Met Gln Leu Leu Leu Val Leu Leu 50 55 60 Ala Leu Ala Ala Ala Ala Ala Gly Ser Gly Arg Leu Ser Cys Leu 65 70 75 Asp Val Trp Ala Ala Ala Ala Glu Cys Gly Arg Gly Leu Gly Ala 80 85 90 Arg Gly Ala Ala Trp Leu Arg Cys Pro Gly Ser Arg Pro Gln Pro 95 100 105 Leu Pro Thr Gly Pro Arg Cys Ile Ser His Trp Arg Pro His Ala 110 115 120 Gln Leu Arg Leu Gly Arg Thr Ser Ala Pro Ser Arg Ser Val Tyr 125 130 135 Ser Gly Ser Ser Gly Ile Ser Cys Pro Phe Ile Arg Ser Leu Leu 140 145 150 Gln Glu Cys Ser Tyr Val Pro Asp Thr Val Asp Met Thr Lys Ile 155 160 165 His Ala Leu Ile Thr Gly Pro Phe Asp Thr Pro Tyr Glu Gly Gly 170 175 180 Phe Phe Leu Tyr Val Phe Arg Cys Pro Pro Asp Tyr Pro Ile Pro 185 190 195 Pro Thr Ser Gly Gln Thr Asp Asp Asn Gly Gln 200 205 132 56 PRT Homo sapiens misc_feature Incyte ID No LI2068768.1.orf32001JAN12 132 Ile Leu Met Gly Pro Ala Trp Trp Leu Thr Pro Leu Ile Leu Thr 1 5 10 15 Leu Trp Glu Ala Thr Gly Gly Arg Ile Thr Arg Ser Arg Asp Arg 20 25 30 Asp His Pro Cys Pro His Gly Glu Thr Pro Ser Leu Leu Lys Met 35 40 45 Pro Lys Leu Ala Gly Cys Gly Gly Ala Cys Leu 50 55 133 171 PRT Homo sapiens misc_feature Incyte ID No LI2118074.1.orf32001JAN12 133 Pro Ser Leu Pro Cys Trp Leu Pro Gly Ala Ala Ala Glu Ser Ser 1 5 10 15 Gly Val Asp Ala Ala Trp Glu Glu Ala Ile Gly Arg Tyr Ile Thr 20 25 30 Gly Leu Ala Phe Thr Met Ala Gly Gly Arg Pro His Leu Lys Arg 35 40 45 Ser Phe Ser Ile Ile Pro Cys Phe Val Phe Val Ala Gly Ser Phe 50 55 60 Cys Tyr Asp Ser Thr Tyr Ala Lys Pro Tyr Pro Gly Pro Glu Ala 65 70 75 Ala Ser Arg Val Pro Pro Ala Leu Val Tyr Ala Leu Val Thr Ala 80 85 90 Gly Pro Thr Leu Thr Ile Leu Leu Gly Glu Leu Ala Arg Ala Phe 95 100 105 Phe Pro Ala Pro Pro Ser Ala Val Pro Val Ile Gly Glu Ser Thr 110 115 120 Ile Val Ser Gly Ala Cys Cys Arg Phe Ser Pro Pro Val Arg Arg 125 130 135 Leu Val Arg Phe Leu Gly Val Tyr Ser Phe Gly Leu Phe Thr Thr 140 145 150 Thr Ile Phe Ala Asn Ala Gly Gln Val Val Thr Gly Asn Pro Thr 155 160 165 Pro His Phe Leu Ser Val 170 134 101 PRT Homo sapiens misc_feature Incyte ID No LI1189068.4.orf22001JAN12 134 Cys Ser Leu Phe Tyr Lys Ala Phe Leu Leu Pro Asp Arg Asn Trp 1 5 10 15 Leu Met Cys Ser Cys Val Arg Ala Asp Cys Phe Asp Asp Pro Tyr 20 25 30 Ser Trp Ser Pro Leu Tyr Pro Ser Leu Phe Ala Tyr Asn Ile Val 35 40 45 Val Pro Ser His Ser Asp Ala Gly Thr Arg His Val Asp Leu Phe 50 55 60 Leu Ala Asn Glu Met Ser Ile Tyr Met Lys Gln Thr Gly Ser Phe 65 70 75 Lys Gly Gly Leu Pro Ser Cys Ser Leu Pro Val Pro Met Arg Thr 80 85 90 Trp Leu Ile Ser Trp Arg Val Tyr Val Asp Val 95 100 135 186 PRT Homo sapiens misc_feature Incyte ID No LI2118704.1.orf12001JAN12 135 Gly Ala Leu Arg Pro Gly Arg Cys Thr Val Gly Ala Cys Leu Trp 1 5 10 15 Ser Gly Gln Gly Arg Ser Gln Leu Pro Trp Leu Ala Glu Arg Cys 20 25 30 Gly Gly Arg Gly Ala Gly Gly Asn Gln Gly Cys Ala Trp Gly Ser 35 40 45 Gln Ala Ser Met Ser Ser Gly Trp Val Gly Ala Gly Leu Val Gly 50 55 60 Pro Ala Leu Gly Glu Ala Ser Pro Cys His Trp Pro Gln Ala Val 65 70 75 Arg Gly Leu Ser Thr Gln Thr Ser Ser Cys Arg Gly Cys Ala Arg 80 85 90 Ser Pro Arg Ser Ala Ser Leu Met Ala Leu Cys Ser Asn Ser Cys 95 100 105 Trp Ala Ser Ala Ala Ser Pro Gln Gly Arg Ala Arg Asp Leu Leu 110 115 120 Pro Thr Met Pro Glu Pro Pro Leu Pro Thr Val Gly Ser Cys Val 125 130 135 Ala Gln Ala Ser Pro Thr Ser Thr Ala Pro Cys Ser Val Ala Pro 140 145 150 Gly Pro Ile Asp Gln Pro Arg Ala Lys Gly Cys Arg Cys Thr Val 155 160 165 Trp Asp Leu Gln Ala Ala Leu Pro Val Ala Leu Val Trp Asp Pro 170 175 180 Leu Gly Glu Ala Ser Trp 185 136 95 PRT Homo sapiens misc_feature Incyte ID No LI031700.2.orf32001JAN12 136 Pro Pro Glu Thr His Ser Ala Leu Ala Leu Thr Cys Leu Leu Ile 1 5 10 15 Gly Gly Trp Leu Leu Arg Ile Met Thr Ser Arg Thr Pro Leu Leu 20 25 30 Val Thr Ala Cys Leu Tyr Tyr Ser Tyr Cys Asn Ser Arg His Leu 35 40 45 Gln Gln Gly Cys Glu Lys Asn Val Lys Asp Gln Tyr Phe His Ile 50 55 60 Ser Gln Val Pro Glu Thr Gln Lys Thr Glu His Pro Pro Arg Val 65 70 75 Ser Gly Ala Arg Ala Gly His Arg Ala His Val Ala Ile Leu Met 80 85 90 Gly Cys Leu Pro Gln 95 137 81 PRT Homo sapiens misc_feature Incyte ID No LI2120122.1.orf12001JAN12 137 Trp Leu Cys Ala Tyr Phe Leu Leu Val Thr Arg Gly Lys Met Phe 1 5 10 15 Glu Asn Cys Tyr Leu Leu Ile Tyr Lys Asn Val Pro Leu Asn Asn 20 25 30 Phe Pro Ser Leu Thr Ile Phe Arg Asn Gly Ser Lys Val Leu Pro 35 40 45 Ile Gly Thr Trp Ile Leu Trp Asp Lys Trp Lys Glu Tyr Asp Thr 50 55 60 Glu Phe Phe Cys Leu Glu Phe Gln Gly Thr Arg Ala His Tyr Arg 65 70 75 Leu Lys Phe Cys Ala Val 80 138 73 PRT Homo sapiens misc_feature Incyte ID No LI816174.1.orf12001JAN12 138 Ile Cys Ser Asn Leu Asn Ser Phe Leu Leu Arg Arg Lys Asn Leu 1 5 10 15 Thr Glu Gly His Lys Ala Glu Gly Gly Thr Glu Ala Ser Phe Arg 20 25 30 Ala Thr Val Lys Val Tyr Tyr Ala Leu Xaa Trp Ala Gln Trp Leu 35 40 45 Met Pro Val Ile Pro Ala Phe Trp Glu Ala Glu Ala Gly Gly Leu 50 55 60 Leu Gly Val Gly Ser Ser Arg Pro Ala Trp Pro Ser Xaa 65 70 139 101 PRT Homo sapiens misc_feature Incyte ID No LI1189569.11.orf22001JAN12 139 Glu Ala Val Ser Asp Val His Phe Val Pro Ser Gln Gly Asn Gly 1 5 10 15 Ser Leu Glu Arg Leu Gly Ser Ala Cys Gly Ser Pro Gln Ser Gly 20 25 30 Thr Asn Gln Lys Ala Gly Asp Leu Arg Pro Trp His Gln Ala Val 35 40 45 Leu Pro Pro Gln Pro Gly Asp Ser Leu Gln Leu Asn Asp Ser Tyr 50 55 60 Phe Pro Thr Ser Ile Ile Tyr Pro Ser Ser Ala Gln Ile Lys Trp 65 70 75 Gly Thr Gly Arg Lys Asn Arg Ser His Leu Ile Phe Ala Cys Val 80 85 90 Leu Ile Tyr Arg Ser Lys Lys Val Thr Gly Ser 95 100 140 103 PRT Homo sapiens misc_feature Incyte ID No LI413584.1.orf12001JAN12 140 Ser Thr Arg Thr Pro Arg Arg Thr Leu Glu Glu Leu Thr Lys Ala 1 5 10 15 Leu Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr Cys Gln Arg Ala 20 25 30 Tyr Cys His Ile Leu Leu Gly Asn Tyr Cys Val Ala Val Ala Asp 35 40 45 Ala Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr Ala Met 50 55 60 Leu Arg Lys Gly Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala Ala 65 70 75 Ala Leu Asp Arg Phe Tyr Ser Leu Leu Thr Pro Gln Cys Leu Glu 80 85 90 Gln Cys Leu Gly Cys Ser Arg Tyr Leu Ile Ser Ile Cys 95 100 141 94 PRT Homo sapiens misc_feature Incyte ID No LI791042.1.orf22001JAN12 141 Ser Cys Val His Arg Thr Ala Ser Leu Ile Pro Pro Leu Pro Pro 1 5 10 15 Gly Ser Cys Lys Tyr Ser Pro Leu Leu Pro Leu Asn Ser Val Val 20 25 30 Phe Arg Arg Thr Val Ile Thr Leu Met Ser Leu Ile His Pro Phe 35 40 45 Ile Leu Leu Gly Leu Ser Ser Leu Pro Tyr Phe Leu Gln Gln Gly 50 55 60 Phe Thr Lys Ser Pro Pro Pro Leu Arg Pro Ser Pro Lys Lys Leu 65 70 75 Val Ile Pro Thr Ile Phe Cys Leu Val Ile Leu Leu Phe Ser Ile 80 85 90 Leu Asn Tyr Leu 142 98 PRT Homo sapiens misc_feature Incyte ID No LI1167140.1.orf32001JAN12 142 Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Glu 1 5 10 15 Pro Pro Leu Pro Ala Leu Leu Asp Tyr Ile Gln Tyr Asn Ser Tyr 20 25 30 Trp Lys Glu Ile Leu Gln Val Arg Ala Met Trp Gln Asn Leu Thr 35 40 45 Thr Leu Leu His Arg Lys Ala Phe Met Phe Glu Lys Asn Tyr Thr 50 55 60 Asn Thr Asp Cys Glu Lys Asp Ile Asn Ile Cys Leu His Leu Asn 65 70 75 Thr Arg Glu Phe Ile Leu Asn Lys Ser Lys Ile Arg Ala Ile Thr 80 85 90 Val Lys Arg Ser Phe Arg Lys Ile 95 143 70 PRT Homo sapiens misc_feature Incyte ID No LI054831.1.orf22001JAN12 143 Arg His Thr Gln Asp Arg Val Ile Tyr Lys Gly Lys Arg Phe Asp 1 5 10 15 Gly Leu Arg Phe Arg Val Ala Arg Glu Val Ser Gln Ser Trp Gln 20 25 30 Lys Met Lys Glu Glu Gln Arg Asp Val Leu His Glu Ser Val Cys 35 40 45 Ala Glu Lys Leu Pro Phe Ile Lys Pro Ser Asp Phe Met Arg Leu 50 55 60 Ile Tyr Tyr Gln Glu Lys Asp Pro Leu Pro 65 70 144 247 PRT Homo sapiens misc_feature Incyte ID No LI1175083.1.orf22001JAN12 144 Arg Arg Cys Ala Ala Glu Ala Ala Leu Pro Val Cys Gly Lys Ala 1 5 10 15 Gly Ser Thr Pro Gly Arg Arg Val Ala Ala Asp Ile Met Ser Ser 20 25 30 Gly Asn Tyr Gln Gln Ser Glu Ala Leu Ser Lys Pro Thr Phe Ser 35 40 45 Glu Glu Gln Ala Ser Ala Leu Val Glu Ser Val Phe Gly Leu Lys 50 55 60 Val Ser Lys Val Arg Pro Leu Pro Ser Tyr Asp Asp Gln Asn Phe 65 70 75 His Val Tyr Val Ser Lys Thr Lys Asp Gly Pro Thr Glu Tyr Val 80 85 90 Leu Lys Ile Ser Asn Thr Lys Ala Ser Lys Asn Pro Asp Leu Ile 95 100 105 Glu Val Gln Asn His Ile Ile Met Phe Leu Lys Ala Ala Gly Phe 110 115 120 Pro Thr Ala Ser Val Cys His Thr Lys Gly Asp Asn Thr Ala Ser 125 130 135 Leu Val Ser Val Asp Ser Gly Ser Glu Ile Lys Ser Tyr Leu Val 140 145 150 Arg Leu Leu Thr Tyr Leu Pro Gly Arg Pro Ile Ala Glu Leu Pro 155 160 165 Val Ser Pro Gln Leu Leu Tyr Glu Ile Gly Lys Leu Ala Ala Lys 170 175 180 Leu Asp Lys Thr Leu Gln Arg Phe His His Pro Lys Leu Ser Ser 185 190 195 Leu His Arg Glu Asn Phe Ile Trp Asn Leu Lys Asn Val Pro Leu 200 205 210 Leu Glu Lys Tyr Leu Tyr Ala Leu Gly Gln Asn Arg Asn Arg Glu 215 220 225 Ile Val Glu His Val Ile His Leu Phe Lys Glu Glu Val Met Thr 230 235 240 Lys Leu Ser His Phe Arg Glu 245 145 79 PRT Homo sapiens misc_feature Incyte ID No LI2122897.2.orf22001JAN12 145 Asp Arg Arg Lys Thr Ala Leu Trp Trp Glu Val Arg His Val Cys 1 5 10 15 Ser Asn Ala Ala Leu Leu Phe Phe Thr Pro Leu Arg Cys Leu Gly 20 25 30 Gly Glu Lys His Lys Ser Gly Leu Arg Ala His Leu Val Ile Val 35 40 45 Leu Ser Leu Glu Leu Asn Tyr Asp Ile Asp Ser Phe Ala His Met 50 55 60 Phe Phe Ala Asp Leu Leu Leu Ile Ile Thr Leu Leu Ser Cys Tyr 65 70 75 Ile Pro Phe Cys 146 56 PRT Homo sapiens misc_feature Incyte ID No LI2053195.3.orf32001JAN12 146 Gln Tyr Thr Leu Pro Ala Leu Val Ile Met Tyr Phe Val Ile Phe 1 5 10 15 Pro His Pro Cys Glu Cys Thr Leu Tyr Asn Thr Pro Ser Pro Pro 20 25 30 Leu Arg Arg Tyr Phe Val Ile Cys Ser Pro Thr Leu Lys Lys Val 35 40 45 Leu Cys Asn Val Leu Pro Thr Leu Cys Thr Leu 50 55 147 208 PRT Homo sapiens misc_feature Incyte ID No LI439397.6.orf22001JAN12 147 Arg Val Pro Leu Thr Ser Arg Pro Glu Asp Thr Thr His Asn Arg 1 5 10 15 Arg Ser Arg Gly Met Val Gln Ser Ser Gly Phe Glu Leu Ser Tyr 20 25 30 Leu Glu Lys Val Ser Glu Val Lys Asp Thr Val Arg Arg Gln Ser 35 40 45 Leu Leu His His Leu Cys Ser Leu Val Leu Gln Thr Arg Pro Glu 50 55 60 Ser Ser Asp Leu Tyr Ser Glu Ile Pro Ala Leu Thr Arg Cys Ala 65 70 75 Lys Val Asp Phe Glu Gln Leu Thr Glu Asn Leu Gly Gln Leu Glu 80 85 90 Arg Arg Ser Arg Ala Ala Glu Glu Ser Leu Arg Ser Leu Ala Lys 95 100 105 His Glu Leu Ala Pro Ala Leu Arg Ala Arg Leu Thr His Phe Leu 110 115 120 Asp Gln Cys Ala Arg Arg Val Ala Met Leu Arg Ile Val His Arg 125 130 135 Arg Val Cys Asn Arg Phe His Ala Phe Leu Leu Tyr Leu Gly Tyr 140 145 150 Thr Pro Gln Ala Ala Arg Glu Val Arg Ile Met Gln Phe Cys His 155 160 165 Thr Leu Arg Glu Phe Ala Leu Glu Tyr Arg Thr Cys Arg Glu Arg 170 175 180 Val Leu Gln Gln Gln Gln Lys Gln Ala Thr Tyr Arg Glu Arg Asn 185 190 195 Lys Thr Gln Ala Gly Glu Met Leu Thr Val Met Leu Val 200 205 148 104 PRT Homo sapiens misc_feature Incyte ID No LI816379.6.orf22001JAN12 148 Gly Gly Leu Ala Glu Val Arg Lys Cys Ile His Phe Gly Ala Lys 1 5 10 15 Thr Arg Asp Leu Leu Gly Gly Cys Arg Ser Ala Leu Ser Ser Asn 20 25 30 Pro Ala Ser Cys Ile Leu Pro Pro Trp Ser Gln Asp Asp Trp Pro 35 40 45 Asp Ile Thr Ser Asp Leu Arg Pro Ala Ser Ser Ile Ser Gln Ser 50 55 60 Leu Thr Pro Lys Val Pro Ala His Cys Ser Val Leu Asn Asn Cys 65 70 75 Arg Cys Phe Leu Ser Ser Leu Val Ser Met Ser Thr Leu Ile Phe 80 85 90 His Asn Phe Leu Phe Ile Ser Tyr Ser Asp Ile Ala Leu Trp 95 100 149 73 PRT Homo sapiens misc_feature Incyte ID No LI2123452.4.orf32001JAN12 149 Ile Leu Ser Pro Thr Thr Ile Ala Asn Ile Pro Phe Leu Ser Ala 1 5 10 15 Gly Gln Phe Phe Cys Gly Asn Lys Tyr Cys Asp Lys Lys Glu Gly 20 25 30 Leu Lys Ser Trp Glu Val Asn Phe Gly Tyr Ile Glu His Gly Glu 35 40 45 Lys Arg Asn Ala Leu Val Lys Leu Arg Leu Cys Gln Glu Cys Ser 50 55 60 Ile Lys Leu Asn Phe His Arg Gln Glu Lys Arg Met Met 65 70 150 81 PRT Homo sapiens misc_feature Incyte ID No LI474559.8.orf32001JAN12 150 Thr Ala Gly Asn Ser Leu Asp Lys Gly Leu Gly Ala Ser Glu Asn 1 5 10 15 Phe Pro Thr Arg Leu Pro Gln Arg Asp Phe Pro Thr Arg Lys Asp 20 25 30 Ala Pro Gln Lys Pro Ala Ser Leu Gly Gly Asp Phe Leu Ala Pro 35 40 45 Trp Ala Leu Ala Arg Gly Pro Tyr Glu Phe Lys Val Phe Phe Ile 50 55 60 Trp His Tyr Ala Glu His Leu Arg Gly Pro Arg Leu Thr Trp Arg 65 70 75 Val Asn Tyr Trp Arg Leu 80 151 158 PRT Homo sapiens misc_feature Incyte ID No LI1089871.1.orf32001JAN12 151 Asp Arg Gly Asn Ser Cys Asp Ser Ser Ser Lys Ser Arg Asn Arg 1 5 10 15 Gly Trp Lys Pro Met Arg Glu Thr Leu Asn Val Asp Ser Ile Phe 20 25 30 Ser Glu Ser Glu Lys Arg Gln His Ser Pro Arg His Lys Pro Asn 35 40 45 Ile Ser Asn Lys Pro Lys Ser Ser Lys Asp Pro Ser Phe Ser Asn 50 55 60 Trp Pro Lys Glu Asn Pro Lys Gln Lys Gly Leu Met Thr Ile Tyr 65 70 75 Glu Asp Glu Met Lys Gln Glu Ile Gly Ser Arg Ser Ser Leu Glu 80 85 90 Ser Asn Gly Lys Gly Ala Glu Lys Asn Lys Gly Leu Val Glu Gly 95 100 105 Lys Val His Gly Asp Asn Trp Gln Met Gln Arg Thr Glu Ser Gly 110 115 120 Tyr Glu Ser Ser Asp His Ile Ser Asn Gly Ser Thr Asn Leu Asp 125 130 135 Ser Pro Val Ile Asp Gly Asn Gly Thr Val Met Asp Ile Ser Gly 140 145 150 Val Lys Glu Thr Val Cys Phe Arg 155 152 84 PRT Homo sapiens misc_feature Incyte ID No LI289608.1.orf32001JAN12 152 Gly Thr Arg Ile Leu Asn Ser Gly Gly Gly Gly Cys Ser Glu Pro 1 5 10 15 Arg Ser His His Cys Thr Pro Ala Trp Val Thr Glu Thr Leu Ser 20 25 30 Gln Lys Gln Thr Lys Thr Gly Met Thr Asp Thr Ile Cys Thr Tyr 35 40 45 Leu Tyr Leu Tyr Ile Asn Ile Tyr Lys Glu Ser Tyr Ala His Met 50 55 60 His Asp Thr Cys Ile Tyr Met Ile His Arg Cys His Thr Trp Leu 65 70 75 Tyr Ser Asn Gly Tyr Pro Trp Tyr Ala 80 

What is claimed is:
 1. An isolated polynucleotide selected from the group consisting of: a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of NO:1-75, b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of NO:1-75, c) a polynucleotide complementary to the polynucleotide of a), d) a polynucleotide complementary to the polynucleotide of b), and e) an RNA equivalent of a)-d).
 2. An isolated polynucleotide of claim 1, comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-75.
 3. An isolated polynucleotide comprising at least 60 contiguous nucleotides of a polynucleotide of claim
 1. 4. A composition for the detection of expression of secretory polynucleotides comprising at least one of the polynucleotides of claim 1 and a detectable label.
 5. A method for detecting a target polynucleotide in a sample, said target polynucleotide having a sequence of a polynucleotide of claim 1, the method comprising: a) amplifying said target polynucleotide or fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof.
 6. A method for detecting a target polynucleotide in a sample, said target polynucleotide comprising a sequence of a polynucleotide of claim 1, the method comprising: a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide or fragments thereof, and b) detecting the presence or absence of said hybridization complex, and, optionally, if present, the amount thereof.
 7. A method of claim 5, wherein the probe comprises at least 30 contiguous nucleotides.
 8. A method of claim 5, wherein the probe comprises at least 60 contiguous nucleotides.
 9. A recombinant polynucleotide comprising a promoter sequence operably linked to a polynucleotide of claim
 1. 10. A cell transformed with a recombinant polynucleotide of claim
 9. 11. A transgenic organism comprising a recombinant polynucleotide of claim
 9. 12. A method for producing a secretory polypeptide, the method comprising: a) culturing a cell under conditions suitable for expression of the secretory polypeptide, wherein said cell is transformed with a recombinant polynucleotide of claim 9, and b) recovering the secretory polypeptide so expressed.
 13. A purified secretory polypeptide (SPTM) encoded by at least one of the polynucleotides of claim
 2. 14. An isolated antibody which specifically binds to a secretory polypeptide of claim
 13. 15. A method of identifying a test compound which specifically binds to the secretory polypeptide of claim 13, the method comprising the steps of: a) providing a test compound; b) combining the secretory polypeptide with the test compound for a sufficient time and under suitable conditions for binding; and c) detecting binding of the secretory polypeptide to the test compound, thereby identifying the test compound which specifically binds the secretory polypeptide.
 16. A microarray wherein at least one element of the microarray is a polynucleotide of claim
 3. 17. A method for generating a transcript image of a sample which contains polynucleotides, the method comprising the steps of: a) labeling the polynucleotides of the sample, b) contacting the elements of the microarray of claim 16 with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample.
 18. A method for screening a compound for effectiveness in altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide sequence of claim 1, the method comprising: a) exposing a sample comprising the target polynucleotide to a compound, under conditions suitable for the expression of the target polynucleotide, b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the compound and in the absence of the compound.
 19. A method for assessing toxicity of a test compound, said method comprising: a) treating a biological sample containing nucleic acids with the test compound; b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide of claim 1 under conditions whereby a specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence of a polynucleotide of claim 1 or fragment thereof; c) quantifying the amount of hybridization complex; and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound.
 20. An array comprising different nucleotide molecules affixed in distinct physical locations on a solid substrate, wherein at least one of said nucleotide molecules comprises a first oligonucleotide or polynucleotide sequence specifically hybridizable with at least 30 contiguous nucleotides of a target polynucleotide, said target polynucleotide having a sequence of claim
 1. 21. An array of claim 20, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 30 contiguous nucleotides of said target polynucleotide.
 22. An array of claim 20, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 60 contiguous nucleotides of said target polynucleotide
 23. An array of claim 20, which is a microarray.
 24. An array of claim 20, further comprising said target polynucleotide hybridized to said first oligonucleotide or polynucleotide.
 25. An array of claim 20, wherein a linker joins at least one of said nucleotide molecules to said solid substrate.
 26. An array of claim 20, wherein each distinct physical location on the substrate contains multiple nucleotide molecules having the same sequence, and each distinct physical location on the substrate contains nucleotide molecules having a sequence which differs from the sequence of nucleotide molecules at another physical location on the substrate.
 27. An isolated polypeptide selected from the group consisting of: a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, b) a naturally occurring polypeptide comprising an amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:76-152.
 28. An isolated polypeptide of claim 27, comprising a polypeptide sequence selected from the group consisting of SEQ ID NO:76-152. 